Multi-chamber syringe

 

The invention relates to medical equipment, namely, devices for injection in a syringe with the drug substance. The device includes a piston cylinder reservoir with the substance of the piston rod in the form of rolling a sealed vessel with the substance and the device that is the case for the formation of a hermetic mobile connection hole of the rolling piston rod-tank, compression piston or piston chamber, provided with a channel having an exit on the side wall and out into the lumen of the piston cylinder. The outputs of the internal channel of the device may be located outside of the lumen of the piston rod of the reservoir, and the device itself can be made to move in the bore of the piston rod of the tank and to be independently movable in the channel of the compression piston with proximal flap for tight closure of the opening of the channel when moving the device or internal closing the hole of the outer sash and the compression compartment in the form of a feedback move. The technical result consists in the creation of a syringe with a sealed chamber and a simple mechanism or device for moving fluid between OSISA to medical technology, namely, devices for injection in a syringe with the drug substance.

A device in the form of a syringe, comprising a pneumatic cylinder with a piston to move the piston rod in the cylindrical housing of the reservoir of the syringe (1). The disadvantage of this syringe is the design complexity and the lack of a device for moving fluid between the chambers, which does not allow to produce syringes simultaneously with a dry substance and a solvent. The disadvantage of the other devices is the use of special crumbling walls, which requires the use of special materials (2).

The objective of the invention is to provide a syringe with a sealed chamber and a simple mechanism or device for moving fluid between cells without the destruction of the elements of the syringe, including various medicinal substances.

This task is solved in that the device for injection in a syringe with the drug substance in a sealed chamber includes a piston cylinder reservoir with the substance of the piston rod in the form of rolling a sealed vessel with the substance and hydrodynamic compression device, which is the case for the formation of a sealed movable connection with overstyle holes of the piston rod-tank conduit for the movement of the fluid, having access to a side wall or the side plane of the housing and exit into the lumen of the piston cylinder, and the outputs of the internal channel of the device may be located outside of the lumen of the piston rod of the reservoir, and the device itself can be made to move in the bore of the piston rod of the tank and to be independently movable in the channel of the compression piston proximal closing flap for tight closure of the opening of the channel when moving the device or internal closing the hole of the outer sash and the compression compartment in the form of a feedback move.

In Fig.1 shows the component parts of the syringe in the section, side view. In Fig.2 shows the syringe with dual substance in the collection, the cut, side view. In Fig.3, 4, 5 shows the principle of operation of the syringe with dual substance in the section, side view.

The device 1 has a (Fig.1, 2) piston rod 2, is designed as a sealed tank type bottle with a movable sealing device 3 or the tube, the piston 4, is made or at the end of the tank 2 with the formation of the rolling piston, or piston ring on mobile device 3, the compression piston 5, the piston is howling rod 2 (Fig.1, 2), which is a movable element of the device is designed as a sealed tank or container type bottle with one outlet or exit 8. The lumen or chamber 9 of the piston rod 2 includes one of the substances, for example a liquid substance 10 (medicinal solution or solvent), or a dry substance of the medicinal product. The piston cylinder 6 is a standard element of the syringe and can be used as a sealed cylinder-reservoir. At the exit end of the piston rod-tank 2 may have the actual piston 4 in the form of a piston rim of the protruding edges of the tank walls, separate, fixed on the end of movable elastic partition 4 with hole, ensuring the tightness of the rolling connection with the wall of the piston cylinder 6 for the compression movement of the fluid. Output 8, which is less than the diameter of the lumen 9, the bottle 2 with the substance 10 is sealed movable inside the tube or the outlet 8 is hermetically closed (Fig.1, 2, 3) special gidroustroystva 3 (option 1) with an output channel for movement of the fluid, the second variant with internal compression piston 5, closing the compression compartment in the rear part of cilindric the Fig.1-5) the compression piston may have an additional element in the form of flaps. This device 3 can be shorted output 8 of the tank 2 as a normal tube mobile education mobile tight connection in the initial state or located between the sealed chamber of the device with the location of the device in the projection or plane of the outlet of the piston rod-tank and when moving to push inside a separate mobile tube at the outlet 8 of the piston rod of the tank 2, as well as to connect with the tube in a single device when used for their fabrication of heterogeneous materials. In all cases, the device is made with housing for sealed and including a movable connection with the outlet of the rolling piston rod-tank. When using a syringe with dual substance unit 3 separates the openings of the chambers 9 of the piston rod of the reservoir and the lumen 12 of the piston-cylinder reservoir 6, and when the syringe moves the liquid substance between 10 tanks and Vice versa. Compression hydrodynamic device 3 can have one output channel 13, closed at the inner end, partially or fully cylindrical shape with an output of an external opening 14 at the end face and the inner wychock out, and within the lumen 9 of the rolling piston rod-tank 2, and the output outer hole 14 in all variants is located outside and opens into the lumen 12 of the piston-cylinder reservoir 6. Due to the formation of a sealed movable connection with the wall of the outlet 8 hydrodynamic compression device 3 can be moved inside the lumen 9 of the rolling piston rod of the tank when the pressure on it from the outside, for example to resistant rim 16, which can be done as a matter of fact the piston 4. By moving the hydrodynamic device 3 one of the outputs in the form of internal openings 15 in the side wall of the channel 13 is moved in the lumen 9 of the tank and you may receive an output to move the liquid from one chamber to another. When combined with the plug device 3 output channel can be combined with tube device 11, the output channel can be in the form of a separate element to pass through the device outputs at the ends, with the inner hole can be opened in place of the connection device 3 with the tube in the lateral plane, where it is performed by a side exit or circular groove. When moving the combined device 3 HH fluid. Thus, spaced apart along the longitudinal axis and in different planes of the channel outputs allow you to create communication between the tanks when moving inside the lumen of the piston rod of the reservoir unit 3 is performed in a variant of mobile devices.

The compression piston 5 in the second embodiment of the syringe (Fig.1, 2) is in the form of independently movable element of the device with the possibility of reciprocating motion in a cylindrical channel 13 device 3 and hermetically closes in the rear, internal part of the channel 13 of the compression of the air compartment 17. In this embodiment (Fig.1-5) device 3 forms a movable sealed connection with the compression piston and the channel 13 performs the function of the output channel for movement of the fluid and the channel for the movement of the compression piston. The main function of internal compression piston as a movable element piston mechanism in the second embodiment of the device opening and closing from the inside interior of the outlet 15 of the device 3 depending on the movement of the piston rod and the pressure changes in the lumen 12 of the piston cylinder 6. Situated at the level of the inner bore 15 in the initial state, the compression piston 5 hermeti the STI when you move it from external pressure. When the pressure of the compression piston 5 starts to move before the mobile device 3 due to less friction or resistance in movable connection with the channel wall 13 than in the movable connection of the mobile device 3 with the wall of the bore 7 of the tank. Reverse movement of the compression piston 5 is due to the pressure in the compression compartment 17, which may have a return spring.

In the third embodiment (Fig.1, 4) syringe compression piston 5 in the proximal part has a special element in the form of a mobile closing of the sash 18, which closes the side opening on the inner side at the maximum movement of the compression piston 5 to the inside, leaving a free outlet for movement of the fluid between the chambers through the channel 13 and the inner outlet opening 15 in a range of intermediate pressure. This allows you to lock and move the device 3 inside, avoiding pressure equalization at the time of partial internal displacement of the outlet 15 of the mobile device 3 inside the lumen of the rolling piston, a reservoir 2. In addition, the use of the compression piston 5 with option proximal sash 18 allows repoliticisation device 3 to move a single tube in the piston rod-tank 2.

Proximal locking flap 18, and the distal 19 can be presented (Fig.2) in a separate, adjacent to the inner wall of the channel element type side of a bent plate or damper, fixed to the compression piston. In another embodiment, a movable proximal flap 18 and, accordingly, the distal flap 19 can represent the corresponding portion of the side wall of the compression piston 5, between which logged out 20 to move the liquid, representing either the channel 21 in the case of compression of the piston with the inner outlet opening 22 on the side wall and the outer outlet 23 at the proximal end of the compression piston 5, or output to move the liquid may be an open laterally of the l-shaped groove on the side wall of the compression piston 5 distal to the closing of the sash 18. The distal side surface of the compression piston 5 or distal flap 19 can overlap the inner outlet port 15 in the initial state (option 2) and at a pressure that is used during the introduction of the solution to the patient. This allows you to close the output for reverse movement of the fluid at the time of introduction of the drug solution, the state is in the lumen of the piston rod-tank. In the first embodiment of the syringe can be used to arrange the outer movable valve in the form of half rings in the transverse outer groove of the housing of the mobile device 3 at the level of the inner bore 15 or longitudinal folds in the longitudinal groove, which in the initial state pressed by the wall of the bore 8 and close the bore 15. If you move the device 3 inside the lumen 9 output 20 will be closed until full movement of the outer sash in the lumen of the piston, a reservoir and release it from the transverse groove when the pressure in the piston cylinder, sufficient to move the tube 3. This allows you to fully move the internal hole 15 into the lumen 9 of the piston, a reservoir 2. When combined mobile device and a separate run through the output channel for the liquid and a cylindrical, closed at one end, a channel for compression of the piston, the latter may have a proximal closing the damper in the form of the thrust ring, which closes the outlet port through the output channel on the outer edge of the unit 3 when the movement of the compression piston in the cylindrical channel. The principle of this device is similar to option 3. Thus, isorna 5 prevents the equalization of pressure between the tanks to full internal displacement of the outlet 15 into the lumen 9 of the piston rod of the tank 2. Mobile device 3, the compression piston 5 and the actual tube can be made of the same material as the syringe or for different elements of the device may use different materials.

The piston cylinder 6 is a standard element of the syringe and piston mechanism in the form of a housing with a cylindrical channel 12, within which moves a piston rod-tank 2 and the piston 4, is sealed adjacent the inside walls of the cylindrical channel 12 to provide a piston effect. The output of the cylindrical piston chamber are made either in the form of the adapter 7 for removable needle, or the needle is soldered directly at the outlet of the piston chamber and is closed by a cap. The piston cylinder 6 and the piston rod-tank 2 may be a double layer, where the inner wall is made of glass and outer plastic, which makes storing the dry substance in a glass tank more stable. When placed in the piston cylinder 6 dry substance of the medicinal product there is always a part of the air space, which creates the pressure necessary to move the movable elements of the device. The syringe works and complete fill porshneva perimeter to the inner wall of the cylindrical channel 12 mobile partition with a hole in the form of actual rubber piston 4, acting as a piston rim of the end face of the rolling piston rod-tank 2 or the piston rim 16 of the mobile device 3. As a variant, the device 1 can have two actual piston 4 of the piston rim of the piston rod-tank 2 or the actual piston and mobile device 3, which in the device to form an air space or outer compression compartment to the reverse move advanced into the lumen 9 of the mobile device 3 in the first embodiment. Thus, the formation of mobile hermetic connection device 3 with the wall of the piston cylinder 6 allows to form the outer compression compartment to the reverse movement of the device 3.

The device 1 with two substances in one embodiment, represents a (Fig.2) piston rod-tank 2 with the solvent 12 (water), which are sealed hermetically at the output 8 of the mobile device 3 so that the outer weekend 14 and 15 internal opening of the channel 13 are located outside the lumen 9 of the piston rod-tank, fixed on the end of the piston rod-tank 2 itself piston 4. In the lumen of the cylindrical channel 13 of the movable tube 3 is inserted a compression piston 5 to azueta between the piston rims 16 and 19 of the elements of the mobile device. Movable piston rod-tank 2 with mobile device 3 is inserted into the lumen 12 of the piston cylinder 6, where previously entered dry substance 24 drug. Thus due to the tight connection of the actual piston 4 with the wall of the piston cylinder clearance is sealed from the entrance. The adapter 7 or needle cap cap, hermetically closing the exit of the lumen 12 of the piston cylinder. After sterilization of the syringe is a medical form with two different substances in a single device and a simple mechanism for moving the liquid to form a solution of the drug directly into the syringe. A similar variant of the device, where the liquid substrate is in the piston chamber 6, and a dry substance in the lumen of the piston rod of the tank.

The device with the two substances in the first embodiment (Fig.2, 4) works as follows. When pressed, the movable piston rod-tank 2, the latter moves within the hermetically closed piston-cylinder 6, increasing the pressure of air in the lumen 12 of the piston cylinder 6, where the dry substance 24 drug. When the pressure of the mobile device 3 is it the outlet 15 on the side wall of the channel 13 of the lumen 12 of the piston cylinder 6 into the lumen 9 of the piston rod of the tank 2. Mobile device 3 can move from one extreme position, for example, a dry substance of the drug or fluid. In a variant of the syringe with external compression compartment after moving the inner discharge opening 15 is closed the space between movable relative to each other piston rim 16 and the piston 4, which form the outer compression compartment with high pressure. When moving internal output holes 15 in the clearance 9 is formed an outlet for movement of the fluid between the chambers through the channel 13 of the movable tube 3 and is aligned pressure between the chambers. After moving the fluid from the piston rod of the tank 2 into the lumen 12 of the piston cylinder 6 or Vice versa in another embodiment, and reducing the pressure in the piston cylinder 6 (moving the piston rod-tank 2 back) increased pressure in the outer compression compartment moves the mobile device 3 to the initial position with the reverse movement of the interior of the outlet 15 of the lumen 9 of the piston rod-tank. When this is blocked, communication between the camera and the syringe is ready for injection of the drug to the patient. Device operation the pressure of the air environment is designed in such a way that giving the s pressure, in which is introduced a solution to the patient. In the variant with the outer flap opens side opening 15 to move the liquid at its full travel inside when the projection hole 15 is fully moved in the lumen of the vessel. In this case eliminates the pressure compensation in a partial movement of the holes 15 in the lumen of the vessel. In the second variant of the device, when the initial pressure increase at the beginning (Fig.2, 3, 4) the compression piston 5 begins to move in the internal compression channel 13 of the mobile device 3, compressing the air in the compression compartment 17 and opening the inner outlet port 15. Upon further movement of the rolling piston rod-tank 2 and increase the pressure begins to move inside of the lumen 9, as in the first embodiment, directly to the mobile device 3 with the inner outlet 15, forming the output to move the liquid between the separated chambers. After moving the liquid 10 in the camera with a dry substance 24 is formed a solution of a medicinal product 25. At low pressures (abstraction of the piston rod-reservoir ago) increased pressure in the outer or inner compression compartment moves peredvijenie hole 15 of the lumen 9 of the tank, either the compression piston 5 again closes the opening 15 or the output in the inner channel 13 of the mobile device. In embodiments of the device without valve pressure equalization between the chambers 9 and 12 is already in a partial movement of the inner bore 15 of the tube into the lumen of the piston rod of the tank 2, which may impede the free movement of fluid between the chambers through a partial section of the inner hole. These drawbacks are eliminated in the embodiment of the device with the flap, in particular in the variant where the compression piston is provided (Fig.1, 2) is a special element in the form of proximal trailing sash 18. The operation of this device is shown in Fig.3, 4, 5. When moving the piston rod of the tank 2 and the pressure in the piston cylinder 6 compression piston 5 begins to move in the inner channel (Fig.3) until the maximum pressure in the compression compartment 17 by moving the internal projection of the outlet 15 closing flap 18, which closes the opening 15 and an outlet for pressure relief or movement of the fluid. In the combined device 3 when the movement of the compression piston 5 closes the outlet channel at the outer end. When dallasite effect pressure relief mobile device 3 is moved so the inner outlet port 15 is fully open into the lumen 9 of the tank. With some abstraction of the piston rod-tank 2 ago and partial reduction of pressure in the piston cylinder 6 compression piston 5, and with it the shutter 18 due to the increased pressure in the compression compartment 17 depart back for some distance, thereby releasing the aperture 15 and forming the outlet 20 to move the liquid between the chambers. While holding the piston rod-tank 2 in this position, you are moving the fluid 10 from an opening 9 of the piston rod of the tank 2 into the lumen 12 is hermetically closed piston-cylinder 6. After movement of the fluid piston rod-tank 2 is given or back to its original position, reducing the pressure in the piston cylinder 6 and the compression piston 5 is returned to its original or nearly original position. Thus the lateral surface of the compression piston in the distal side of the sash 19 again closes the inner opening 15 or the hole is displayed by moving the movable tube 3 back pressure in the outer compression compartment. Thus, the volume of air or fluid in the piston cylinder with the substance provides for Lenogo movement of mobile device 3 and the compression piston 5, that allows you to create a temporary channel for movement of the fluid and to divide the tank with the introduction of the solution of the drug to the patient. With the introduction of the solution of the drug to the patient used the pressure of the air does not reach the value sufficient to move the compression piston 5 or the mobile device 3, which prevents the movement of fluid in the opposite direction.

This device can be widely used in industrial pharmacology for the production of finished dosage forms of certain drugs, in particular syringes with two medicinal substances.

Sources of information

1. RF application No. 95115764, a 61 M 5/20. Date of publ. 1997 09.08.

2. WO 98/20921 A1, 22.05.98.

Claims

1. The device is a syringe with sealed tanks with substance and piston mechanism comprising a piston cylinder, piston and piston rod, characterized in that the compression has a hydrodynamic device in the form of a housing forming a sealed mobile connection and air compression compartment with one or more elements of the piston mechanism, provided with a channel for moving the liquid exits the lumen of the piston cylinder and the BRCS in the form of a tank, and outputs of the internal channel hydrodynamic compression device located outside of the lumen of the piston rod of the reservoir, and the device is made to move in the bore of the piston rod of the tank when the pressure in the piston cylinder, wherein the compression compartment presents air space between the piston holding device and the piston.

3. The device according to PP.1 and 2, characterized in that provided with independently movable in the internal output channel compression hydrodynamic device compression piston, closing the compression of the air compartment in the rear part of the channel formation device of the reverse movement and provided with a movable closing flap, made with the possibility of moving into a projection of one of the outlet openings of the channel and sealed circuit when the maximum pressure in the piston cylinder reservoir with retroactive effect in the range of intermediate pressure.

4. The device according to PP.1-3, characterized in that the compression piston is made as posted movable sash, closing the hole on the side wall of the housing, between which there is an exit to move gigaspora stock-tank and has a trailing inner outlet channel fixed sash in the open groove.

 

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1 ex

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