A method of treating urogenital infections

 

(57) Abstract:

The invention relates to medicine, namely to methods of treatment of chronic bacterial infections. The method of treatment involves the use of a biologically active drug, namely polyvalent vaccine antigen isolated from strains of Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Staphyloccocus aureus. The vaccine lead subcutaneously 5-fold, with a total dose of 0.9 mg the First injection of polyvalent vaccines is carried out at a dose of 0.1 mg followed by four injections of 0.2 mg with an interval between them 3-5 days. Thus the rate of introduction of the patient polyvalent vaccine alternate with a course of antibiotic treatment. The method provides rapid relief of clinical symptoms and exacerbation of the disease, persistent remission due to the activation of various elements of the immune system.

The invention relates to medicine, namely to methods for treating chronic urogenital bacterial infectious processes.

Among urological diseases, the most frequent cause of complaints to the doctor is the bacterial exacerbation of chronic inflammatory processes of the urinary tract in women and men in the higher age of sexual activity. Due the in the world and affects more than 9-12% of the male population, among men of reproductive age, the frequency of occurrence of this disease is 50%. In women of childbearing age dominated by chronic cystitis, pyelonephritis and oophoritis.

Disease caused by urogenital infections are among the most frequent causes of morbidity in the world (Krasnopolsky C. I. Bulletin of the Russian Association of obstetricians-gynecologists, T. 1, No. 2, 1994, S. 12).

There is a method of treatment of urogenital infections by injecting the patient orally, intrahalo and/or rectal biologically active ingredients immunomodulating, regenerating and protective actions, which are used lysozyme, or alpha-2 interferon, or hyaluronic acid, or lysozyme and hyaluronic acid, or alpha-2 interferon and hyaluronic acid. Additionally, the patient is injected with vitamins E and C, as bacteria-eubiotics enter the dry weight of Bifidobacterium bifidum No. 791, or two-3, or Lactobacillus acidophilus 100 al, Lactobacillus acidophilus NK1, Lactobacillus acidophilus TO3W24(EN 146526, a 61 K 35/74, 1999).

However, the known method of treatment has limited effectiveness of treatment, as used in the above method, the biologically active the acceleration treat a wide range of urogenital infections increased remission of the disease and normalization of immune homeostasis.

This technical result is achieved in that in the method of treating urogenital infections comprising the administration to a patient of biologically active drug, according to the invention as a biologically-active drug use polyvalent vaccine antigen isolated from strains of Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli and Staphylococcus aureus, injected it subcutaneously 5-fold, with a total dose of 0.9 mg, the first injection of polyvalent vaccines is carried out at a dose of 0.1 mg followed by four injections of 0.2 mg with an interval between them 3-5 days, with the introduction of the patient polyvalent vaccine alternate with a course of antibiotic treatment.

The use of the above polyvalent vaccine contributes to the activation of macrophages and PAL, increases the functional activity at the expense of the synthesis of IL-1 with subsequent proliferation of T-lymphocytes and the formation of IL-2, interferon increases the levels of serum and secretory immunoglobulins.

Men in the analysis of medical records of 75 patients with a diagnosis of chronic bacterial prostatitis” indication polyvalent vaccine b is vaccine approaches were (1) the existence of a secret of a prostate gland conditionally pathogenic bacteria, antigens which are part of a multivalent vaccine in the diagnostic titer of more than 104and (2) reduction of non-specific immunological reactivity of the organism and/or specific immunoglobulins. Polyvalent vaccine patients were injected subcutaneously at intervals of 3-5 days. The first immunization dose was 0.1 mg, four next - 0.2 mg. After the course of vaccine therapy in serum of patients with prostate was determined by the presence of specific antibodies using the response of the passive haemagglutination single antigenic complexes vaccine.

It is shown that after vaccine therapy in patients with bacterial prostatitis was significantly prolonged remission in average up to 1.5 years; more quickly stoped clinical symtomatic; in some patients resistant to standard treatment, was able to achieve remission.

Example 1. The patient Abroskin A. A., born in 1968 appealed with complaints of pain in the sacral area of whining character, as well as periodic urethral discharge within 8 months. In the anamnesis the patient has suffered chlamydia (1995), anaplasmosis (1996), trichomoniasis (1999). Also the patient was treated in February 2002 regarding the Course of treatment consisted in the use of antibiotics, was alternated rulide 150 mg 2 times a day and abaktal 400 mg 2 times a day for 10 days every drug, nystatin 500000 Units 3 times a day, imunomoduliruyuschee therapy was used cycloferon/m one injection a day.

The patient received comprehensive urological examination. Rectal-prostate age of sizes, testovaty consistency, inhomogeneous boundary contribute, slightly painful on palpation. Magdalena groove traced. Microscopy of prostate secretion: color - yellowish, leukocytes - 20-35 in the field of view, erythrocytes - a single in the preparation of the cells is not defined, macrophages isolated in the product, lecithin grain - a small number, microflora - a large number of gram-positive cocci, typical representatives of the genus Staphylococcus. Microscopy of urethral discharge: epithelial cells 5-7 in the field of view, the leukocyte - 20-30 in the preparation of erythrocytes is the unit in the product microflora - a large number of gram-positive cocci. Ultrasound examination of the prostate revealed signs of chronic prostatitis - capsule thickened Central portion of the breast hypoechogenic, there are hyperechoic inclusions. When gentiano the ll, Trichomonas is not detected. Bacteriological examination of urethral discharge isolated Staphylococcus aureus 107 CFU/ml, determined antibioticotherapy strain. The results of the survey were diagnosed: Chronic infection of the lower urinary tract - prostatitis, urethritis. Patients received a course of combination therapy. Immunotherapy - polyvalent vaccine was administered subcutaneously, first immunizing dose was 0.1 mg next four to 0.2 mg every introduction of five days. Antibiotic therapy (taking into account the results of antibiogram) is ciprofloxacin 250 mg 2 times a day, nystatin 500000 Units. 3 times a day for 10 days. The patient also underwent 10 sessions of massage of the prostate and 10 sessions of ultrasound therapy on the area of the prostate gland (used apparatus for ultrasonic therapy UST - 1.03). Symptoms disappeared on the 6th day from the beginning of treatment. After a course of antibiotic therapy, the patient underwent a course of recovery of disturbed intestinal and urogenital tract with drugs: hilak-Forte 40 drops 3 times a day and Bifidumbacterin 5 doses × 3 times a day for 10 days. When control bacteriological study through month - the new way a negative. During the year subsequent monitoring of patient symptoms did not recur. Immunological studies after vaccination VP-4 revealed a higher titer of specific antibodies, normalization of immune homeostasis.

Example 2. The patient Kremnev K. K., born in 1964 he complained of dull pain in the right iliac region, radiating to the right testicle and lower potency (weak erection). For the first time such complaints appeared 3 years ago - disturbed 1 semiannually. As the intensity of symptoms was small, the urologist, the patient is asked only in October 2002, despite the fact that the diagnosis of chronic prostatitis was established in 2000 in City Clinical hospital №83. In October 2002, the patient underwent a course of symptomatic therapy in urology office at the place of residence (bacteriological analysis and PCR diagnostics were not performed). The treatment consisted in the use of antibiotics: doxycycline 0.1 to 2 times a day, nystatin 500000 UNITS 3 times a day for 2 weeks.

Conducted comprehensive urological examination.

Rectal-prostate age of sizes, testovaty consistent is nnenna palpation. Magdalena groove traced. Microscopy of prostate secretion: color - yellowish, leukocytes - more than 50 in the field of view, erythrocytes - a single in the preparation of epithelial cells was not determined, macrophages isolated in the product, lecithin grain - a small number, microflora - a large number of staphylococci. Ultrasound examination of the prostate revealed signs of chronic prostatitis - Central part of the gland hypoechogenic, there are hyperechoic inclusions, seminal vesicles expanded to 2 see the secret of the prostate gland using PCR detected DNA of ureaplasmas. Bacteriological examination of urethral discharge was identified Staphylococcus aureus 105The coed/ml and determined the sensitivity to causal chemotherapeutic drugs. The results of the survey were diagnosed: Chronic bacterial prostatitis. Patients received a course of combination therapy. Immunotherapy - polyvalent vaccine was administered subcutaneously, first immunizing dose was 0.1 mg next four to 0.2 mg every introduction of three days. Antibiotic therapy (taking into account the results of antibiogram) is ciprofloxacin 250 mg 2 times a day, nystatin 500000 UNITS - raspokoval therapy on the area of the prostate gland. Symptoms disappeared for 8 days from the start of treatment. After a course of antibiotic therapy the patient was assigned hilak-Forte 40 drops 3 times a day and Bifidumbacterin 5 doses 3 times a day for 10 days. When control bacteriological analysis after 2 months, the secret of the prostate gland was determined by the presence of microbial cells of Staphylococcus aureus 103CFU/ml of Polymerase chain reaction for STIs negative. Immunological studies after vaccination revealed a higher titer of specific antibodies, normalization of immune homeostasis. Clinical symptomatology was completely absent during the 1.5 years of observation.

Women in the analysis of medical records of 20 patients were allocated 2 randomized groups of patients, comparable to the diagnosis, age, severity of illness, an ongoing course of bacterial therapy.

Group 1 patients, which used polyvalent vaccine was introduced following nosological forms: acute bilateral salpingo-oophoritis (SOF) - 4 (20%) women, subacute bilateral SOF - 8 (40%) women and bilateral chronic SOF in the acute stage - 8 (40%) patients. Comorbidities and Olonia (chronic bronchitis, tonsillitis and so on) and gastrointestinal tract (chronic gastritis, chronic nonspecific colitis). In 12 (60%) patients were registered bowel dysfunction (constipation, flatulence etc). All 20 women were noted Beli: in 4 cases, mucous, 12 - cheesy, 4 - purulent and 8 cases were diagnosed with Candida vaginitis.

Group 2 patients - control, was also presented 20 women suffering from chronic purulent inflammation of the genitals, passing a course of conventional therapy.

Studies have shown that in the group of patients treated with immunotherapy, there is a positive clinical dynamics. After the treatment the pain was gone by the 2nd day in 10 (50%), to the 3 rd - 2 (10%) and 4-mu - 8 (40%) patients. Temperature is normalized to the 3 rd day in 16 (80%) patients, 5-th day - in 4 (20%). Disorders of bowel function, observed a total of 12 patients (60%) women, on the background of immunotherapy stopped on the 5-6th day. Abnormal discharge from the vagina was noted in 16 (80%) cases, purulent and cheesy discharge to the 3 rd day got lighter color, by the 5th - became bright and clear, and by the 10th day Beli stopped.

Example 3. The patient Sonin H. I., 1936 p such bouts of cystitis began with the end of 1999 after radiotherapy, held in November 1999 after resection of a polyp of the rectum with symptoms of malignancy detected by microscopic examination of the polyp after resection. Effects of acute cystitis was observed every 1-2 months. During exacerbation of the process the patient received courses of urbanisation and herbal diuretics. The effect of therapeutic interventions was short-lived. The patient underwent complex urological examination. Urinalysis revealed a makrogematuriya and leukocyturia, occurring against the background of bacteriuria. Ultrasound examination of the kidneys and bladder showed signs of chronic pyelonephritis and chronic cystitis. The patient examined by a gynecologist diagnosed chronic salpingo-oophoritis. When genodiagnostic using polymerase chain reaction DNA of chlamydia, ureaplasmas, mycoplasmas, Gardnerella and Trichomonas not found. Bacteriological test urine isolated Escherichia coli 108CFU/ml and Staphylococcus aureus - 107CFU/ml Determined antibioticotherapy strains. The results of the survey were diagnosed: Chronic urogenital infection - chronic oophoritis, pyelonephritis, radiation cystitis. Patients received a course of combination therapy. Immunore - 0.2 mg with an interval of introducing five days. Antibiotic therapy: based on the results of antibiogram - ciprofloxacin 250 mg 2 times a day, nystatin 500000 UNITS 3 times per day, trichopol 250 mg 3 times a day for 15 days. Patients received 5 bladder instillation with chlorhexidine 0.5% to 100 ml and 10 sessions of ultrasound therapy on the area of the bladder. Symptoms disappeared for 8 days from the start of treatment. After a course of antibiotic therapy the patient is administered a course of restoration of violated the normal microflora of the intestine and urogenital tract with drugs: hilak-Forte 40 drops 3 times a day and Bifidumbacterin Forte 5 doses 3 times a day for 10 days. When control bacteriological analysis conducted after a month or urine is sterile, polymerase chain reaction on DNA pathogens of sexually transmitted diseases, is negative. Within 1.5 years subsequent observation of patient symptoms did not recur. Immunological studies after vaccination revealed a higher titer of specific antibodies, normalization of immune homeostasis.

The above examples showed that when using the claimed process is accelerated treatment SHIROKANE homeostasis.

A method of treating urogenital infections, including introduction to the patient a biologically active drug, characterized in that the biologically active drug use polyvalent vaccine antigen isolated from strains of Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Staphyloccocus aureus, lead her subcutaneously 5 times with a total dose of 0.9 mg, the first injection of polyvalent vaccines is carried out at a dose of 0.1 mg followed by four injections of 0.2 mg with an interval between them 3-5 days, with the introduction of the patient polyvalent vaccine alternate with a course of antibiotic treatment.



 

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