The common way to diagnose progressive psoriasis

 

(57) Abstract:

The invention relates to medicine, namely to laboratory methods of skin diseases and can be used to diagnose common progressive psoriasis. The invention consists in the separation of serum proteins and determination of contents of fractions of alpha-2 and gamma globulins from 3 to 5 a week since the intensification of the increase in the content of alpha-2 globulin 60-80% of normal, and gamma globulins by 30-40% from the norm of 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with active current, and when the normal value of alpha 2-globulin and gamma-globulin for 3-4 weeks and save this content to 4-5 week or the increase in the content of alpha-2 and gamma-globulin in 5-10% of normal for 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with passive current. The advantage of the invention is to improve the reliability of diagnosis.

The invention relates to medicine, namely to laboratory methods of skin diseases and may be the diagnosis of psoriasis by examining serum (article A. A. Archipenko etc.Changes in the content of the reactants of the acute phase of inflammation in the blood serum of patients with psoriasis before and after treatment. Abstracts of scientific papers scientific-practical conferenceTopical issues of treatment of sexually transmitted infections and chronic dermatoses, Ekaterinburg, 2002, page 25).

This method allows you to diagnose psoriasis on the basis of the set of indicators established when conducting biochemical studies of blood. These studies are carried out in different laboratories, they require large financial costs and time, which consequently affects the accuracy and timeliness of diagnosis.

A known method for the diagnosis of common progressive psoriasis involving separation of serum proteins and determination of contents of fractions of alpha-2 and gamma globulin at the time of exacerbation (article Y. Y. ashmarina, etc.About changes in the protein composition of the blood of patients with certain dermatoses. Bulletin of dermato the integral of the blood, obtained in the study of protein fractions of blood serum. As the evaluation criteria selected fractions of alpha-2 and gamma - globulin as the most informative from the point of view of the severity of the inflammatory process and the immune status of the organism. In addition, there are increased levels of alpha-2-globulin and gamma - globulin at the time of exacerbation.

The disadvantage of this method is the lack of differential diagnosis of common progressive psoriasis, allowing to estimate a form of the disease, which significantly limits its capabilities.

For example, patients with the passive form of the widespread progressive psoriasis at the time of exacerbation alpha - 2 - globulin and gamma - globulin corresponds to the normal value or increases very slightly, so the probability of a diagnosis of psoriasis with passive flow according to the criteria at the time of exacerbation low, as evidenced by authors known way, pointing to page 15 of the above information, that the increase in alpha-2 globulins was found only in 1/5 surveyed, and gamma-globes the increased functionality of the method due to differential assessment of the nature of the current progressive widespread psoriasis, what is necessary for the timely appointment of a combination of various therapeutic measures, depending on the nature of the disease.

This task is achieved in that in the method for the diagnosis of common progressive psoriasis involving separation of serum proteins and determination of contents of fractions of alpha-2 and gamma-globulin at the time of exacerbation, additionally determine the fractions of alpha-2 and gamma - globulin in the process of the disease from 3 to 5 a week since the intensification of the increase in the content of the alpha-2 globulin 60-80% of normal, and gamma globulins by 30-40% from the norm of 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with the active form of the flow, and when the normal value of alpha 2 - globulin and gamma-globulin for 3-4 weeks and save this content to 4-5 week or elevated levels of alpha-2 and gamma-globulin in 5-10% of normal for 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with passive flow.

In contrast to the known method in the proposed definition content Falco their content varies depending on the nature of the disease, from state General reactivity of the organism, which provides more information, and thereby increases the reliability of the diagnosis.

The implementation of the method is illustrated with specific examples.

Example 1. Patient I. 33 years, and/b 129, at entry: skin have multiple specific lesions, the diagnosis-a common psoriasis.

Upon admission to the hospital, in the acute period of the fractions of alpha-2 and gamma-globulin in the blood serum was 13% and 20.5% respectively of the total amount of protein (at a rate of 7-11% and 13-19%, respectively). By the 3rd week of illness alpha-2-globulin was 15% of the total number of protein, which corresponds to the increase of their content in 67% of normal (7-11%), and gamma-globulin 22% of the total number of protein, which corresponds to the increase of their content by 40% from normal (13-19%). Subsequently to the beginning of the 5th week of the alpha-2 and gamma-globulin was 11% and 18% respectively, which corresponds to the normal value (7-11%, 13-19%). The result of these studies clarified the diagnosis of common psoriasis with active flow. In accordance with this assigned therapeutic treatment, which is the mortality of the body, for example, antihistamines, and gemodez, methotrexate, and ointments and shampoos affecting local process.

Example 2. Patient P. 44, and a/b 62(19372), the skin have multiple specific lesions, the diagnosis - a common psoriasis.

Upon admission to the hospital, in the acute period of the fractions of alpha-2 and gamma-globulin in the blood serum was 9% and 16.5% respectively of the total number of protein, which corresponds to the normal value(7-11% 13-19%, respectively). By the 3rd week of illness alpha-2-globulin was 10% of the total number of protein, which corresponds to the norm (Norma-11%), and gamma-globulin 19% of the total number of protein, which corresponds to the norm (norm 13-19%). Subsequently to the beginning of the 5th week of the alpha-2 and gamma-globulin was 10.5% and 18.5%, which also corresponds to the normal value.

The result of these studies clarified the diagnosis of common psoriasis with passive flow. In accordance with this prescribed treatment, which consisted in taking a fortifying preparations, providing increased nonspecific resistance of the body, such as vitamins B6, 12, PUVA with axial the soba will provide for consistency deagostini due to differential assessment of the nature of the current progressive spread of psoriasis. This will allow time to conduct a complex of therapeutic measures, depending on the nature of the disease that will speed up the recovery.

The common way to diagnose progressive psoriasis involving separation of serum proteins and determination of contents of fractions of alpha-2 and gamma-globulin at the time of acute illness, characterized in that it further determine the fractions of alpha-2 and gamma globulin in the process of the disease from 3 to 5 a week since the intensification of the increase in the content of alpha-2 globulin 60-80% of normal, and gamma globulins by 30-40% from the norm of 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with active current, and when the normal value of alpha 2-globulin and gamma-globulin for 3-4 weeks and save this content to 4-5 week or elevated levels of alpha-2 and gamma-globulin in 5-10% of normal for 3-4 weeks and reduced their content to normal by 4-5 week diagnose common progressive psoriasis with passive current.



 

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