Biologically active additive "female herb"
The invention relates to the pharmaceutical industry and is used as an adjuvant in chronic inflammatory diseases of the urinary system in women. A drug for prevention and adjunctive therapy in the treatment of chronic inflammatory diseases of the genitourinary system of female contains dry concentrate of the extract of nettle leaves, dry concentrate infusions of St. John's wort, dry concentrate propolis tincture, dry concentrate of the extract of leaves mother and stepmother, dry concentrate of the extract of the fruit of the barberry, dry extract immortelle, ascorbic acid, bran, starch, calcium stearate and sugar, taken in a certain ratio. The drug is made in the form of tablets by weight of 0.55, the Drug promotes the effective treatment of chronic inflammatory diseases of the urinary system in women. 3 table.
The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in chronic inflammatory diseases of the urogenital system in the hydrated registry biologically active additives to food, M, Kohelet, 2000, S. 338), incorporating chamomile flowers, calendula flowers, motherwort herb, oak bark, leaf, sage leaf plantain, eucalyptus leaf and used as a tonic with anti-inflammatory effects in chronic diseases of the genitourinary system in women.
Known biologically active food Supplement herbal tea "Mary" (Pilate T. L. (ed) Federal register of biologically active food additives, M., Kohelet, 2000, S. 342), incorporating fruit trees, birch leaves, flowers, calendula, licorice root, chamomile flowers, herb, flowers of Filipendula or herb Echinacea, marjoram, and used as an aid in chronic inflammatory diseases of the urinary system in women.
A disadvantage of the known drugs is the lack of a balanced complex of vitamins and microelements, as also observed in individual patients, individual intolerance to some of their components, as well as inconvenience in use, connected with the preparation of the solution (tea) of these additives.
The objective of the invention is to develop a new available lekarstven featured gynecological diseases.
The invention is aimed at expanding the range of alternative gynecological medicines, to compensate for individual intolerance to some medicinal components.
Proposed drug for the prevention and adjunctive therapy in the treatment of chronic inflammatory diseases of the urinary system in women, including dry concentrate of the extract of nettle leaves, dry concentrate infusions of St. John's wort, dry concentrate propolis tincture, dry concentrate of the extract of leaves mother and stepmother, dry concentrate of the extract of the fruit of the barberry, dry extract immortelle, ascorbic acid, and bran, starch, calcium stearate and sugar in the following ratio of components, g a tablet weight of 0.55 g:
dry concentrate of the extract of nettle leaves is 0.0002-0,0016
dry concentrate infusions of St. John's wort 0,000175-0,0014
dry concentrate propolis tincture 0,000175-0,0014
dry concentrate of the extract of leaves
mother-and-stepmother 0,0000075-of 0.00006
dry concentrate of the extract of the fruit of the barberry 0,0000075-of 0.00006
dry extract immortelle 0,0050-0,0200
ascorbic acid 0,0200-0,0500
Krajicek active additive “Women's herb”.
The proposed additive is recommended for use as an anti-inflammatory, antibacterial, hemostatic, reduce pain, hyperemia of mucous, accelerates epithelization, preventing the development of fungal, bacterial infections remedy in treatment of chronic and acute gynecological diseases (colpitis, cervicitis, adnexitis, erosive processes), with dysfunctional and menopausal bleeding.
The optimum ratio of components obtained experimentally. And while the impact of these components of the drug on the human body are known, their use in new capacity and in small doses it is a new effect that allows you to use the new feature as a dietary Supplement.
Biologically active additive "Female herb" in the form of tablets obtained as follows.
0,29 kg of fruit of barberry weighed in enameled capacity of 10 l and fill in 8 l of water at room temperature, insist on a boiling water bath for 30 min with frequent stirring, then add 0,29 kg leaves mother and stepmother, and continue to insist on a boiling water bath for 25 minutes. Cool 45 minutes at room the number of water. Filtered through 4 layers of gauze.
The output of infusion - 5,8 kg
The sugar in the number of 73.8 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. For this sugar load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.
The output of crushed sugar - 73,0 kg
Bran, in the amount of 10.4 kg, weighed, visually looking at the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. For this bran load portions in the hopper. Crushed bran through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.
The output of crushed bran - 10,3 kg
In an enamelled vessel is brought to a boil 5.8 kg infusion. Separately prepare a suspension of starch in water, to do this, take the starch in an amount of 0.6 kg and 1.0 kg of water. Stir the mixture and add in the boiling solution with constant stirring, paste argument is, ascorbic acid is sifted through a sieve with the hole diameter of 1 mm calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm Water, Hypericum tincture, propolis and nettle extract is filtered through 4 layers of gauze.
In a mixer with the cover open load 73,0 kg powdered sugar, 9.7 kg of starch, crushed bran 10,3 kg, farmakopejny dry extract immortelle 2.9 kg and stirred for 10 minutes. Moisturize pharmacopeias tincture (3,5% of dry) Hypericum 2.9 kg, pharmacopeias tincture (3,5% of dry) propolis 2.9 kg and pharmacopeial extract (4% dry) nettle 2,9 kg Stirred for 10 minutes, then add 3.5 kg of starch paste and stir for another 10 minutes.
Yield - 111,95 kg
Hydrated tablets weight in the number 111,95 kg laid out on paper in the trays, the layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40 to 45°With the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 hours to a constant weight, with occasional stirring (not less than 3 times). Control is the possibility of product - no more than 2%. Dry tablet weight is directed to a dry granulation.
The output of the dry tablet weight - 96,45 kg
The dried mixture in an amount of 96,45 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through a mesh with holes of diameter 1.5 to 2.0 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate load when the cover is open in the mixer. In dry granular pellet mixture in the mixer add ascorbic acid in the amount of 5.8 kg, stirred for 10 minutes and add the sifted calcium stearate in an amount of 1.03 kg Include a mixer and stirred for 5 minutes. The finished granulate is passed on tableting.
The output of the finished granulate - 101,0 kg
From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Turn on the engine. Pre-set engine speed in accordance with a bulk weight of the pressing zone and the height of the tablet. When starting the machine includes a vacuum cleaner.
The tablet diameter and 12.0±0.3 mm; the height of the tablet to 4.0±0.3 mm; average weight of tablet - 0.55 g ± 0,03.
In the e l e C the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.
Yield - 100,45 kg
The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.
The output of finished tablets to 99.9 kg
The sequence of operations is the same, regardless of the number of prepared composition.
BAD "Women's herb" contains the famous authorized for use in medical practice medicines which are in the specified combination (see table 1, examples 1-4) provide for the reduction or disappearance of symptoms of the urinary system in women.
As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and short ATA - calcium stearate.
Available in tablet form, which is convenient to use, has a long shelf life (2 years).
BAD “Women's herb” was administered to women in postabortal period, with the aim of prevention of inflammatory complications. Patients in the control group received standard therapy, including trichopol (metronidazole).
Preliminary studies (to abortion) was detected in all surveyed women favourable gynecological status: Beli ordinary character, redness of the vulva and vagina are not expressed, erosive processes are not marked. Data culture diagnostics confirmed the absence of pathogens, sexually transmitted diseases, and Trichomonas, GN, Candida.
Observations showed that patients in the observed group during a one-week period after surgery, changes in gynecological status were noted. Examination of the patients revealed a favorable gynaecological background, no signs of endometritis or inflammatory process other localization. Pathological bleeding was not observed.
Examination of smears confirmed the favorable condition of the genital tract. The number e is(see table 2).
The original study of vaginal microbiocenosis have observed women did not reveal substantial pathogenetic changes in the composition of the microflora. However, most patients have observed some lack of symbiotic flora.
BAD “Women's herb” has had a positive impact on vaginal microbiocenosis. Along with the suppression of conditionally pathogenic microorganisms, it stimulates the development of symbiotic bacteria, mainly lactobacilli.
In the control group watched the aggravation of dysbacteriosis in the vaginal ecosystem. Noted depressant effects used therapy for anaerobic part of the microbiocenosis, which negatively affected the composition of the commensal microflora. Significantly increased the number of women with a deficit of bifidobacteria (from 15% at baseline to 46% after treatment). Less marked changes underwent lactoflora, however, its content in the vaginal content was decreased in 10% of patients. Conventional therapy has different effects on the conditional-pathogenic microorganisms, inhibiting the development of hemosiderosis strains of Staphylococcus and without affecting the content hemosiderosis cienie on the development of small populations drojjepodobnykh Candida (see table 3).
In further studies, the BAD “Women's herb” was assigned patients with gynecologic pathology of inflammatory Genesis (adnexitis, colpitis) in 60% of cases with installed Candida, chlamydia, cardinalate and trichomoniasis etiology in the background of appropriate therapy.
The source in both the main and control groups complaining of severe pain in the lower part of the abdomen showed all patients with exacerbation of chronic adnexitis (at least 3 points on 3-point scale), they have 100% of cases there was a strong pain, swelling and infiltration of the field of appendages and 90% expressed adhesions region appendages.
In all patients (100%) with obesity (regardless of cultural diagnostics) noted a pronounced redness of the vulvar tissues of the vagina and (90-100%) of the cervix.
On the background of the treatment with the inclusion of the BAD "Women's herb" to a 14-day therapy, significant improvement in clinical symptoms as obesity and XP. the adnexitis to 14 days of therapy was observed in 80% of patients (compared with 40% in the control group).
To 30 days combined therapy in 100% reported good clinical results (80% complete and 20% partial) compared uppy decreased palpation symptoms of adhesions in the pelvic area.
It is important to note that all patients of the main group was eliminated in the initial positive culture diagnostics (against candidiasis, trichomoniasis, and even gardinella), while in 50% of patients in the control group (who had a positive sowing) were maintained in spite of identical specific therapy.
A drug for prevention and adjunctive therapy in the treatment of chronic inflammatory diseases of the urinary system in women, characterized in that it contains a dry concentrate of the extract of nettle leaves, dry concentrate infusions of St. John's wort, dry concentrate propolis tincture, dry concentrate of the extract of leaves mother and stepmother, dry concentrate of the extract of the fruit of the barberry, dry extract immortelle, ascorbic acid, and bran, starch, calcium stearate and sugar in the following ratio of components, g a tablet weight of 0.55 g:
Dry concentrate of the extract of nettle leaves is 0.0002 - 0,0016
Dry concentrate infusions of St. John's wort 0,000175 - 0,0014
Dry concentrate propolis tincture 0,000175 - 0,0014
Dry concentrate infusion
leaves mother and stepmother 0,0000075 - of 0.00006
Ascorbic acid 0,0200 - 0,0500
Bran 0,0200 - 0,0650
Starch 0,0200 - 0,0650
Calcium stearate 0,0050 - 0,0100
Sugar The Rest