Electrochemical destruction, surgical removal and photodynamic method for treating and preventing from intraocular neoplasms

FIELD: medicine.

SUBSTANCE: method involves intravitreously introducing two electrodes into intraocular neoplasm after carrying out vitrectomy and retinotomy to expose the intraocular neoplasm. The electrodes are manufactured from platinum group metal. Electrochemical destruction is carried out with current intensity of 100 mA during 1-10 min or 10 mA during 10 min in changing electrodes polarity and their position in the intraocular neoplasm space, and the electrodes are removed. 0.1-1% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, intravitreous laser radiation is carried out in parallel light beam of wavelength equal to 661-666 nm is applied at a dose of 30-120 J/cm2.The transformed retina and tumor destruction products are intravitreally removed. Boundary-making endolasercoagulation of retinotomy area is carried out after having smoothed and compressed retina with perfluororganic compound. The operation is finished with placing sutures on sclerotomy and conjunctiva. Platinum, iridium or rhodium are used as the platinum group metals. Another embodiment of the invention involves adjusting position and size of the intraocular neoplasm in trans-scleral diaphanoscopic way. Rectangular scleral pocket is built above the intraocular neoplasm to 2/3 of sclera thickness with its base turned away from limb. Several electrodes are introduced into intraocular neoplasm structure via the built bed. The electrodes are manufactured from platinum group metal. Electrochemical destruction is carried out with the same current intensity in changing electrodes polarity and their position in the intraocular neoplasm space, and the electrodes are removed. Superficial scleral flat is returned to its place and fixed with interrupted sutures. 0.1-1% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg after having carried out vitrectomy and retinotomy. Visual control of intraocular neoplasm cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, intravitreous laser radiation is carried out in parallel light beam of wavelength equal to 661-666 nm is applied at a dose of 30-120 J/cm2. The transformed retina and tumor destruction products are intravitreally removed using vitreotome. Boundary-making endolasercoagulation of retinotomy area is carried out after having smoothed and compressed retina with perfluororganic compound. The operation is finished with placing sutures on sclerotomy and conjunctiva. Platinum, iridium or rhodium are used as the platinum group metals. The number of electrodes is equal to 4-8.

EFFECT: reduced risk of metastasizing.

4 cl, 13 dwg

 

The invention relates to medicine, namely to ophthalmology, to methods of electrochemical degradation, surgical resection and photodynamic relapse prevention intraocular neoplasms their Central location.

There is a method of surgical treatment and surgical removal of tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with its subsequent replacement by silicone oil (see Jose Garsia-Arumi, MD, Laura Sararols, MD, Vincent Martinez, MD, Borja Cjrcjstegui, MD, "Vitreoretinal Surgery and endoresection in high posterior choroidal melanomas, RETINA, 21:445-452, No. 5, 2001).

However, the known method when its use does not allow the deletion in full (within healthy tissue) intraocular tumors, remission of tumor cells in the surgical field, does not preclude the dissemination of tumor cells and metastasis.

The basis of the invention is to provide a method of electrochemical degradation, surgical resection and photodynamic relapse prevention of intraocular tumors, allowing for its use to achieve the total destruction of intraocular tumors, exceptions on the delivery of tumor cells in the surgical field, reduce the risk of tumour cell dissemination and metastasis.

The problem is solved in that a method of electrochemical degradation, surgical resection and photodynamic relapse prevention of intraocular tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with its subsequent replacement by silicone oil, a distinctive feature of which is that after vitrectomy and retinotomy with exposure of intraocular tumors intravitreal in intraocular neoplasm introduce two electrodes made of platinum group metal, carried out the electrochemical degradation of intraocular tumors with amperage 10-100 mA within 1-10 minutes when changing the polarity of the electrodes and their location the volume of intraocular tumors, remove the electrodes, and then intravenously injected as a photosensitizer 0.1 to 1% aqueous solution of chlorine selected from the group Photolon, Radachlorin or photoditazine at a dose of 0.8-1.1 mg/kg, carry out a visual inspection of the fluorescence of the cells of intraocular tumors using fluorescent diagnostics is IKI, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spend it intravitreal laser irradiation parallel light beam with a wavelength of 661-666 nm within 60-180 seconds for a total dose of irradiation 30-120 j/cm2then using vitrectomy intravitreal remove the degradation products of the tumor tissue, and after unfolding and crushing the retina performancesin connection spend the restrictive endolasercoagulation section retinotomy, and the surgery is completed by suturing the areas of sclerotome and conjunctiva. As a platinum group metal electrodes using platinum, iridium or rhodium.

In the clinical practice of using the proposed method, electrochemical destruction, surgical resection and photodynamic relapse prevention of intraocular tumors, it was found that using all the selected parameters of the proposed method achieved the following technical result: the total destruction of intraocular tumors with the exception of leaving tumor cells in the surgical field, reduced the risk of tumour cell dissemination and metastasis.

To illustrate the proposed method on the drawings schematically shown its core the main stages (option 1) (Fig.1-6).

Implementation of the proposed method is illustrated by the following clinical examples.

Example 1. Patient M., 56 years old, was admitted to the Kaluga branch of IRTC “eye microsurgery” with suspected tumors of the choroid right eye.

When the survey was diagnosed with melanoma of the choroid OD. Localization of lesions in the posterior pole of the eye. The size of the tumor by ultrasound B-scan: 10 to 12 mm, the size of prominence - up to 5 mm During PHAGE was detected characteristic "spotted" fluorescence in tumors.

Previously spent clarifying the true boundaries of the tumor by the method of transillumination.

At the preparatory stage after processing operating margins held anesthetic management. Spent vitrectomy and retinotomy with exposure of intraocular tumors. Then intravitreal in intraocular neoplasm introduced two electrodes made of platinum, and spent the electrochemical degradation of intraocular tumors with rated current of 10 mA for 10 minutes when changing the polarity of the electrodes and their location on the volume of intraocular tumors. The electrodes were removed and intravenous introduced as a photosensitizer 1% aqueous solution of chlorine, namely Radachlorin dose of 0.8 mg/kg of the ATEM has carried out a visual inspection of fluorescence of cells intraocular tumors using fluorescent diagnostics, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spent his intravitreal laser irradiation parallel light beam with a wavelength of 661 nm for 180 sec with a total dose of 120 j/cm2. Using vitrectomy intravitreal removing products of destruction of tumor tissue, and after unfolding and crushing the retina performancesin connection held restrictive endolaser coagulation section retinotomy. Performancesee connection was replaced with a silicone oil, and the operation is finished suturing the areas of sclerotome and conjunctiva.

When the control ULTRASOUND after 6 months on the location of the mass was determined by dense scar up to 1 mm thick. Installed total destruction of intraocular tumors, excluded the remission of tumor cells in the surgical field, reduced the risk of tumour cell dissemination and metastasis.

Example 2. Patient R., 67 years old, was admitted to the Kaluga branch of IRTC “eye microsurgery” with suspected tumors of the choroid of the left eye.

When the survey was diagnosed with melanoma of the choroid OS. Localization of lesions in the posterior pole of the eye. The size of the tumor by ultrasound In the functional is: 9 to 11 mm, the value of prominence - up to 5 mm During PHAGE was detected characteristic "spotted" fluorescence in tumors.

Previously spent clarifying the true boundaries of the tumor by the method of transillumination.

At the preparatory stage after processing processing operating margins held anesthetic management. Spent vitrectomy and retinotomy with exposure of intraocular tumors. Then intravitreal in intraocular neoplasm introduced two electrode made of iridium, and spent the electrochemical degradation of intraocular tumors with rated current 100 mA for 1 minute when the polarity of the electrodes and their location on the volume of intraocular tumors. The electrodes were removed and intravenous introduced as a photosensitizer 0.1% aqueous solution of chlorine, namely Radachlorin, at a dose of 1.1 mg/kg Then carried out a visual inspection of fluorescence of cells intraocular tumors using fluorescent diagnostics, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spent his intravitreal laser irradiation parallel light beam with a wavelength of 666 nm for 60 sec with a total dose of 30 j/cm2. Using vitrectomy of intravitreal is removed degradation products of the tumor tissue, and after unfolding and crushing the retina performancesin connection held restrictive endolaser coagulation section retinotomy. Performancesee connection was replaced with a silicone oil, and the operation is finished suturing the areas of sclerotome and conjunctiva.

When the control ULTRASOUND after 6 months on the location of the mass was determined by dense scar up to 1 mm thick. Installed total destruction of intraocular tumors, excluded the remission of tumor cells in the surgical field, reduced the risk of tumour cell dissemination and metastasis.

The invention relates to medicine, namely to ophthalmology, to methods of electrochemical degradation, surgical resection and photodynamic relapse prevention of intraocular tumors at their peripheral localization.

There is a method of surgical treatment and surgical removal of tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with its subsequent replacement by silicone oil (see Jose Garsia-Arumi, MD, Laura Sararols, MD, Vincent Martinez, MD, Borja Cjrcjstegui, MD, "Vitreoretinal Surgery and endoresection in high posterior choroidal melnomas, RETINA, 21:445-452, No. 5, 2001).

However, the known method when its use does not allow the deletion in full (within healthy tissue) intraocular tumors, remission of tumor cells in the surgical field, does not preclude the dissemination of tumor cells and metastasis.

The basis of the invention is to provide a method of electrochemical degradation, surgical resection and photodynamic relapse prevention of intraocular tumors, allowing for its use to achieve the total destruction of intraocular tumors, exceptions separation of tumor cells in the surgical field, reducing the risk of tumour cell dissemination and metastasis.

The problem is solved in that a method of electrochemical degradation, surgical resection and photodynamic relapse prevention of intraocular tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with subsequent replacement by silicone oil, the distinguishing feature of which is the fact that before vitrectomy pre transcleral diafan skopicki precise localization and dimensions of intraocular tumors, then 2/3 of the thickness of the sclera above the intraocular neoplasm form a scleral pocket rectangular base from limb, formed through the bed is introduced into the structure of intraocular neoplasms multiple electrodes made of platinum group metal, changing the polarity of conduct electrochemical destruction of intraocular tumors with amperage 10-100 mA for 1-10 minutes and remove the electrodes, the superficial scleral flap returns to its place and fixed with interrupted sutures, and after vitrectomy and retinotomy intravenously injected as a photosensitizer 0.1 to 1% aqueous solution of chlorine selected from the group Photolon, Radachlorin or photoditazine, in a dose of 0.8 to 1.1 mg/kg, then carry out a visual inspection of the fluorescence of the cells of intraocular tumors using fluorescent diagnostics, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spend it intravitreal laser irradiation parallel light beam with a wavelength of 661-666 nm within 60-180 seconds for a total dose of irradiation 30-120 j/cm2then remove intravitreal using vitrectomy products of destruction of tumor tissue, and after unfolding and crushing the retina performancesin connection spend on ogranichitelnyh the endolasercoagulation section retinotomy, and the surgery is completed by suturing the areas of sclerotome and conjunctiva. As a platinum group metal electrodes using platinum, iridium or rhodium, and the number of electrodes selected from 4 to 8.

In the clinical practice of using the proposed method, electrochemical destruction, surgical resection and photodynamic relapse prevention of intraocular tumors, it was found that using all the selected parameters of the proposed method obtained the following technical result: achieved total destruction of intraocular tumors, excluded the remission of tumor cells in the surgical field, reduced the risk of tumour cell dissemination. Implemented prevention of metastasis.

To illustrate the proposed method on the drawings schematically shows his main stages (option 2) (Fig.1-7).

Implementation of the proposed method is illustrated by the following clinical examples.

Example 1. Patient B., 56 years old, was admitted to the Kaluga branch of IRTC “eye microsurgery” diagnosis “melanoma of the choroid of the right eye”. Localization of tumor - postequalization in the lower outer quadrant. The size of the tumor according to the ULTRASONIC B-scanning: 6 to 8 mm and a height of prominence 4 mm.

To prepare Inom a post-processing step processing operating margins held anesthetic management. Then transscleral diaphanoscopy said localization and dimensions of intraocular tumors. Then 2/3 of the thickness of the sclera above the intraocular neoplasm formed scleral pocket rectangular base from the limbus. Through the formed bed introduced into the structure of intraocular tumors electrode 4, made of rhodium. Spent the electrochemical degradation of intraocular tumors with rated current of 10 mA for 10 minutes and removed the electrodes. The superficial scleral flap was returned to its place and recorded interrupted sutures. Spent vitrectomy and retinotomy. Then intravenously introduced as a photosensitizer 1% aqueous solution of chlorine, namely Photolon, at a dose of 0.8 mg/kg Conducted a visual inspection of fluorescence of cells intraocular tumors using fluorescent diagnostics, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spent his intravitreal laser irradiation parallel light beam with a wavelength of 666 nm for 60 sec with a total dose of 120 j/cm2. Intravitreal using vitrectomy removing products of destruction of tumor tissue. He shrugged and pressed the retina by piptochaetium and spent restrictive endolaser coagulation Uch is STCA retinotomy. Parfocality replaced by silicone oil. The operation was finished suturing the areas of sclerotome and conjunctiva.

When the control ULTRASOUND after 6 months on the location of the tumors was determined flat seams up to 1 mm thick. Later in the follow-up period of 1.5 years signs of recurrence was not detected. Installed total destruction of intraocular tumors, excluded the remission of tumor cells in the surgical field, reduced the risk of tumour cell dissemination and metastasis.

Example 2. Patient R., 67 years old, was admitted to the Kaluga branch of IRTC “eye microsurgery” diagnosis “melanoma of the choroid of the right eye”. Localization of tumor - postequalization in the lower outer quadrant. The size of the tumor according to the ULTRASONIC B-scanning: 7 to 8 mm and a height of prominence 4 mm.

At the preparatory stage after processing processing operating margins held anesthetic management. Then transscleral diaphanoscopy said localization and dimensions of intraocular tumors. Then 2/3 of the thickness of the sclera above the intraocular neoplasm formed scleral pocket rectangular base from the limbus. Through the formed bed introduced into the structure of intraocular tumors electrodes 8 made of IRI the Oia. Spent the electrochemical degradation of intraocular tumors with rated current 100 mA for 1 minute and removed the electrodes.

The superficial scleral flap was returned to its place and recorded interrupted sutures. Spent vitrectomy and retinotomy. Then intravenously introduced as a photosensitizer 0.1% aqueous solution of chlorine, namely photoditazine, at a dose of 1.1 mg/kg Conducted a visual inspection of fluorescence of cells intraocular tumors using fluorescent diagnostics, and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spent his intravitreal laser irradiation parallel light beam with a wavelength of 661 nm for 120 seconds with a total dose of 30 j/cm2. Intravitreal using vitrectomy removing products of destruction of tumor tissue. He shrugged and pressed the retina by performability, held tranchitella the endolasercoagulation section retinotomy. Tributylamine replaced by silicone oil. The operation was finished suturing the areas of sclerotome and conjunctiva.

When the control ULTRASOUND after 6 months on the location of the tumors was determined flat seams up to 1 mm thick. Later in the follow-up period of 1.5 years signs of recurrence does not detect the O. Installed total destruction of intraocular tumors, excluded the remission of tumor cells in the surgical field, reduced the risk of tumour cell dissemination and metastasis.

1. A method of surgical removal of intraocular tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with its subsequent replacement by silicone oil, characterized in that prior to surgical removal of intraocular tumors injected two electrodes made of platinum group metal, and conduct electrochemical destruction of intraocular tumors with rated current of 10 mA for 10 min or with rated current 100 mA for 1 min when changing the polarity of the electrodes and their location, remove the electrodes, and then intravenously injected as a photosensitizer 0,1-1%initial aqueous solution of chlorine selected from the group Photolon, Radachlorin or photoditazine at a dose of 0.8-1.1 mg/kg, carry out a visual inspection of the fluorescence of the cells of intraocular tumors using fluorescent diagnostics and upon reaching the maximum level of saturation of intraocular tumors photosensitizer PR who lead his intravitreal laser irradiation parallel light beam with a wavelength of 661-666 nm at a total dose of irradiation 30-120 j/cm 2then using vitrectomy intravitreal remove the degradation products of the tumor tissue, and after unfolding and crushing the retina performancesin connection spend restrictive endolasercoagulation section retinotomy, and the surgery is completed by suturing the areas of sclerotome and conjunctiva.

2. The method according to claim 1, characterized in that as a platinum group metal electrodes using platinum, iridium or rhodium.

3. A method of surgical removal of intraocular tumors, including performing a vitrectomy, retinotomy with subsequent exposure of intraocular tumors, surgical removal of intraocular tumors, smoothing retina performancesin connection with subsequent replacement by silicone oil, characterized in that prior to the vitrectomy pre transcleral diaphanoscopy precise localization and dimensions of intraocular neoplasms, then 2/3 of the thickness of the sclera above the intraocular neoplasm form a scleral pocket rectangular base from limb, formed through the bed is introduced into the structure of intraocular neoplasms multiple electrodes made of platinum group metal, changing the polarity of conduct electrochemical degradation of DNAs is reglazing neoplasms with rated current of 10 mA in for 10 min or with rated current 100 mA for 1 min and remove the electrodes, the superficial scleral flap returns to its place and fixed with interrupted sutures, and after vitrectomy and retinotomy intravenously injected as a photosensitizer 0.1 to 1%aqueous solution of chlorine selected from the group Photolon, Radachlorin or photoditazine at a dose of 0.8-1.1 mg/kg, then carry out a visual inspection of the fluorescence of the cells of intraocular tumors using fluorescent diagnostics and upon reaching the maximum level of saturation of intraocular tumors photosensitizer spend it intravitreal laser irradiation parallel light beam with a wavelength of 661-666 nm at a total dose of irradiation 30-120 j/cm, then remove intravitreal using vitrectomy products destruction of tumor tissue, and after unfolding and crushing the retina performancesin connection spend restrictive endolasercoagulation section retinotomy, and the surgery is completed by suturing the areas of sclerotome and conjunctiva.

4. The method according to claim 3, characterized in that as a platinum group metal electrodes using platinum, iridium or rhodium, the number of electrodes selected 4 - 8.



 

Same patents:

FIELD: medicine.

SUBSTANCE: the present innovation deals with treating vascular cutaneous neoplasms, such as nevus flammeus and gemangiomas. Light-thermal impact at energy ranged 39-47 J/sq. cm should be performed in two stages, and between them, 2-3 wk after the onset of vascular resistance at the first stage one should perform beta-therapy daily for 2-3 d at single dosage being 20 g. Then, 3 wk later it is necessary to conduct the second stage of light-thermal impact by starting at energy value being 42 J/sq. cm, not less. The method enables to shorten therapy terms due to applying combined method to affect vascular cutaneous neoplasms.

EFFECT: higher therapeutic and cosmetic effect.

1 ex

FIELD: medicine.

SUBSTANCE: method involves applying transscleral diaphanoscopic examination method for adjusting intraocular neoplasm localization and size. Rectangular scleral pocket is built 2/3 times as large as sclera thickness which base is turned from the limb. Several electrodes manufactured from a metal of platinum group are introduced into intraocular neoplasm structure via the built scleral pocket. Next to it, intraocular neoplasm electrochemical destruction is carried out in changing electrodes polarity with current intensity of 100 mA during 1-10 min, and the electrodes are removed. Superficial scleral flap is returned to its place and fixed with interrupted sutures. 0.1-2% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, transpupillary laser radiation of 661-666 nm large wavelength is applied at a dose of 30-120 J/cm2. the operation is ended with placing sutures on conjunctiva. Platinum, iridium or rhodium are used as the metals of platinum group. The number of electrodes is equal to 4-8. 0.1-1% khlorin solution, selected from group containing photolon, radachlorine or photoditazine, is additionally repeatedly intravenously introduced in 2-3 days at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, repeated laser irradiation of the intraocular neoplasm is carried out with radiation dose of 30-45 J/cm2.

EFFECT: complete destruction of neoplasm; excluded tumor recurrence; reduced risk of tumor cells dissemination.

3 cl, 3 dwg

FIELD: medicine.

SUBSTANCE: method involves creating tunnel between sclera and Tenon's capsule in intraocular neoplasm projection. Intraocular neoplasm localization and size is adjusted by applying transscleral diaphanoscopic examination method. 0.1-0.3 ml of photosensitizing gel based on viscoelastic of hyaluronic acid, selected from group containing chealon, viscoate or hyatulon, is transsclerally introduced into intraocular neoplasm structure using special purpose needle in dosed manner. The photosensitizing gel contains khlorin, selected from group containing photolon, radachlorine or photoditazine in the amount of 0.1-1% by mass. Flexible polymer magnetolaser implant is extrasclerally introduced into the built tunnel in intraocular neoplasm projection zone under visual control using guidance beam. The implant has permanent ring-shaped magnet axially magnetized and producing permanent magnetic field of 3-4 mTesla units intensity, in the center of which a short focus scattering lens of laser radiator is fixed. The lens is connected to light guide in soft flexible envelope. The implant is arranged with its north pole turned towards the intraocular neoplasm so that implant laser radiator lens is extrasclerally arranged in intraocular neoplasm projection zone. The implant light guide is sutured to sclera 5-6 mm far from the limb with single interrupted suture. The implant is covered with conjunctiva and relaxation sutures are placed over it. Light guide outlet is attached to temple using any known method. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, transscleral intraocular neoplasm laser radiation treatment is carried out via laser light guide and implant lens using divergent laser radiation at wavelength of 661-666 nm. The treatment course being over, the flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, neodymium-iron-boron or samarium-iron-nitrogen. 0.1-1% khlorin solution as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is additionally intravenously introduced in 2-3 days at a dose of 0.8-1.1 mg/kg and repeated laser irradiation of the intraocular neoplasm is carried out with radiation dose of 30-45 J/cm2 15-20 min later during 30-90 s.

EFFECT: complete destruction of neoplasm; excluded its further growth.

4 cl

FIELD: medicine.

SUBSTANCE: method involves making incision in conjunctiva and Tenon's capsule of 3-4 mm in size in choroid hemangioma projection to sclera 3-4 mm far from limb. Tunnel is built between sclera and Tenon's capsule to extrasclerally introduce flexible polymer magnetolaser implant through the tunnel to the place, the choroid hemangioma is localized, after performing transscleral diaphanoscopic adjustment of choroid hemangioma localization and size, under visual control using guidance beam. The implant has permanent ring-shaped magnet in the center of which a short focus scattering lens of laser radiator is fixed. The lens is connected to light guide in soft flexible envelope. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 2-3 mTesla units intensity. It is arranged with its north pole turned towards the choroid hemangioma so that extrascleral implant laser radiator disposition. The other end of the implant is sutured to sclera 5-6 mm far from the limb with two interrupted sutures through prefabricated openings. The implant is covered with conjunctiva and relaxation sutures are placed over it. Light guide outlet is attached to temple using any known method. 0.1-1% khlorin solution is injected in intravenous bolus dose of 0.8-1.1 mg/kg as photosensitizer and visual control of choroid hemangioma cells fluorescence and fluorescent diagnosis methods are applied. After saturating choroid hemangioma with the photosensitizer to maximum level, transscleral choroid hemangioma laser radiation treatment is carried out via laser light guide and implant lens using divergent laser radiation at wavelength of 661-666 nm with total radiation dose being equal to 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the intraocular neoplasm, repeated laser irradiation of the choroid hemangioma is carried out with radiation dose of 30-60 J/cm2.

EFFECT: enhanced effectiveness of treatment.

4 cl

FIELD: medicine.

SUBSTANCE: method involves introducing 0.1-0.3 ml of photosensitizing gel preliminarily activated with laser radiation, after having removed neovascular membrane. The photosensitizing gel is based on a viscoelastic of hyaluronic acid containing khlorin, selected from group containing photolon, radachlorine or photoditazine in the amount of 0.1-2% by mass. The photosensitizing gel is in vitro activated with laser radiation having wavelength of 661-666 nm during 3-10 min with total radiation dose being equal to 100-600 J/cm2. The gel is introduced immediately after being activated. To compress the retina, vitreous cavity is filled with perfluororganic compound or air to be further substituted with silicon oil. The operation is ended with placing sutures on sclerotomy and conjunctiva areas. Compounds like chealon, viscoate or hyatulon are used as viscoelastic based on hyaluronic acid. Perfluormetylcyclohexylperidin, perfluortributylamine or perfluorpolyester or like are used as the perfluororganic compound for filling vitreous cavity.

EFFECT: excluded recurrences of surgically removed neovascular membrane and development of proliferative retinopathy and retina detachment; retained vision function.

3 cl, 5 dwg

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FIELD: medicine.

SUBSTANCE: method involves applying transscleral diaphanoscopic examination method for adjusting intraocular neoplasm localization and size. Rectangular scleral pocket is built 2/3 times as large as sclera thickness which base is turned from the limb. Several electrodes manufactured from a metal of platinum group are introduced into intraocular neoplasm structure via the built scleral pocket. Next to it, intraocular neoplasm electrochemical destruction is carried out in changing electrodes polarity with current intensity of 100 mA during 1-10 min, and the electrodes are removed. Superficial scleral flap is returned to its place and fixed with interrupted sutures. 0.1-2% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, transpupillary laser radiation of 661-666 nm large wavelength is applied at a dose of 30-120 J/cm2. the operation is ended with placing sutures on conjunctiva. Platinum, iridium or rhodium are used as the metals of platinum group. The number of electrodes is equal to 4-8. 0.1-1% khlorin solution, selected from group containing photolon, radachlorine or photoditazine, is additionally repeatedly intravenously introduced in 2-3 days at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, repeated laser irradiation of the intraocular neoplasm is carried out with radiation dose of 30-45 J/cm2.

EFFECT: complete destruction of neoplasm; excluded tumor recurrence; reduced risk of tumor cells dissemination.

3 cl, 3 dwg

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The invention relates to medicine, namely to prevention devices, and is intended to affect the scalp, stimulation and hair growth

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Dental capsule // 2229860
The invention relates to medicine, specifically to dentistry, and can be used for the treatment of periodontal diseases and diseases of the mucous membranes of the oral cavity, in particular stomatitis
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FIELD: medicine.

SUBSTANCE: method involves intravenously administering 0.1-1% aqueous solution of khlorin, selected from group containing photolon, radachlorine or photoditazine at a dose of 0.2-0.5 mg/kg or 0.2-1% aqueous solution of porphyrin like photogem at a dose of 0.2-1 mg/kg. Laser irradiation of blood is carried out 5-15 min later after beginning photosensitizer injection into cubital vein of one arm via laser light guide set in advance in the cubital vein of the other arm during 10-40 min at wavelength of 661-666 nm and power of 20-50 mW one session per day during 3-10 days with the aqueous solution of khlorin used as the photosensitizer, or laser irradiation of blood with wavelength equal to 630-633 nm during 10-45 min with power of 20-50 mW one session per day with the aqueous solution of porphyrin used as the photosensitizer. Repeated intravenous administration of photosensitizer is carried out 1-3 months later combined with repeated laser irradiation of blood.

EFFECT: reduced risk of tumor cells dissemination and metastasis development.

2 cl

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