Method for treating acquired neurosensory impaired hearing

FIELD: medicine, otolaryngology.

SUBSTANCE: the present innovation deals with introducing neomycin sulfate antibiotic in granules prepared by the following technique. Tablet of neomycin sulfate 1.0g should be put into a vial with 100 ml distilled water till tablet's decomposition. Then vial's content should be shaken and kept till suspension sedimentation. In a day one should take 1 ml of supernatant liquid to be put into another vial and diluted with distilled water at 1:100 ratio. This procedure should be repeated 4 times more, moreover, during the last procedure one should apply alcohol for dilution. Then one should transfer the drop of alcoholic solution into a vial with granules out of milk sugar to then shaken and kept open for 1 d till granules" drying up. The suggested preparation should be applied per 1 granule under the tongue, moreover, multiplicity and duration of the above-suggested intake should be matched individually by patient's sensitivity and obtaining the clinic effect. The method enables to improve the value of tonic threshold audiometry by about 30-50 dB, decrease perception threshold of vocal range frequencies and widen the range towards high frequencies.

EFFECT: higher efficiency of therapy.

1 dwg

 

The invention relates to medicine, namely to otolaryngology.

Known in medicine the following methods of treatment of sensorineural hearing loss:

Wristcuff, Uddevalla. Restore hearing in acute sensorineural hearing loss in childhood. Attending physician, 1999, No. 4, C16-18.

Aigopad, Moubarak. Pharmacotherapy for sensorineural hearing loss, S.-Petersburg Academy of Sciences. state honey. University. Pavlov. SPb. Publishing house of St. Petersburg state medical University. 1999. 23 C.

Yemelyanov. Comparative evaluation of the efficacy of treatment of sensorineural hearing loss antibioticos and noantibiotics etiology midokalma in combination with nootropilum.

Journal of otolaryngology, 1997, No. 4, p.20-23.

All of the above analogues, based on the use of pharmacological agents for the treatment of sensorineural hearing loss (NT), according to the authors, the goal is to halt the progression of HT and only lead to subjective improvement in the subjective ear noise. When the objective control of hearing through tone threshold audiometry positive changes audiological curves is not detected. This despite the fact that all prescription drugs have their own side effects.

Thus, the disadvantages of such analogs are:

1) the Use of pharmacological drugs with side what ffecti,

2) the high Cost of treatment

3) the Need for parenteral administration of drugs,

4) the Main disadvantage of the described methods of treatment is that the treatment effect is subjective and is associated only with the disappearance of ear noise without objective improve hearing function.

Prototype: prototype we have used the Method for the treatment of sensorineural hearing loss” under the application №96-111557/14 published 1998.04.20.

Description of the prototype: the Invention relates to medicine, namely to otolaryngology, and may find application in the treatment of disorders of auditory function. The method allows for a short course of treatment at 10-35 dB to improve auditory function in both acute and chronic forms of the disease. To do this, patients who have reduced blood levels of the protein ceruloplasmin and increased the content of substances with mol. wt. 300-5000 D, injected human ceruloplasmin intravenously in the amount of 1.5 mg/kg for 5-7 days.

The disadvantages of the prototype are:

1. The need determination in blood protein ceruloplasmin and substances with an average mol. wt. 300-5000 D, since the efficiency of the introduction of ceruloplasmin in this category of patients will depend on their content in the blood. The effect is expected if the content of ceruloplasmin in the blood is lowered.

2. Need parenter the form of further administration of the drug.

Wasmainly allergic reactions with the introduction of protein drugs. Although protein is homologous, the possibility of sensitization still exists.

4. The high cost of treatment method.

The purpose of the claimed invention: Treatment of acquired sensorineural hearing loss antibioticos and noantibiotics etiologii in children and adults, regardless of the duration of the disease.

The invention consists in the use of the drug NBS, which dosage form is aminoglycoside antibiotic neomycin, prepared by serial dilution of the drug in water to reduce the content of active substance in the dosage form.

The method of preparation of the drug NBS: 1 tablet neomycin sulfate containing 0.1 g of the substance is placed in a vial with 100 ml of distilled water. After the tablet will disintegrate, the contents of the vial shaken, then leave before the deposition of sediment. Through the day of the supernatant take 1 ml in another vial and diluted with distilled water in the ratio 1:100. So do 4 more times, but in recent times diluted with alcohol.

Then a drop of alcohol solution neomycin transferred into a vial with pellets made from milk sugar and shake. Leave the bottle open for 1 day.

After drying the granules dosage form is th is new.

For the treatment of patients with drug use 1 pellet per reception, and the reception frequency is determined individually depending on the sensitivity of the patient.

The duration of treatment determined by clinical effect.

A specific example of the method. Case 1. Isaev, Magomedali born in 1993 POS. Tarki, 8th Becomes 23.

Hearing loss in both ears, at the age of 1.5 years for pneumonia received antibiotics treatment, presumably gentamicin. Hearing problems seen in six months. Does not speak (mutism). In the examination diagnosed with sensorineural hearing loss IY Art.

The results of treatment are presented in tone threshold audiogram. A - original audiogram, B - audiogram after 4 months of drug treatment NBS.

As can be seen from tiga, there is a decrease in the perception of hearing over a range of frequencies, and the curve of the air conductivity at frequencies above 1000 Hz, the threshold of perception is 80-90 dB. Curved bone conduction at a frequency of 500 Hz is determined by the gap curve. The described changes are symmetric, i.e. two-way.

After 4 months of treatment along the curve of the air conductivity is determined by the decrease of the threshold of perception in the frequency range from 1000 to 8000 Hz in average by 10-15 dB. Moreover, the curve of the bone conduction is determined by the extension of the range vosprinimat the number of frequencies up to 4000 Hz, the lower threshold of frequencies at 500 Hz 15 dB (figb). This coincided with the fact that the child started to listen to the sounds from the TV, I began to wear a hearing aid (prior to that, he flatly refused to do so), started to say her mother's name.

Signs, distinctive features of the prototype. In our case, for the treatment of sensorineural hearing loss is used aminoglycoside antibiotic neomycin in small doses, sufficient for the treatment of HT, but not having toxic or allergenic effects on the body of the patient. For the application of the NBS does not require determination of ceruloplasmin and substances mol. weight of 300-5000 Forth In the prototype is used parenteral use ceruloplasmin provided a reduced content of a specified drug in the blood, which in essence is the substitution therapy. In our case, the dosage form NBS applied under the tongue that allows rapid absorption, has no irritating effect on the gastrointestinal tract. For purposes NBS does not require prior identification of any blood.

The usefulness of the Method of drug treatment NBS is highly efficient, has no contraindications. In addition, boasts a low cost of preparation. Since neomycin approved for use in Russia and described in the States is authorized Pharmacopoeia, there is no need to obtain permission for its clinical application.

A method for the treatment of acquired sensorineural hearing loss by the introduction of patient antibiotic neomycin sulfate granules prepared as follows: the pill neomycin sulfate 1.0 g was placed in a vial with 100 ml of distilled water to the disintegration of the tablet, then the contents of the vial is shaken out and leave before the deposition of sediments through the day of the supernatant take 1 ml in another vial and diluted with distilled water in the ratio 1:100, so do another 4 times, the last time dilute alcohol; then a drop of alcohol solution is transferred into a bottle with pellets made from milk sugar and shake, leave the bottle open for a day before drying the granules; drug take 1 pellets under the tongue, while the frequency and the duration of treatment is determined individually on the sensitivity of the patient and obtaining clinical effect.



 

Same patents:

The invention relates to medicine and can be used to obtain biologically active substances from the blood serum of animals and birds, are useful for the treatment or correction of a hearing impairment, sexual activity, spatial memory; and to increase physical endurance, stimulate proliferation of embryonic brain cells; useful in Parkinson's disease

The invention relates to medicine, namely to otolaryngology
The invention relates to medicine, in particular to the ENT, and can be used for the treatment of chronic purulent mesotympanic
The invention relates to medicine, in particular to the ENT, and can be used for the treatment of chronic inflammation trepanations cavity after radical surgery on the middle ear

The invention relates to medicine, namely to homeopathic, treatment and prevention tools for internal and external use, has tonic, anti-inflammatory, wound healing, detoxifying, anti-microbial, antianginal, anti-atherosclerotic, antioxidant, antihypoxic, neuroprotective, sedative, cardioprotective, anti-arrhythmic, angioprotective, stress-protective, immunotropic, antifungal, nephroprotective, hepatoprotective, gastroprotective, thermoprotector, lipoic, megaproducer, radioprotective, and retinoprotective anticoordination action

The invention relates to medicine

The invention relates to medicine, namely purulent surgery
The invention relates to medicine, in particular for laboratory diagnosis

The invention relates to polymer compositions of antibiotics and can be used in medicine and veterinary medicine

The invention relates to veterinary medicine, in particular to long-acting drugs for the treatment of animal diseases caused by bacteria and chlamydia

The invention relates to the field of veterinary medicine

The invention relates to the field of clinical medicine - Phthisiology and can be used in the treatment of patients with caseous pneumonia to reduce the severity of the intoxication syndrome, normalization of blood system, withdrawal side effects from anti-TB therapy

The invention relates to the field of medicine and relates to a pharmaceutical for the treatment of skin diseases

The invention relates to medicine, cosmetology and can be used to treat acne

The invention relates to medicine, in particular to cosmetology, and can be used for prevention of infectious complications in the operation of mechanical dermabrasion using antiseptic
The invention relates to medicine, namely to laser ENT surgery

The invention relates to medicine and can be used for cleaning and processing, especially in the area of personal hygiene
The invention relates to medicine, in particular to the ENT, and can be used for the treatment of chronic purulent mesotympanic
The invention relates to medicine and can be used for the treatment of chronic nonspecific tonsillitis
Up!