Device for the diagnosis of brain edema

 

The invention relates to medicine, in particular to neurosurgery, and can be used for the diagnosis of brain edema is at its focal lesions. The device includes a frequency generator, a pulse shaper various forms, amplifier with current output and the inductor magnetic induction. Additionally it contains the unit of measurement of magnetic induction, interface unit, an input connected to the output of the measurement unit, a personal computer, an input connected to the output interface block, and inputs the frequency generator, shaper pulses of different shapes and amplifier with current output. This embodiment of the device provides improved precision diagnostic localization of focal lesions and the severity of brain edema. 4 Il.

The invention relates to medicine, in particular to neurosurgery, and can be used for the diagnosis of brain edema is at its focal lesions.

A device for the diagnosis of brain edema by high frequency electromagnetic resonance impedancometry, in which the sensitive element is used resonant circuit containing the condenser base is (from 100 kHz to 1.1 MHz, RF patent №2136207 class. And 61 5/00). The device also includes a high frequency generator and the measuring unit.

The inductor is part of a resonant oscillating circuit containing an additional capacitor in parallel to the coil winding. Using this device measures the impedance of the oscillating circuit at the resonant frequency without a biological object with a biological object placed within the windings of the measuring coil, calculate the ratio of the obtained values and the value of 1.4 or more to be diagnosed with brain edema.

The disadvantage of this device is:

First, when using operating frequencies from 100 kHz to 1.1 MHz and above becomes significant conductivity cell membranes. Therefore, the measurement results will reflect the total extracellular and intracellular conductivity content of the studied parts of the brain. Therefore, differentiation of swelling from swelling of the brain (extracellular from intracellular fluid) according to the contactless electromagnetic high-frequency electromagnetic resonance impedancometry impossible.

Secondly, there is no possibility of ODA the skull and adjacent brain structures and is the estimate of the total conductivity of the contents of the head, including the skin, the aponeurosis, the bones of the trunk of a skull, which in turn makes a significant error in the measurements of the true impedance of the brain.

In addition, when high-frequency electromagnetic resonance impedancometry at frequencies of 0.1 to 1.1 MHz electromagnetic waves in biological object only to a depth of 2-3 cm Therefore, an objective assessment of the extent of damage of the cortex and subcortical structures of the brain is impeded.

The technical result of the invention is to improve the accuracy of diagnosis localization of focal lesions and the severity of brain edema.

The technical result is achieved in that the device for the diagnosis of brain edema, containing the frequency generator, the output of which is connected to the input of the shaper pulses of different forms, the output of which is connected to the input of the amplifier with a current output, the output of which is connected to the input of the inductor magnetic induction, further comprises a personal computer connected to the connection unit, and the unit of measurement of magnetic induction, consisting of a sensor of the magnetic induction and the measuring circuit, the output kotormovie pulses and amplifier with current output.

The operation of the device illustrated by figures, where: Fig.1 presents a diagram of the device of Fig.2 - scanning vertically; Fig.3 - scanning horizontally; Fig.4 - scanning in a spiral or consistently by all the components.

The device for implementing the method comprises the following elements: a frequency generator 1 with smoothly adjustable frequency from 1 Hz to 200 Hz, the pulse shaper 2, various shapes (rectangular, triangular, sine wave with a steep front and gradually falling back-to-back and Vice versa), the amplifier with current output 3, exciting magnetic induction from 0.1 to 50 MT; the inductor 4, the object of study 5; unit of measurement of magnetic induction 6 at the receiving side consisting of a magnetic induction sensor 7 and the measuring unit 8; block pairing with your PC, 9; personal computer 10.

The device operates as follows.

The magnetic flux of a given frequency from the output of the frequency generator 1 is fed to the input of the pulse shaper 2, the output of which is connected to the input of the amplifier with current output 3. The output of the amplifier 3 is connected to the input of the inductor 4. According to the current value sets the value of the magnetic field in the inductor, which passes through the biological the range unit of measurement of magnetic induction 6, consisting of a magnetic induction sensor 7 and the measuring circuit 8, the output of which is connected to the input of the block pair with the computer 9, the output of which is connected to the input of the personal computer 10, and with the control input of the frequency generator 1, the pulse shaper 2 and the amplifier with current output 3.

The personal computer 10 according to a given program sets the frequency, the shape of the pulses and the value of the magnetic induction on the value of the current, the magnitude of which is directly proportional to the value of the magnetic induction in the coil 4.

Parameters for a given inductor 4 (external and internal diameter and number of turns) program in the computer calculates the exact value of the induction on the centerline of the inductor. At the beginning of the operation of the device is additionally calibrated measuring magnetic induction 6 at the receiving side. All data prior to the operation of the device is recorded in the computer (kind of magnetic field, frequency, form excitatory pulses, the parameters of the inductor, the calculated and experimentally calibrated values of the magnetic induction on the centerline). Next, determine the scan cycle of the centerline of the inductor 4 synchronously with the induction sensor 7 at the receiving side, mounted precisely in the axial lineuse. The value of the magnetic induction at the receiving side are entered into the computer and compared with the magnetic induction, the set on the transmission side. Next, for a given program by comparing the obtained results with the norm defined for different brain structures, diagnose localisation of focal lesions and the severity of brain edema.

The body of a man, being by nature diamagnetic, absolutely transparent to magnetic fields. Therefore, the choice of frequencies affecting the magnetic induction is determined only supplied diagnostic task and the design of the inductor. The frequency set in the range from 1 to 200 Hz (in increments of 0.1 Hz) that can accurately make the diagnosis of brain edema at the optimum device parameters due to the fact that the natural frequency of brain potentials in the range of 1 to 100 Hz. In addition, in this frequency range, the magnetic flux is distributed in the extracellular space and depends on the volume and content of electrolytes. The extracellular space of nervous tissue provides for the maintenance of homeostasis and reflects the level of metabolic activity of the cells.

 

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FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

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