Method for treating mastitis-suffering cows

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with inspecific therapy of mastitis in cows to prevent the development of resistant races of microorganisms. One should intracisternally inject antiseptic preparation for mastitis-suffering cow as neutral anolyte with redox potential ranged +350 - +600 mV and concentration of oxidants being 150-350 mg/l by active chlorine obtained out of 0.3-0.5%-sodium chloride solution in diaphragmatic electrolysis due to impact of direct current of 1.5-5.0 A power and 16-32 V tension at current density being 500-550 A/sq. m. Moreover, antiseptic preparation should be introduced intracisternally into affected quarter of cow's udder at 10-15 sq. cm once-thrice daily for 2-5 d.

EFFECT: higher efficiency of therapy.

1 cl, 4 ex

 

The invention relates to the field of veterinary medicine and veterinary sanitation, in particular nonspecific therapy of mastitis in cows.

Mastitis is a common disease that causes substantial economic loss to the livestock farms due to the culling of animals, reducing their productivity and milk quality. One of the causes of mastitis are unsanitary housing conditions of animals and incorrect operation of the milking apparatus, facilitating the penetration of pathogenic and conditionally pathogenic microorganisms (staphylococci, streptococci, Escherichia coli and others) in their mammary gland. Proceeds mastitis in subclinical and clinical (serous, serous, catarrhal, catarrhal, purulent, fibrinous) form.

Known methods and means of treatment of mastitis in animals with antimicrobial, chemical and biological agents, including various antibiotics (mectizan-A) (A.S. USSR №417139, BI No. 8, 1974), sulfa (mastered) (A.S. USSR №563979, BI No. 3, 1977), schrotenboer (deferol-A) (A.S. USSR №692126, BI. No. 19, 1980) and other medications.

A significant drawback listed antibacterial drugs is that prolonged use of antibiotics marked the emergence of resistant to races of microorganisms, which results in dalnas the m to decrease the effectiveness of treatment with these drugs; sulfa and nitrofuranovye drugs have a relatively low antimicrobial spectrum of activity, no effect on viruses; all antiseptics do not possess antioxidant activity, have a negative impact on the activity of phagocytosis in the breast, in addition, these drugs are expensive.

The technical effect of the invention is to improve the efficiency of treatment by preventing the formation of resistant races of microorganisms, but does not have the disadvantages listed above.

The technical effect is achieved in a method of treatment of cows with mastitis, including intracisternally the introduction of antiseptic, the fact that as an antiseptic use neutral anolyte with a redox potential of +350 to +600 mV and concentration of oxidants 150-350 mg/l active chlorine obtained from 0,3-0,5% solution of sodium chloride in the diaphragm electrolyzer by exposure to constant electric current power from 1,5 to 5,0 and voltage 16-32 V At a current density of from 500 to 550 a/m2. The technical effect is achieved by the fact that the antiseptic agent is injected into the affected udder quarter intracisternally based 10-15 cm31-2 times a day for 2-5 days.

The authors experimentally tested the regime and those who ologia obtain neutral anolyte with the definition of the necessary physico-chemical parameters for the treatment of mastitis in farm animals.

Neutral anolyte, the authors received on diaphragm flow-through electrolytic reactor type PAM from weak (0,3-0,5%) solutions of edible salt. Neutral anolyte with stable physical and chemical indicators is synthesized with a cathode-anode processing salted water when the potential on the electrodes (anode, cathode) of 1.5 to 5.0 and 16-32 V At a current density of from 500 to 550 a/m2. Get neutral anolyte has a pH of 7-8, redox potential (ORP) from + 350 to + 600 mV and concentration of oxidants 150-350 mg/l active chlorine.

Studies found that the neutral analyte:

- has a biocidal activity against the causative agents of mastitis in animals; however, Staphylococcus, Streptococcus, enteropathogenic bacteria Escherichia coli group (bgcp), Proteus in the suspension test with protein protection perish in neutral anolyte for 3-15 min;

in recommended doses has no irritating and sensitizing properties;

- not mutagenic, teratogens and embryotoxic effect;

- in addition to biocides has proliferatum (recovery of damaged tissues) and anti-adhesive (reduces microcolonial bacteria) effect and stimulates the phagocytosis of blood leukocytes in complicated (purulent) forms of mastitis;

- PR is the reduction of economic costs of treating sick animals with mastitis in the tens and hundreds of times compared to other drugs.

In the patent literature is not well-known technical solutions similar to the claimed, i.e. the proposal meets the criteria of the invention of “novelty.”

For the first time the possibility of the application of electrochemically activated solutions of sodium chloride for the treatment of mastitis cows that provides in the breast elimination of the causative agents of mastitis, proliferation (repair) damaged tissue, reduce microcolonial bacteria due to the anti-adhesive action, stimulates the phagocytic activity of neutrophils in milk, i.e. the proposal meets the criterion of “inventive step”.

Getting a neutral anolyte is produced in units of domestic production, i.e. the sentence “industrially applicable”.

The invention is illustrated in the following examples.

Example 1. Prepare a 0.3%solution of sodium chloride, is passed through a diaphragm electrolyzer type TEM at a constant electric current of 1.5 a and a voltage of 16 V At a current density of 500 a/m2thus the composition 1, with the following physico-chemical parameters: the concentration of oxidants (active chlorine) - 150 mg/l redox potential of +350 mV.

Example 2. Prepare a 0.5%solution of sodium chloride, is passed through a diaphragm electrolyzer type TEM PR is a constant electric current of 5.0 a and a voltage of 32 V At a current density of 550 a/m 2thus the composition 2, with the following physico-chemical parameters: the concentration of oxidants (active chlorine) - 350 mg/l redox potential of +600 mV.

Example 3. Prepare a 0.4%solution of sodium chloride, is passed through a diaphragm electrolyzer type TEM at a constant electric current of 3.25 and a voltage of 24 V At a current density of 525 a/m2while receiving part 3, with the following physico-chemical parameters: the concentration of oxidants (active chlorine) - 250 mg/l redox potential of +475 mV.

Example 4. Compounds 1-3, obtained according to examples 1-3 was used for treatment of cows with subclinical and acute clinical (serous or serous-catarrhal) mastitis in comparison with the drug mectizan-A. For each form of mastitis was taken on 5 cows. Neutral anolyte was introduced intracisternal using a syringe of 10 cm3once a day after milking with an interval of 24 hours Prior to administration of the compositions of the affected quarter was carefully Stivali, the tip of the nipple rubbed with cotton wool soaked in 70%alcohol. After the introduction of the compositions of spent light massage a quarter of the udder from the bottom up to the best of their distribution within the udder.

To cure cows required 2-3-fold (in advanced cases 4-5-fold) introduction the neutral is on anolyte in the quarter. Full recovery of treated cows compounds 1-3 occurred 3-5 days with therapeutic efficacy within 90-100% compared to 7-8 days when using the prototype and its effectiveness in the range of 60-70%.

Thus, the inventive composition can reduce the recovery time of cows suffering from mastitis, 1.4-2.5 times. This is because the neutral anolyte (electrochemically treated sodium chloride) provides recovery of cows suffering from mastitis, due to the wide spectrum of antimicrobial activity, antioxidant properties and stimulation of phagocytosis of leukocytes in milk. In addition, the use of the proposed structure reduces the multiplicity of its introduction in 3 times. Offer may be used for the treatment of mastitis in other species of farm animals: sheep, goats, mares, camels.

1. The method of treatment of cows with mastitis, including intracisternally introduction of the antiseptic agent, characterized in that as an antiseptic use neutral anolyte with a redox potential of +350 to +600 mV and concentration of oxidants 150-350 mg/l active chlorine obtained from 0,3-0,5% solution of sodium chloride in diaphragm electrolysis by exposure to constant electric current power from 1,5 to 5,0 and voltage 16-32 In at a density that is from 500 to 550 a/m 2.

2. The method according to claim 1, wherein the antiseptic agent is injected into the affected udder quarter intracisternal based 10-15 cm21-3 times a day for 2-5 days.



 

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FIELD: veterinary science.

SUBSTANCE: the present innovation deals with inspecific therapy of mastitis in cows to prevent the development of resistant races of microorganisms. One should intracisternally inject antiseptic preparation for mastitis-suffering cow as neutral anolyte with redox potential ranged +350 - +600 mV and concentration of oxidants being 150-350 mg/l by active chlorine obtained out of 0.3-0.5%-sodium chloride solution in diaphragmatic electrolysis due to impact of direct current of 1.5-5.0 A power and 16-32 V tension at current density being 500-550 A/sq. m. Moreover, antiseptic preparation should be introduced intracisternally into affected quarter of cow's udder at 10-15 sq. cm once-thrice daily for 2-5 d.

EFFECT: higher efficiency of therapy.

1 cl, 4 ex

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