The method of treatment of childhood cancer

 

(57) Abstract:

The invention relates to medicine, namely to Oncology, and can be used in the treatment of cancer in different locations and the extent of the malignant process in childhood. The method includes polychemotherapy. This anticancer drugs in single doses intended for children, is dissolved in a healthy donor lymph adult in the number of 400-600 ml, incubated for 1 hour at T +37°C and intravenous drip sick child, only 2-3 injections per treatment. If necessary, repeat the treatment. The method improves the treatment efficiency due to the additional stimulation of the immune system healthy donor lymph, which is more adapted to the body of children, while reducing toxic effects of chemotherapy.

The invention relates to medicine, namely to Oncology, and can be used in the treatment of cancer in different locations and the extent of the malignant process in children, chemotherapy.

Known "Method of treatment of lung cancer" (see patent No. 2107494 from 27.03.98, bull. No. 9, a 61 K 31/00, 35/26) by intravenous lymph, inkberrow the persons used in the treatment of non-small cell lung cancer chemotherapeutics in the situation when patients are unable to fence lymph due to metastasis of the tumor in the lymph nodes in the area of the thoracic duct and its squeezing or due to anatomical features of the flow (diffuse type). In such cases, using donor lymph. The application of the method provides the clinical efficacy of treatment of patients with non-small cell lung cancer and the need for further clinical research to patients at other sites.

Known "Method of treatment of malignant lymphoma in children (see kN. Durnov L. A., Bujny A. F., Akhmedov, B. P. Pediatric Oncology. Dushanbe, Maarif, 1986, S. 87 and 88). The method includes conducting inductive chemotherapy in children with I and II stages of the process, as well as generalized and disseminated stages III and IV, scheme DOP: dopan 3 mg/m217 and 14 days of the cycle inside, vincristine 1-4 mg/m21 and 8 day intravenously, natulan 100 mg/m2in 1-14 days, every day, inside, prednisolone 20 mg/m2in some cases, 30 mg/m2in 1-14 days, every day, inside.

Known schemes of chemotherapy, as above, malignant lymphomas are accompanied by intoxication: dyspeptic symptoms as nausea, vomiting, stomatitis, gingivitis is the same treatment, destination haemostimulating therapy.

The technique of the complete method has its own distinctive features associated with localization, prevalence processes, patients, and may not be transferred without modification for the treatment of cancer at other sites, with the feature of the malignant process, patients according to sex, age, concomitant diseases requiring further research in this area of cancer treatment using donor lymph.

The aim of the invention is the provision of lymph cancer in childhood when no intake in children and increase the effectiveness of treatment.

This objective is achieved in that in the treatment of children with malignant tumors of varying degrees of tumor-lymphocytotropic, due to the extremely small calibre thoracic duct, large trauma operative approach to the channel and a small number of vessels, use of donor lymph healthy human adult, in the amount of 600 ml, dissolved in donor lymph anticancer drugs in single doses, incubated for 1 hour when the temperature is repeat the treatment.

The novelty of the invention "Method of treatment of childhood cancer" is that because of the inability of the fence lymph in children of cancer patients when conducting lymphocytotropic apply lymph healthy adult and combine it with anticancer drugs, incubated in turning one hour and, drip, intravenous sick child.

From experience Rostov cancer research Institute of the RF Ministry of health know about the increase in the activity of chemotherapeutic agents to the tumor when breeding them in the lymph, as in the natural environment. It listed us patents for inventions, we selected as analog and prototype. Meanwhile fence lymph in childhood is almost impossible due to the extremely small calibre thoracic duct, large trauma operative approach to the channel, in addition, a very small amount of lymph, which can be obtained even in the case of a successful operation, virtually eliminates the potential for the conduct of autolymphochemotherapy the child. Using developed at the Institute of methods of hemolymphoreticular within specific cancer contingent unacceptable due to the fact that the between the, for the salvation of the child, you must use the lymph from zdorovogo person. People are willing to become donors, to give the NHL for the sake of saving a child's life. Thus, for the first time in the history of medicine is a sampling of lymph from a healthy person with its subsequent use for dissolution of chemotherapy and intravenous resulting solution to a sick child.

In addition, it should be noted that with hemolymph introduce a large number of lymphocytes bearing on its surface an alien for the patient-recipient antigens, and it is known to cause stimulation of the immune system. Thus, it is the combined effect of lymph with chemotherapy, on the one hand, and non-specific stimulation of protective forces of the organism on the other. This additional stimulation of the immune system without the introduction of exogenous immunomodulators and there is a distinctive feature of hemolymphoreticular from autolymphochemotherapy, in General, and, with the use of donor lymph in childhood in the treatment of malignant diseases has been lower toxic manifestations, a higher percentage of regression of the tumor.

The invention of "a Method of treating cancer in children is their children's profile cancer institutes cancer clinics and other medical institutions involved in the treatment of children with malignant tumors of various localizations.

The invention is a Method of treatment of childhood cancer" is as follows.

Unlike traditional chemotherapy in the treatment of malignant tumors of different localization and extent of the process in childhood, polychemotherapy spend on the natural environment of the organism, which is more adapted to the body of children, has immunostimulating effect. The need for donor lymph for children with lymphocytotropic caused by the following conditions: the inability of the fence autolife in the area of the thoracic duct in children due to the extremely small calibre thoracic duct, large traumatic surgical approach to the channel, a small number of lymph, which could be obtained even in the case of a successful operation, a small number of vessels and, finally, in connection with the prevalence of cancer and metastasis. Is hemolymphoreticular under the conditions: compatibility with the ABO system from the adult, NIA-hyperoval. On the day the transaction hemolymphoreticular bottle with donor lymph in the volume of 200 ml extract from the refrigerator, warmed to room temperature. The calculation of the number of required donor lymph child produced according to the standard technique: 20 ml per 1 kg of body weight of the child, number of chemotherapy drugs also calculated according to the standard technique: a single dose at 1 m2the surface of the body of the child. The composition of anticancer drugs, doses used with regard to the state of health of the power system, age, fluid intake, the location and extent of tumor. Then in allogeneic lymph administered cytostatics in single doses, incubated with lymph in thermostat at a temperature of +37°C for 1 hour and injected, drip for 2-3 hours, then repeat homelistings 1-2 days, before the introduction of the course doses of chemotherapy, 2-3 injections for treatment, if necessary, repeat the treatment. Lymphocytotropic donor lymph carried out at different stages of the malignant process, in different modes, in the preoperative and postoperative periods, after conducting several courses of chemotherapy, depending on therapeutic effect, for BluetoothTM/P>

Technical and economic efficiency "cure childhood cancer" is that increases the efficiency of treatment of children with malignant tumors of different locations with varying degrees of tumor. The inability of the fence lymph in children with malignant tumors during autolymphochemotherapy compensated donor lymph from healthy human adult age. Children, cancer patients receiving donor lymph from a healthy person, tolerate the procedure without complications. Donor lymph has an immunostimulating effect, does not cause toxic reactions. Donor hemolymphoreticular for children with cancer has a high effectiveness of the treatment compared with standard methods of chemotherapy, promotes regression of the tumor, reduces metastasis, and increases survival period, the duration of life of sick children. Great importance has immediate clinical effect: decrease pain, normal temperature, x-ray monitoring shows a decrease in the prevalence of the process, improves the quality of life of children.

A method of treating cancer in children washiest 400-600 ml dissolved anticancer drugs in single-dose, designed for children, incubated for 1 h at 37°C and intravenous drip sick child, only 2-3 injections for treatment, if necessary, repeat the treatment.



 

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