N-heterocyclic derivatives and their use as inhibitors synthase nitric oxide


 

(57) Abstract:

The invention relates to new N-heterocyclic derivatives of the formula (I):

where: A means-OR1-C(O)N(R1R2or-N(R1R21; each X, Y and Z independently represents N or C(R19); each U represents N or C(R5), provided that U is N only when X represents N, and Z and Y denote CR19; each W represents N or CH; V denotes: (1) N(R4); (2) C(R4)H; or (3) a group is directly related to the group -(C(R14R20)n-A represents a 5-6 membered N-heterocyclyl, optionally containing 6-membered ring additional heteroatom selected from oxygen, sulfur and NR6where R6denotes hydrogen, optionally substituted phenyl, 6-membered heterocyclyl containing 1-2 nitrogen atom, optionally substituted 5-membered heterocyclyl containing 1-2 nitrogen atom, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl,1-6alkoxycarbonyl, acetyl, etc. 4 N. and 40 C.p. f-crystals, 7 PL.

The technical field

This invention relates to a series of N-heterocyclic compounds and their derivatives, which are effective inhibitors of sentai inventions

Nitrogen monoxide (NO) is involved in a number of different physiological processes, including relaxation of smooth muscle, inhibition of platelets, nerve transmission, immune regulation and the erection of the penis. The nitric oxide produced in different conditions virtually all nucleated mammalian cells. It is believed that a number of pathological conditions associated with abnormal production of NO, including stroke, non-insulin-dependent diabetes, septic hypotension caused by shock, rheumatoid arthritis and multiple sclerosis. Nitric oxide is synthesized in biological tissues by the enzyme called synthase nitric oxide (NOS), which uses NADPH and molecular oxygen for the oxidation of L-alanine in the citrulline and nitric oxide.

Synthase nitric oxide (NOS) there are at least three isoforms, which can be divided into two main categories: structural and induced. Identified two structural isoforms, which are dependent on calcium and calmoduline, and one inducible isoforms. The structural isoforms include (1) a neural isoform, NOS-1 or nNOS, which is found in the brain and skeletal muscle, and (2) the endothelial isoform, NOS-3 or eNOS, which is found in abjecta effects of NOS inhibitors according to the present invention.

Inducible isoform (NOS2 or iNOS) is formed in virtually all nucleated mammalian cells under the influence of inflammatory cytokines or lipopolysaccharide. Her presence in macrophages and epithelial cells of the lung deserves special attention. This inducible isoforms are not stimulated by calcium and is not blocked by antagonists of calmoduline. It contains several closely related cofactors, including FMN, FAD and tetrahydrobiopterin.

The nitric oxide generated by inducible form of NOS, is directly related to the pathogenesis of inflammatory diseases. In experimental animals using NOS inhibitors can treat hypotension caused by lipopolysaccharide or factor tumor necrosis. Causes of cytokine-induced hypotension can be septic shock, hemodialysis and interleukine therapy of cancer patients. Based on this we can assume that the iNOS inhibitor should be treated effectively cytokine-induced hypotension. In addition, a recent study revealed the role of NO in the pathogenesis of inflammatory diseases, suggesting that inhibitors of NOS should take effective action in inflammation of the intestine, drama in adults (ARDS) and myocarditis. They can also be effective adjuvants for short-term immunosuppression in organ transplantation.

The diversity and wide range of action of NO in physiological processes requires special attention be paid drug treatment of diseases associated with NO. Because endogenous production of NO is the result of related but different isoenzymes, differential inhibition of NOS isoenzymes can make the treatment more selective and reduce the number of side effects.

A brief statement of the substance of the invention

One object of this invention are the compounds of formula (I), formula (II) and formula (III):

where:

And means-R1, -OR1, -C(O)N(R1R2, -P(O)[N(R1R2]2, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1, -SO2NHC(O)R1,-NHSO2R22, -SO2N(R1)H, -C(O)NHSO2R22and-CH=NOR1;

each X, Y and Z independently represents N or C (R19);

each U represents N or C (R5), provided that U is N THE/SUP>)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C(O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group including hydrogen, optional the P>9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2together with the nitrogen atom to which they are attached represent optionally substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl]-C(O)N(R1R2, -[C1-C8alkyl]-N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, [C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, the l, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S(O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl] -C(H)[C(O)OR16]2and -[C0-C8alkyl] -C(O)N(R1R16;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8, -C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, parilamentary, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2-C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

in the form of a single stereoisomer, mixture of stereoisomers or pharmaceutically acceptable salts.

Another object of this invention are the compounds of formula (IV):

where:

AA denotes an amino acid;

X, Y and Z then when X represents N, and Z and Y denote CR19;

W represents N or CH;

R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2together with the nitrogen atom to which they are attached represent optionally substituted N-heterocyclyl;

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S(O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl] -C(H)[C(O)OR16]2and -[C0-C8alkyl] -C(O)N(R1R16;

each R9independently selected from the group including halogenated, is illuminated by one or more substituents, selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R19denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21denotes hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, means not semidemocracies optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

t is zero, one, or two;

in the form of a single isomer, mixtures of isomers, or pharmaceutically acceptable salt.

Another object of this invention are the compounds of formula (Va), formula (Vb) or formula (Vc):

where:

In denotes a condensed 5 - or 6-membered optionally substituted carbocyclic or heterocyclyl; and

And means-R1, -OR1-C(O)N(R1R2, -P(O)[N(R1R2]2, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1, -SO2NHC(O)R1, -NHSO2R22, -SO2N(R1)H, -C(O)NHSO2R22and-CH=NOR1;

each X and Y independently represents N or C(R19);

V denotes N(R4), S, O or C(R4)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C(O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is the ovii, that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optional substituted hidrocharme they are attached, denote optionally substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl]-C(O)N(R1R2, -[C1-C8alkyl] -N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R6choose from a group including at the SUB>alkyl]-R11, acyl, -C(O)R8, -C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2, -C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group including the but substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they prisoedinenii, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

in the form of a single stereoisomer, mixture of stereoisomers or pharmaceutically acceptable salts.

Another object of this invention is a compound of formula (VIa), formula (VIb) or formula (VIc):

where:

In denotes a condensed 5 - or 6-membered optionally substituted carbocyclic or heterocyclyl; and

And means-R1, -OR1-C(O)N(R1R2, -P(O)[N(R1R2]2, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1, -SO2NHC(O)R1, -NHSO2R22, -SO2N(Rl)H, -C(O)NHSO2R22and-CH=NOR1;

each X and Y independently represents N or C(R19);

V denotes N(R4), S, O or C(R4)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C(O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 is less heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heteroclada substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl]-C(O)N(R1R2, -[C1-C8alkyl]-N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2, -C(O)-R23-N(R1)C(O)-R23-N(R1R2, -C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, allowability, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocy optionally substituted aralkyl; and

R23denotes an amino acid residue;

in the form of a single stereoisomer, mixture of stereoisomers or pharmaceutically acceptable salts.

Another object of this invention are the compounds of formula (VIIa), formula (VIIb) or formula (VII):

where

And means-R1, -OR1, -C(O)N(R1R2, -P(O)[N(R1R2]2, -N(R1)C(O)R2, -N(R16)C(O)OR SIG2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1, -SO2NHC(O)R1, -NHSO2R22, -SO2N(R1)H, -C(O)NHSO2R22and-CH=NOR1;

each X, Y and Z independently represents N or C(R19);

each U represents N or C(R5), provided that U is N only when X represents N and Z and Y denote CR19;

V denotes N(R4), S, O or C(R4)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C(O)-,

-O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r S="ptx2">when And indicates-OR1, -N (R1) C (O) R2, -N (R16) C (O) OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl]-C(O)N(RlR2, -[C1-C8alkyl]-N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted and the 1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl]-C(O)or SIG16, -[C0-C8alkyl] -C(H)[C(O)OR16]2and -[C0-C8alkyl] -C(O)N(R1R16;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8-C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2-C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group vklyuchayushchego substituted by one or more substituents, selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, S="ptx2">or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

in the form of a single stereoisomer, mixture of stereoisomers or pharmaceutically acceptable salts.

Another object of this invention is a compound of formula (VIII):

where two elements of X, Y and Z represent nitrogen and the third element represents CH.

Another object of this invention are the compounds of formula (A), formula (IXb) or formula (CHD):

where:

denotes solid media;

L denotes the balance link;

each X, Y and Z independently represents N or C (R19);

each U represents N or C(R5), provided that U is N only when X represents N and Z and Y denote CR19 Q is chosen from the group includes a direct link, -C(O)-, -O-, -C(=N-R1)-, -S(O)t-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl] -C(O)N(R1R2, -[C1-C8alkyl] -N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3 may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when the including hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S(O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl] -C(H)[C(O)OR16]2and -[C0-C8alkyl]-C(O)N(R1R16;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8-C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2, SUP>8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl ecoprofile, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

in the form of a single stereoisomer, mixture of stereoisomers or pharmaceutically acceptable salts.

Another object of this invention is a pharmaceutical composition containing the above compound of formula (I), formula (II) or formula (III) and a pharmaceutically acceptable carrier.

Another object of this invention is a method of obtaining compounds of formula (I), formula (II) and formula (III):

where:

And means-R1, -OR1, -C(O)N(R1R2, -P(O)[N(R1R2]2, -N(Rl)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(1)H, -C(O)NHSO2R22and-CH=NOR1;

each X, Y and Z independently represents N or C(R19);

each U represents N or C(R5), provided that U is N only when X represents N and Z and Y denote CR19;

V denotes N(R4), S, O or C(R4)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C(O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is equal to n is optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2together with the nitrogen atom to which they are attached represent optionally substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl] -C(O)N(R1R2, -[C1-C8alkyl] -N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminomar/SUP>)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl] -C(H)[C(O)OR16]2and -[C0-C8alkyl] -C(O)N(R1R16;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8, -C(O) -[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, neobyazatelnoe substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2-C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

each R11independently selected from the group consisting of cyano, di(alkoxy)Ala is every R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

who is that

(a) one Aquitaine with one equivalent of chlorine substituted compounds of the formula (XII):

where X, Y and Z independently represent N or C(R19);

U denotes N or C(R5), provided that U is N only when X represents N and Z and Y denote CR19and provided that X, Y and Z may not be all of C(R19) when U represents C(R5);

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S(O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N(R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl]-C(H)[C(O)OR16]2and -[C0-C8alkyl]-C(O)N(R1R16;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R

and

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

that gives compound of formula (XIII):

(b) specified compound of formula (XIII) is subjected to interaction with the compound of the formula (XIVa), formula (XIVb) or formula (XIVc):

where:

And means-R1, -OR1, -C(O)N(R1R2, -P(O)[N(R1R2]2, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1, -SO2NHC(O)R1, -NHSO2R22, -SO2N(R1)H, -C(O)NHSO2R22and-CH=NOR1;

V denotes N(R4), S or O;

Q is chosen from the group comprising a direct bond, -C (O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

t is zero, one, or two;

denotes optionally substituted N-heterocyclyl;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2together with the nitrogen atom to which they are attached represent optionally substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, it is Kil]-N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, alkoxy and imidazolyl);

or, when Q represents-N(R6)- or a direct link with R3, R3may optionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8, -C(O) -[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optional the output heterocyclyl, alkoxycarbonylmethyl, carboxyethyl, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH) -N(CN)R1-C(O)-R23-N(R1R2-C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, alkylsulfonamides;

, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

R23denotes an amino acid residue;

that gives compound of formula (I), formula (II) or formula (III).

Another object of this invention is the CLASS="ptx2">where:

And denotes-C(O)N(R1aR2;

each X, Y and Z independently represents N or C (R19);

each U represents N or C(R5), provided that U is N only when X represents N and Z and Y denote CR19;

V denotes N(R4), S, O or C(R4)H;

each W represents N or CH;

Q is chosen from the group comprising a direct bond, -C (O)-, -O-, -C(=N-R1)-, -S(O)tand-N(R6)-;

m is zero or an integer from 1 to 4;

n is zero or an integer from 1 to 3;

q is zero or one;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero;

when And indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(where t is zero) or-NHSO2R22, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, -N(R1)C(O)R2, -N(R16)C(O)OR2, -N(R1R21, -N(R16)C(O)N(R1R16, -S(O)tR1(when t is zero) or-NHSO2R22, m and n cannot be both equal to zero;

denotes optionally substituted carbocyclic or optionally substituted N-heterocyclyl;

R1adenotes hydrogen;

each R1and R2independently selected from the group comprising hydrogen, optionally substituted C1-C20alkyl, optionally substituted cycloalkyl, -[C0-C8alkyl]-R9, -[C2-C8alkenyl]-R9, -[C2-C8quinil]-R9, -[C2-C8alkyl]-R10(optionally substituted by hydroxyl), -[C1-C8]-R11(optionally substituted by hydroxyl), optionally substituted heterocyclyl;

or R1and R2together with the nitrogen atom to which they are attached represent optionally substituted N-heterocyclyl;

R3selected from the group comprising hydrogen, alkyl, cycloalkyl, optionally substituted aryl, halogenated, -[C1-C8alkyl]-C(O)N(R1R2, -[C1-C8alkyl]-N(R1R2, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11and heterocyclyl (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl, ulkopoliittinen to be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylammonium, dialkylaminoalkyl and-C(=NR18)-NH2;

or Q-R3taken together , represent-C(O)HE, -C(O)N(R1R2, -C(=NH)-N(R1R2or

R4selected from the group comprising hydrogen, alkyl, aryl, aralkyl and cycloalkyl; provided that when a represents-R1or1, R4cannot be hydrogen, and when V represents CH, R4may additionally be hydroxy-group;

R5selected from the group comprising hydrogen, halogen, alkyl, halogenated, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S(O)t-R16, -N(R16R21, -N(R16)C(O)N(R1R16, -N (R16)C(O)OR16, -N(R16)C(O)R16, -[C0-C8alkyl] -C(O)OR16, -[C0-C8alkyl]-C(H) [C(O)OR16]2and -[C0-C8alkyl]-C(O)N(R1R16;

R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8-C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optional zalesny aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2, -C(O)-R23-N(R1)C(O)-R23-N(R1R2-C(O)-N(R1)-R23-C(O)OR1;

each R8and R9independently selected from the group including halogenated, cycloalkyl (optionally substituted with halogen, cyano, alkyl or alkoxy), carbocyclic (optionally substituted by one or more substituents selected from the group comprising halogen, alkyl and alkoxy), and heterocyclyl (optionally substituted by alkyl, aralkyl or alkoxy);

each R10independently selected from the group comprising halogen, alkoxy, optionally substituted, aryloxy, optionally substituted, Alcoxy, optionally substituted-S(O)t-R22acylamino, amino, monoalkylamines, dialkylamino, (triphenylmethyl)amino, hydroxy, meacci)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylamines and dialkylaminoalkyl;

each R12, R13, R14, R15, R17and R20independently denotes hydrogen or alkyl;

each R16independently represents hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl;

R18denotes hydrogen, NO2or toluensulfonyl;

each R19independently denotes hydrogen, alkyl (optionally substituted by hydroxyl), cyclopropyl, halogen or halogenated;

each R21independently represents hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C(O)R22or-SO2R22;

or R21together with R1and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

or R21together with R16and the nitrogen atom to which they are attached, represents optionally substituted N-heterocyclyl;

each R22independently denotes an alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;

and

where:

U, V, W, X, Y and Z have the above values;

R2, R3, R12, R13, R14, R15, R17and R20have the above values;

denotes solid media;

and L denotes the remainder of the link of the formula (X)

where unsaturated valence in the right part of the formula indicates the place of attachment to the solid carrier, and unsaturated valency in the left part of the formula indicates the place of attachment to the ligand;

that gives the above compound of formula (I), formula (II) and formula (III).

Another object of this invention is a method of treating diseases caused by disturbances in the production of nitric oxide, which is that the mammal with abnormal production of nitric oxide is administered a therapeutically effective amount of the above compounds of formula (I), formula (II), formula (III), formula (IV), formula (Va), formula (Vb), formula (Vc), formula (VIa), formula (VIb), formula (VIc), formula (VIIa), formula (VIIb) or formula (VIIc).

Detailed description of the invention

Definition

"Alkyl" means a radical with a straight or branched hydrocarbon chain, which consists only of carbon atoms and hydrogen, contains no unsaturation, has from one to eight carbon atoms and attached to the rest of the molecule by a single bond, for example, methyl, ethyl, n-propyl, 1-methylethyl (isopropyl), n-butyl, n-pentyl, 1,1-dimethylethyl (tert-butyl) and the like. Alkyl radicals having more than eight carbon atoms, labeled as "[Cx-Cyalkyl], where x and y indicate the number of carbon atoms. The alkyl radicals may be optionally substituted by one or more substituents which are independently selected from the group including halogen, hydroxy, alkoxy, carboxy, carbonyl, alkoxycarbonyl, cyano, amino, monoalkylamines, dialkylamino, nitro, alkylthio, amidino, aryl, heterocyclyl, aryloxy, Alcoxy, acylamino, aminocarbonyl, monoalkylamines and dialkylaminoalkyl.

"Alkenyl" means a monovalent or divalent radical with a straight or branched chain consisting solely of carbon atoms and hydrogen, contains at least one double bond and has from one to eight carbon atoms, for example, ethynyl, producvity radical with a straight or branched chain, which consists only of carbon atoms and hydrogen, contains at least one triple bond and has from one to eight carbon atoms, for example, ethinyl, prop-1-inyl, but-1-inyl, Penta-1-inyl, Penta-3-inyl and the like.

"Alkoxy" means a radical of the formula-ORawhere Rais the above alkyl radical, for example, methoxy, ethoxy, propoxy and the like.

"Alkoxycarbonyl" means a radical of the formula-C(O)ORawhere Rais the above alkyl radical, for example, methoxycarbonyl, etoxycarbonyl, n-propoxycarbonyl and the like.

"Alkoxycarbonyl" means a radical of the formula-Ra-C(O)ORawhere Raindependently is above alkyl radical, for example, 2-(methoxycarbonyl)ethyl, 3-(etoxycarbonyl)propyl, 4-(n-propoxycarbonyl)butyl and the like.

"Alkylsulfonyl" means a radical of the formula-N(H)S(O)2-Rawhere Rais the above alkyl radical, for example, methylsulfonylamino, ethylsulfonyl and the like.

"Alkylsulfonyl" means a radical of the formula-S(O)2-Rawhere Rais the above alkyl radical, for example, met>is the above alkyl radical, for example, methylthio, ethylthio, n-propylthio and the like.

"Amidino" means a radical of the formula-C(NH)-NH2.

"Amino" means a radical of the formula-NH2.

"Aminocarbonyl" means a radical of the formula-C(O)NH2.

"Aminosulfonyl" means a radical of the formula-S(O)2NH2.

"Aryl" means phenyl or nattily radical. The aryl radical may be optionally substituted by one or more substituents selected from the group comprising hydroxy, mercapto, halogen, alkyl, alkenyl, quinil, phenyl, phenylalkyl, phenylalkyl, alkoxy, phenoxy, funeralcare, halogenated, halogenoalkane, formyl, nitro, cyano, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyethyl, generalkonsulat, amidino, ureido, alkoxycarbonyl, amino, monoalkylamines, dialkylamines, monophenyltin, monovinylacetylene, sulfonylamino, alkylsulfonyl, aminoalkyl, monoalkylamines, dialkylaminoalkyl, monofilaments, monovinylacetylene, acyl, carboxylic, alkoxycarbonylmethyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, aminocarbonyl, monoalkylammonium the above alkyl radical and Rbis the above aryl radical, for example, benzyl and the like. The aryl radical may be optionally substituted by the above substituents.

"Aryloxy" means a radical of the formula-or SIGbwhere Rbis the above aryl radical, for example, phenoxy, naphthoxy and the like. The aryl radical may be optionally substituted by the above substituents.

"Aryloxyalkyl" means a radical of the formula-C(O)or SIGbwhere Rbis the above aryl radical, for example, phenoxycarbonyl.

"Arakaki" means a radical of the formula-ORcwhere Rcis the above Uralkali radical, for example, benzyloxy and the like. Uralkaliy radical may be optionally substituted by the above substituents.

"Arelaxation" means a radical of the formula-C(O)ORcwhere Rcis the above Uralkali radical, for example, benzyloxycarbonyl and the like. Uralkaliy radical may be optionally substituted by the above substituents.

"Allumination" means a radical of the formula-C(O)N(Rb)N, where Rbis the above aryl radical, naprakstaami.

"Arylamination" means a radical of the formula-S(O)2N(Rb)N, where Rbis the above aryl radical, for example, phenylenesulfonyl and the like. The aryl radical may be optionally substituted by the above substituents.

"Arylsulfonyl" means a radical of the formula-S(O)2-Rbwhere Rbis the above aryl radical, for example, phenylsulfonyl and the like. The aryl radical may be optionally substituted by the above substituents.

"Arylsulfonamides" means a radical of the formula-C(O)N(H)S(O)2-Rbwhere Rbis the above aryl radical, for example, vinylsulfonylacetamido and the like. The aryl radical may be optionally substituted by the above substituents.

"Acyl" means a radical of the formula-C(O)Raand-C(O)Rbwhere Rais the above alkyl radical and Rbis the above aryl radical, for example, acetyl, propionyl, benzoyl and the like.

"Acylamino" means a radical of the formula-N(H)-C(O)-Raand-N(H)-C(O)-Rbwhere Rameans of the above alkyl radical and Rbwill oznaczenie divalent radical with a straight or branched chain, which consists only of carbon atoms and hydrogen, contains no unsaturation and has from one to eight carbon atoms, for example, methylene, ethylene, propylene, n-butylene, and the like. Alkalinity radical may be optionally substituted by one or more substituents selected from the group including alkyl, hydroxy, -N(R16R21or-C(O)N(R1R16where R1, R16and R21have the values specified in section "a Brief statement of the substance of the invention".

"Amino acid means a bivalent radical of formula-N(R1R23C(O)-, where R1matter listed for R1in the section "a Brief statement of the substance of the invention", and R23is amino acid residue. "Amino acid residue" means alkylenes chain between the nitrogen atom and a carboxyl group, which is substituted by a different "side chains" of known amino acids. For example, amino acid residues of the amino acids comprise a carbon atom (attached to the carboxyl group and the nitrogen atom) and a side chain. For example, the amino acid residue alanine is-C(CN)3-; amino acid residue serine is-C(CH2IT)- and so on. Therefore, the term "aminokislotami such amino acids are alanine, asparagine, N--trailerparkin, aspartic acid, tert-butyl ester of aspartic acid, arginine, Ng-Mtr-arginine, cysteine, S-trailsystem, glutamic acid, tert-butyl ester of glutamic acid, glutamine, N-tricolpate, glycine, histidine, N1m-tritylation, isoleucine, leucine, lysine, N-BOC-lysine, methionine, phenylalanine, Proline, serine, O-tert-butyltin, threonine, tryptophan, Nlm-Vos-tryptophan, tyrosine, valine, sarcosine, L-alanine, chloro-L-alanine, 2-aminoadamantane acid, 2-(methylamino)somalina acid, D,L-3-aminoadamantane acid, (R)-(-)-2-aminoadamantane acid, (S)-(+)-2-aminoadamantane acid, D-leucine, L-leucine, D-Norvaline, L-Norvaline, L-2-amino-4-pontenova acid, D-isoleucine, L-isoleucine, D-norleucine, 2,3-diaminopropionic acid, L-norleucine, D,L-2-aminocaproic acid, -alanine, D,L-3-aminobutyric acid, 4-aminobutyric acid, 4-(methylamino)butyric acid, 5-aminosalicilova acid, 5-aminocaproic acid, 7-aminoheptanoic acid, 8-aminocaproic acid, 11-mindcanvas acid, 12-aminododecanoic acid, carboxymethylamino, D-serine, D-homoserine, L-homoserine, D-allochrony, L-allochrony, D-threonine, L-threonine, D,L-4-amino-3-hydroxipropionic acid, D,L-3 is tankerenemy acid, 1-amino-1-cyclohexanecarbonyl acid, 5-amino-1,3-cyclohexadiene-1-carboxylic acid, 2-amino-2-norbornanamine acid, (S)-(-)-2-azetidin-carboxylic acid, CIS-4-hydroxy-D-Proline, CIS-4-hydroxy-L-Proline, TRANS-4-hydroxy-L-Proline, 3,4-degidro-D,L-Proline, 3,4-degidro-L-Proline, D-pipecolinate acid, L-pipecolinate acid, nikotinova acid, isonicotinamide acid, mimosine, 2,3-diaminopropionic acid, D,L-2,4-diaminobutane acid, (S)-(+)-diaminobutane acid, D-ornithine, L-ornithine, 2-meteoriten, N--methyl-L-lysine, N-methyl-D-aspartic acid, D,L-2-methylglucamine acid, D,L-2-aminoadipate acid, D-2-aminoadenosine acid, L-2-aminoadipate acid, (+/-)-3-aminoadenosine acid, D-cysteine, D-penicillamine, L-penicillamine, D,L-homocysteine, S-methyl-L-cysteine, L-methionine, D-atonin, L-atonin, S-carboxymethyl-L-cysteine, (S)-(+)-2-phenylglycine, (R)-(-)-2-phenylglycine, N-phenylglycine, N-(4-hydroxyphenyl)glycine, D-phenylalanine, titillans, (S)-(-)-indoline-2-carboxylic acid, -methyl-D,L-phenylalanine-methyl-D,L-phenylalanine, D-homophenylalanine, L-homophenylalanine, D,L-2-florfenicol, D,L-2-forfinally, D,L-3-forfinally, D,L-4-forfinally, D,L-4-chlorophenylalanine, L-4-chlorophenylalanine, 4-bromo-D,L-phenylalanine, 4-iodine-D-Fenin, D-tyrosine, L-tyrosine, O-methyl-L-tyrosine, 3-fluoro-D,L-tyrosine, 3-iodine-L-tyrosine, 3-nitro-L-tyrosine, 3,5-diid-L-tyrosine, D,L-DOPA, L-DOPA, 2,4,5-trihydroxyphenyl-D,L-alanine, 3-amino-L-tyrosine, 4-amino-D-phenylalanine, 4-amino-L-phenylalanine, 4-amino-D,L-phenylalanine, 4-nitro-L-phenylalanine, 4-nitro-D,L-phenylalanine, 3,5-dinitro-L-tyrosine, D,L--methyltyrosine, l--methyltyrosine, (-)-3-(3,4-dihydroxyphenyl)-2-methyl-L-alanine, D,L-threo-3-fennelseed, TRANS-4-(aminomethyl)cyclohexanecarbonyl acid, 4-(aminomethyl)benzoic acid, D,L-3-aminobutyric acid, 3-aminocyclohexanecarboxylic acid, CIS-2-amino-1-cyclohexanecarbonyl acid, -amino--(p-chlorophenyl)butyric acid (Baclofen), D,L-3-aminophenylamino acid, 3-amino-3-(4-chlorophenyl)propionic acid, 3-amino-3-(2-nitrophenyl)propionic acid and 3-amino-4,4,4-cryptomelane acid.

"Carbocyclic" means a stable radical with 3 to 15-membered ring consisting of carbon atoms and hydrogen. In accordance with the purposes of this invention carbocyclic radical may be a monocyclic, bicyclic or tricyclic ring system and may include a condensed or bridged ring system, with the specified ring system may be partially and Slany. Examples of such carbocyclic radicals include, but are not limited to, cycloalkyl radicals (above), norbornane, norbornene, substituted, bicyclo[2.2.2]octane, phenyl, naphthalenyl, indanyl, indenyl, azulene, fluorene, anthracene and the like. Carbocycle ring may be substituted by R6described in the section "a Brief statement of the substance of the invention", or by one or more substituents selected from the group comprising hydroxy, mercapto, halogen, alkyl, alkenyl, quinil, phenyl, phenylalkyl, phenylalkyl, alkoxy, phenoxy, funeralcare, halogenated, halogenoalkane, formyl, nitro, cyano, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyethyl, generalkonsulat, amidino, ureido, alkoxycarbonyl, amino, monoalkylamines, dialkylamines, monophenyltin, monovinylacetylene, sulfonylamino, alkylsulfonyl, aminoalkyl, monoalkylamines, dialkylaminoalkyl, monofilaments, monovinylacetylene, acyl, carboxylic, alkoxycarbonylmethyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, aminocarbonyl, monoalkylammonium and dialkylaminoalkyl.

"Cycloalkyl" means stable, 3-10-membered monocycle is, what, for example, cyclopropyl, cyclobutyl, cyclohexyl, decaline and the like. Except where otherwise noted, in this description, the term "cycloalkyl" means cycloalkyl radicals, which are optionally substituted by one or more substituents independently selected from the group including alkyl, halogen, hydroxy, amino, cyano, nitro, alkoxy, carboxy and alkoxycarbonyl.

"Carboxy" means a radical of the formula-C(O)HE.

"Carboxylic" means a radical of the formula-Ra-C(O)OH, where Rais the above alkyl radical, for example, carboxymethyl, 2-carboxyethyl, 3-carboxypropyl and the like.

"Di(alkoxy) alkyl" means a radical of the formula-Ra(ORa)2where each Raindependently is above alkyl radical, and groups ORacan be attached to any carbon atom in the group Rafor example, 3,3-dimethoxypropane, 2,3-dimethoxypropane and the like.

"Dialkylamino" means a radical of the formula-N(RaRawhere each Raindependently is above alkyl radical, for example, dimethylamino, diethylamino, (methyl)(ethyl)amino, and the like.

"Dialkyl the data alkyl radical, for example, dimethylaminoethyl, methylaminomethyl, diethylaminoethyl, dipropylthiocarbamate, ethylpropylamine and the like.

"Dialkylaminoalkyl" means a radical of the formula-S(O)2N(RaRawhere each Raindependently is above alkyl radical, for example, dimethylaminomethyl, methylaminomethyl, diethylaminosulfur, dipropyleneglycol, ethylpropylamine and the like.

"Halogen" means bromine, chlorine, iodine or fluorine.

"Halogenated" means the above-mentioned alkyl radical, substituted by one or more of the above Halogens, for example, trifluoromethyl, deformity, trichloromethyl, 2,2,2-triptorelin, 1-vermeil-2-foretel, 3-bromo-2-forproper, 1-methyl bromide-2-bromacil and the like.

"Halogenoalkane" means a radical of the formula-ORdwhere Rdis the above halogenosilanes radical, for example, triptoreline, deformedarse, trichlormethane, 2,2,2-triptoreline, 1-vermeil-2-floratone, 3-bromo-2-forproperty, 1-methyl bromide-2-bromoethoxy and the like.

"Heterocyclyl" means a stable radical with 3 to 15-membered ring which consists of carbon atoms is the invention heterocyclyl radical may be a monocyclic, bicyclic or tricyclic ring system, which may include a condensed or bridged ring system; the atoms of nitrogen, carbon or sulfur in heterocyclyl radical may be optionally oxidized; the nitrogen atom can be optionally and stereoselectivity; and heterocyclyl radical may be partially or fully saturated or aromatic. Heterocyclyl radical may be attached to the main structure at any heteroatom or carbon atom that allows you to get a stable connection. Examples of such heterocyclyl radicals include, but are not limited to, azepine, azetidine, acridines, benzimidazolyl, benzodioxolyl, benzodioxane, benzothiazolyl, benzoxazolyl, benzopyranyl, benzofuranyl, benzothiazol, carbazolyl, cinnoline, decahydroquinoline, DIOXOLANYL, furyl, isothiazolin, hinokitiol, imidazolyl, imidazolyl, imidazolidinyl, isothiazolinones, indolyl, isoindolyl, indolinyl, isoindolyl, indolizinyl, isoxazolyl, isoxazolidine, morpholine, naphthyridine, oxadiazole, octahedrally, activitiesunder, 2-oxopiperidine, 2-oxopiperidine, 2-oxopyrrolidin, 2-oxoazetidin, oxazolyl, oxazolidinyl, peligrosa, urinal, pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolidine, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, hintline, honokalani, chinoline, hinokitiol, ethenolysis, thiazolyl, diazolidinyl, thiadiazolyl, triazolyl, tetrazolyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydroisoquinoline, thienyl, thiomorpholine, dimorpholinyldiethyl and thiomorpholine. Heterocyclyl radical may be optionally substituted by R6described in the section "a Brief statement of the substance of the invention", or may be optionally substituted by one or more substituents selected from the group comprising hydroxy, mercapto, halogen, alkyl, alkenyl, quinil, phenyl, phenylalkyl, phenylalkyl, alkoxy, phenoxy, funeralcare, halogenated, halogenoalkane, formyl, nitro, cyano, amidino, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyethyl, generalkonsulat, ureido, alkoxycarbonyl, amino, monoalkylamines, dialkylamines, monophenyltin, monovinylacetylene, aminoalkyl, monoalkylamines, dialkylaminoalkyl, monofilaments, monovinylacetylene, alkylsulphonyl, carboxyethyl, alkoxycarbonylmethyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, aminocarbonyl what about the link" means any component, able to selectively split with the release of solid media remainder of the compounds of the present invention. See, for example, Greene and Wuts, Protective Groups in Organic Synthesis, 2nded., Wiley (1991). Typical remnants of the link and the corresponding splitting reagents are shown in the following table 7.

"Monoalkylamines" means a radical of the formula-N(H)Rawhere Rais the above alkyl radical, for example, methylamino, ethylamino, propylamino and the like.

"Monoalkylamines" means a radical of the formula-C(O)N(H)Rawhere Rais the above alkyl radical, for example, methylaminomethyl, ethylaminomethyl, propylaminoethyl and the like.

"Monoalkylbenzenes" means a radical of the formula-S(O)2N(H)Rawhere Rais the above alkyl radical, for example, methylaminomethyl, ethylaminomethyl, propylaminosulfonyl and the like.

"N-heterocyclyl" means the above heterocyclyl radical, which contains at least one nitrogen atom and attached to the main structure of this nitrogen atom. N-heterocyclyl radical can contain up to three additional Genil, azetidinol, indolyl, pyrrolyl, imidazolyl, tetrahydroisoquinoline, peligrosamente, tetrazolyl, triazolyl, oxazinyl and the like, which may be optionally substituted by the substituents described above for heterocyclyl radicals. In addition to the optional substitution of the substituents mentioned above for heterocyclyl radical, N-heterocyclyl radical may be optionally substituted by R6described above under "Summary of the substance of the invention".

"Phenylalkyl" means the above-mentioned alkyl radical, substituted phenyl radical, for example, benzyl and the like.

"Optional" or "optionally" means that the described phenomenon can take place or not, and that this description includes all cases when a specified event or condition occurs and all the cases when it is not. For example, "optionally substituted aryl" means aryl radical may be substituted or not, and that the description includes both substituted aryl radicals, and unsubstituted aryl radicals. The term "-[S2-C8alkyl]-R10(optionally substituted by hydroxyl)" means that the alkyl has an optional replacement. The same online substituted-S(O)tR22" means that all the substituents R22have an optional replacement.

"Phenylalkyl" means the above alkanniny radical, substituted phenyl radical.

The term "pharmaceutically acceptable salts" means salts derived from pharmaceutically acceptable non-toxic acids or bases including inorganic acids and bases and organic acids and bases. If the compounds of the present invention is basic, salts may be derived from pharmaceutically acceptable non-toxic acids, including inorganic and organic acids. Pharmaceutically acceptable salt accession acid compounds of the present invention will be received, using acetic acid, benzosulfimide (benzilate), benzoic, camphorsulfonic, lemon, atenololbuy, formic, gluconic, glutamic, Hydrobromic, hydrochloric, isetionate, lactic, maleic, malic, almond, methansulfonate, mucus, nitrogen, pambou, Pantothenic, phosphoric, succinic, sulfuric, tartaric, paratoluenesulfonyl acid and the like. When the compounds contain acidic side chain, a pharmaceutically acceptable salt, connected Alicia, lithium, magnesium, potassium, sodium and zinc or organic salts derived from lysine, N,N’-dibenziletilendiaminom, chloroprocaine, choline, diethanolamine, Ethylenediamine, meglumine (N-methylglucamine) and procaine.

"Solid support" means a substance, on which the synthesis of compounds according to this invention, and represents beads or resin. The term "solid support" includes balls, pills (pellets, disks, fibers, gels, or particles such as granulated cellulose, granulated porous glass, silica gels, granular polystyrene, optionally crosslinked with divinylbenzene, optionally grafted to the polyethylene glycol and optionally having such functional groups as amino, hydroxy, carboxy or halogen-containing group, granular graft copolymer, granular polyacrylamide, granulated latex, granulated dimethylacrylamide, optionally crosslinked with N,N’-bis-acryloylmorpholine, glass particles coated with hydrophobic polymer, and so on, i.e. the substance, having a solid or semi-solid surface; and soluble carriers, such as low-molecular seamless polystyrene.

"Therapeutically effective amount" means such kolichestvennie described below diseases, caused by disturbances in the production of nitric oxide. The number of compounds according to this invention, which is a "therapeutically effective amount" varies depending on the connection, the nature and severity of the disease and the age need of the subject, but can be easily determined by the expert in this field, taking into account his knowledge and this description of the invention.

"Treatment" means drug therapy disease incurred by the entity in the result of disturbances in the production of nitric oxide, and includes:

(i) the prevention of the occurrence of the disease in the subject, especially in the case when such a subject is predisposed to this disease, but its symptoms not yet diagnosed;

(ii) the suppression of the disease, i.e. the cessation of its development;

or

(iii) the attenuation of the disease, that is, the regression of the disease.

The output of all products described here, the reaction is expressed in percent of theoretical yield.

Most of the compounds described herein has one or more asymmetric centers and thus can form enantiomers, diastereomers, and other stereoisomeric forms that can be defined is for amino acids. In the scope of the present invention includes all such possible isomers, as well as their racemic and optically pure forms. Optically active (R)- and (S)- or (D) and (L)-isomers can be obtained by using chiral synthons or chiral reagents, or by means of known methods. When these compounds are ethylene double connection or other centers of geometric asymmetry, and unless specified otherwise, it is considered that these compounds include E and Z geometric isomers. Likewise, all tautomeric forms are also included in the scope of this invention.

The nomenclature used in this description of the invention is a modified form of item I. U. P. A. C., in which compounds of this invention are referred to as amide derivatives. For example, the connection according to this invention:

has the following title, namely 2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]pentanedione. Except where otherwise indicated, it is believed that the names of the compounds include all the individual stereoisomers, enantiomers, racemates and mixtures thereof.

The use of compounds according to the present invention

Nitric oxide, obrazovannyh diseases, as well as to diseases, which, although not considered to be inflammatory, however, can be caused by cytokines, which locally increase the formation of i-NOS. Compounds according to this invention, used alone or in combination with other pharmaceuticals can effectively treat mammals, preferably humans, suffering from diseases caused by disturbances in the production of nitric oxide. Such pathological conditions include, but are not limited to, the following additional conditions:

multiple sclerosis (Parkinson, J. F. et al., J. Mol. Med. (1997), Vol.75, pp.174-186); stroke and cerebral ischemia (Iadecola, C. et al., J. Neurosci. (1997), Vol.17, pp.9157-9164); Alzheimer's disease (Smith, M. A. et al., J. Neurosci. (1997), Vol.17, pp.2653-2657; Wallace, M. N. et al., Exp. Neurol. (1997), Vol.144, pp.266-272); HIV-related dementia (Adamson D. C. et al., Science (1996), Vol.274, pp.1917-1921); Parkinson's disease (Hunot, S. et al., Neuroscience (1996), Vol.72, pp.355-363); meningitis (Koedel, U. et al., Ann. Neurol. (1995), Vol.37, pp.313-323); extensive cardiomyopathy and congestive heart failure (M. Satoh et al., J. Am. Coil. Cardliol. (1997), Vol.29, pp.716-724); atherosclerosis (Wilcox, J. N. et al., Arterioscler. Thromb. Vasc. Blol. (1997), Vol.17, pp.2479-2488); restenosis or stenosis of the graft, septic shock and hypotension (Petros, A. et al., Cardiovasc. Res. (1994), Vol.28, pp.34-39); hemorrhagic shock (Thiemermann, C. et al., Proc. Natl is RNA distress syndrome in adults lung damage caused by Smoking or solid particles (Ischiropoulos, H. et al.. Am.J.Respir.Crit. Care Med. (1994), Vol.150, pp.337-341; Van Dyke, K., Agents Actions (1994), Vol.41, pp.44-49); pneumonia caused by pathogenic microorganisms (Adler, N. et al., J. Exp. Med. (1997), Vol.185, pp.1553-1540); trauma, with different etiology (Thomae, K. R. et al., Surgery (1996), Vol.119, pp.61-66); rheumatoid arthritis and osteoarthritis (Grabowski, P. S. et al., Br.J.Rheumatol. (1997), Vol.36, pp.651-655); glomerulonephritis (Weinberg, J. B. et al., J. Exp. Med. (1994), Vol.179, pp.651-660); systemic lupus erythematosus (Belmont, H. M. et al., Arthritis Rheum. (1997), Vol.40, pp.1810-1816); inflammatory bowel disease such as ulcerative colitis and Crohn's disease (Godkin, A. J. et al., Eur.J.Clin. Invest. (1996), Vol.26, pp.867-872; Singer, I. I. et al., Gastroenterology (1996), Vol.111, pp.871-885); insulin-dependent diabetes (McDaniel, M. L., et al., Proc. Soc. Exp. Biol. Med. (1996), Vol.211, pp.24-32); diabetic neuropathy or nephropathy (Sugimoto, K. and Yagihashi, S., Microvasc. Res. (1997), Vol.53, pp.105-112; Amore, A. et al., Kidney Jnt. (1997), Vol.51, pp.27-35); acute and chronic rejection of transplanted organs (Worrall, N. K. et al., Transplantation (1997), Vol.63, pp.1095-1101); a disorder of vessels of the graft (Russel, M. E. et al., (1995), Vol.92, pp.457-464); homologous disease (Kichlan, K. et al., J. Immunol. (1996), Vol.157, pp.2851-2856); psoriasis and other inflammatory skin disorders (Bruch-Gerharz, D. et al., J. Exp.Med. (1996), Vol.184, pp.2007-2012); and cancer (Thomson, L. L. et al., Cancer Res. (1997), Vol.57, pp.3300-3304).

Join in when used alone or in combination with other drugs, usually used for this purpose. As examples of such applications without any restrictions lead to inhibition of fertilization, the suppression of the sensitivity of the endometrium and delayed implantation (alone or in combination with progesterone antagonist); contraception after intercourse (alone or in combination with progesterone antagonist); stimulation of miscarriage (in combination with antiprogestins and prostaglandin); labor management and control of delivery; treatment of isthmic-cervical insufficiency (alone or in combination with progesterone or a progestin); treatment of endometriosis (alone or in combination with other drugs, including LHRH agonists/antagonists, antiprogestin or progestins, sequential or simultaneous introduction). See, for example, the following references: Chwalisz, K. et al., J. S.Gynecol. Invest. (1997), Vol.4, No.1 (Supplement), page 104a, which deals with the inhibition of fertilization, the suppression of the sensitivity of the endometrium and delay implantation or contraception after intercourse using these compounds, used alone or in combination with an antagonist of progesterone; Chwalisz, K. et al., Prenat. Neonat. Med. (1996), Vol.1, pp.292-329, which describes the stimulation of miscarriage with the species and the control of delivery; and Chwalisz, K. et al., Hum. Reprod. (1997), Vol.12, pp.101-109, which describes the treatment of isthmic-cervical insufficiency using these compounds, used alone or in combination with progesterone or a progestin.

The specialist in this area should also be apparent that the compounds of the present invention include 1-substituted imidazoles. Compounds of this class have been previously described as related to a particular mechanism, hemmathagama inhibitors family of cytochrome P450 (Maurice, M. et al., FASEB J. (1992), Vol.6, pp.752-8) besides the fact that they are inhibitors of the synthesis of nitric oxide (Chabin, R. N M. et al., Biochemistry (1996), Vol.35, pp.9567-9575). Compounds of the present invention can be also effective inhibitors of specific members of the family of cytochrome P450, which include, but are not limited to, the P450 enzymes involved in the biosynthesis of steroids and retinoids (Masamura et al., Breast Cancer Res. Treat. (1995), Vol.33, pp.19-26; Swart, P. et al., J. Clin.Endocrinol. Metab., Vol.77, pp.98-102; Docks, P. et al., Br.J.Dermatol. (1995), Vol.133, pp.426-32) and in the biosynthesis of cholesterol (Burton, P. M. et al., Biochem. Pharmacol. (1995), Vol.50, pp.529-544; and Swinney, D. C. et al., Biochemistry (1994), Vol.33, pp.4702-4713). Compounds with imidazole may also have antifungal activity (Aoyama, Y. et al., Biochem. Pharmacol. (1992), Vol.44, pp.1701-1705). Inhibitory Dawuda systems analysis, specially designed for interest P450 isoforms. These analyses included in the above link. An additional example of isoforms of cytochrome P450 mammals inhibiting compounds of the present invention, is a cytochrome P450 3A4, which can be investigated according to the method described in the article Yamazaki et al., Carcinogenesis (1995), Vol.16, pp.2167-2170.

The test compounds of the present invention

Synthase nitric oxide are complex enzymes that catalyze the conversion of L-arginine into nitric oxide (NO) and citrulline. Catalysis occurs during two consecutive okislenii group guanidine L-arginine.

Compounds of the present invention was evaluated by analyzing synthase nitric oxide on the basis of a cell by measuring the amount of oxidation product of nitric oxide in the conditioned medium of cultured cells. Line monocytic cells of mouse RAW 264.7 and J774 well described in the scientific literature as cells able to produce >10 μm nitrite in response to immunostimulation.

Induction of iNOS in monocytes mouse RAW 264.7

Macrophages of mouse RAW 264.7 was obtained from the American type culture collection (Rockville, Maryland). They were placed in the (supportive environment). The NOS activity was measured using fluorescence analysis of the oxidation product of nitric oxide, nitrite (Diamani et al., Talanta (1986), Vol.33, pp.649-652). The induction of iNOS (inducible synthase nitric oxide) was stimulated by treatment of the cells with lipopolysaccharide and interferon. The following describes this method of analysis.

Cells are harvested, diluted supportive environment to 500,000 cells/ml and seeded in 96-well plates in 100 μl/well. Tablets incubated over night at 37 ° °C in an atmosphere containing 5% CO2. Then the medium was replaced with 90 μl TOGETHER medium containing 10% FBS, 100 units/ml penicillin, 100 μl streptomycin, 2 mm glutamine, 100 units/ml interferon-and 2 μg/ml of lipopolysaccharide. In four holes type N-guanidinate-L-arginine (negative control sample) with a final concentration of 200 μm using a 10 μl 2 mm initial solution in 100 mm HEPES, pH of 7.3+0.1% of DMSO, and the other four wells add 100 mm S/0.1% based buffer DMSO (positive control sample). Compound is dissolved to 10 times the final concentration in HEPES/DMSO and 10 μl of these solutions are transferred to 96-well plate. Tablets incubated for 17 hours at a temperature of 37°C in the atmosphere, steriade Aut 15 μl of 2,3-diaminonaphthalene (10 μg/ml of 0.75 M Hcl solution) and incubated for 10 minutes at room temperature. Then add 15 ál of 1N NaOH solution and measured fluorescence emission at 405 nm, using the wavelength of excitation, 365 nm. The enzyme activity in experimental wells expressed in percent using positive and negative control samples. Signal-to-noise ratio is >10 for this analysis.

Compounds according to this invention, tested using this assay, demonstrated the ability to inhibit the formation of nitric oxide.

You can use different tests in vivo, to determine the effectiveness of the compounds according to this invention for treatment of diseases caused by disturbances in the production of nitric oxide, such as arthritis. Below is a description of this analysis using rats.

The effect of the compounds according to the present invention caused by the adjuvant arthritis in rats.

Male Lewis rats were injected with intradermally (proximal quarter of the tail with 0.1 ml of Mycobacterium butyricum in incomplete Freund's adjuvant (10 mg/ml). Experimental animals were injected subcutaneously or filler (acidified saline, 1 ml/kg), or compound of the present invention (3, 10 or 30 mg/kg), starting from the next day after immunity is. liricheskie symptoms (see below) was identified in all the limbs 3 times per week throughout the study. Rats painlessly cut through 34-35 days after immunization. At the time of the killing made a radiological study (see below) of the hind legs, took a sample of blood for clinical chemistry analysis of blood and determination of concentrations of drugs (only the group receiving the highest dose of a compound; 6 or 12 hours after the last dose), did cut the liver to determine possible toxicity, then the hind legs were preserved for histopathological analysis.

Clinical assessment - the status of each paw was evaluated according to the following scale:

0 - no signs of inflammation;

1 - mild redness, the first signs of swelling, flexible joint;

2 - moderate redness, average tumor, flexible joint;

3 - redness, significant swelling and deformity of the legs, the first signs of ossification of the joint;

4 - redness, severe swelling and deformity of the legs, complete ossification of the joint.

Radiological assessment of the status of each hind paw was evaluated 0-3 points on all of the following options:

Compounds according to this invention is effective treating arthritis in rats in the process of performing this analysis.

The expert in this field must also be known that there are numerous analyses of the activity of isoforms of NOS (iNOS, nNOS and eNOS), which can be used to assess the biological activity of the compounds of the present invention. These methods include analyses of native isoforms of NOS in the tissues investigated ex vivo (Mitchell et al., Br.J.Pharmacol. (1991, Vol.104, pp.289-291; Szabo et al., Br.J.Pharmacol. (1993), Vol.108, pp.786-792; Joly et al., Br.J.Pharmacol. (1995), Vol.115, pp.491-497), as well as analyses of cultures of primary cells and cell lines (Forstermann et al., Eur. J. Pharmacol. (1992), Vol.225, pp.161 to 165; Radmoski et al., Cardiovasc. Res. (1993), Vol.27, pp.1380-1382; Wang et al., J. Pharmacol. Exp. Ther. (1994), Vol.268, pp.552-557). The specialist in this area should also be obvious that recombinant NOS enzymes can be expressed in heterologous cells by the method of temporal transfection (Karlsen et al., Diabetes (1995), Vol.44, pp.753-758), stable transfection (McMillan et al., Proc. Natl. Acad. Sci. (1992), Vol.89, pp.11141-11145; Sessai et al., J. Biol. Chem. (1995), Vol.270, pp.17641-17644) or transfection lytic virus (Busconi & Michel, Mol. Pharmacol. (1995), Vol.47, pp.655-659; List et al., Biochem. J. (1996), Vol.315, pp.57-63) using cDNA synthase nitric oxide. Heterologous expression can be obtained ), Vol.47, pp.655-659; List et al., Biochem. J. (1996), Vol.315, pp.57-63), in yeast (Sari et al., Biochemistry (1996), Vol.35, pp.7204-7213) or bacteria (Roman et al., Proc. Natl. Acad. Sci. (1995), Vol.92, pp.8428-8432; Martasek et al., Biochem. Biophys. Res. Commit. (1996), Vol.219, pp.359-365). You can use any of these heterologous systems for the analysis of iNOS, nNOS and eNOS to assess the biological activity of the compounds of the present invention.

Introduction compounds of the present invention

You can use any reasonable method of introduction to the needy to a subject an effective dose of the compounds according to this invention. For example, you can use oral, rectal, parenteral (subcutaneous, intramuscular, intravenous), transdermal, and similar techniques. Dosage forms include tablets, lozenges, dispersions, suspensions, solutions, capsules, patches and the like.

The pharmaceutical compositions of the present invention contain compounds according to this invention as the active ingredient; in addition, they may also contain a pharmaceutically acceptable carrier and optionally other pharmaceutical ingredients. Devices such as starch, sugar, microcrystalline cellulose, diluents, granulating agents, lubricating wisecracking introduction (such as powders, capsules and tablets), and solid preparations for oral administration is more preferable compared to liquid preparations for oral administration. Methods of obtaining such drugs are well known in this field.

Due to the ease of the introduction of tablets and capsules are the most preferred dosage forms for oral administration; in this case, use solid pharmaceutical carriers. If desired, the tablets can be coated with standard water or waterless methods. In addition to the above conventional dosage forms of the compounds of the present invention can be used to enter special means for the controlled or delayed release and devices for administration of medicinal drugs.

The pharmaceutical compositions of the present invention suitable for oral administration can be obtained in the form of discrete forms, such as capsules, starch wafers or tablets each containing a predetermined amount of the active ingredient in the form of powder or granules or as a solution or suspension in an aqueous liquid, non-aqueous liquid, emulsion oil in water or III, but all of these methods should include the stage of mixing the active ingredient with a carrier consisting of one or more ingredients. Typically, these compositions have, uniformly mixing the active ingredient with liquid carriers or finely powdered solid carriers, or both together, and then, if necessary, the product form the desired shape.

Preferred embodiments of the inventions

Certain embodiments of this invention are more preferred. A preferred group of compounds of formula (I), formula (II) and formula (III) are the compounds of formula (I) having the formula (Ia), formula (Ib) or formula(IC):

A preferred subgroup of compounds of this group are compounds in which a denotes-OR1-C(O)N(R1R2, - (R16)C(O)N(R1R16, -N(R1)C(O)R2or N(R1R21; V denotes N(R4); and W represents CH.

A preferred class of compounds of this subgroup are compounds in which a represents-C(O)N(R1R2; q, r and n are zero; R1denotes hydrogen; R2indicates the lowest AROD, halogen, alkyl or alkoxy.

A preferred subclass of compounds of this class are compounds in which R9denotes phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, acid, 2-thienyl or morpholinyl.

Another preferred subgroup of compounds of this group are compounds in which a represents-C(O)N(R1R2; m is zero; Q represents a direct link with R3; and R3denotes hydrogen.

The preferred compound of this subgroup is N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]ndimethylacetamide.

Another preferred group of compounds of formula (I), formula (II) and formula (III) are the compounds of formula (II) having the formula (IIA), formula (IIb) or formula (IIc):

A preferred subgroup of compounds of this group are compounds in which N-heterocyclyl selected from the group including piperidinyl, piperazinil, pyrrolidinyl, morpholinyl, thiomorpholine, azetidine, indolyl, pyrrolyl, imidazolyl, tetrahydroisoquinoline and peligrosamente.

The preferred class of travel is that there is a connection formula (IId), formula (IIE) or formula (IIf):

A preferred subclass of compounds of this class are compounds in which a denotes-OR1-C(O)N(R1R2, -N(R16)C(O)N(R1R16, -N(R1)C(O)R2or N(R1R21; W represents CH; and R6selected from the group comprising hydrogen, alkyl, cycloalkyl, -[C1-C8alkyl]-R8, -[C2-C8alkyl]-R10, -[C1-C8alkyl]-R11, acyl, -C(O)R8, -C(O)-[C1-C8alkyl]-R8alkoxycarbonyl, optionally substituted aryloxyalkyl, optionally substituted arelaxation, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonyl, carboxylic, optionally substituted arylsulfonyl, aminocarbonyl, monoalkylamines, dialkylaminoalkyl, optionally substituted allumination, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, arylamination, arylsulfonamides, optionally substituted N-heterocyclyl, -C(=NH)-N(CN)R1-C(O)-R23-N(R1R2, -C(O)-R23-N(R1)C(O)-R23-N(R1R2and-C(O)-N(R1)-R231R2; R1denotes hydrogen; R2denotes lower alkyl, -[C1-C8]-R9or -[C1-C8]-R10; R6denotes hydrogen, acetyl, tert-butoxycarbonyl, 4-methoxyphenylalanine, 4-methoxyphenethyl, methoxycarbonyl, methyl or benzyl; R5denotes hydrogen, halogen, alkyl or alkoxy; and n is 0 or 1. In this group of preferred compounds, more preferred are compounds in which R2denotes-CH2-R9or -[C1-C8]-R10; R9denotes aryl or substituted aryl; and R10means methylthio. In this group of more preferred compounds the most preferred are compounds in which R2denotes-CH2-R9; R6denotes hydrogen, acetyl or tert-butoxycarbonyl; and R9denotes phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, methylthiophenyl, chlorophenyl, carboxyphenyl, acid or 2-thienyl. In this group, the most preferred compounds, particular preference is given to compounds in which R5denotes chlorine, R6denotes acetyl, and R9means paratool, or compounds in which R5will obosnovanie chlorine, R6denotes Woodard and R9denotes 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl, or compounds in which R5denotes chlorine, R6denotes tert-butoxycarbonyl and R9denotes 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl.

Preferred compounds in this category you can choose from the following list:

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-(2-methyl-1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-triazole-1-yl)pyrimidine-4-yl]-4-[(dimethylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]-1-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-(acetyl)-N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide and

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-3-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-carboxamide.

Another predpochtitel, that is, the compound of formula (IIg), formula (IIh) or formula (IIi):

A preferred subclass of compounds of this class are compounds in which a denotes-OR1-C(O)N(R1R2, -N(R16)C(O)N(R1R16, -N(R1)C(O)R2or N(R1R21; and W represents CH.

The preferred compounds of this subclass are compounds in which a represents-C(O)N(R1R2; R1denotes hydrogen; R2denotes lower alkyl or -[C1-C8alkyl]-R9; R5denotes hydrogen, halogen, alkyl or alkoxy; and n is zero or one. More preferred compounds of this subclass are compounds in which R2denotes lower alkyl or-CH2-R9and R9represents 4-methoxyphenyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl or 3,4-acid.

Preferred compounds in this category you can choose from the following list:

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxy-phenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-IU the Jn-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[2,6-bis(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide and

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]piperidine-2-ndimethylacetamide.

Another preferred class of compounds of this subgroup are compounds in which N-heterocyclyl is pyrrolidinyl, i.e. the compound of formula (IIj), formula (IIk) or formula (IIm):

A preferred subclass of compounds of this class are compounds in which a denotes-OR1-C(O)N(R1R2, -N(R16)C(O)N(R1R16, -N(R1)C(O)R2or N(R1R21; and W represents CH.

The preferred compounds of this subclass are compounds in which a represents-C(O)N(R1R2; R1denotes hydrogen; R2denotes lower alkyl or -[C1-C8alkyl]-R9; R5denotes hydrogen, halogen, alkyl or alkoxy; and n is zero or one. More preferred compounds of this subclass are compounds having the R-configuration of the atom C-2 pyrrolidinone to the="ptx2">N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(4-methoxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamid and

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide.

Additional preferred compounds within the above group can be selected from the following list:

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]thiomorpholine-2-ndimethylacetamide;

N-[(1,3-dioxolane-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]azetidin-2-carboxamide and

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]morpholine-2-carboxamide.

Another preferred group of compounds of formula (I), formula (II) and formula (III) are SOER CLASS="ptx2">A preferred subgroup of compounds of this group are compounds in which a represents optionally substituted phenyl or optionally substituted naphthyl.

Another preferred group of compounds of formula (I), formula (II) or formula (III) are compounds in which each of X, Y or Z represents C(R19and every U denotes C(R5).

Another preferred group of compounds of formula (I), formula (II) or formula (III) are compounds in which each of X, Y or Z represents N and each U denotes C(R5).

Another preferred group of compounds of formula (I), formula (II) or formula (III) are compounds in which each X represents N, each Z or Y denotes C(R19and every U denotes n

Another preferred group of compounds of formula (I), formula (II) or formula (III) are compounds in which one of X, Y and Z represents N and the others represent C(R19and

U denotes C(R5).

A preferred group of compounds of the formula (IV) are compounds of formula (IVa), formula (IVb) or formula (IVc):

A preferred subgroup of the connectivity at the-carbon atom of this acid.

Another preferred subgroup of compounds of this group are compounds where the amino acid is the amino acid with D-configuration at the carbon atom indicated acid.

Another preferred subgroup of compounds of this group are compounds in which R1denotes hydrogen; R2denotes lower alkyl or -[C1-C8alkyl]-R9; and R5denotes hydrogen, halogen, alkyl or alkoxy.

A preferred class of compounds of this subgroup are compounds in which R9denotes phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, 2-thienyl, acid or morpholinyl.

A preferred group of compounds of the formula (Va), formula (Vb) or formula (Vc) are compounds in which each X and each Y represents N; each W represents CH; and means condensed optionally substituted heterocyclyl.

A preferred subgroup of compounds of this group are the compounds of formula (Vba):

where a denotes-OR1-C(O)N(R1R2, -N(R16)C(O)N(R1R16, -N(R16)C(O)R2or N(R1R

The preferred compound of this subgroup is N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)purine-6-yl]piperidine-2-ndimethylacetamide.

Of the compounds of formula (VII), formula (VIIb) or formula (VIIc) is more preferred compound is N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(pyridin-3-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide.

Of the compounds of the formula (VIII) is more preferred compounds are of 4,6-dichloro-2-(1H-imidazol-1-yl)pyrimidine and 2, 4-dichloro-6-(1H-imidazol-1-yl)pyrimidine.

From the remnants of the link used in this invention, preference is given to the photolytic splitting of communication of the formula (X):

where unsaturated valence in the right part of the formula indicates the place of attachment to the solid carrier, and unsaturated valency in the left part of the formula indicates the place of attachment to the ligand.

Obtaining the compounds of the present invention

Compounds according to this invention can be synthesized in two General ways, one of which (solid phase) can be considered as a variation of another (liquid-phase). A common way of liquid-phase synthesis is presented on the following scheme reacts-C(O)N(R1R2. Obviously, similarly you can get other compounds according to this invention. The following reaction scheme 1 PG denotes acceptable protective group; m, n, q, r, Q, U, W, X, Y and Z have the values listed in the section "a Brief statement of the substance of the invention; V denotes N(R4), S or O (where R4has the values specified in section "a Brief statement of the substance of the invention"); and R1, R2, R3, R12, R13, R14, R15, R17and R20have the values specified in section "a Brief statement of the substance of the invention".

The reaction scheme 1 (see the end of the description).

As a rule, the compounds of formula (I) are obtained as follows: one equivalent of the compound of formula (XI) is added in one portion to a solution of one equivalent of the compound of formula (XII) having at least two substituent substituted by a nucleophile, and 1.1 equivalent of base trialkylamine (such as triethylamine) in a polar, aprotonin a solvent such as THF or methylene chloride, which gives a compound of formula (XIII). After the reaction the resulting mixture was purified by the known methods.

The compounds of formula (XIVcc) synthesized by methods that are well known in one protective group for Deputy V. The compounds of formula (XIVaa) are produced on a commercial basis, usually in a protected form, or can be easily synthesized by well known methods. Preferred protective groups are BOC (tert-butoxycarbonyl) and Fmoc (fluorenylmethoxycarbonyl), although in certain cases it is possible to use other groups, such as CBZ (benzyloxycarbonyl), Thos (trichlorocyanuric). The functional group in the side chain can be protected, as is well known in the field of peptides, groups Trt (triphenylmethyl), tBu (tert-butyl), ACM (atsetamidometil) and the like. The protected compounds of formula (XIVaa) is subjected to interaction with the corresponding amine, which gives the compounds of formula (XIVbb), and remove the protective group to obtain the compounds of formula (XIVcc) by methods well known in the field of peptides.

One equivalent of the compound of formula (XIVcc) are added to a solution of one equivalent of the compound of formula (XIII) and one equivalent of a base in a polar, aprotic solvent such as THF. The reaction mixture is heated to a temperature at which the reaction is completed within a time period less than 16 hours. After the reaction, the compound of formula (I) clear and and the th connection, where And represents-N(R1)C(O)R2can be obtained from the corresponding acids of formula (XIVaa) rearrangement of Hoffmann acid in the amine, followed by acylation of the corresponding acid in the above-described conditions. In many cases, the desired diamine can be purchased commercially.

The compounds of formula (I) where And denotes urea, can be obtained by the interaction of the compounds of formula (I) where And denotes-N(R1R21(where R1denotes hydrogen and R21denotes hydrogen, alkyl, aryl or aralkyl) with isocyanate. Similarly, the compounds of formula (I) where And denotes the carbamate, can be obtained by the interaction of the compounds of formula (I) (where And denotes-N(R1R21where R1denotes hydrogen and R21denotes hydrogen, alkyl, aryl or aralkyl) alkylchlorosilanes or rearrangement Curtis azide carboxylic acid compounds of the formula (XIVaa) in the presence of the corresponding alcohol.

A particular variant of the General method for the synthesis of compounds according to this invention is shown in the following reaction scheme 2 for 6-chloro-2-(1-imidazolyl)-4-pyrimidinamine, which contains the remainder of the D-thienylallylamine and one equivalent of a base, such as N-methylmorpholine in THF. After two minutes add one equivalent of piperacillin and leave the mixture to warm to room temperature. After thirty minutes the reaction mixture was passed through a layer of celite and all volatiles removed under reduced pressure, giving N-Boc-D-titillans-piperonylic.

N-BOC-D-thienemanniella in methanol is treated with acetylchloride. After 45 minutes, all volatiles removed under reduced pressure, giving the hydrochloride, D-thienemanniella.

One equivalent of imidazole add one portion to a solution of one equivalent of trichloropyridine and 1.5 equivalents of triethylamine in THF. After the reaction, the reaction mixture was poured into a saturated aqueous solution of ammonium chloride and extracted three times with ethyl acetate. The combined organic layers washed with saturated salt solution and dried. The reaction mixture was filtered and all volatiles removed under reduced pressure. The resulting product, 2-imidazolyl-4,6-dichloropyrimidine (compound of formula (VIIIa)) allocate flash chromatography (20% ethyl acetate in hexane) as not quite white solid.

Two equivalent hydrochloride D--titillans (VIIIa) and three equivalents of base Hunya (diisopropylethylamine) in THF. After completion of the reaction remove all volatiles and produce the resulting product (compound of formula (IAA)).

The following is a specific example of the synthesis of the hydrochloride of sarkozyproclaimed.

Isobutylparaben (226 μl, of 1.73 mmol) are added to a solution of N-Boc-sarcosine (1,73 mmol) and N-methylmorpholine (192 μl, of 1.73 mmol) in THF. After two minutes add piperacillin (216 ml of 1.73 mmol) and leave the mixture to warm to room temperature. After thirty minutes the reaction mixture was passed through a layer of celite and all volatiles removed under reduced pressure, giving N-Boc-sarasinorum (531 mg, 95%) as a white solid.1H NMR (Dl3) to 2.41 (s, 3H), of 3.28 (s, 2H), 4,39 (d, 2H), 5,95 (s, 2H), 6, 80 (m, 3H), 7,43 (SHS, 1H), 9,04 (SHS, 1H).

N-Boc-sarasinorum (500 mg, 1.54 mmol) in methanol (10 ml) is treated with acetylchloride (1 ml). After 45 minutes, all volatiles removed under reduced pressure, giving the hydrochloride sarkozyproclaimed (395 mg, quantitative yield) as a sticky solid.

The imidazole (9.5 g, 140 mmol) is added in one portion to a solution of trichloropyridine (24,7 g, 135 mmol) and triethylamine (30 ml, 216 mmol) in THF (500 ml). After 16 hours the reaction mixture is practical layers washed with saturated salt solution and dried over gSO4. The reaction mixture is filtered and remove all volatiles under reduced pressure. 2-Imidazolyl-4,6-dichloropyrimidine (compound of formula (VIIIa)) (being 9.61 g, 33%) was isolated flash chromatography (20% ethyl acetate in hexane) as not quite white solid.1H NMR (Dl3) 7,13 (s, 1H), 7,25 (s, 1H), 7,76 (s, 1H), and 8.50 (s, 1H).

Hydrochloride sarkozyproclaimed (50 mg, 0,19 mmol) are added to a solution of 2-imidazolyl-4,6-dichloropyrimidine (VIIIa) (20 mg, 0,093 mmol) and substrate Hunya (50 μl, 0.29 mmol) in THF (1 ml). After 16 hours to remove all volatile matter and produce the product in the form of a waxy solid (29 mg, 78%).1H NMR (Dl3) 3,2 (s, 3H), 4,25 (s, 2H), to 4.38 (s, 2H), 5,88 (s, 2H), 6.30-in loops, 1H), 6.42 per (CL, 2H), 6,65 (m, 3H), 7,05 (s, 1H), 8,40 (s, 1H).

The following is one specific example of the synthesis of compounds of formula (HS).

Vos-pyrrolidine (3.0 g, 17.5 mmol) is dissolved in a simple ether (35 ml) and tetramethylethylenediamine (TMEDA) (2,03 g, 17.5 mmol), cooled to -78°C and add second-utility (1.3 M, 13.5 ml, 18 mmol). The mixture is stirred for 1 hour and add allylbromide simple ether (5 ml). The reaction mixture was left to warm to room temperature, quenched with water and separate the organic layer. The organic layer PR is the residue purified by chromatography on silica gel (hexane/ethyl acetate (9:1) to give the olefin (0.50 g, 14%).1H NMR (Dl3) 5,65-to 5.85 (m, 1H), 5,00-5,20 (m, 2H), 3,70-3,90 (m, 1H), 3,20 is-3.45 (m, 2 H), 2,35-2,60 (m, 1H), 2.00 in of 2.20 (m, 1H), 1,60-2,00 (m, 4H), 1,45 (s, N)). Olefin (500 mg, is 2.37 mmol), 5-bromo-1,3-benzodioxole (476 mg, is 2.37 mmol), triethylamine (478 mg, 4,74 mmol), tri-o-tolylphosphino (96 mg, 0.31 mmol) and Pd(OAc)2(26 mg, 0.12 mmol) dissolved in CH3JV and heated under reflux overnight in an argon atmosphere. Add one equivalent (476 mg) bromide and Pd(OAc)2(52 mg, 0.24 mmol) and continue heating the mixture under reflux for another 4.5 hours. The reaction mixture is filtered and the solvent is evaporated. The remainder absorb simple ether and successively washed with water, 1 m solution of NaH2PO4, water and saturated salt solution and dried. The solvent is removed and the product purified by chromatography (silica gel, hexane:ethyl acetate, 4:1) give 152 mg (19%) of the BOC-protected [(1,3-benzodiox-5-yl)prop-2-enyl]pyrrolidine (1H NMR (Dl3) of 6.90 (s, 1H), 6,70-to 6.80 (m, 2H), 6.35mm (d, 1H), 3,80-3,95 (m, 1H), 3,25-3,50 (m, 2H), 2,45-2,70 (m, 1H), measuring 2.20 to 2.35 (M, 1H), 1.70 to 2,00 (M, 4H), 1,45 (s, N)). The BOC group is removed under standard conditions.

The following is one specific example of a General synthesis of compounds according to this invention.

To butyl alcohol (3 ml) is added 2-fluoro-4-diisopropylethylamine) (0,042 ml, 0.24 mmol). The reaction mixture is stirred at a temperature of 90°C for 6 hours and diluted with ethyl acetate. Organic matter is washed with a saturated solution of NH4Cl and saturated salt solution, dried (gSO4) and remove the solvent in vacuo. Chromatography of the residue (CH2CL2/Meon, 10/1) to give 42 mg of porporino. Toburen (18,9 mg, 0.046 mmol) was dissolved in DMSO and subjected to interaction with TMS-imidazole (0.10 g, 0.66 mmol) and CsF (61 mg, 0.40 mmol). The reaction mixture is stirred at a temperature of 130°C for 72 hours, diluted with ethyl acetate and washed with saturated solution of NH4Cl and saturated salt solution. The organic layer is dried (MgSO4), the solvent is removed in vacuo and the residue chromatographic (CH2CL2/Meon, 19/1), yield 12 mg of N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)purine-6-yl]piperidine-2-ndimethylacetamide.

The following is one specific example of the synthesis.

To a THF (10 ml) was added the acid chloride cyanuric acid (158 mg, 0.85 mmol), N-[(1,3-benzodioxol-5-yl) methyl] piperidine-2-ndimethylacetamide (47 mg, 0,17 mmol) and imidazole (58 mg, 0.85 mmol). The reaction mixture is stirred for 12 hours and diluted with ethyl acetate. Organic matter is washed with saturated rastia balance (hexane/ethyl acetate, 4/1) gives 60 mg dichlorotriazines. Dihlotiazid (20 mg, 0,047 mmol) is dissolved in THF and subjected to interaction with S-imidazole (0,009 ml, 0.06 mmol) and CsF (11 mg, 0.07 mmol) at 0°C. the Reaction mixture was left to warm to room temperature, stirred for 4 hours, diluted with ethyl acetate and washed with saturated solution of NH4Cl and saturated salt solution. The organic layer is dried (gSO4), the solvent is removed in vacuo and the residue chromatographic (ethyl acetate/hexane/Meon, 4/4/1), which gives about 6.5 mg of N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-chloro-5-(1H-imidazol-1-yl)triazine-2-yl]piperidine-2-ndimethylacetamide.

The following is one specific example of the synthesis.

To a solution of indole-5-carboxylic acid (0.50 g, 3.1 mmol) in Meon (25 ml) add trimethylsilyldiazomethane prior to the allocation of gas. The solution is concentrated and dissolved in CH2CL2and washed with a saturated solution Panso3and a saturated solution of salt. The organic layer is dried (MgSO4) and the solvent is removed in vacuo, giving of 0.54 g of ester. (1H NMR (Dl3) of 3.95 (s, 3H), 6,63 (s, 1H), 7,25 (m, 1H), 7,40 (d, 1H), 7,95 (d, 1H), 8,25-8,4 (SHS, 1H), 8,45 (s, 1H)). The resulting ester (100 mg, of 0.58 mmol) dissolved in DMF (10 ml) and add 4-chloro-2-imidazol-1-ispirit in vacuum, the residue is dissolved in CH2Cl2and washed with a saturated solution Panso3and a saturated solution of salt. The organic layer is dried (MgSO4), the solvent is removed in vacuo and the residue chromatographic (CH2CL2/Meon, 19/1) that give 68 mg (37%) pyrimidine (1H NMR (Dl3) of 3.95 (s, 3H), 6.90 to (s, 1H), 7,25 (m, 2H), 7,80 (m, 1H), 7,95 (s, 1H), 8,10 (d, 1H), and 8.4 (s, 1H), and 8.50 (d, 1H), 8,70 (m, 2H)). The pyrimidine dissolved in a mixture of THF/water (1/1) and add LiOH (6 mg, 0.21 mmol). The mixture is heated at a temperature of 60°C for 3 hours, remove the solvent in vacuo and acidified with a solution of Hcl in methanol. The solvent is removed in vacuum, dissolved in DMF and treated with HATU (42 mg, 0.11 mmol), DIEA (37 mg, 0.21 mmol) and piperacillin (26 ml, 0.21 mmol). The mixture is stirred for 18 hours, the solvent is removed in vacuum, the residue is dissolved in CH2CL2and washed with a saturated solution Panso3and a saturated solution of salt. The organic layer is dried (gSO4), the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 19/1), which gives 2 mg (4%) N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]indole-6-carboxamide; 1H NMR (Dl3) a 3.75 (s, 2H), 5,95 (s, 2H), 6,80-of 6.90 (m, 2H), 7,05-to 7.15 (m, 2H), 7,25 (m, 2H), 7,75-a 7.85 (m, 2H), 8,00 (with the compounds according to this invention is the synthesis of N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrole-2-carboxamide [MS:(403,2 M+N)+], which is obtained similarly to the method described above to obtain N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]indole-6-carboxamide.

In the following reaction scheme 3 shows a method of preparing compounds according to this invention, in which U represents CR5(where R5denotes hydrogen), and X, Y and Z denote CR19(where R19denotes hydrogen)

The above synthesis can be performed as follows. To a benzene (20 ml) was added 1-(3-AMINOPHENYL)imidazole (755 mg, 4.7 mmol), complex ethyl ester of 7-chloro-3-exogamous acid (982 mg, 4.7 mmol), NaH2PO4(667 mg, 4.7 mmol), I2(60 mg, 0.23 mmol) and molecular sieve 4 angstroms (500 mg). The mixture is heated under reflux for 6 hours and introduce an additional number of I2(60 mg). The reaction mixture is stirred for 16 hours and filtered, the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 98/2), which gives 120 mg (8%) complex ethyl ester 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acrylic acid (1H NMR (Dl3) a 7.85 (s, 1H), 7,05 is 7.50 (m, 6N), 4,80 (s, 1H), 4,15 (kV, 2H), 3.45 points (t, 2H), 2,4 (t, 2H), 1,5-1,8 (m, 6N), of 1.30 (t, 3H). The resulting ester (120 mg, 0.38 mmol) dissolved in Meon (giving 60 hours, then the reaction mixture is filtered, the solvent is removed in vacuo and the residue chromatographic (ethyl acetate/hexane, 1/1), giving 24 mg complex ethyl ester 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid (compound of formula XV). The resulting ester (24 mg, 0,076 mmol) dissolved in 5% NaOH solution in methanol. The mixture is stirred for 16 hours, acidified with a solution of model HC1 in methanol, the solvent is removed in vacuum and the residue is dissolved in DMF. Add piperacillin (1 EQ.), the basis Hunya (2 EQ.) and HATU (1 EQ.). After the reaction, the reaction mixture was partitioned between water and ethyl acetate. The organic layer is separated, washed with water and dried. The solvent is removed in vacuo and the residue chromatographic (ethyl acetate/Meon, 98/2), giving 6 mg of the compounds of formula (Ibb), N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-ndimethylacetamide. 1H NMR (Dl3) 7,80 (s, 1H), 7,10-7,30 (m, 4H), 6,50-6,70 (m, 5H), 5,90 (s, 2H), 4,20 is 4.35 (m, 2H), 3,85 (SHS, 1H), 3,50 (t, 2H), 2.95 and (d, 1H), 2,35 is 2.55 (m, 2H), 1,4-1,9 (m, 6N); MS: (419 M+H)+.

The following reaction scheme 4 shows a method of preparing compounds according to this invention, in which a denotes-OR1

To DMF (100 ml) is added 4-chloro-2-imidazol-1-Yeremey (0,50 GRE 80°C for 5 hours, the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 19/1), which gives 349 mg (46%) of 1-[(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanol (compound of formula (XVI)) (1H NMR (Dl3) 8,54 (s, 2H), 8,11 (d, 1H), 7,82 (t, 1H), 7,11 (d, 1H), 6,44 (d, 1H), 3,60 (m, 2H), 3,03 (m, 1H), 1.77 in (m); MS: 274 (M+N)+. To a solution of 1-[(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanol (25 mg, 0,092 mmol) in DMF (5 ml) is added NaH (60% dispersion in oil, 5,5 mg, 0.14 mmol), then piperonylic (17 mg, 0.10 mmol) and chloride tert-butylamine. The mixture is stirred for 16 hours at a temperature of 80°C, the solvent is removed in vacuo and the residue partitioned between a saturated solution of NH4Cl and CH2CL2. The organic layer is separated and dried (MgSO4), the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 19/1), which gives 13 mg(35%) 4-[2-[[(1, 3-benzodioxol-5-yl)methoxy]ethyl]piperidine-1-yl]-2-(1H-imidazol-1-yl) pyrimidine (compound of formula (Icc));1H NMR (Dl3) charged 8.52 (s, 1H), with 8.05 (d, 1H), 7,80 (s, 1H), to 7.09 (s, 1H), 6.73 x (m, 3H), of 6.45 (d, 1H), to 5.93 (s, 2H), 4,30 (s, 2H), of 3.45 (m, 2H), 2.95 and (m, 1H), 1.55V (m); MS: 408,7 (M+H)+.

The compounds of formula (XVI) can be used to obtain other compounds of this invention, as shown in the reaction scheme ASS="ptx2">The above synthesis can be performed as follows. To a solution of 1-[(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanol (compound of formula (XVI)) (236 mg, 0.86 mmol) and methanesulfonamide (99 mg, 0.87 mmol) in CH2Cl2(20 ml) is added TEA (87,5 mg, 0.87 mmol). The mixture is stirred for 16 hours at 0°C, add methanesulfonanilide (99 mg, 0.87 mmol) and TEA (87,5 mg, 0.87 mmol) and heat the solution to room temperature. The solution is stirred for 1 hour, washed with a saturated solution of NH4Cl and saturated salt solution, dried (gSO4) and remove the solvent in vacuo, giving 276 mg (91%) of the compounds of formula (XVII) (1H NMR (Dl3) 8,72 (s, 1H), 8,15 (d, 1H), 7,89 (s, 1H), 7,18 (s, 1H), 6,46 (d, 1H), 4,24 (m, 3H), 2.95 and (s, 3H), 2,18 (m, 6N), 1,76 (m). MS: AZN 352.5 (M+N)+. A solution of the compounds of formula (XVII) (100 mg, 0.28 mmol) and compound of formula (XVIII) (429 mg, 2,84 mmol) in CH2CL2(7.5 ml) is stirred for 16 hours and add DMF (7.5 ml). The mixture is stirred for 2 hours, the solvent is removed in vacuo and the residue partitioned between a saturated solution of NH4Cl and CH2Cl2. The organic layer is separated, washed with saturated salt solution and dried (MgSO4), the solvent is removed in vacuo and the residue chromatographic (CH1H NMR (Dl3) and 8.50 (s, 1H), 8,08 (d, 1H), to 7.77 (s, 1H), was 7.08 (s, 1H), 6,66 (m, 3H), to 6.43 (d, 1H), 5,91 (s, 2H), 3,60 (d, 2H), 3,00 (m, 1H), 2.57 m (m, 2H), 2,02 (m, 1H), 1,65 (m). MS: 407,8 (M+N)+.

To a THF (3 ml) is added N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine (8 mg, 0.03 mmol), base Hunya (8 mg, 0.06 mmol) and acetic anhydride (4 mg, 0.04 mmol). The mixture is stirred for 16 hours, the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 19/1), which gives 8 mg (60%) N-acetyl-N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine (compound of formula (Igg);1H NMR (Dl3) 8,48 (s, 1H), 8,08 (d, 1H), 7,76 (s, 1H), to 7.09 (s, 1H), 6,66 (m, 3H), 6,33 (m, 1H), 5,94 (s, 1H), 5,91 (s, 1H), 4,43 (m, 3H), 3,40 (m, 2H), 2,11 (d, 3H), 1.14 in (m); MS: 450,0 (M+N)+.

Alternative to THF (3 ml) is added N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine (8 mg, 0.03 mmol), base Hunya (8 mg, 0.06 mmol) and methanesulfonamide (4.5 mg, 0.04 mmol). The mixture is stirred for 16 hours, the solvent is removed in vacuo and the residue chromatographic (CH2Cl2/MeOH, 19/1) that give 7 mg (51%) of N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(methylsulphonyl)piperidine-2-ethanamine (coedine,20 (m, 2H), 2,80 (s, 3H), 1.14 in (m); MS: 485,7 (M+N)+.

To DMF (5 ml) is added the compound of formula (XVII) (50 mg, 0.14 mmol), base Hunya (28 mg, 0.21 mmol) and N-methylpiperazine (28 mg, 0,17 mmol). The mixture is stirred for 16 hours at a temperature of 80°C, the solvent is removed in vacuo and the residue partitioned between a saturated solution of NH4Cl and CH2CL2. The organic layer is separated, washed with saturated salt solution and dried (gSO4), the solvent is removed in vacuo and the residue distributed between ethyl acetate and water. The organic layer is separated, washed with saturated salt solution and dried (gSO4), the solvent is removed in vacuo and the residue chromatographic (ethyl acetate/Meon, 19/1) that give 7 mg (12%) N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methylpiperidin-2-ethanamine (compound of formula (Idd);1H NMR (Dl3) 8,53 (s, 1H), 8,07 (d, 1H), 7,80 (s, 1H), 7,10 (s, 1H), 6,78 (s, 1H), 6,69 (m, 2H), to 6.43 (d, 1H), of 5.92 (s, 2H), 3,40 (m, 2H), 2,97 (m, 1H), 1,80 (m); MS: 422,0 (M+H)+.

In reaction scheme 6 illustrates another method of preparing compounds of the present invention, in which V denotes C(R4)H

The above synthesis can be performed as follows. To a solution of LDA (1.28 g, 12 mmol) in TG is t for 15 minutes and added dropwise 3,3-dimethylacrylamide (1,79 g, 12 mmol) in THF (5 ml). The reaction mixture is heated to room temperature, add water and ethyl acetate. The organic layer is separated, the solvent is removed in vacuo and the residue chromatographic (ethyl acetate/hexane, 1/19), which gives to 2.06 g (74%) of 2,4-dichloro-6-(4-methyl-3-pentenyl)pyrimidine (1H NMR (Dl3) to 7.15 (s, 1H), 5,10 (t, 1H), 2,80 (t, 2H), 2,45 (m, 2H), 1.70 to (s, 3H), of 1.55 (s, 3H)). To a solution of NaIO4(17 g, 81 mmol) and KMnO4(251 mg, of 1.59 mmol) in water is added TO2CO3(1.29 g, 9,38 mmol) and 2,4-dichloro-6-(4-methyl-3-pentenyl)pyrimidine (of 2.06 g, 8.9 mmol) in tert-butanol. The reaction mixture is stirred for 16 hours, acidified to pH 3 and extracted with ethyl acetate. The organic layer is extracted with an aqueous solution Panso3. The aqueous layer was acidified to pH 3 and extracted with ethyl acetate. The organic layer is dried and the solvent is removed in vacuo, giving 980 mg of 3-(2,4-dichloropyrimidine-6-yl)propionic acid (compound of formula (XIX)),1H NMR (Dl3) 7,30 (s, 1H), 3,05 (t, 2H), 2,90 (t, 2H). The resulting acid is subjected to reaction combination with piperacillin under standard conditions using isobutylphthalate and N-methylmorpholine that gives compound of formula (XX). Then add imidazole in standard conditions (1-trimethylsilylimidazole the General formula (Ihh)); MS: 386 (M+N)+.

A common method of solid-phase synthesis can be defined as the total synthesis according to the reaction scheme 1, where R1replaced the split connection at the connection point to the derived polymeric resin. At the end of this scheme of the synthesis the resin otscheplaut and R1becomes hydrogen. As before, the solid-phase synthesis is illustrated in the reaction scheme 7 in a specific example of piperidylamine, but in this case, the amino acid is a piperazine-2-acetic acid

In this solid-phase synthesis group, which should be R1attached to the biodegradable resin bond, such as 2-nitrobenzyl residue, which can photolytic split. In the above example, piperacillin (see above), the protected BOC-group, is subjected to the interaction with 4-(methyl bromide)-3-nitrobenzoic acid, giving the BOC-protected compound of formula (XXI), which is then attached to the free amine synthetic media, which is derived from lysine and having a functional amino group. In this case, cross-linked polystyrene grafted to polyethylene glycol, 1% DVB-crosslinked polystyrene or crosslinked polydimethylsilane suspended in a polar aprotic solvent, Taco is imennogo linker Sinton and binder reagent, such as diisopropylcarbodiimide (DIC), dicyclohexylcarbodiimide (DCC), the acid chloride of bis(2-oxo-3-oxazolidinyl)phosphinic acid (THIEF) or O-(7-asobancaria-1-yl)-1,1,3,3-tetramethylhexadecane (HATU), and the optional acylation catalyst, such as dimethylaminopyridine (DMAP) or hydroxybenzotriazole (NOVT). The mixture is stirred at room temperature for 1-24 hours, or until the end of the reaction, determined by the test ninhydrin. The resin is washed several times with one or more appropriate solvents to remove excess reagents and by-products that gives compound of formula (XXII) on the resin.

The compounds of formula (XXII) in the resin removes the protective group to obtain the compounds of formula (XXIII), which is suspended in a polar aprotic solvent such as methylene chloride or DMF. Add an excess of appropriately protected compound of formula (XXIV) with a binding agent, such as HATU, THIEF or DIC, in addition, optional add an acylation catalyst, such as DMAP or NOT. Alternatively, the resin can be added excess activated compounds of formula (XXIV), such as a symmetrical anhydride or allford. The mixture is shaken for 1-24 hours udalit excess reagents and by-products, that gives compound of formula (XXV) on the resin.

The compounds of formula (XXV) on the resin removes the protective group to obtain the compounds of formula (XXVI), which is suspended in a polar aprotic solvent such as DMF or THF. Add an excess of acceptable compounds of formula (VIIIb) and an excess of base, such as triethylamine or diisopropylethylamine. The mixture is stirred and heated to 50 to 100°C for 1-24 hours, cooled and washed several times with acceptable solvent to remove excess reagents and by-products that gives compound of formula (IXaa) on the resin. The compound of formula (IXaa) on the resin is subjected to an optional processing to cancel the protection of a functional group, which is part of sintana that gives compound of formula (Iii).

For the synthesis of compounds in which the structure of the substitution of the piperazine reversed (in particular, the following examples 95-102), the method described in the previous paragraph, can be changed a little. The compounds of formula (XXV) on the resin removes the protective group of the piperidine with getting amine, which is then dissolved or suspended in an inert solvent, such as methylenechloride. Add excess adequately protected acid containing the simulation, such as DMAP or NOT. Alternatively, the resin can be added excess activated form of the acid, such as a symmetrical anhydride or allford. The mixture is shaken for 1-24 hours at room temperature and washed several times with one or more appropriate solvents to remove excess reagents. The resulting product is suspended in a polar aprotic solvent such as DMF or THF. Add an excess of acceptable compounds of formula (VIIIb) and an excess of base, such as triethylamine or diisopropylethylamine. The mixture is stirred and heated to 50 to 100°C for 1-24 hours, cooled and washed several times with acceptable solvent to remove excess reagents and by-products, which gives a connection on the resin, similar to the compound of formula (IXaa) on the resin, in which a pyrimidine is attached to piperazinediones acid in position 4.

The compound obtained in the resin, which is similar to the compound of formula (IXaa) on the resin, suspended in proton solvent such as methanol or a mixture of acetonitrile-water, stirred and subjected to photolysis for removal of the target product from the resin. Filtration and evaporation of the filtrate gives the crude product, which is then the amino group (0.80 mmol) are suspended in 20 ml of methylene chloride and treated 1,05 g linker acid (2.4 mmol), 0,50 ml DIC (3.2 mmol) and 20 mg of DMAP (0.16 mmol). The mixture is shaken at room temperature for 20 hours and washed ten times with methylene chloride, which gives a compound of formula (XXII) on the resin. The compound of formula (XXII) in the resin is treated with a 50% solution triperoxonane acid (TFU) in methylene chloride at room temperature for 2 hours, washed ten times with methylene chloride, 15% triethylamine in methylene chloride for 10 minutes and another 5 times with methylene chloride. The compound of formula (XXII) on the resin with a remote protective group is suspended in 12 ml of methylene chloride and treated 1,444 g of compound of formula (XXIV) (3.2 mmol), 1,216 g HATU (3.2 mmol) and 1.3 ml of diisopropylethylamine (7.2 mmol). The mixture is shaken for 16 hours at room temperature and washed 5 times that gives compound of formula (XXV) on the resin. Fmoc group is removed by processing the connection 30% piperidine in DMF, then 777 mg of the obtained compound of formula (XXVI) in the resin (0.35 mmol) is subjected to interaction with 320 mg of 2-imidazolyl-4-chloropyrimidine (compound of formula (VIIIb) in the presence of 0.61 ml diisopropylethylamine (3.5 mmol) in 12 ml of DMF at 80°C for 15 hours, cooled to room temperature and washed with DMF and methylene chloride, which gives a compound of formula (IXaa) resin. Kony is a compound of formula (Iii) (31%). The crude product was purified flash chromatography (elwira a mixture of ethyl acetate:hexane:Meon, 4:1:1). The BOC-protected amine is treated with 3 ml of a mixture of 30% TFU-methylene chloride for 1 hour and dried in vacuo, giving the product in quantitative yield.

Connection piperazinediones acid of the formula (XXIV) used in the above method of synthesis, and many others described in this application, are synthesized as follows. Twelve milliliters (50 mmol) of N,N’-dibenziletilendiaminom, 14 ml (100 mmol) Et3N and 250 ml of toluene is mixed at 0°C and add 7 ml (50 mmol) of methyl 4-bromocrotonate (7 ml, 50 mmol). The reaction mixture is slowly warmed to room temperature, stirred for 24 hours, filtered, concentrated in vacuo to education residue and treated with 10% aqueous Hcl solution (300 ml). The mixture is again filtered and the filtrate washed with ethyl acetate (2×100 ml). The filtrate is alkalinized TO a2CO3and extracted with ethyl acetate (3×150 ml). The combined extracts washed with saturated salt solution, dried over gSO4and concentrated in vacuo obtaining of 13.7 g of methyl 1,4-dibenzylpiperazine-2-acetate.1H NMR (Dl3) 2,28-of 2.50 (m, 4H), 2,5-2,75 (m, 4H), 3,1 (SHS, 1H), 3,42 (d, 2H), 3,52 (d, 1H), 3,6 (s, 3H), of 3.75 (d, 1H), 7, Prov.) and 3 g of 10% Pd/C mix and hydronaut H2(pressure of 3.5 bar (50 psi) for 24 hours. The reaction mixture is filtered, the filtrate was concentrated in vacuo to remove most of the Meon, the rest is alkalinized TO a2CO3to pH 9-10 and at 0°With the added slowly to 9.8 g (40 mmol) of BOC-ON. The reaction mixture was stirred at 0°C for 1 hour, allowed to warm to room temperature, stirred for 2 hours and extracted with ethyl acetate (2×200 ml). The combined extracts are treated with 50 ml of 10% solution of Hcl (aqueous). The aqueous layer was washed with ethyl acetate, alkalinized TO a2CO3and extracted three times with ethyl acetate. The combined organic layers washed with saturated salt solution, dried (gSO4) and concentrated in vacuo, giving 7,89 g of methyl 4-BOC-piperazine-2-acetate;1H NMR (Dl3) 1,4 (, N), 2,31 (DD, 1H), 2,37 (DD, 1H), 2,55 (W, 1H), 2,69-to 3.02 (m, 4H), of 3.75 (s, 3H), 3,88 (W, 2N).

Portion (of 5.2 g, 20 mmol) methyl 4-BOC-piperazine-2-acetate, obtained in the previous phase is mixed with 60 ml of THF and 60 ml of 1 N NaOH (aqueous) and stirred at room temperature for 6 hours to saponification difficult methyl ester. The reaction mixture was cooled to 0°C, adjusted to pH 9-10 with 10% Hcl solution (water) and added to 5.2 g (20 mmol) th) to maintain a pH of 9-10 for 1 hour and acidified with 10% Hcl solution to pH 1. The reaction mixture is extracted twice, the combined organic layers washed with saturated salt solution, dried over MgSO4and concentrated in vacuo, giving 8,56 g target 4-BOC-1-Fm-piperazine-2-acetic acid (compound of formula (XXIV));1H NMR (Dl3) 1,4 (, N), of 2.5-3.0 (m, 5H), 3,9-4,2 (m, 6N), and 4.5 (m, 1H), 7,25 (m, 4H), 7,32 (m, 4H), of 7.48 (d, 4H), of 7.75 (d, 4H).

In those cases, when instead of 4-BOC-1-Fm-piperazine-2-acetic acid (compound of formula (XXIV)) using 4-BOC-1-Fm-piperazine-2-carboxylic acid starting material gain, dissolving the 5.25 g (25,85 mmol) 2-piperazinecarboxamide acid · 2hcl in 160 ml of a mixture of dioxane/H2About (1:1) and bringing the pH to 11 with 50% NaOH (aqueous). Slowly add (portions) solution 7,21 g (29,28 mmol) of BOC-ON in 40 ml of dioxane, keeping while adding a pH equal to 11 with 50% NaOH (aqueous). The reaction mixture was stirred at room temperature for 5 hours, cooled to 0°C and adjusted to a pH of 9.5 with 50% NaOH (aqueous). Slowly add (portions) solution 7,34 g (28,37 mmol) of FMOC-Cl in 40 ml of dioxane, keeping while adding pH 9.5 with 50% NaOH (aqueous). The mixture is heated to room temperature, stirred for 20 hours, washed with ethyl ether (3 = 150 ml)tub over Na2SO4concentrate in vacuo to a volume of 150 ml and cooled to -20°C for the night. The obtained solid substance is filtered off, washed with hexane and dried in vacuum, giving 5.4 g of the target 4-BOC-1-Fm-piperazine-2-carboxylic acid.

Alternatively, 4-BOC-morpholine-3-carboxylic acid, which can be used instead of the compounds of formula (XXIV) the following reaction scheme 7 to obtain other compounds of this invention was prepared as follows. To a solution of complex methyl ester 4-phenylmethylsulfonyl-5-one-3-carboxylic acid (5.1 g, 20,5 mmol) in 100 ml THF is slowly added borane/DMS (10 M solution, 2.5 ml), cooling the mixture to 0°C. the Solution is allowed to warm to room temperature and stirred for 18 hours. Then add water (100 ml) and extracted with a mixture of ethyl acetate. The organic layers dried over gSO4and concentrate. The resulting oil is purified on a column of silica gel, elwira a mixture of ethyl:hexane (3:7), which gives morpholine (3.0 g, 64%). Morpholine (3.0 g, 12.75 mmol) was dissolved in 50 ml Meon and add 10% Pd/C (10 mg). The mixture is stirred at room temperature in an atmosphere of H2for 16 hours. The mixture is then filtered through celite and concentrated. The oil obtained is 4 hours, concentrate, absorb CH2Cl2and washed with water, saturated solution Panso3and a saturated solution of salt. The organic layer is dried over gSO4and concentrate to obtain 2.8 g (89%) of ester. The obtained ester is dissolved in the Meon (30 ml) and add NaOH (1.4 g, 35 mmol). The solution is stirred for 4 hours heating under reflux, concentrated, acidified with 1 N Hcl solution and extracted with CH2Cl2. The organic layer is dried (MgSO4) and concentrated, giving 4-BOC-morpholine-3-carboxylic acid as a white solid (2.4 g, 90%).1H NMR (Dl3) of 1.40 (m, N), 3,20-to 3.50 (m, 2H), 3,70 (m, 2H), 3,90 (m, 1H), 4,30 with 4.65 (m, 2H).

Instead of the compounds of formula (XXIV) in reaction scheme 7, you can use 1-Vos-peligrosas-2-acetic acid, which is obtained as follows. N-Boc-peligrosas (1.06 g, 6,16 mmol) in a simple ether is treated with TMEDA (715 mg, 6,16 mmol) and second-butyllithium (1.3 M solution, 4,74 ml, 6,16 mmol) at a temperature of -78°C. the Reaction mixture is slowly heated to -40°C, stirred for 1 hour, cooled to -78°C and treated with a solution of 3,3-dimethylacrylamide (918 mg, 6,16 mmol) in a simple ether. The reaction mixture is heated to room temperature and quenched with woes dried (gSO4), the solvent is removed in vacuo and the product purified by chromatography (silica gel, Huck-San:ethyl acetate, 95:5), giving olefin (300 mg, 21%,1H NMR (Dl3) of 5.05-5,20 (m, 1H), 3,55-of 3.80 (m, 2H), 2,60-of 2.75 (m, 1H), 1,90-of 2.20 (m, 3H), 1,10-of 1.80 (m, 22N). To a solution of NaIO4(2.17 g, 10.2 mmol) and KMPO4(32 mg, 0.2 mmol) in 45 ml of water is added TO the2CO3(162 mg, 1.18 mmol) and a solution of olefin (300 mg, 1.12 mmol) in tert-butanol (11 ml). The reaction mixture is stirred for three days, acidified to pH 3 and extracted with ethyl acetate. The organic layer is washed with water and saturated salt solution, dried (gSO4) and remove the solvent in vacuo, giving 1-Vos-peligrosas-2-acetic acid (250 mg, 87%).1H NMR (Dl3) 4,20 is 4.45 (m, 1H), 3,55-of 3.80 (m, 1H), 2.00 in 2,80 (m, 4H), 1,10-of 1.80 (m, N).

Instead of the compounds of formula (XXIV) in reaction scheme 7, you can also use 4-BOC-morpholine-3-acetic acid, which is obtained as follows from the complicated ethyl ester 4-benzylmorphine-3-acetic acid (Brown, G. R.; Foubister, A. J.; Stribling, D. J., Chem. Soc. Perkin Trans. 1 (1987), p.547). Benzyl group is subjected to hydrogenolysis (Pd(OH)2H2) and get N-Boc-derivative, by treatment with di-tert-BUTYLCARBAMATE, then complex ethyl ester hydrolyzing is a reaction scheme 7, you can use 1-Vos-pyrrolidin-2-propionic acid, which is obtained as follows. Vos-pyrrolidin (5.0 g, 29.2 mmol) is dissolved in a simple ether (35 ml) and added TMEDA (3.0 g, 20 mmol), cooled to -78°C, and second-utility (1.3 M solution, 17 ml, 22 mmol). The mixture is stirred for 1 hour and add allylbromide (5,1 ml, 57 mmol). The reaction mixture is heated to room temperature, quenched with water and separate the organic layer. The organic layer is dried (MgSO4) and the solvent is removed in vacuum to obtain olefin (2.9 g, 47%).1H NMR (Dl3) 5,65-to 5.85 (m, 1H), 5,00-5,20 (m, 2H), 3,70-3,90 (m, 1H), 3,20 is-3.45 (m, 2H), 2,35-2,60 (M, 1H), 2.00 in of 2.20 (m, 1H), 1,60-2,00 (m, 4H), 1,45 (s, N)). The olefin (1.0 g, 4.7 mmol) in THF (20 ml) at 0°With the added borane/THF. The mixture is heated to room temperature, stirred for 1 hour and add H2O2(30%, 14 ml) and 3 N NaOH solution (3.2 ml). The reaction mixture was distributed with ethyl acetate and separated. The organic layer is dried and concentrated in vacuo. The residue add to NaIO4(1.2 g, 5.4 mmol) and RUO Li4(10 mg, 0.08 mmol) in water (100 ml) and acetone (10 ml). The reaction mixture is stirred for 1 hour, concentrated and extracted with CH2Cl2. The organic layer is extracted with 1 N NaOH solution. The aqueous layer was washed with CH2CL2, acidified with 1 N Hcl solution and irreligion-2-propionic acid. 1H NMR (Dl3) of 1.40 (m, N), 1,60-2,00 (m, 6N), of 2.20 (m, 2H), 2.40 a (m, 2H), 3,30 (m, 2H), 3,90 (m, 1H).

Instead of the compounds of formula (XXIV) in reaction scheme 7, you can also use 4-Vos-thiomorpholine-3-carboxylic acid, which is obtained as follows. To add THF hydrochloride complex ethyl ester of cysteine (1,15 g, 6,18 mol), triethylamine (of 4.17 ml, 30 mmol) and dibromoethane (of 2.51 ml, 6.2 mmol). The mixture is stirred for 1 hour, heated under reflux for 16 hours and filtered solids. The solvent is removed in vacuo and the residue chromatographic on silica gel with getting complicated ethyl ester thiomorpholine acid (0,94 g, 87%). The resulting ester (15.3 g, 95 mmol) dissolved in a mixture of dioxane/water (1/1) and add di-tert-BUTYLCARBAMATE (24 g, 110 mmol) and LiOH. The mixture is stirred for 3 hours, the solvent is removed in vacuo and the pH adjusted to 3 by adding S3and extracted with ethyl acetate. The organic layer was separated, washed with a saturated solution of salt, dried (MgSO4) and remove the solvent in vacuo, giving of 17.4 g (78%) of 4-BOC-thiomorpholine-3-carboxylic acid.1H NMR (Dl3) a 1.45 (m, N), a 2.45 (m, 1H), 2,71 (m, 1H), 2,93 (m, 1H), 3,10 (m, 1H), 3,29 (m, 1H), 4,11 (m, 1H), 4,19 (m, 1H, 5,20 (m, 1H).

VM is odorou obtained as follows. To THF (50 ml) is added methylpropanal (1.0 ml, 8.6 mmol), base Hunya (1.5 ml, 8.6 mmol) and N-Boc-2-aminoethanethiol (1.5 g, 8.6 mmol). The reaction mixture is stirred for 3 hours, poured into a saturated solution of NH4Cl and extracted with ethyl acetate. The organic layer was washed with a saturated solution of salt, dried (MgSO4) and remove the solvent in vacuo. Chromatography (hexane/ethyl acetate, 6/1) gives the methyl ester of N-Boc-2-aminoethanethiol acid. The resulting ester was dissolved in CH2Cl2(80 ml) and add TFU (20 ml). The mixture is stirred for 1 hour and remove the solvent in vacuo. The residue is added to a solution of toluene and TEA (2.5 ml). The mixture is stirred for 16 hours, the solvent is removed in vacuo and the residue chromatographic obtaining thiomorpholine. The resulting ester (18.0 g, 95 mmol) dissolved in a mixture of dioxane/water (1/1) and add di-tert-BUTYLCARBAMATE (19.6 g, 90 mmol) and LiOH. The mixture is stirred for 12 hours, remove the solvent in vacuo, adjusted pH to 3 by adding S3and extracted with ethyl acetate. The organic layer was separated, washed with a saturated solution of salt, dried (MgSO4) and remove the solvent in vacuo, giving a 20.3 g (86%) 4-Vos-thiomorpholine-3-acetic (s, 1H).

Instead of the compounds of formula (XXIV) in reaction scheme 7, you can also use 4-Vos-thiomorpholine-2-acetic acid, which is obtained as follows. To THF (100 ml) is added di-ethylfuran (3,27 ml, 820 mmol), DBU (7,22 ml, 50 mmol) and hydrochloride aminoethanethiol (and 2.26 ml, 20 mmol). The reaction mixture is heated under reflux for 16 hours, poured into a saturated solution Panso3and extracted with ethyl acetate. The organic layer was washed with a saturated solution of salt, dried (MgSO4) and remove the solvent in vacuo. Chromatography (ethyl acetate) gives thiomorpholine (2,61 g, 70%). The resulting ester was dissolved in THF (50 ml) and added dropwise borane/DMS (3 ml, 30 mol). The mixture is stirred for 16 hours and quenched by adding ethanol. In the reaction mixture was bubbled gaseous Hcl and heat it under reflux for 2 hours. The solvent is removed in vacuo and the residue suspended in 0.5 M NaOH solution and CH2Cl2. The organic layer is separated, dried (Na2SO4) and remove the solvent in vacuo. Chromatography on silica gel (Meon/ethyl acetate) gives the original substance (0.71 g, 29%) and thiomorpholine (1.26 g, 56%). The resulting ester (3.0 g, to 11.4 mmol) dissolved in a mixture of dioxane/water (1/1) and add di-tert-butylcatechol pH to 3, adding KHSO4and share with ethyl acetate. The organic layer was separated, washed with a saturated solution of salt, dried (MgSO4) and remove the solvent in vacuo, giving 2.20 g (81%) of 4-BOC-thiomorpholine-2-acetic acid.1H NMR (Dl3) of 1.44 (m, N), at 2.59 (m, 4H), 3,17 (m, 1H), 3,2-4,0 (m, 4H).

In reaction scheme 7 shows a method of synthesis, the implementation of which is obtained in advance, a protected compound of formula (XXI) is associated with the resin, remove the protective group and is subjected to interaction with a protected compound of formula (XXIV). The specialist should be obvious that if you change the sequence of reactions you can get the same piperonyl-aminomethylbenzoic resin with remote protective group. The following is an example of this sequence of reactions. This example also shows how you can change the structure of substitution in the ring piperazinediones acid.

4-methyl bromide-3-nitrobenzoic acid (819 mg, 3,15 mmol) and HOBt (426 mg, 3,15 mmol) absorb 15 ml of DMF, added DIC (795 mg, 6,30 mmol) and the contents stirred for 30 minutes at room temperature. The resulting mixture was added to the resin and shaken overnight. The resin is filtered, washed and dried as indicated above. For this slamin (1.51 g, 10 mmol), and shaken over the weekend at the end of the week. The resin is filtered, washed and dried (1,507 g) N1-Fmoc-N4-BOC-piperazine-2-acetic acid (978 mg, 2.1 mmol), HATU (798 mg, 2.1 mmol) and DIEA (542 mg, 4.2 mmol) are mixed in DMF and added to the resin. The mixture is shaken for 24 hours, after which the resin was filtered, washed and dried in the usual way; the weight of the resin is 1,693 was Obtained resin absorb 15 ml of 30% (in weight ratio) of piperidine in DMF and shaken for 2 hours for removal of Fmo-protective group. The resin is filtered, washed and dried in the usual way; the weight of the resin is 1,588, Resin, acetic anhydride (591 mg, 5.8 mmol) and DIEA (748 mg, 5.8 mmol) absorb 15 ml of methylene chloride and shaken overnight for acylation in position N1. The resin was filtered, washed with methylene chloride and dried in a vacuum oven for 5 hours. The resin is shaken with 15 ml of a mixture of TFU:methylene chloride ((1:1) for 1 hour for removal of the tert-BOC-protective group at position N4. The resin is filtered and washed with methylene chloride (5×15 ml), 20% triethylamine in methylene chloride (5×15 ml) and again with methylene chloride (5×15 ml). After drying, the weight of the resin is 1,294, 669 mg of the resin obtained in the previous phase, DIEA (1C within 24 hours. The resin was filtered, washed (DMF), methanol and methylene chloride) and dried. Portion (377 mg) of the resin obtained in the previous phase, suspended in methanol and subjected to photolysis at a temperature of 50°C for 6 hours. The solution is filtered, the solvent removed and the residue purified by chromatography (silica gel, methylene chloride:methanol, 95:5), yield 14 mg Results1H NMR and MS compatible with the proposed structure.

The compounds listed in tables 1 through 7 (see end of text) are typical compounds of this invention and synthesized the above-described method. All these compounds inhibit iNOS at concentrations of less than 25 microns.

Linking group L connect the fragment of the corresponding compounds (I) with a solid carrier S in the compound of formula (IX). In the course of obtaining the compounds of formula (I) splitting the compounds of formula (IX) data group L break down these chemicals.

The following compounds are obtained by the methods discussed in this description:

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imides is n-4-yl]amino]-3-hydroxy-N-[(1,3-benzodioxol-5-yl)methyl]propanamide;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]pentanedione;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(nitramino)methyl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]pentanone;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-(thiophene-2-yl)-N-[3-(morpholine-4-yl)propyl]propanamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[2,6-bis(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]-1-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[phenylmethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-phenylethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(thiophene-2-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(methyl)piperazine-2-ndimethylacetamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-(methylthio)-N-[(1,3-benzodioxol-5-yl)methyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-[(4-methoxyphenyl)methyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-[2-(3,4-acid)ethyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-(methyl)butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-[(1,1-dimethylethyl)thio]-N-[3-(methylthio)propyl]propanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-[(1,1-dimethylethyl)thio]-N-[3-(phenyl)propyl]propanamide;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]-2-tiefenbronn;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-(butyl)-2-tiefenbronn;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]-2-tiefenbronn;

2-[[6-chloro-2-(1H-imidazol-1-Gasol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]ndimethylacetamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]propanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]pentanedione;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]pentanedione;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanedione;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(nitramino)methyl]amino]pentanone;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-5-[[imino(amino)methyl]amino]pentanone;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]pyrrolidin-2-carboxamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-5-[[imino(nitramino)methyl]amino]pentanone;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(imino)methyl]amino]pentanone;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-hydroxy-N-[4-(hydroxycarbonyl)phenyl]methyl]pyrrolidin-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-hydroxide;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[3-(methylsulphonyl)propyl]benzoylpropionic;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-6-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]hexanamide;

5-amino-N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanone;

5-amino-N-butyl-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanone;

4-[(3-hydroxy-3-oxopropyl)amino]-3-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-oxobutanoic acid;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl](methyl)amino]-N-[(pyridine-4-yl)methyl]ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methylpiperidin-2-carboxamide;

N-[2-(3,4-acid)ethyl]--[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-2-tiefenbronn;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-methylpentanoic;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanedione;

N-[2-(3,4-acid)ethyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-methylpentanoic;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-Zol-1-yl)pyrimidine-4-yl]amino]benzoylpropionic;

5-[[amino(imino)methyl]amino]-6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(phenylmethyl)pentanone;

N-[(1,3-benzodioxol-5-yl)methyl]-1,4-bis[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-[[(phenyl)amino]carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-[(methoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(acetyl)-N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-1-methylpiperazin-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-1-methylpiperazin-2-ndimethylacetamide;

1-butyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(furan-2-yl)methyl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-butyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-butyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(2,3-acid)methyl]-1-butyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-1-[(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-1-[(4-methoxyphenyl(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(indan-5-yl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(2,3-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[[2-(phenyl)cyclopropyl]amino]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(4-ethoxyphenyl)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxan-6-yl) methyl]-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(1,3-benzodioxan-6�]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-acid)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-acid)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(3,4-acid)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[3-(3,4-acid)propyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imida who yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methylphenoxy)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-were)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-(isopropylpyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(4-methylphenoxy)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(3-methyl-1-oxo is]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(2,6-acid)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-dimetilfenil)methyl]-1-(methoxyacetyl)-4-[6-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)Perim propyl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(4-were)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-chlorophenyl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(Tetra-yl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(3-methoxyphenyl)ethyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-2-yl)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-Cail)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,5-acid)methyl]-1-[(tetrahydrofuran-2-yl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-ethoxyphenyl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[2-(3,4-acid)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[3-(3,4-acid)propyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-were)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(phenoxyacetyl)-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazinediones-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(4-methoxyphenyl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-[(4-methoxyphenyl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-(6-herperidin-2-yl)-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

1-(acetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylsulphonyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylsulfinylphenyl)methyl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[[2-(etoxycarbonyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]A4-yl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-dimethoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(n-octyl)sulfonyl-4L)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-3-yl)methyl]piperazine-2-carboxamide;

1-(4-were)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(4-were)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine the ol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-forfinal)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-forfinal)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzo is midin-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-trifluoromethyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-chlorophenyl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-l-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-ethyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminomar"ptx2">1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-m who yl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2,4-acid)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimido the ol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-beat]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(cyclopropyl)piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-(1H-imidazol-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(furan-2-yl)methyl]piperazine-2-ndimethylacetamide;<2-carboxamide;

1-(phenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodi the DIN-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-((phenyl)methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-chloro-arbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-men-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]piperazine-2-carboxamide;

1-(pyridine-3-yl)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(pyridine-3-yl)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodiox-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-carboxamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrim the ENT-2-(-1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[3-(3,4-acid)propyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[3-(3,4-acid)propyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxepin-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-vinylcyclopropyl)piperazine-2-carboxamide;

1-methylsulphonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-ethyl pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(4-methoxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-dihydroxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-octyl-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-(phenylpropyl)-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(pyridine-3-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(morpholine-4-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(2-methoxypyridine-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-carboxamide;

N-[(2-methylpyridin-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-carboxamide;

N-[(1,3-benzodiox who-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]-N-octylated;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](phenylmethyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][(1,3-benzodioxol-5-yl)methyl]amino]ndimethylacetamide;

N-[(3,4-acid)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][(morpholine-4-yl)ethyl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methylethyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-oxy)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[4-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-2-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[4-(1H-imidazol-1-yl)-6-methylpyrimidine;

N-[(4-triptoreline)methyl]-3-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-3-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]propionamide;

N-[(1,3-benzodioxol-5-oxy)ethyl]-2-(1H-imidazol-1-yl)pyrimidinylidene-4-amine;

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-(2-methyl-1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-(2-methyl-1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(4-nitrophenyl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[[4-(acetylamino)phenyl]methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[[4-(methylsulfonylamino)phenyl]methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[(2,3-dihydrobenzofuran-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[(indan-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-(1-oxoprop-methanamine;

N-[(1,3-benzodioxol-5-yl)methylcarbamoyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-methanamine;

N-[(4-methoxyphenoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-methanamine;

N-[(4-methoxyphenyl)methylcarbamoyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-methanamine;

N-[(1,3-benzodioxol-5-yl)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ethanamine;

2,4-bis(1H-imidazol-1-yl)-6-methylpyrimidin;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-5-methylpyrimidin-4-yl]-4-(phenylmethyl)piperazine-3-ndimethylacetamide;

N-[(3,4-acid)ethyl]-6-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methyl-5,6,7,8-tetrahydropyrido[5,6-C]pyrimidine-4-amine;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]-4-methylcobalamin;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-methylcobalamin;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-4-methylsulfonylmethane;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(butylthio)butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(cyclopropyl)methyl]-3-[(3,4-di is l)methyl]-3-methyl-3-[(phenylmethyl)thio]butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-chlorophenyl)methyl]-3-tiefenbronn;

5-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]pentanone;

5-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,4-benzodioxan-6-yl)ethyl]pentanone;

7-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-(2-vinylcyclopropyl)heptanone;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-[(3-chloro-4-methoxyphenyl)ethyl]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,4-benzodioxan-6-yl)ethyl]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-methoxyphenyl)ethyl]ndimethylacetamide;

4-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-chlorophenyl)ethyl]pyridine-3-propanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,4-benzodioxan-6-yl)ethyl]isoquinoline-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-metile the-methylphenoxy)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpr the]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]thiomorpholine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]thiomorpholine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazo the-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,4-acid)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]-N-[(1,3-benzodioxol-5-yl)ethyl]ndimethylacetamide;

1-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]-N-[(1,4-benzodioxan-6-yl)ethyl]ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-methylpiperazin-2-carboxamido>

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-methylpiperazin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-methoxyphenyl)methyl]-4-methylpiperazin-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[[4-(2-methoxyethoxy)phenyl))methyl]-4-methylpiperazin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazolidin-4-yl]-N-[(cyclopropyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(indan-5-yl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-metrel]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-al]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-(2-vinylcyclopropyl)-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(3,4-dichlorophenyl)methyl]Piper)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorobiphenyl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)IU benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,5-acid)methyl]-4-[(1,4-shall xol-5-yl)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thiophenyl)ethyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3,5-acid)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1-substituted)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-[(pyridine-3-yl)meth is l)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-aceta the Razin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1-substituted)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-METI the DIN-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-acetylpiperidine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(what evils-1-yl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-,4-benzodioxan-2-yl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-vinylcyclopropyl)-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(cyclopropyl)-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(indan-5-yl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-holdem">1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[[4-(2-methoxyethoxy)phenyl]ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-vinylcyclopropyl)-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-2-yl)-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-5-yl)-4-(3-methyl-is)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imida is 2">1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-5-yl)-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-3-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-labels is n-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid) IU Setenil)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-dimetilfenil)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(pyridine-3-icarb the-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazin Outil]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-pyridinyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)the feast of the l-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1-methylpyrrole-2-yl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3,4-acid)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-l-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-them;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-indanyl)-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-the">1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxepin-6-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-the ol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(octylsilane)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-chlorophenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)METI is)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,6-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,5-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-substituted)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(propeity]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-is CLASS="ptx2">1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(propylaminoethyl)piperazine-2-ACL)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;cetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-thienyl)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-and the tx2">1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-(cyclopropyl)-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-indanyl)-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-m the ENT-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(cyclohexyl the yl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyp the l]-N-[(4-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-indanyl)-4-(cyclohexanecarbonyl)enaminocarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(vinylsulfonylacetamido)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(vinylsulfonylacetamido)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(vinylsulfonylacetamido)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(2,3-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(Finl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

e;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-thienyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-and the ethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,3-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-were)methyl]-4-[(4-methoxy is 4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1 ሺ;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-furyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1 is rimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin is imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-indanyl)-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(5-indanyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphe is 4-yl]-N-[(4-were)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-and the pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-eazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-"ptx2">1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[-(3-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-be the one-4-yl]-N-[(3,4-acid)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylethanolamine)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methylethanolamine)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(butoxycarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(f the methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(phenylmethoxy)carbonyl]perazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(1,4-benzodioxan-N-[(1,4-benzodioxan-6-yl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1-methylpyrrole-2-yl)ethyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[1-(phenylmethyl)piperidine-4-yl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-cyanocyclohexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(2,2-dimethoxymethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-creditimpaired-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine--N,N-[bis(2-cyanoethyl)]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N,N-[bis(2-cyanomethyl)]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(4,4-diethoxybutane)piperidine-2-ndimethylacetamide;

1-(4-forfinal)-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

1-[(1,3-benzodioxol-5-yl)methyl]-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

1-(phenylmethyl)-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

complex ethyl ester 4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine-1-carboxylic acid;

1-(4-chlorophenyl)-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]-4-hydroxypiperidine;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,3-dihydrobenzofuran-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(indan-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(cyclohexyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(naphthalene-1-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-mutilate is kidin-4-yl]-N-[(4-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(morpholine-4-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(cyclooctyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-ethyl-3-hydroxy-1-hydroxymethylpropane)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(morpholine-4-yl)propyl]piperidine-2-azet the LASS="ptx2">1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-methyl-3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-methyl-3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(1-methylheptan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-methylheptan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-methylheptan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-phenylmaleimide-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1,5-diethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(1,5-diethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2-chlorophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(furan-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(furan-2-yl)methyl] piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(furan-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-AC is P>

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-hydroxy-4-methylthiomethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(2-hydroxy-4-methylthiomethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)this is the ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(phenylbutyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(phenylbutyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-hydroxymethylene)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-hydroxymethylene)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-etox the-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-bromophenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-pentylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-pentylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-pentylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(1H-imidazol-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[3-(1H-imidazol-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-]-N-[(2,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(1-phenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[1-(phenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-chlorophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-chlorophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(5-hydroxyphenyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-forfinal)(methyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-forfinal)(methyl)methyl]piperidine-2-aceta[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2,5-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2,5-acid)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(methylethoxy)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-hexylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-hexylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-hexed;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(cyclohexen-1-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-fluoro-5-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-fluoro-5-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-ethoxypropan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-ethoxypropan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-heptylbiphenyl-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-heptylbiphenyl-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-heptylbiphenyl-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-methoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-cyclohexylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-cyclohexylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazo-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-trifloromethyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-octylpyrimidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-octylpyrimidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-hydroxy-3-methylbutyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[1-(4-were)ethyl]piperidine-2-ndimethylacetamide; the evil-1-yl)-6-methylpyrimidin-4-yl]-N-[1-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(4,4-diethoxybutane)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-butoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-butoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(thiophene-2-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(thiophene-2-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(pyrrolidin-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(cyclohexyl) methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclohexyl)methyl]piperidine-2-ndimethylacetamide;

complex ethyl ester 4-[[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]amino]piperidine-1-carboxylic acid;

complex Atleti;

complex ethyl ester 4-[[1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-acetyl]amino]piperidine-1-carboxylic acid;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-forfinal)methyl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-chloro-5-(1H-imidazol-1-yl)triazine-1-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)purine-6-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-(1H-imidazol-1-yl)pyrazin-2-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[2-(1H-imidazol-1-yl)pyrimidine-4-hydroxy]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[2-(1H-imidazol-1-yl)pyrimidine-4-thio]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methylpiperidin-2-ethanamine;

4-[2-[[(1,3-benzodioxol-5-yl)methoxy]ethyl]piperidine-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[[(4-(methoxy)phenoxy]propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[[(4-(methoxy)phenoxy]propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)-6-methylpyrimidin;

4-[2-[(1,3-benzodioxol-5-yl)propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[(1,3-benzodioxol-5-yl)prop-2-enyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-chloro-2-(1H-imidazol-1-yl)-6-(peligrosas-1-yl)pyrimidine;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanol;

4-chloro-2-(1H-imidazol-1-yl)-6-(piperidine-1-yl)pyrimidine;

4-chloro-2-(1H-imidazol-1-yl)-6-(2-ethylpiperidine-1-yl)pyrimidine;

4-fluoro-2-(1H-imidazol-1-yl)-6-[[(3,4-acid)ethyl]amino]pyrimidine;

4-fluoro-2-(1H-imidazol-1-yl)-6-[[(phenyl)ethyl]amino]pyrimidine;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-triazole-1-yl)pyrimidine-4-yl]-4-[(dimethylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-(morpholine-4-yl)-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[[1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzo is-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-(aminocarbonyl)-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-1-[(methoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-3-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-methoxybenzamide;

4-chloro-2-(1H-imidazol-1-yl)-6-[(2-methoxyphenyl)amino]pyrimidine;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]indole-6-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrole-2-carboxamide;

N-[(3,4-acid)ethyl]-2-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-propionamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-3-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-3-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-3-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-3-ndimethylacetamide;

N-[(3,4-dimethoxy the 1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]azetidin-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]morpholine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]morpholine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H -, and-(methylethyl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[6-ethyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(4-chlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(4-were)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(3,4-dimetilfenil)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]peligrosas-2-carboxamide;

2">N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]peligrosas-2-carboxamide;

N-[(3,4-acid)ethyl]-1-[6-CHL is imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]peligrosas-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-(2-pyridin-3-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-dioxolane-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4 is increasedin-2-ndimethylacetamide and

N-[(4-trifloromethyl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]peligrosas-2-ndimethylacetamide.

Although the present invention is described with reference to specific variations in its implementation, the expert in this field should be obvious that this invention can be made various changes and used the equivalent substance, not beyond the scope and essence of the invention. In addition, many modifications can be made to result in concrete terms, substances, compositions, methods and stages of the process in accordance with the objectives, nature and scope of the present invention. All these modifications are included in the scope of the attached claims.

1. The compound of formula (I)

where a denotes-OR);

each U represents N or C(R5), provided that U is N only when X represents N, and Z and Y denote CR19; each W represents N or CH;

V means:

(1) N(R4);

(2) C(R4)H; or

(3) the group directly related to the group -(C(R14R20)n"And denotes a 5-6-membered N-heterocyclyl, optionally containing 6-membered ring additional heteroatom selected from oxygen, sulfur and NR6where R6denotes hydrogen, methyl, optionally substituted phenyl, 6-membered heterocyclyl containing 1-2 nitrogen atom, optionally substituted 5-membered heterocyclyl containing 1-2 nitrogen atom, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, C1-6alkoxycarbonyl, acetyl, -C(O)CH2CH(CH3)2, -C(O)R8, -C(O)-[C1-C6alkyl]-R, where R8denotes cycloalkyl, tetrahydrofuryl or phenyl substituted methoxy, -[C2-C6alkyl]-R10where R10denotes methoxy;

in case (3)

no;

Q is chosen from the group comprising a direct bond, -O-, -N(R6)-, -S(O)twhere t is 0, 1 or 2;

m rave;

r is zero or one, provided that when Q and V represent heteroatoms, m, q, and r cannot all be zero; when a represents-OR1, n, q, and r cannot all be zero; and when Q denotes a heteroatom and a indicates-OR1, m and n cannot both be zero;

each R1and R2independently selected from the group including hydrogen, C1-C6alkyl, -(C1-C6alkyl)-R9where R9denotes phenyl, optionally substituted by one or more C1-4lower alkoxy, C1-4by alkyl, halogen, hydroxy, heterocyclyl, such as benzodioxol, thienyl;

R3selected from the group including hydrogen, C1-6alkyl, phenyl, or when Q represents a direct link with R3or NR6, R3can be aminocarbonyl,-1-4alkoxycarbonyl, monoalkylammonium, dialkylaminoalkyl, C(=NR18)-NH2or Q together with R3denotes hydrogen, HE, NH2, NHTrt, COOH, CONH2S-C1-6alkyl, phenyl or 2-thienyl;

R4selected from the group including hydrogen, C1-6alkyl;

R5selected from the group comprising hydrogen, halogen, C1-6alkyl, halogen-C1-6alkyl;

R18denotes hydrogen, NO2;

in the form of an individual stereoisomer or mixture of stereoisomers, or its pharmaceutically acceptable salt.

2. The compound of formula (I) under item 1, having the formula (Ia), formula (Ib) or formula (IC)

or

3. Connection on p. 2, And in which means-OR1, -C(O)N(R1R2or N(R1R21;

V denotes N(R4); and W represents CH.

4. Connection on p. 3, in which

And denotes-C(O)N(R1R2;

q, r and n are zero;

R1denotes hydrogen;

R2means (C1-C6) alkyl or -(C1-C6) alkyl-R9;

R4denotes hydrogen or (C1-C6) alkyl; and

R5denotes hydrogen, halogen, alkyl.

5. Connection on p. 4, in which R9denotes phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, acid, 2-thienyl.

6. Connection on p. 2, in which

And denotes-C(O)N(R1R2;

m is zero;

Q represents a direct link with R3; and

R3denotes hydrogen.

7. Soy is)amino]ndimethylacetamide.

8. Connection on p. 1, having the formula (IIA), formula (IIb) or formula (IIc)

9. Connection on p. 8, in which N-heterocyclyl selected from the group including piperidinyl, piperazinil, pyrrolidinyl, morpholinyl, thiomorpholine, pyrrolyl, imidazolyl.

10. Connection on p. 9, in which N-heterocyclyl is piperazinil, substituted R6then there is the connection of the formula (IId), formula (IIE) or formula (IIf)

11. Connection on p. 10, in which

And means-OR1,-C(O)N (R1R2or N(R1R21;

W represents CH; and

R6denotes hydrogen, optionally substituted phenyl, 6-membered heterocyclyl containing 1-2 nitrogen atom, optionally substituted 5-membered heterocyclyl containing 1-2 nitrogen atom, aminosulfonyl, monoalkylammonium, dialkylaminoalkyl, C1-6alkoxycarbonyl, acetyl, -C(O)CH2CH(CH3)2, -C(O)R8where R8denotes cycloalkyl or tetrahydrofuryl, aminocarbonyl, substituted cyclohexyl, -C(O)-[C1-C6alkyl]-R10, -[C1-C6alkyl]-R10where R10denotes methoxy is2;

R1denotes hydrogen;

R2means (C1-C6)alkyl, -(C1-C6)alkyl-R9;

R6denotes hydrogen, acetyl, tert-butoxycarbonyl, methoxy-carbonyl, methyl;

R5denotes hydrogen, halogen;

n is 0 or 1.

13. Connection on p. 12, in which

R2denotes-CH2-R9;

R9denotes phenyl or substituted phenyl.

14. Connection on p. 13, in which

R2denotes-CH2-R9;

R6denotes hydrogen, acetyl or tert-butoxycarbonyl; and

R9denotes phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, methylthiophenyl, chlorophenyl, acid or 2-thienyl.

15. Connection on p. 14, in which R5denotes chlorine, R6denotes acetyl, and R9denotes p-tolyl.

16. Connection on p. 14, in which R5denotes chlorine, R6denotes hydrogen and R9denotes p-tolyl.

17. Connection on p. 14, in which R5denotes chlorine, R6denotes hydrogen and R9denotes 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl.

18. Will sachet 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl.

19. Connection on p. 10, selected from the group including

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-(2-methyl-1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[2-(1H-triazole-1-yl)pyrimidine-4-yl]-4-[(dimethylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]-1-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-(acetyl)-N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide and

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-3-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-carboxamide.

20. Connection on p. 9, in which N-heterocyclyl is optionally substituted by piperidinyl, i.e. the compound of formula (IIg), formula (IIh) or formula (IIi)

21. Connection on p. 20, in which

And means-OR1, -C(O)N(R1R2or N(R1R21R2;

R1denotes hydrogen;

R2means (C1-C6)alkyl or -[C1-C6alkyl]-R9;

R5denotes hydrogen, halogen, alkyl; and

n is zero or one.

23. Connection on p. 22, in which R2means (C1-C6) alkyl or-CH2-R9and R9represents 4-methoxyphenyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl or 3,4-acid.

24. Connection on p. 20, selected from the group including

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxy-phenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(morpholine-4-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[2,6-bis(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide and

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methoxypyridine-4-yl]piperidine-2-ndimethylacetamide.

25. Connection on p. 9, kgly (IIk) or formula (IIm)

26. Connection on p. 25, in which

And means-OR1,-C(O)N(R1R2or N(R1R21; and

W represents CH.

27. Connection on p. 26, in which

And denotes-C(O)N(R1R2;

R1denotes hydrogen;

R2represents C1-6alkyl or -(C1-C6alkyl)-R9;

R5denotes hydrogen, halogen, alkyl and

n is zero or one.

28. Connection on p. 27, having the R-configuration of the atom C-2 pyrrolidinyl rings.

29. N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

30. Connection on p. 25, selected from the group including

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(4-methoxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamid and

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide.

31. Connection on p. 9, vybere Roxane;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]thiomorpholine-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]azetidin-2-carboxamide and

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]morpholine-2-carboxamide.

32. Connection on p. 1 of formula (I), in which each X, Y or Z represents C(R19and every U denotes C(R5), where each R19and R5matter specified in paragraph 1.

33. Connection on p. 1 of formula (I), in which each X, Y or Z represents N and each U denotes C(R5), where each R5matter specified in paragraph 1.

34. Connection p. 1 of formula (I), in which each X represents N, each Z or Y denotes C(R19and each U represents N, where each R19matter specified in paragraph 1.

35. Connection on p. 1 of formula (I) in which one of X, Y and Z represents N and the others represent C (R19and U denotes C(R5), where each R19and each R5matter specified in paragraph 1.

36. Compound selected from the group including

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)periksa-5-yl)methyl]piperazine-2-ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-hydroxy-N-[(1,3-benzodioxol-5-yl)methyl]propanamide;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]pentanedione;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(nitramino)methyl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]pentanone;

2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-(thiophene-2-yl)-N-[3-(morpholine-4-yl)propyl]propanamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[phenylmethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[3-phenylpropyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-phenylethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl) - Rev.-2-ndimethylacetamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-(methylthio)-N-[(1,3-benzodioxol-5-yl)methyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-[(4-methoxyphenyl)methyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-[2-(3,4-acid)ethyl]butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-(methylthio)-N-(methyl)butanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-[(1,1-dimethylethyl)thio]-N-[3-(methylthio)propyl]propanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-[(1,1-dimethylethyl)thio]-N-[3-(phenyl)propyl]propanamide;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]-2-tiefenbronn;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-(butyl)-2-tiefenbronn;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]-2-tiefenbronn;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-[(1,1-dimethylethyl)thio]-N-[2-(3,4-acid)ethyl]propanamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]ndimethylacetamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)aid;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]pentanedione;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanedione;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(nitramino)methyl]amino]pentanone;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-5-[[imino(amino)methyl]amino]pentanone;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]pyrrolidin-2-carboxamide;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-5-[[imino(nitramino)methyl]amino]pentanone;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-5-[[amino(imino)methyl]amino]pentanone;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-hydroxy-N-[[4-(hydroxycarbonyl)phenyl]methyl]pyrrolidin-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-hydroxypropanoic;

6-amino-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[2-(3,4-acid)ethyl]hexanamide;

-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-N-[3-(methylsulphonyl)the PCC is Ino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-6-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]hexanamide;

5-amino-N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanone;

5-amino-N-butyl-2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanone;

2-[[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl](methyl)amino]-N-[(pyridine-4-yl)methyl]ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methylpiperidin-2-carboxamide;

N-[2-(3,4-acid)ethyl]--[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-2-tiefenbronn;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-methylpentanoic;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]pentanedione;

N-[2-(3,4-acid)ethyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-4-methylpentanoic;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]-3-hydroxypropanoic;

N-[(1,3-benzodioxol-5-yl)methyl]--[[6-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]benzoylpropionic;

5-[[amino(imino)methyl]amino]-6-[(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(phenylmethyl)pentanone;

N-[(1,3-benzodioxol-5-yl)methyl]-1,4-bis[6-chloro-2-(1H-imidazol-1-DIN-4-yl]-4-[[(phenyl)amino]carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-[(methoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-1-methylpiperazin-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-4-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-1-methylpiperazin-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-1-methylpiperazin-2-ndimethylacetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-1-methylpiperazin-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-butyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-butyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(2,3-acid)methyl]-1-butyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

4-[6-chloro-2-(1H-the Il-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-1-[(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-1-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(2,3-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxan-6-yl)ethyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[[2-(phenyl)cyclopropyl]amino]-1-[(1,3-Ben is l)methyl]-1-[(1,3-benzodioxan-6-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(3,4-acid)methyl]-1-[(pyridin-3-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[3-(3,4-acid)propyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-ethoxyphenyl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methylphenoxy)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-were)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-11N-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-chlorophenyl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-acetamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-[(3-fluoro-4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-ethoxyphenyl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(4-methylphenoxy)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[(4-methoxyphenyl)methyl]-1-acetyl-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1P>

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(2,6-acid)methyl]-1-(3-methyl-1-oxobutyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(3,4-dimetilfenil)methyl]-1-(methoxyacetyl)-4-[6-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,4-benzodioxan-6-yl)methyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(isopropyl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(methoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-(trifluoromethyl)PI is pyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-ethoxyphenyl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[(2-hydroxy-2-oksidoksi)acetyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-carboxamide;

N-[2-(3,4-acid)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[3-(3,4-acid)propyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-were)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-(phenoxyacetyl)-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide; Itemid;

N-[2-(1,4-benzodioxan-6-yl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenyl)methyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-carboxamide;

N-[2-(4-methoxyphenyl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(4-methoxyphenyl)ethyl]-1-(phenoxyacetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[2-(3,4-acid)ethyl]-1-[(4-methoxyphenyl)carbonyl]-4-[2-(1H-imidazol-1-yl)-6-chloropyrimidine-4-yl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-(6-herperidin-2-yl)-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

1-(acetyl)-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylsulfinylphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylsulfinylphenyl)methyl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(etoxycarbonyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperazine-2-ndimethylacetamide;

4-[amino(imino)methyl]-N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-methylsulphonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(4-were)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-3-yl)methyl]piperazine-2-carboxamide;

1-(4-were)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(4-were)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-)methyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-forfinal)sulfonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-()pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(dimethylamino)sulfonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(dimethylamino)sulfonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-chlorophenyl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine the azole-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-propyl)aminocarbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(n-propyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(cyclohexyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)PI is idazole-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-carboxamide;

1-(cyclohexyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)amino is sulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(phenylsulfonyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(Tien-2-yl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)perinatal-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2,4-acid)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(3,4-dichlorophenyl)aminocarbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1 is idazole-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,4-benzodioxan-6-yl)ethyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ka is erasin-2-ndimethylacetamide;

1-(isopropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(isopropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(cyclopropyl)piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(n-butoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]piperazine-2-carboxamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ETH is-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(2-(methoxy)ethoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-(1-methylpropoxy)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(1-methylpropoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N[2-(3,4-dimethoxyphenol-5-yl)methyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(furan-2-yl)methyl]piperazine-2-ndimethylacetamide;

1-(phenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-(phenoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]piperazine-2-carboxamide;

1-(4-methoxyphenoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimethoxy the Jn-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methylphenoxy)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-((phenyl)methoxy)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-ndimethylacetamide;

1-((phenyl)methoxy)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-((phenyl)methoxy)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N is)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(4-methoxyphenyl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-(4-methoxyphenyl)carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-(pyridine-3-yl)carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-(pyridine-3-yl)carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-chloro-4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodiox is-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]piperazine-2-carboxamide;

1-[2-(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperazine-2-ndimethylacetamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]piperazine-2-carboxamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]piperazine-2-carboxamide;

1-[(3,4-dichlorophenyl)methyl]carbonyl-4-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-x is oxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[3-(3,4-acid)propyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[3-(3,4-acid)propyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-ndimethylacetamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-methyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-((1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-isopropyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-carboxamide;

1-[(1,3-benzodioxol-5-yl)methyl]carbonyl-4-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]PL]-N-(2-vinylcyclopropyl)piperazine-2-carboxamide;

1-methylsulphonyl-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(1,3-benzodioxol-5-yl)ethyl]piperazine-2-carboxamide;

in the form of an individual stereoisomer or mixture of stereoisomers, or its pharmaceutically acceptable salt.

37. Connection on p. 1, selected from the group including

N-[(3,4-acid)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-2-carboxamide;

N-[(3,4-dihydroxyphenyl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-(is 1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(morpholine-4-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-carboxamide;

N-[(2-methoxypyridine-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-carboxamide;

N-[(2-methylpyridin-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](phenylmethyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][(1,3-benzodioxol-5-yl)methyl]amino]ndimethylacetamide;

N-[(3,4-acid)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][(morpholine-4-yl)ethyl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)pyrimidine-4-yl](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-l](methyl)amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[4-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-2-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[[4-(1H-imidazol-1-yl)-6-methylpyrimidin-2-yl]amino]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-3-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]propionamide;

N-[(4-triptoreline)methyl]-3-[[2-(3-H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-3-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]propionamide;

N-[(1,3-benzodioxol-5-oxy)ethyl]-2-(1H-imidazol-1-yl)pyrimidine-4-amine;

N-[(4-methoxyphenyl)ethyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-(2-methyl-1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(4-nitrophenyl)methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[[4-(acetylamino)phenyl]methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[[4-(methylsulfonylamino)phenyl]methyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ndimethylacetamide;

N-[(3-chloro-4-methoxyphenyl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-(1-oxopropyl)piperazine-2-ndimethylacetamide;

N-[(4-methoxyphenoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-methanamine;

N-[(4-methoxyphenyl)methylcarbamoyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-methanamine;

N-[(1,3-benzodioxol-5-yl)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]piperidine-2-ethanamine;

2,4-bis(1H-imidazol-1-yl)-6-methylpyrimidin;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)-5-methylpyrimidin-4-yl]-4-(phenylmethyl)piperazine-3-ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)methyl]-4-methylcobalamin;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-methylcobalamin;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-methoxyphenyl)methyl]-4-methylsulfonylmethane;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(butylthio)butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(cyclopropyl)methyl]-3-[(3,4-dimetilfenil)methylthio]propanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(2,5-acid)methyl]-3-methyl-3-[(phenylmethyl)thio]butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-horfe is)methyl]pentanone;

5-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,4-benzodioxan-6-yl)ethyl]pentanone;

7-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-(2-vinylcyclopropyl)heptanone;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-[(3-chloro-4-methoxyphenyl)ethyl]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]ndimethylacetamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-methoxyphenyl)ethyl]ndimethylacetamide;

4-[[2-(3-H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(1,3-benzodioxol-5-yl)ethyl]butanamide;

2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[(4-chlorophenyl)ethyl]pyridine-3-propanamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-meth who yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]thiomorpholine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)menjadikan-5-yl)ethyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

4-[(dimethylmethoxy)carbonyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-3-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl] oksifenil)methyl]piperidine-3-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl](methyl)amino]-N-[(1,3-benzodioxol-5-yl)ethyl]ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-methylpiperazin-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-methylpiperazin-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-mediaperson-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methox-4-methylpiperazin-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[[4-(2-methoxyethoxy)phenyl]methyl]-4-methylpiperazin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(indan-5-yl)methyl]-4-methylpiperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-butylpiperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[is-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-(2-vinylcyclopropyl)-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)methyl]henyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorobiphenyl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(1,3-benzodioxol-5-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]pipelayers-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)>-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(pyridine-3-yl)methyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-1-(4-methoxyphenyl)ethyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(3-fluoro-4-methoxyphenyl)methyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-acetylpiperidine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N - (1,3-benzodioxol-5-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-deferoxamine)ethyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimido toxigenic)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(cyclopropyl)-4-acetylpiperidine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(3-l)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl) - Rev. l-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[[4-(2-methoxyethoxy)phenyl]ethyl]-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-vinylcyclopropyl)-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-2-yl)-4-(3-methyl-1-oxobutyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-5-yl)-4-(3-methyl-1-oxobutyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl is n-4-yl]-N-[(4-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazin-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazines-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(indan-5-yl)-4-(2-methoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1 the ptx2">1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-6-yl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-(tetrahydro-3-furanol)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-carbox-yl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[-(4-methoxyphenyl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-(2-carboxymethoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyridin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3,4-dimethy[(4-methoxyphenyl)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(2-phenoxy-1-oxoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-acid)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-dimetilfenil)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-acetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-in-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)ethyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-(pyridine-3-ylcarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxy-3-chlorophenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)ethyl]-4-[2-(4-methoxyphenyl)-1-oxo is Il]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-pyridinyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1-methylpyrrole-2-yl)ethyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)mate the l]-N-[(3,4-acid)methyl]-4-[2-(4-methoxyphenyl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxy-3-chlorophenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(m>P CLASS="ptx2">1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-P>

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-indanyl)-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(5-indanyl)methyl]-4-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

CLASS="ptx2">1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(methylsulphonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(methylsulphonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-chlorophenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-tx2">1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,6-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(dimethylaminomethyl)pipelineswhen)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,5-acid)methyl]-4-(dimethylaminomethyl)piperazine-2-carboxamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)p the evils-1-yl)-6-methylpyrimidin-4-yl]-N-[-(3-chloro-4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-l-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)pipers)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(propylaminoethyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)ethyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-them-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-(cyclopropyl)-4-(propylaminoethyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(cyclohexyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(ciclopiroxolamine)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-methoxyphenyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-thienyl)ethyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(cyclohexanecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(vinylsulfonylacetamido)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(is zodiacal-5-yl)ethyl]-4-(vinylsulfonylacetamido)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(2,3-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methylphenoxy)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

12-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-chlorophenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[[1,3-benzodioxol-5-yl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-thienyl)ethyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-(phenylenecarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(5-indanyl)methyl]-4-(phenylenecarbonyl)piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,3-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-cryptomaterial-4-yl]-N-[(4-were)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-DIMET is-yl]-N-[(2,5-acid)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,4-benzodioxan-2-yl)ethyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,3-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazin-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclopropyl)methyl]-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-indanyl)-4-[(4-methoxyphenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-dipyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)propyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)butyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methylphenoxy)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-were)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxide-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-dimetilfenil)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-ethylpyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,5-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-[(3,4-dichlorophenyl)aminocarbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-ethoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-were)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-(methoxy is 4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)perimeter)pyrimidine-4-yl]-N-[(3,4-acid)methyl]-4-(methoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-(methylethanolamine)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(methylethanolamine)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-(butoxycarbonyl)piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-differenl)methyl]-4-(butoxycarbonyl)piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(2-methoxyethoxy)carbonyl]etoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]-4-[(2-methoxyethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-chlorophenyl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-aramid;

1-[2-(1H-imidazol-1-yl)-6-methylpyridin-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]-4-[(phenylmethoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-(2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]-4-[(1-methylpropoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chloro-4-methoxyphenyl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-ndimethylacetamide;

1-[6-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-methoxyphenyl)methyl]-4-[(4-metoxi-2-yl)ethyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]-N-[(2,4-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,6-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]-4-[(4-methoxyphenoxy)carbonyl]piperazine-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[1-(phenylmethyl)piperidine-4-yl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(2,2-dimethoxymethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-creditimpaired-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-hydroxy-4-methylthiomethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(4,4-diethoxybutane)piperidine-2-ndimethylacetamide;

1-(4-forfinal)-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

1-[(1,3-benzodioxol-5-yl)methyl]-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

1-(phenylmethyl)-4-[1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-acetyl]piperazine;

1-(4-chlorophenyl)-4-[1-[2-(1H-imidazol-1-(2,3-dihydrobenzofuran-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(cyclohexyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-ethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-etylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-ethyl-3-hydroxy-1-hydroxymethylpropane)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(morpholine-4-yl)propion-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-methyl-3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-methyl-3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-phenylmaleimide-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(2-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(pyrrolidine-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1,5-diethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1,5-diethylhexyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-N-[(2-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2-forfinal)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2-chlorophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(pyridine-2-yl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(2-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2-methoxyphenyl)ethyl]PI is amide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-were)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3,4-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3,4-acid)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(phenylbutyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(phenylbutyl)Pieper CLASS="ptx2">1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-hydroxymethylene)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,5-acid)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-bromophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-bromophenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-pentylpyridine-2-aceta-methylpyrimidin-4-yl]-N-pentylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(1H-imidazol-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[3-(1H-imidazol-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-chlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-chlorophenyl)methyl)piperidine-2-ndimethylacetamide;

1-[2-1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(2,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(2,4-dichlorophenyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(1-phenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[1-(phenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-ethoxy-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-ethoxy-4-methoxyphenylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-chlorophenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(5-hydroxyphenyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-butylpiperazine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-forfinal)(methyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-forfinal)(methyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2,5-acid)ethyl]piperidine-2-ndimethylacetamide;

3-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(2,5-acid)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(2,5-acid)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-ethoxy-3-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-and what phenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(methylethoxy)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-hexylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-hexylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-hexylpyridine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3-fluoro-5-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3-fluoro-5-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-ethoxypropan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-ethoxypropan)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-methoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(1-cyclohexylethyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imida Yeremey-4-yl]-N-[(4-trifloromethyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-trifloromethyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(4-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(4-forfinal)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[2-(3-bromo-4-methoxyphenyl)ethyl]pyrrolidin-2-carboxamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-phenylpropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(1-hydroxy-3-methylbutyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[1-(4-were)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[1-(4-were-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(4,4-diethoxybutane)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-triptoreline)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-(3-butoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-(3-butoxypropyl)piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[2-(thiophene-2-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[2-(thiophene-2-yl)ethyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[3-(pyrrolidin-1-yl)propyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylethylamine-4-yl]-N-[(cyclohexyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(cyclohexyl)methyl]piperidine-2-ndimethylacetamide;

1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-forfinal)methyl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-(1H-imidazol-1-uridin-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-(1H-imidazol-1-yl)pyrazin-2-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-6-chloro-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-(1H-imidazol-1-yl)pyrimidine-4-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[2-(1H-imidazol-1-yl)pyrimidine-4-hydroxy]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-2-[2-(1H-imidazol-1-yl)pyrimidine-4-thio]ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-methylpiperidin-2-ethanamine;

N-acetyl-N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ethanamine;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-(methylsulphonyl)piperidine-2-ethanamine;

4-[2-[[(1,3-benzodioxol-5-yl)methoxy]ethyl]piperidine-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[[(4-(methoxy)phenoxy]propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[[(4-(methoxy)phenoxy]propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)-6-methylpyrimidin;

4-[2-[(1,3-benzodioxol-5-yl)propyl]pyrrolidin-1-yl]-2-(1H-imidazol-1-yl)pyrimidine;

4-[2-[(1,3-benzodioxaphosphorin-2-ethanol;

4-chloro-2-(1H-imidazol-1-yl)-6-(piperidine-1-yl)pyrimidine;

4-chloro-2-(1H-imidazol-1-yl)-6-(2-ethylpiperidine-1-yl)pyrimidine;

4-fluoro-2-(1H-imidazol-1-yl)-6-[[(3,4-acid)ethyl]amino]pyrimidine;

4-fluoro-2-(1H-imidazol-1-yl)-6-[[(phenyl)ethyl]amino]pyrimidine;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-(morpholine-4-yl)-2-(1H-imidazol-1-yl)pyrimidine-4-yl]piperidine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-[bis(etoxycarbonyl)methyl]-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-1-[(methoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[6-(aminocarbonyl)-2-(1H-imidazol-1-yl)pyrimidine-4-yl]-1-[(methoxy)carbonyl]piperazine-2-ndimethylacetamide;

N-[(1,3-benzodioxol-5-yl)methyl]-3-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-4-methoxybenzamide;

4-chloro-2-(1H-imidazol-1-yl)-6-[(2-methoxyphenyl)amino]pyrimidine;

N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]indole-6-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrole-2-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-2-propionamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-2-propionamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]pyrrolidin-3-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]pyrrolidin-3-ndimethylacetamide;

N-[(3,4-acid)ethyl]-1-[2-(1H-imidazol-1-yl)-6-ethylpyrimidine-4-yl]pyrrolidin-3-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,3-benzodioxol-5-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(1,4-benzodioxan-6-yl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(3,4-acid)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(3,4-acid)ethyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(4-methoxyphenyl)methyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-N-[(4-methoxyphenyl)methyl]morpholine-2-carboxamide;

4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]-N-[(1,3-benzodioxol-5-yl)methyl]morpholine-2-ndimethylacetamide;

4-[2-(1H-imidazol-1-yl)-6-mutilations-1-yl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol-1-yl)-6-(methylethyl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[6-ethyl-2-(1H-imidazol-1-yl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)ethyl]-4-[2-(1H-imidazol-1-yl)pyrimidine-4-yl]morpholine-3-carboxamide;

N-[(4-methoxyphenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(4-chlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(3,4-dichlorophenyl)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(4-were)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(3,4-dimetilfenil)methyl]-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]morpholine-3-carboxamide;

N-[(1,3-benzodioxol-5-yl)methyl]-2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]ndimethylacetamide;

38. Pharmaceutical composition having the effect of inhibitors synthase nitric oxide-containing compound of the formula (I) under item 1 in the form of an individual stereoisomer or mixture of stereoisomers, or its pharmaceutically acceptable salt.

39. A method of treating diseases caused by disturbances in prod is piticescu effective amount of the compounds of formula (I) under item 1 in the form of an individual stereoisomer, or a mixture of stereoisomers, or its pharmaceutically acceptable salt.

40. The method according to p. 39, in which the specified disease, caused by disturbances in the production of nitric oxide, selected from the group comprising multiple sclerosis, stroke or cerebral ischemia, Alzheimer's disease, HIV-related dementia, Parkinson's disease, meningitis, extensive cardiomyopathy and congestive heart failure, atherosclerosis, restenosis or stenosis of the graft, septic shock and hypotension, hemorrhagic shock, asthma, respiratory distress syndrome in adults, lung damage caused by Smoking or solid particles, pneumonia, caused by pathogenic microorganisms, trauma, have different etiology, rheumatoid arthritis and osteoarthritis, glomerulonephritis, systemic lupus erythematosus, inflammatory bowel diseases such as ulcerative colitis and Crohn's disease, insulin-dependent diabetes, diabetic neuropathy or nephropathy, acute and chronic rejection of transplanted organs, the disorder of vessels of the graft, homologous disease, psoriasis and other inflammatory skin diseases, and cancer.

41. The method according to p. 40, in which the disease is multiple of scle.40, in which the disease is extensive cardiomyopathy.

44. The method according to p. 40, in which the disease is congestive heart failure.

Priorities for items:

19.02.1997 on p. 36;

17.02.1998 on PP.1-35, 37-44.



 

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