Vaginal suppositories for the treatment of imperative incontinence urination

 

(57) Abstract:

The invention relates to the field of pharmaceutical industry and relates to vaginalnyj suppositories for the treatment of imperative incontinence urination. The invention lies in the fact that the proposed vaginalnye suppositories contain oxybutynin, estriol, lipophilic suppozitornyj basis at a specific ratio of components. The invention provides a receiving means to reduce the dose of oxybutynin and eliminate side effects from its use.

The invention relates to medicine, in particular to the gynecologist, and can be used for the treatment of imperative urinary incontinence due to neuromuscular dysfunction of the urinary bladder.

It is known the use of oxibutinina /4-(diethylamino)-2 butenjoy ether-cyclohexyl-alpha-hydroxypentadecanoic acid, have antispasmodic and myotropic activity in the neurogenic bladder, idiopathic bladder instability, hyperreflexia and dysfunction of the detrusor and used in the form of oral pills (Register of medicines of Russia “encyclopedia of drugs,“ release 9, 2002, S. 630).

The disadvantages of this investibility bladder) and side effects, such as dry mouth, nausea, vomiting, decreased motility of the stomach and intestines and allergic reactions.

The objective of the invention is a medicinal product for the treatment of imperative incontinence urination in women more active and does not cause dry mouth, nausea, vomiting, decreased motility of the stomach and intestines.

This problem is solved vaginal suppositories composition weight.h.:

Oxybutynin 0,0025-0,005

Estriol 0,0005-0,001

Lipophilic suppozitornyj

the basis To 3.00

Candles were prepared in accordance with GF XI ed., so 2. S. 151-154 “Suppositories” method of making medicinal substances in suppozitornyj basis (suppory, cocoa butter and other).

The examples of the preparation of suppositories.

Example 1.

To 2997 g of melted cocoa butter add 2.5 g of oxibutinina and 0.5 g of estriol and stirred anchor stirrer until a homogeneous mass, and then hot suppozitornyj was poured into a special socket and cool. Get 100 suppositories weighing 3 g

Example 2.

To 2995 g melted superina M add 5 g of oxibutinina and 5 g of estriol and get suppositories similar to that described in example 1.

Example 3.

Patient L., 64, addressed to the “Center of women's health after 40” with complaints of vaginal dryness for 4 years, incontinence of urine within 3 years. Menopause 13 years. The patient was examined and was not treated prior to the treatment Center.

When examination revealed the instability of the detrusor, hyperreflexia, hypotension.

When pelvic ultrasound formations are not revealed.

MRI of the spine showed signs of intervertebral osteochondrosis, deforming spondylosis, at the level of L1-L3sclerosis reflex bone plates.

The opinion of the neurologist: arterial hypertension.

Assigned Triptan on 1 t 2 times a day.

One month after treatment was complaining of severe dry mouth after taking the tablets Driptane.

It was recommended to use vaginal suppositories (example 1) and 1 suppository per day.

At the reception after a week, no complaints, there is an overall improvement.

According to the U.S. (after 6 months of treatment) - instability of the detrusor not found.

The combination of oxybutynin and variety of the AI due to the blood supply to the detrusor, improves the proliferation of urothelia along with the vaginal epithelium, which, in turn, promotes optimal absorption of oxybutynin.

The proposed tool allows you to reduce the dose of oxybutynin and eliminate side effects.

In the treatment of 12 patients were able to reduce the dose of oxibutinina 2 times and no noted side effects from its use.

The treatment for imperative incontinence urination on the basis of oxibutinina, characterized in that it is made in the form of vaginal suppositories, further comprises estriol and lipophilic suppository basis in the following ratio, wt.h.:

oxybutynin 0,0025-0,005

estriol 0,0005-0,001

lipophilic suppozitornyj basis To 3.0



 

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