Method and device for absorbing humidity from unit of volume of expired air

FIELD: medicine; medical engineering.

SUBSTANCE: method involves connecting patient to device via bite-board. The patient makes expiration via tube connected to inlet valve of respiratory sack. The expired air is accumulated in the respiratory sack in the amount of equal to the respiratory sack volume. Timer is set for 15 min after being filled. Microcompressor pumps the air expired by the patient via tube filled with silicagel at constant flow rate. The patient goes on filling the respiratory sack with expired air while the microcompressor is operating. After the timer expires, 0.5-1.0 ml of humidity is obtained from the expired air adsorbed on silicagel. Single-use tube containing silicagel is soldered and kept in frost chamber until its biochemical examination is carried out. The device has airtight respiratory sack having inlet and outlet valves. The inlet valve is connected to tube provided with bite-board. The outlet valve is connected to tube containing silicagel layer.

EFFECT: humidity sampling independence of patient state.

2 cl, 1 dwg

 

The invention relates to medicine, namely to Pediatrics.

According to most researchers perfect the examination must meet the following conditions: to be non-invasive, quite specific, sensitive and simple to perform. From non-invasive methods used in recent years, become more and more widespread study of various metabolic indices in moisture condensate of exhaled air (Adrianova E.N. et al., 1999). Draws attention to the possibility of studying readily available material - exhaled breath condensate (EBC). The method of obtaining it is very simple, does not require special skills and tools that allows you to use it even on an outpatient basis. Wide application of the CDF due to the fact that about 30% surfactant disposed through the upper respiratory tract and in addition to the individual components of the surfactant in the CDF found many substances (hormones, electrolytes, peroxidation products, biologically active substances), which play a critical role in the pathogenesis of various diseases. The rationale for the use of moisture condensate exhaled serve as a parallel study arespiratory lung function, lipid, mineral and electrolyte composition of the blood.

As a prototype obtain a condensate of exhaled air is and the method used Geedorah ("Atraumatic method of investigation of the surface-active properties of the lung (surfactant)", methodical recommendations, Minsk, 1981. - 15 C.), which is based on the ability of moisture exhaled air to condense at low temperature in a special device.

Collection of exhaled breath condensate is carried out in a well-ventilated area at a constant humidity and temperature. Before collecting the condensate within 10 minutes the patient adapts to the conditions of collection and acquainted with the methodology of the future research. When preparing and conducting studies provide clean condensate collection, to ensure that through the hands of the medical staff and the patient, as well as with laboratory glassware and mouthpiece in the collected material were not products of pollution. To this end, patients were asked to carefully remove the lip area traces of possible contamination of gauze cloth moistened with rubbing alcohol, and then offer three times to rinse your mouth with warm boiled water and drink 0.5 cups of water. After this procedure the patient is seated and attached to the prototype device Geedorah ("Atraumatic method of investigation of the surface-active properties of the lung (surfactant)", guidelines, Minsk, 1981. - 15 S.), through the mouthpiece connected to the capacitor, placed in a container of coolant, which is a glass bottle filled with snow or in the Oh with ice cubes. The condenser is made detachable and consists of a glass cylinder with a diameter of 10 mm and vozduhoprovodyaschih glass tube with a diameter of 20 mm, the end of which fits inside the cylinder. The tube has a shirt cylindrical, hermetically covering the cylinder, which made the cut. For discharge of collected condensate cylinder is separated from the tube.

Collection of exhaled breath condensate is made within 15 minutes. You need to process the entire collection of condensate patient properly, uniformly and freely breathed in, and breath made only through the nose. After turning off the subject from the condensate in the condenser, carefully wash the walls with ramparts and trace amounts volumetric measure the total number of condensate and conduct biochemical studies of its composition.

Some disadvantages of the method are:

1. The definition of indicators in 1 ml of exhaled breath condensate, without regard to the individual blagojelatel lungs capacity, which depends on the patient's age and presence of diseases of the respiratory system, resulting in underestimation blagojelatel lung function time collecting exhaled breath condensate may take up to 30 minutes

2. The need for uniform long breath (standard conditions), which makes it difficult to use the W of the device in critically ill and young children.

3. The requirement of the standard conditions at the time of collection of condensate (temperature, humidity), which affects the rate of condensation and its number.

Some drawbacks are:

1. The need to use as a cooler snow or ice, which results during the collection of material to a gradual increase in the coolant temperature.

2. The design of the device does not allow the extraction of the material in disposable dishes.

3. The technical complexity of manufacturing glass condenser (requires the development of individual drawings and special equipment for manufacturing systems).

4. The fragility of the material of the capacitor (glass) requires frequent replacement and especially careful use of the device in children and elderly patients.

The authors propose a method and a device for obtaining adsorbate moisture from a unit volume of exhaled air. Per unit volume take the amount of exhaled air, equal to 19.5 DM3that allows you to obtain the necessary biochemical studies volume (0.5-1.0 ml) of the adsorbate moisture exhaled air. The volume of 19.5 DM3selected on the basis of 1 liter of exhaled air is obtained 0,047-0,042 ml moisture exhaled breath condensate (Sidorenko GI et al. 1981), and carried out what I biochemical studies requires 0.5-1.0 ml of adsorbate moisture exhaled air, which is confirmed empirically survey of 780 children of different ages.

Device for collecting adsorbate moisture exhaled air (see drawing) consists of a sealed breathing bag of the medical plastic 250×190 mm (1), provided with two valves: an inlet valve (2) and outlet valve (3). Inlet valve (2) connected to a disposable plastic tube (4) with a diameter of 10 mm and a length of 150 mm, equipped with a mouthpiece (5). Outlet valve (3) connected to a disposable plastic tube (6) with a diameter of 5 mm, length 10 mm, which is filled with a layer of silicagel 540A displacement of 1 cm3(7), kept in the tube (6) breathable (cotton) plug (8). Medical disposable syringe with a volume of 2 cm3trying to silica gel displacement of 1 cm3. Surgical probe placed a cotton plug (8) in a disposable tube (6), length 250 mm, from its beginning fall asleep selected silica gel (7) using a syringe. To the outer end of the tube (6) connected microcompressor “ELIT-801” (10) through a plastic tube (9) with a diameter of 5 mm, length 800 mm

The method is as follows: collection of adsorbate moisture exhaled air is held in any comfortable for the patient room. The patient is carefully wipe the area of the lips and hands gauze cloth moistened with distilled water, offered three times to rinse your mouth with warm key is jachenau water, comfortable seat and attach to the device through the mouthpiece. The patient breathes out through a tube connected to the inlet valve breathing bag. The exhaled air is accumulated in the respiratory bag, equal to the volume of the breathing bag (which is achieved due to the presence of valves). After filling the breathing bag includes a timer for 15 minutes and connect the microcompressor, which pumps the exhaled breath of the patient, the air from the bag through the tube with silica gel at a constant speed of 1300 cm3/min. In the process of microcompressor the patient continues to fill the breathing bag exhaled air through a system of tubes. After 15 minutes of the microcompressor volume pumped through silica gel air is 19.5 l, on average, can be obtained from 0.5-1.0 ml of moisture exhaled air, adsorbed on silica gel. After the off timer turn off the microcompressor and the patient is disconnected from the system. From the system remove disposable tube with silica gel, sealed its ends by means of a spirit lamp and stored in a freezer before carrying out biochemical studies (determination of total lipids, phospholipids and their fractions standard methods).

The advantages of this method are:

1. This method allows you to define the components of exhaled air per unit volume exhaled is on air (19,5 DM 3at standard conditions, which is especially important as in various diseases varies the volume of respiration and flagovedeniya pulmonary function.

2. The basis of this method is the principle of adsorption and not condensation, which avoids the use of the cooler.

3. Does not require the length and evenness of breath (standard conditions), which allows to use this method in young children and seriously ill.

The advantages of the device are:

1. The design of the device provides for the collection of material in a single system, eliminating the ingress of artefacto.

2. Technical simplicity and availability.

3. The use of plastic tubes and bags for collecting exhaled air causes the sustainability and reliability of the system, and complete safety studies in children, the elderly and the seriously ill.

4. The possibility of use in the clinic, hospital, schools of any level without compliance with the standard requirements of the room (temperature, humidity).

1. The method of adsorption of moisture from the unit volume of exhaled air using the device to obtain adsorbate moisture exhaled air, which consists in the fact that through the mouthpiece of the patient attached to the device and through a tube connected to vhodni the valve breathing bag, the patient breathes out, the exhaled air to accumulate in the breathing bag volume equal to the volume of the breathing bag, after filling it includes 15 min timer and connect the microcompressor, which pumps the exhaled breath of the patient, the air from the bag through the tube with silica gel at a constant speed, and the patient continues to fill the breathing bag exhaled air during operation of the microcompressor, after turning off the timer receive 0.5-1.0 ml of moisture exhaled air, adsorbed on silica gel, disposable tube with silica gel sealed and stored in a freezer until biochemical analysis.

2. A device for receiving adsorbate moisture exhaled air, comprising a sealed breathing bag from medical grade plastic size 250×190 mm, equipped with inlet and outlet valves, the inlet valve is connected to a disposable plastic tube with a diameter of 10 mm and a length of 150 mm, equipped with a mouthpiece, and the output valve is connected with a disposable plastic tube with a diameter of 5 mm and a length of 1000 mm, which is filled with the layer of silicagel 5/40A displacement of 1 cm3held in the tube breathable cotton tube, and the tube is placed in a length of 250 mm from the beginning of the tube and to the outer end of the tube diameter of 5 mm and a length of 800 mm connect the microcompressor through the Plaza is ichovouu tube.



 

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FIELD: medicine; medical engineering.

SUBSTANCE: method involves connecting patient to device via bite-board. The patient makes expiration via tube connected to inlet valve of respiratory sack. The expired air is accumulated in the respiratory sack in the amount of equal to the respiratory sack volume. Timer is set for 15 min after being filled. Microcompressor pumps the air expired by the patient via tube filled with silicagel at constant flow rate. The patient goes on filling the respiratory sack with expired air while the microcompressor is operating. After the timer expires, 0.5-1.0 ml of humidity is obtained from the expired air adsorbed on silicagel. Single-use tube containing silicagel is soldered and kept in frost chamber until its biochemical examination is carried out. The device has airtight respiratory sack having inlet and outlet valves. The inlet valve is connected to tube provided with bite-board. The outlet valve is connected to tube containing silicagel layer.

EFFECT: humidity sampling independence of patient state.

2 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: method involves determining prognostic parameter values like those of lung ventilation function after spoken rational and irrational test texts. Three values are calculated from the obtained data using linear classification functions. They are compared and functional cerebral asymmetry pattern is to be predicted from their values.

EFFECT: high accuracy and reliability of prognosis.

FIELD: medicine, pulmonology.

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EFFECT: higher efficiency of diagnostics.

2 ex

FIELD: medical engineering.

SUBSTANCE: device has controller, indication unit, unit for setting standard breathing parameters, amplifier transformer, breathing movement transducer, amplification control unit and power supply source. The indication unit has linear indicator of patient breathing, linear indicator of standard breathing, linear indicator of standard breathing frequency and breathing rhythm mismatch indicator. The breathing rhythm mismatch indicator has photodiode unit and acoustic unit.

EFFECT: accelerated treatment course.

5 dwg

FIELD: medicine, pulmonology.

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EFFECT: higher efficiency of therapy.

2 ex

Oxiorespirator // 2250074

FIELD: medical engineering.

SUBSTANCE: device has inlet tube having temperature gage which output is connected to input of unit for calculating breathing period and indication unit. It has infrared transducer placed on inlet tube bite-board. Unit for calculating blood saturation with oxygen is connected to infrared transducer output. The integrator and indicator are connected in series to the unit to additionally enable blood saturation with oxygen and controlling dependency on breathing period. Keyboard which output is connected to the second input of the integrator is available. The third input is connected to output of unit for calculating breathing period.

EFFECT: wide range of functional applications.

1 dwg

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2 ex

FIELD: medicine.

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EFFECT: high accuracy of diagnosis.

2 dwg

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