Method for preventing metritis-mastitis-agalactia at primary weakness of delivery in sows

The invention relates to the field of veterinary medicine, relates to a method of prevention metritis-mastitis-agalactia and endometritis in sows with the primary weakness of childbirth.

In terms of pig-breeding complexes in the year-round bezvygulnym content sows often (40% of cases and more) is the primary weakness of the birth, manifested by increase in the length of the generic act for more than 5 hours, more frequent cases (1.3-2.5 times) birth of the dead pigs, and increased (1.5-2.5 times) the incidence of postpartum diseases.

Known methods of prevention of postpartum diseases in sows, including intrauterine infusion of antibiotics (oxytetracycline, chloramphenicol, neomycin, and others) and sulfonamides (norsulfazola, streptocide), nitrofuranovye drugs (furazolidone, furagin) /Register medicines in Russia. Sixth edition, revised and enlarged./ CH. edit Û.F. Krylov, M.: “radar-2000”, 1998. - S. 1072; Reference Vidal. Drugs in Russia: a Handbook, M.: Astra Pharm Service, 1996, 1296 S.; Sokolov E Pharmacology, 2nd ed., revised and expanded, M.: Kolos, 2000/.

The disadvantage of the above funds is their low efficiency due to the rapid decrease of the sensitivity of microorganisms to the use of drugs.

Known methods of preventive the IKI postpartum diseases in sows by intramuscular injection of antibiotics (penicillin, streptomycin and other), as well as drugs that enhance the contractile function of the uterus (pituitrin, nevigation and others).

As the prototype is considered a method of prevention of postpartum diseases in sows, including double introduction of hormonal drug oxytocin. Oxytocin is a peptide hormone (oktapeptidom) gipotalyamo-pituitary system. The main property of oxytocin is its ability to cause contraction of the smooth muscle elements of the muscles of the uterus and myoepithelial breast cells. This action is connected with its influence on the cell membrane /Shumsky NI Is the contractile function of the uterus in the development of postpartum diseases in pigs and their prevention: author. dis. on competition of a scientific degree of the candidate of veterinary Sciences. - Voronezh, 1987, p.18-19/.

However, this method is not effective enough, because oxytocin does not affect the metabolism of steroid hormones in the blood of sows disorder which occurs when the primary weakness of births and is one of the causes of postpartum diseases.

The technical result of the invention is the increased efficiency.

This result is achieved by the combined use of oxytocin and chatrapati.

Chatrapatti - integrated product consisting of a synthetic analogue of prostaglandin f-2 alpha bug is Osceola, triterpene glucoside, dimethyl sulfoxide and phosphate buffer. The drug has a regulating effect on the yellow body of the ovary, reduces the secretion and relieves the inhibitory effect of progesterone on gipotalyamo-pituitary system that promotes growth and development of follicles in the ovaries, increasing the level of estrogen in the blood, the manifestation of estrus, hunting and subsequent ovulation of Mature follicles /Instruction for use chatrapati in veterinary medicine and animal husbandry. - Appr. GOS. Commission of the USSR food and procurement 27 December 1989/

Chatrapati causes resorption of yellow bodies in the ovaries and enhances contractile function of the uterus.

The method is as follows.

Sows with primary weakness after childbirth diagnosis and 1.5 hours oxytocin intramuscularly at a dose of 15 UNITS/100 kg of body weight, and 2-4 hours after separation of placenta - once intramuscularly injected chatrapati dose of 1 ml

Data analysis in the scientific and patent literature revealed no way to prevent metritis-mastitis-agalactia and endometritis in sows with the primary weakness of the birth with the use of these drugs by the proposed scheme that indicates compliance of the proposed technical solution the criterion of “novelty”.

New in the proposed method, the two what is the use of the drug oxytocin and additionally chatrapati 2-4 hours after separation of the placenta. The essential feature is the combined use of oxytocin and chatrapati in which oxytocin is used twice: after diagnosis and after 1.5 hours, and chatrapati introduced through 2-4 hours after separation of the placenta, which can significantly reduce the incidence of sows metritis-mastitis-agalactia and endometritis. High preventive effect is achieved through a complex pharmacological effects of drugs that enhance the action of each other.

The essence of the method is illustrated by example.

Example. Rationale efficiency

Experience in determining the effectiveness of oxytocin in combination with laterposition performed on 209 sows were divided according to the principle analogues into four groups.

The diagnosis of primary weakness partum sows were placed on the length of birth intervals pigs: second - 25 minutes or more, third - 20 minutes or more.

Sows of the first group twice: the first time after diagnosis in the primary weakness of the birth and again after 1.5 hours was administered oxytocin dose of 15 UNITS/100 kg of body weight, the second intramuscularly once were injected with chatrapati dose of 1 ml in 2-4 hours after separation of placenta, third - oxytocin was administered twice in the first group and additionally chatrapati 2-4 hours after separation of the placenta is at a dose of 1 ml, and the animals of the fourth group of drugs were not administered (control).

The results of the experiment are shown in the table.

The tests showed that two-oxytocin sows with the primary weakness of delivery reduces the incidence of postpartum diseases is 1.81 times, including metritis-mastitis-agalactia in 2,84 times. The purpose chatrapati reduces the incidence of postpartum sows diseases 1.51 times, including metritis-mastitis-agalactia in 3,69 times.

Using the proposed method reduced the incidence of sows with the primary weakness of childbirth postpartum disease 2.5 times, including metritis-mastitis-agalactia in 8,67 times.

These studies show that the greatest effect of the proposed method is achieved to prevent the most severe form of postpartum diseases - metritis-mastitis-agalactia. Using the proposed method exceeds the total effect of the use of oxytocin and chatrapati for the prevention of this disease. Double use of oxytocin resulted in reducing the incidence of sows metritis-mastitis-agalactia in 2,84 times. Use one chatrapati reduced morbidity in 3,69 times. The total effect of reducing the incidence was 6,53 times. The proposed pic is b has the effect of reducing the incidence of metritis-mastitis-agalactia in 8,67 times.

Studies have confirmed the feasibility and effectiveness of the proposed technical solutions. The inventive method has a high prophylactic efficacy and can be recommended for use in veterinary practice.

The way to prevent metritis-mastitis-agalactia and endometritis in sows with the primary weakness of the genera, including two oxytocin, characterized in that it further intramuscularly chatrapati 2-4 h after separation of the placenta at a dose of 1 ml