Antihelminthic agent

 

(57) Abstract:

The invention relates to the field of creation of deworming drugs of plant origin. Antihelminthic agent contains wormwood, tansy and cloves and excipients, and wormwood is included in the form of dry extract and powder of grass and leaves, tansy - in the form of dry extract and powder of the flowers, and cloves in powder form flower buds in the following ratio, wt.%: extract of wormwood 0,7-2,0 powder, wormwood 1,7-10,0, extract of tansy of 2.8 to 8.0, powder tansy 5,7-14,3, clove powder 28,6-72,0, excipients else. Antihelminthic agent is made in pill and capsule form. The tool is not irritating and allergenic activity. 2 C.p. f-crystals.

The invention relates to medicine, namely to funds on the basis of medicinal plants for the treatment of parasitic diseases.

The use of plants for the treatment of parasitic diseases has been known since ancient times. Currently available synthetic antigen-Minnie drugs do not always meet the needs of professionals, are expensive and can have side effects. So ponchiki known antiparasitic tincture p. Of the Russian Federation No. 2182012, which is a tincture of pericarp biologically Mature walnut to drop fruit from the pericarp when the ratio of components, wt.%:

The pericarp of Mature walnut 4-6

An aqueous solution of alcohol 94-96

Also known drug for p. the Russian Federation No. 2132693 of the alcoholic tincture of walnut and wormwood and cloves. The drug additionally includes grapefruit seed extract, and the drug is prepared in the following ratio, wt. PM components is 100 wt. including walnut tincture:

Ground wormwood 60-150

Ground cloves 50-200

The grapefruit seed extract 50-150

The closest technical solution, taken as a prototype, is the triad No. 1, developed by Professor, doctor of medical Sciences C. A. Ivanchenko (“HLS” No. 8 (140), 1999) In the triad No. 1 Professor C. A. Ivanchenko includes: common tansy (flower basket), herb wormwood and clove powder. All components of the composition have sokogonnym, anthelmintic, antimicrobial, antiseptic and antipyretic effect.

The disadvantage of the proposed structure is that all of componentdesigner conditions, it is very difficult to dose and to take together all of these components. Another disadvantage of this structure is that to achieve a therapeutic effect it is necessary to use a fairly large dose of the drug that causes patients difficulties when taken.

The present invention is the expansion of the range of deworming drugs based on medicinal plants by creating a new dosed tools in solid form obtained industrially.

The problem is solved by creating a new deworming drugs, containing wormwood, tansy and cloves, and it further comprises an excipient, while wormwood is included in the composition in the form of a dry extract, and powdered herbs and leaves, tansy - in the form of a dry extract, and cloves in powder form flower buds in the following ratio, wt.%:

Extract of wormwood 0,7-2,0

Powder wormwood 1,7-10,0

Extract of tansy 2,8-8,0

Powder tansy 5,7-14,3

The clove powder 28,6-72,0

Excipients Else

The problem is solved also by the fact that the new antihelminthic agent has tableted or encapsulated form, also pills could be the e solid dosage deworming drugs which is simple to use, as its single doses are not too large and it does not require dosage, and which can be produced on an industrial scale.Novelty and inventive step invented means is that based on vegetable raw materials created a tool-similar synthetic anthelmintic drugs, which can be produced industrially, with the optimal number and type of each component, as well as their ratio, which allowed us to obtain a therapeutically effective dose of active substances in the usual medicines solid tableted or encapsulated form.

The basis for the development of new deworming drugs are three known vegetable component: wormwood, tansy, cloves.

Leaves and grass wormwood (Artemisia absinthium L.) contain essential oils, azulene, gameswin, organic acids, glycosides, flavonoids. Wormwood (Artemisia absinthium) normalizes the gastrointestinal tract, improves digestion, increases office bile and improves its outflow, stimulates the secretion of gastric juice, has antiparasitic effect, especially effective in situations in which there are sesquiterpene lactones, -thujone, a-thujone, a ketone, camphor, borneol, molting; flavonoids: quercetin, luteolin, rutin, apigenin and others; organic acids, bitter, tannins, sugars, vitamin C, carotenoids, macro - and microelements. Common tansy increases the secretion of the glands of the gastrointestinal tract and relaxes his muscles, has analgesic, anti-inflammatory and antihelminthic effect, destroys intestinal parasites.

Flower buds of clove (clove - Cariophyllus aromaticus) contain a large amount of essential oil, the main component of which is eugenol, which has strong antiseptic effect. Clove stimulates appetite, reduces the processes of fermentation and putrefaction in the intestines, destroys the eggs of worms.

Thus, all components of the composition have antiparasitic action. Tansy and wormwood kill adult parasites, and cloves destroys the eggs of worms. In addition to the antiparasitic action of all components contribute to the normalization of the disturbed functions of the body, primarily the gastrointestinal tract, liver.

In the proposed composition wormwood and tansy used in the form of powders above-ground parts of plants is th way for example, a water-alcohol extraction, followed by drying, and containing in concentrated form all the active components of the plants. However, the application only extracts undesirable, as the extracts are very hygroscopic. On the other hand, the use of dry powders, plants also disadvantageous, because in this case are large single dose, which is not very useful when administered. The presence of the proposed composition of plant raw materials in powder form contributes to the replenishment of biologically active substances possibly lost during extraction.

Thus, the combination in the composition of the powders of the above-ground parts of plants and their dry extracts in the claimed amounts by adding the required amount of physiologically acceptable excipients allows you to save as much as possible of biologically active substances of plants and create a solid dosage comfortable for admission into a form suitable for the production of industrially.

Because all the components of the composition has a bitter taste, and wormwood and tansy, moreover, and poisonous, it is clear how important accurate calculation of the dose in a single tablet or capsule. As a result of studies, the calculation of the Sabbath.">Extract of wormwood 0,7-2,0

Powder wormwood 1,7-10,0

Extract of tansy 2,8-8,0

Powder tansy 5,7-14,3

The clove powder 28,6-72,0

Excipients Else

To give a mixture of these powders flowability and formemost in the composition add a certain amount of physiologically acceptable auxiliary substances, such as calcium stearinovokisly, microcrystalline cellulose, Aerosil, methylcellulose, titanium dioxide, TWIN-8. The specific composition and amount of these substances in the final product depends on the preparative form (tablet or capsule) and its mass. Typically, the number of auxiliary substances does not exceed 2 wt.%.

The invention is illustrated by examples.

Example 1. For capsules weight 0.2 g take 0,0142±0.0002 g of dry extract of tansy, 0,0038±0.0001 g of dry extract of wormwood, 0,0286±0.0004 g of crushed flowers of tansy, 0,0086±is 0.0002 shredded grass and leaves of wormwood, 0,1430±0,0010 crushed flower buds of clove, 0,0018±0.0002 calcium stearinovokisly.

Example 2. For tablets weighing 0.5 g take 0,0142±0.0002 g of dry extract of tansy, 0,0038±0.0001 g of dry extract of wormwood, 0,0286±0.0004 g of crushed flowers of tansy, 0,0086±0,00 stearinovokislogo, 0,1950±0,0010 g microcrystalline cellulose, 0,0050±0.0002 g of Aerosil, 0,0629±0.0002 g of methylcellulose, 0,0119±0.0002 g of titanium dioxide, 0,0252±0.0004 g TWEEN-80.

Collected in this way the product is a coated tablets, the cross section from greenish-brown to brown with light and dark specks or powder (capsule contents) from greenish-brown to brown with light and dark shades, with specific, spicy smell.

The results of clinical testing described funds, commercial titled the "Triad Evalar", show that the vehicle meets the standards and requirements of ND, SanPiN, has satisfactory organoleptic properties and good appearance, irritating and allergenic action, safe for the health.

As can be seen from the above, the proposed tool is simple to manufacture. The product includes only natural vegetable components, the combined effect of which exceeds the impact of individual its constituent components.

Cooking preparations carried out on known equipment, using well-known when using the invention consists in the fact, that expanding the range of domestic preparations based on vegetable raw materials for the treatment of parasitic diseases.

1 Antihelminthic agent containing wormwood, tansy and cloves, characterized in that it further includes an auxiliary substances, and wormwood is included in the form of dry extract and powder of grass and leaves, tansy - in the form of dry extract and powder of the flowers, and cloves in powder form flower buds in the following ratio, wt.%:

Extract of wormwood 0,7-2,0

Powder wormwood 1,7-10,0

Extract of tansy 2,8-8,0

Powder tansy 5,7-14,3

The clove powder 28,6-72,0

Excipients Else

2. Antihelminthic agent by p. 1, characterized in that it has a tableted or encapsulated form.

3. Antihelminthic agent by PP.1 and 2, characterized in that the film-coated tablets.



 

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SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

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