Antiseptic ointment for udder

FIELD: agriculture, animal husbandry, organic chemistry.

SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.

EFFECT: valuable antiseptic properties of ointment.

2 cl, 1 tbl, 22 ex

 

The present invention relates to the field of agriculture, mainly animal and can be used for sanitary treatment of the udder of lactating cows in prevention and rapid healing of external damage to the udder and teats (crack initiation), prevention of mastitis, increased cleanliness of milk on microbiological indicators.

Known antiseptic agent containing as an antimicrobial Quaternary ammonium compounds [1, 2]. However, destroying the majority located on the surface of the udder Nesporova microorganisms, some funds are poorly effective against Pseudomonas aeruginosa causing mastitis propagating in violation of milking hygiene [3]. The technical effect of the invention is the enhancement of antimicrobial activity, the expansion of the spectrum of antibacterial action while reducing the irritating properties with respect to the skin of the udder.

The technical effect is achieved by the fact that antiseptic ointment containing the active agent, cationic surface-active compound, lower glycols, glycols and water, characterized in that it further comprises monopoloy ether of ethylene glycol and higher polyethylene glycols, in the following ratio com is onenow, wt.%:

Cationic surface-active compound is 0.01 to 3.0

Monopoloy ether of ethylene glycol 0,05-2,0

The lower glycol 20-30

Glycerin 15-25

The highest glycol 15-30

Water - the rest

The technical effect is achieved also in antiseptic ointments that as cationic surface-active compounds using N-alkyl-N-alkoxycarbonylmethyl chloride, or alkyldimethylbenzylammonium chloride or pyridinium bromide or pyridinium chloride, or 1,2-ethylenebis(N-methylcarbamoylmethyl)ammonium dichloride, or ethylhexylacrylate chloride or chlorhexidine.

The technical effect is achieved also in antiseptic ointments that as the lower use glycol 1,2-propylene glycol, or polyethylene glycol 300, or polyethylene glycol 400.

The technical effect is achieved also in antiseptic ointments that as the highest use of polyethylene glycol polyethylene glycol 1500, or polyethylene glycol 3000, or polyethylene glycol 4000 or peg 6000.

Quaternary (bischetvertichnoe) ammonium germicidal compounds and other cationic surfactants used in medicine and veterinary medicine as self medication, and as active components in the composition with asevich antiseptics outdoor applications [4, 5].

Monopoloy ether of ethylene glycol (MPAA) - viscous colorless liquid, refers to non-toxic substances, well tolerated integumentary tissues of humans and animals. Used as a fixative and solvent perfumes in perfume and cosmetic industry, as well as friendly solvent inks for ballpoint pens and felt-tip pens [6, 7].

Glycerin is a trivalent aliphatic alcohol series, not with General and local toxic properties for humans and animals, has a diverse application in various industries, is used as a component of perfumes, cosmetics and pharmaceuticals [8].

Glycols (polypropylenglycol, propylene glycols, triethylene glycol) permitted for use in medicine, veterinary and life[9, 10, 11].

The polyethylene glycol (PEG, polyethylene oxides) have antimicrobial properties, are easily mixed with each other, have no taste and smell. Oral, intravenous and intramuscular do not show toxicity to warm-blooded. PEG with a molecular weight of 300, 1500 (mix), 4000, 5000, 6000 included in the Pharmacopoeia of the United States and several European countries (England, Germany, and others). We have allowed the PEG - 400, PEG - 1500 and PEG - 4000 [11].

In the scientific and patent literature is not well-known technical solutions similar to the claimed, i.e. predlozhenietaiwan the criterion of “novelty”.

We first established that the use of only the above-mentioned components in the claimed amounts to produce the claimed technical effect of the increase in bactericidal activity, the expansion of the spectrum, reducing annoying and General toxic properties, i.e. the proposal meets the criterion of “significant differences”.

The present invention solves the current problem of veterinary medicine to fight mastitis in cattle, i.e. the proposed solution meets the criterion of “industrial applicability”.

The invention is illustrated in the following examples.

Example 1. Antiseptic ointment is prepared by mixing 0.01 g of N-alkyl-N-alkoxycarbonylmethyl chloride and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of propylene glycol - 1,2 and homogenized. Then make a mixture of 15 g of polyethylene glycol 3000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, thus obtaining the structure 1 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest

Example 2. Antiseptic ointment is prepared by mixing 3.0 g of N-and the Kil-N-alkoxycarbonylmethyl chloride and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin, to the obtained mixture is added 30 g of propylene glycol - 1,2 and homogenized. Then make a mixture of 30 g of polyethylene glycol 3000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 2 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 3. Antiseptic ointment is prepared by mixing 1.5 g of N-alkyl-N-alkoxycarbonylmethyl chloride and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of propylene glycol - 1,2 and homogenized. Then make a mixture of 25 g of polyethylene glycol 3000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 3 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 4. Antiseptic ointment is prepared by mixing 0.01 g of alkyldimethylbenzylammonium chloride and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of al is of langille 300 and homogenized. Then make a mixture of 15 g of polyethylene glycol 1500, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 4 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest

Example 5. Antiseptic ointment is prepared by mixing 3.0 g of alkyldimethylbenzylammonium chloride and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 300 and homogenized. Then make a mixture of 30 g of polyethylene glycol 1500, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 5 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 6. Antiseptic ointment is prepared by mixing 1.5 g of alkyldimethylbenzylammonium chloride and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of polyethylene glycol 300 and homogenized. Then make a mixture of 25 g of polyethylene glycol 1500, again with eshivot and constant rotation of the agitator bring water to the mixture to 100 g, while receiving structure 6 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 7. Antiseptic ointment is prepared by mixing 0.01 g of cetylpyridinium bromide and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of polyethylene glycol 400 and homogenized. Then make a mixture of 15 g of polyethylene glycol 4000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 7 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest.

Example 8. Antiseptic ointment is prepared by mixing 3.0 g of cetylpyridinium bromide and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 400 and homogenized. Then make a mixture of 30 g of polyethylene glycol 4000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 8 with the following ratio of components, wt.%:

Cation the e surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 9. Antiseptic ointment is prepared by mixing 1.5 g of cetylpyridinium bromide and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of polyethylene glycol 400 and homogenized. Then make a mixture of 25 g of polyethylene glycol 4000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 9 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 10. Antiseptic ointment is prepared by mixing 0.01 g of cetylpyridinium chloride and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of polyethylene glycol 400 and homogenized. Then make a mixture of 15 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, thus obtaining the structure 10 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

In SSI polyethylene glycol 15

Water - the rest

Example 11. Antiseptic ointment is prepared by mixing 3.0 g of cetylpyridinium chloride and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 400 and homogenized. Then make a mixture of 30 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 11 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 12. Antiseptic ointment is prepared by mixing 1.5 g of cetylpyridinium chloride and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of polyethylene glycol 400 and homogenized. Then make a mixture of 25 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, thus obtaining the structure 12 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 13. Antiseptic ointment is prepared by mixing 0.01 to the 1,2-ethylenebis(N-methylcarbamoylmethyl)ammonium dichloride and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin, to the resulting mixture are added 20 g of polyethylene glycol 400 and homogenized. Then make a mixture of 15 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 13 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest

Example 14. Antiseptic ointment is prepared by mixing 3.0 g of 1,2-ethylenebis(N-methylcarbamoylmethyl)ammonium dichloride and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 400 and homogenized. Then make a mixture of 30 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 14 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 15. Antiseptic ointment is prepared by mixing 1.5 g of 1,2-ethylenebis(N-methylcarbamoylmethyl)ammonium dichloride and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerol, obtained from the thou add 25 g of polyethylene glycol 400 and homogenized. Then make a mixture of 25 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 15 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 16. Antiseptic ointment is prepared by mixing 0.01 g of ethylhexylacrylate chloride and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of polyethylene glycol 400 and homogenized. Then make a mixture of 15 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 16 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest

Example 17. Antiseptic ointment is prepared by mixing 3.0 g of 1-ethylhexylacrylate chloride and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 400 and homogenized. Then make a mixture of 30 g of polyethylene glycol 000, once again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 17 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 18. Antiseptic ointment is prepared by mixing 1.5 g of ethylhexylacrylate chloride and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of polyethylene glycol 400 and homogenized. Then make a mixture of 25 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 18 with the following ratio of components, wt.%:

Cationic surface-active compound 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water - the rest

Example 19. Antiseptic ointment is prepared by mixing 0.01 g of chlorhexidine and 0.05 g montenerodomo ether of ethylene glycol, 15 g of glycerin to the mixture are added 20 g of polyethylene glycol 400 and homogenized. Then make a mixture of 15 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water poluchennymi to 100 g, while receiving part 19 with the following ratio of components, wt.%:

Cationic surface-active compound is 0.01

Monopoloy ether of ethylene glycol 0,05

The lower glycol 20

Glycerin 15

The highest glycol 15

Water - the rest

Example 20. Antiseptic ointment is prepared by mixing 3.0 g of 1 chlorhexidine and 2.0 g montenerodomo ether of ethylene glycol in 25 g of glycerin to the mixture is added 30 g of polyethylene glycol 400 and homogenized. Then make a mixture of 30 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving structure 20 with the following ratio of components, wt.%:

Cationic surface-active compound 3,0

Monopoloy ether of ethylene glycol 2,0

The lower glycol 30

Glycerin 25

The highest glycol 30

Water - the rest

Example 21. Antiseptic ointment is prepared by mixing 1.5 g of chlorhexidine and 1.0 g montenerodomo ether of ethylene glycol 20 g of glycerin to the mixture is added 25 g of polyethylene glycol 400 and homogenized. Then make a mixture of 25 g of polyethylene glycol 6000, again mixed by the continuous rotation of the agitator bring water to the mixture to 100 g, while receiving part 21 with the following ratio of components, wt.%:

Cationic surface-the active connection 1,5

Monopoloy ether of ethylene glycol and 1.0

The lower glycol 25

Glycerin 20

The highest glycol 25

Water the rest

Example 22. Experimental study of antimicrobial properties of compounds 1-22 obtained according to examples 1-22 were performed by standard methods. As the test microbes used reference culture: (reference strains) Staphylococcus aureus 209 P Eseherichia coil 1257 and Pseudonionas aeruginosa 1677. Bacterial concentration was determined by suspension: for all compounds 1-22, with exposure of 10 minutes and a temperature of 20°With respect to the listed crops it is 2-3%, with the same conditions antiseptic emulsion prepared according to known recipe (standard released in 2003 factory “Veterinary”, , Gus-Khrustalny), showed bactericidal activity under the same conditions in concentration 12-16% against E. coli. 1257 and Staph. aureus 209 R. as for the Ps. aeruginosa 1677, this pathogen was resistant to the effects of the base variant of the drug (control).

Table 1 shows the results of the study of antimicrobial effect of compounds 1-22 offer antiseptic ointments largest diameter of the zones of no growth of microbial lawn on meat-peptone agar in Petri dishes. From table 1 it is evident that the proposed options ointment (examples 1-22) are superior to the prototype area of no growth in 2-3 RA is a, as well as expanding the range of actions such pathogens as Pseudonionas aeruginosa 1677. Experimentally it was found that the ointment, which consisted monopoloy ether of ethylene glycol and polyethylene glycol - 3000, have the most pronounced action against members of the microflora found on the surface of the udder. At the same time, options that do not contain these compounds, antimicrobial activity was distributed mainly in 1257 E. coli and Staph. aureus 209 P, and a much weaker or no effect on Ps. aeruginosa 1677.

The biological effect of developed ointments (compounds 1-22) on top of the tissue studied by introducing into the eyes of rabbits whole undiluted components of the claimed mixture and applying them to areas depilitory leather, size 3×4 cm2within 30 days, with subsequent review of allergenic action. During the whole period of the experiments no signs of irritation, inflammation and sensitization were observed. In control animals, the conjunctiva and skin of which was treated in a similar way the control ointment, noted a transient flushing of the eyes and melkopuzyrchatuyu the desquamation of the superficial layer of the epithelium of the skin.

Thus, the claimed ointment drug significantly better than the known antiseptic emulsion antimicrobial AK is Yunosti in relation used in the experience of microorganisms and, at the same time, it is much better tolerated integumentary tissues of warm-blooded animals.

Table 1

Antimicrobial activity options antiseptic ointment and individual components (method of diffusion in agar)
No.Options antiseptic ointmentStat. indicatorsThe diameters of zones of inhibition of growth of test bacteria, mm
   St. aureus 209 PE.coli 1257Ps. Aerugenosa 1677
123456
1Control 1 (prototype)M±M

n
13,2±0,7

10
10,1±0,4

10
0,2±0,05

10
2Control 2 (3% p-p ketamine in glycerol)M±M

n

P
21,3±1,8

10

<0,01
15,5±2,1

10

<0,01
0,2±0,03

10

<0,1
Control 3 (2% aq MPAA* glycerin)M±M

n

P
0

10

<0,01
11,3±0,8

10

<0,01
14,1±1,0

10

<0,01
4Control 4 (25% p-beg**-3000 glycerol)M±M

n

P
0

10

<0,01
11,3±0,8

10

<0,1
14,1±1,0

10

<0,01
5Control 5 (1% R-R PEG-6000 in glycerol)M±M

n

P
0

10

<0,01
11,3±0,8

10

<0,1
14,1±1,0

10

<0,01
6Composition 1M±M

n

P
23,4±1,2

10

<0,01
29,1±1,9

10

<0,01
16,4±1,2

10

<0,01
7Part 2M±M

n

P
28,2±1,4

10

<0,01
32,2±1,4

10

<0,01
19,3±0,9

10

<0,01
8Part 3M±M

n

P
30,6±2,1

10

<0,01
35,3±1,7

10

<0,01
22,6±1,1

10

<0,01
9Part 4M±M

n

P
24,6±1,6

10

<0,01
28,2±0,9

10

<0,01
17,3±1,3

10

<0,01
10Part 5M±M

n

P
27,7±1,1

10

<0,01
31,6±1,6

10

<0,01
20,9±1,9

10

<0,01
11Part 6M±M

n

P
32,2±0,8

10

<0,01
35,2±1,5

10

<0,01
of 21.9±1,5

10

<0,01
12Part 7M±M

n

P
25,1±1,5

10

<0,01
27,7±0,8

10

<0,01
16,9±1,7

10

<0,01
13Part 8M±M

n

P
28,0±1,4

10

<0,01
30,2±1,9

10

<0,01
20,1±1,8

10

<0,01
14Part 9M±M

n

P
30,3±1,3

10

<0,01
35,5±1,1

10

<0,01
22,3±0,9

10

<0,01
15Part 10M±M

n

P
26,4±1,9

10

<0,01
28,5±1,4

10

<0,01
17,6±1,5

10

<0,01
Continuation of table 1
123456
16Part 11M±M

n

P
28,7±2,0

10

<0,01
32,9±1,1

10

<0,01
19,5±1,3

10

<0,01
1712M±M

n

P
29,3±1,7

10

<0,01
34,9±0,8

10

<0,01
21,6±1,4

10

<0,01
18Composition 13M±M

n

P
23,1±1,8

10

<0,01
27,9±1,3

10

< 0,01
18,1±2,1

10

<0,01
19Composition 14M±M

n

P
29,5±1,5

10

<0,01
30,9±1,6

10

<0,01
21,6±1,9

10

<0,01
2015M±M

n

P
31,6±1,4

10

<0,01
33,6±1,3

10

<0,01
22,1±1,7

10

<0,01
21Part 16M±M

n

P
25,1±1,8

10

<0,01
27,1±1,8

10

<0,01
16,7±1,5

10

<0,01
22Part 17M±M

n

P
28,4±0,9

10

<0,01
31,7±1,2

10

<0,01
18,9±1,2

10

<0,01
2318M±M

n

P
31,2±1,5

10

<0,01
34,3±1,7

10

<0,01
21,7±1,5

10

<0,01
24Part 19M±M
< / br> n

P
24,9±1,1

10

<0,01
28,3±2,1

10

<0,01
17,7±1,6

10

<0,01
25Composition 20M±M

n

P
30,3±1,4

10

<0,01
32,1±1,4

10

<0,01
20,3±0,8

10

<0,01
26Composition 21M±M

n

P
31,9±1,9

10

<0,01
35,2±0,9

10

<0,01
22,9±1,3

10

<0,01
27Composition 22M±M

n

P
32,6±1,3

10

<0,01
36,3±1,1

10

<0,01
22,7±1,5

10

<0,01
* - MoFE e - monopoloy ether

** PEG - polyethylene glycol

Note: statistic p calculated with respect to control group 1.

References

1. Agiliance. Antiseptic modern technology veterinary science and animal husbandry. M., 1999, JSC “VBF”, s.43-50.

2. Agiliance, Gaetano, VBA, Touchful. Antiseptic for the outer is the first treatment of the udder farm animals. RF patent №2054928, MKI6A 61 K 7/40, BI No. 6, 1996.

3. Heydrich and Wrench. Mastitis in farm animals. TRANS. with it. M - 1968. - S-239.

4. Weltruhm, Wedshare, Tinsukia. Antiseptic // bed, - Vol.2, 1975. - Ñ.38-41.

5. Heathington, Pinaleno. Antiseptics in surgery, 1987, P.75-90.

6. Loaners. Chemicals in household and industry, 1969.

7. Vellamo. Cosmetic chemistry. TRANS. Finland 1990, pp.118-154.

8. Viewaskew. Means and methods of sterilisation used in medicine. - M - 1973, s.

9. Tietomaa. Disinfectants, bed, - V.7, - P.58.

10. Nseefeld. Nonionic detergents. - 1965. - S-326.

11. Liegemen, Gagerman and other Glycols and their use in biology and medicine. IMEI, 1984, T. 4, p.17.

1. Antiseptic ointment containing the active agent, cationic surface-active compound, lower glycols, glycols and water, characterized in that it further comprises monopoloy ether of ethylene glycol and higher glycols in the following ratio, wt.%:

Cationic surface-active compoundof 0.01 to 3.0
Monopoloy ether of ethylene glycol0,05-2,0
The lower glycol20-30
Glizer is n 15-25
Highest peg15-30
WaterRest

2. Antiseptic ointment according to claim 1, characterized in that the cationic surface-active compounds using N-alkyl-N-alkoxycarbonylmethyl chloride, or alkyldimethylbenzylammonium chloride or pyridinium bromide or pyridinium chloride, or 1,2-ethylenebis(N-methylcarbamoylmethyl)ammonium dichloride, or ethylhexylacrylate chloride or chlorhexidine.

3. Antiseptic ointment according to claims 1 and 2, characterized in that the lower use glycol 1,2-propylene glycol, or polyethylene glycol 300, or polyethylene glycol 400.

4. Antiseptic ointment according to claims 1 and 2, characterized in that as the highest use of polyethylene glycol polyethylene glycol 1500, or polyethylene glycol 3000, or polyethylene glycol 4000 or peg 6000.



 

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The invention relates to chemical-pharmacological industry and relates to an inhibitor of the expression of integrin, comprising as active ingredient a compound sulfonamida formula IaIbthat means, containing an inhibitor of the expression of integrin formula IaIbfor the treatment of arteriosclerosis, psoriasis, osteoporosis, angiogenesis, retinal angiogenesis, diabetic retinopathy, inflammatory diseases, and how to prevent, treat or alleviate disease associated with increased expression of integrin
The invention relates to veterinary medicine, in particular for the treatment of hypothyroidism in rabbits
The invention relates to the field of veterinary medicine

The invention relates to pharmaceutical industry and relates to inhibitors lks-channel simultaneous action as inhibitors KQT1 channel to obtain drugs for the treatment of diseases caused by helminths and ectoparasites, while inhibitors KQT1 channel have high selectivity and are non-toxic to warm-blooded animals and humans
The invention relates to the field of pharmaceutical industry and relates to anti-inflammatory, regenerative and anti-microbial action
The invention relates to medicine, in particular to the ENT, and can be used for the treatment of chronic purulent mesotympanic

The invention relates to the field of pharmaceutical industry and relates to a method and composition containing acetylcholine

The invention relates to new N,N-dimethyl-N-alkyl-N-[alkoxyl(ethylenoxy)carbonylmethyl] ammonium chlorides of General formula (1), where R1, R2- aliphatic hydrocarbon radical containing 10 to 16 carbon atoms; n is the average degree of oksietilirovannye equal to 3, having a fungistatic and bactericidal activity, and which additives governing viscoelastic properties associated multicomponent oil systems

The invention relates to N-[alkoxyl(ethylenoxy)carbonylmethyl]ammonium chlorides of the formula (I) having fungistatic and bactericidal activity, and method of production thereof

FIELD: agriculture, animal husbandry, organic chemistry.

SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.

EFFECT: valuable antiseptic properties of ointment.

2 cl, 1 tbl, 22 ex

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