The method of treatment of acute postpartum endometritis in cows
The invention relates to the field of veterinary obstetrics. The proposed method involves the introduction of suppositories made on the basis of the filler is polyethylene glycol and the active substance - thick fraction of the product dry sublimation hazel, where dense fraction of 1.75...of 2.25%, the filler - else, enter intrauterine 3-4 pieces once a day until complete recovery. The method allows to significantly shorten the treatment of acute postpartum endometritis in cows, to achieve a stable therapeutic effect and reduce the days of infertility in animals. 1 PL.
The invention relates to the field of veterinary obstetrics, and can be used for the treatment of acute postpartum endometritis in cows.
There is a method of treatment of postpartum diseases, in particular of endometritis in cows by intrauterine injection of furazolidone sticks  (medicines for veterinary use. The Handbook. Kazan, 2000, Ed. by F. G. Nabiev, R. H. I, 2 o'clock, 518 S. / S. 589).
However, when the uterus endometritis in cows infected with various species of pathogenic bacteria, but also fungi of various genera. In this regard, is to the use of chemotherapeutic and antibiotic drugs leads to irritation of the mucous membrane of the uterus. In addition, during long-term use appear resistant forms of microorganisms to this antibiotic, with drugs, enter in the uterus, within 1-2 hours come in milk, resulting throughout the course of treatment, and long after its completion it may not be used in human food. Part furazolidone suppositories antibiotic has a low solubility in water and apply formative framework does not provide a uniform distribution of active substances on the surface of the uterus and quick selection of the suppository.
The purpose of the invention is the increased fertility, reduced treatment time, reduced number of days of infertility and a decrease in fertilization in the treatment of acute postpartum endometritis in cows.
This objective is achieved in that, by forming the base, which is polyethylene glycol, is added to the active ingredient - dense fraction of the product of the destructive distillation of hazel (1,75...2,25%), which has strong antimicrobial and fungenes action. Suppositories injected into the uterine cavity for 3-4 pieces oulanem signs of endometritis in cows offered suppositories were injected into the uterine cavity for 3-4 pieces each day once before recovery.
In the treatment of 53 cows with acute purulent-catarrhal endometritis after the second or third injection exudate started to buy catarrhal-purulent character, the amount of exudate gradually decreased, subsequently turned into a hazy, viscous mucus, which is a thin layer covers the mucous membrane of the vagina. The selection transparent viscous mucus was observed in average after 6-7 introduction of the drug. Complete cessation of discharge from the uterus, most cows came from 8-10 days after drug administration. Of the 53 cows 10 mucus secretion continued for 11-13 days. The release of the uterus from the exudate was closely linked with the restoration of her motor functions. In animals with acute purulent-catarrhal endometritis, accompanied by complete atony of the uterus (head 21), already after 3 injections, suppositories rectal study clearly felt uterine contractions when stroking. Full recovery of motor function of the uterus was observed in the majority of cows in 6-8 days except 5 cows restoring contractility of the uterus occurred only at 18-20 days of starting treatment.
Simultaneously with the recovery of motor function of the patient's uterine origin is tecnost walls of the uterus gradually decreased. Most patients cows to 8-10 day the uterus was located on the pubic fusion, its size is closer to normal values.
With the recovery of the rigidity of the uterus at the same time there were changes in the cervix. Usually 6-8 day of the cervical canal was narrowed and 9-13 day were closed. The redness of its mucous membrane disappeared.
At 4-5 days after injection of the drug in animals of the digestive tract were recorded improvement gum and increase contractions of the rumen.
Therapeutic efficacy of suppositories with Ledenika presented in the table.
In the treatment of postpartum purulent-catarrhal endometritis in cows offered the drug in comparison with the known (furazolidone sticks) on average reduces the number of injections 1.6 times the duration of treatment is shortened by 2 days, the clinical recovery occurs before 2 days, the time from start of treatment until pregnancy is reduced by 10.8 per day, decreases the index of fertilization 0.05 and 1.4% increases the number of pregnant animals from 1st insemination.
The advantage of the new drug compared to furazolidone sticks is to increase therapeutic effect of the spray effect that allows you to reap the economic benefits by reducing the cost of treatment.
The source of information
1. Pharmaceuticals for veterinary use. The Handbook. Kazan, 2000, Ed. by F. G. Nabiev, R. H. I, 2 o'clock, S. 518-589.
The method of treatment of acute postpartum endometritis in cows, including the introduction of suppositories, characterized in that the suppositories made on the basis of the filler is polyethylene glycol and the active substance - thick fraction of the product dry sublimation hazel, where dense fraction of 1.75...of 2.25%, the filler-else, enter intrauterine 3-4 pieces once a day until complete recovery.
where a is a 2-tetrahydrofuryl, 2-furyl, substituted linear or branched alkyl containing from 1 to 5 carbon atoms, benzyloxy group or phenoxyalkanoic group, a substituted linear or branched alkyl containing from 1 to 5 carbon atoms and/or alkoxy group containing from 1 to 4 carbon atoms, or an enantiomer, diastereoisomer or pharmaceutically acceptable salt of such compounds, and to pharmaceutical compositions based on these compounds, which are able to improve the condition associated with sexual dysfunction
You know the "zelibor" (tablets) with antioxidant, hepatoprotective, immunomodulatory properties and produce FF "Darnitsa", Ukraine
in which R represents an aromatic acyl fragment, which optionally has one or more substituents, which may be the same or different and which are selected from hydroxy, methoxy and amino