A method of treating epilepsy

 

(57) Abstract:

The invention relates to medicine, namely neurosurgery and neurology, and can be used to treat patients with various forms of epilepsy resistant to drug therapy. A patient with drug-resistant epilepsy in the background of anticonvulsant therapy produce procaine blockade of the starry host, and then intravenously injected westrope tool. While all treatment activities carried out under dynamic electrophysiological control. The method allows to increase the effectiveness of the treatment.

The invention relates to medicine, namely neurosurgery and neurology, and can be used to treat patients with various forms of epilepsy resistant to drug therapy.

There is a method of treatment of epilepsy surgery, including the removal of the epileptic focus and epileptogenic stimuli. Widely used open surgery or stereotactic methods, involving the interruption of ways, conductive epileptic activity, the inhibition or stimulation of various brain structures involved in epileptogenesis (Zotov Y. C., the collected works of the Polenov research neurosurgical Institute them. Professor A. L. Polenov. - 1993. - S. 56-160). However, there are a large number of patients that surgical intervention is not indicated.

A prototype of the proposed method is a method of treatment of epilepsy with application of intravenous drip vasotropic funds (Charles C. A. Treatment of nervous diseases. - Moscow. - 1996, S. 652). Under the influence of infusion vasotropic means normalization of blood pressure, increased blood volume, increased suspension properties of the blood, decreases its viscosity, reduced blood flow in small capillaries. Westrope tool (reopoliglyukin) to introduce 250 ml or 400 ml of intravenous drip. The disadvantage of this method is that westrope tool (reopoliglyukin) operates mainly in the small capillaries and practically does not affect the main cerebral vessels.

The invention is directed to a method of treatment of epilepsy by hemodynamic, providing a reduction in the frequency of epileptic seizures, as well as the improvement of bioelectric activity (BEA) of the brain.

The invention consists in that a patient with drug-resistant epilepsy prey all treatment activities carried out under dynamic electrophysiological control.

The inventive method differs from the prototype in that it further before the introduction vasotropic tools produce procaine blockade of the stellate node under dynamic electrophysiological control. Blockade of the stellate node contributes to lowering the tone of the main arteries, relieves spasms and, thus, improves the blood supply to the brain, as it has a positive effect on the hemodynamics of the Central nervous system, which helps to reduce the frequency of epileptic seizures and to improve the performance of the BEA brain.

The method is as follows:

In a patient with drug-resistant epilepsy of various etiologies amid continuing anticonvulsant therapy produce background recording of electroencephalogram (EEG). Then on the side of the localization of the epileptic focus or the prevailing changes in the BEA produce procaine blockade of the starry host, while imposing 8-15 ml of 1% solution of novocaine. After blockade record EEG, observe the tendency of positive changes of bioelectric potentials. Then intravenously injected westrope tool in the conventional amounts, for example, 400 ml reopoligliukina. On EEG dynamics in register further zip in the treatment of 18 patients with epilepsy of various etiologies, suffering from drug-resistant seizures. In 16 patients noted a decrease in the frequency of epileptic seizures and improvement in the BEA.

Here is an example extract from and/b No. 1671.

Patient K. A. D., 25 years old, suffers from epilepsy traumatic etiology with a age 13 years. The frequency of attacks - 4-5 times a month on the background of constant anticonvulsant therapy. From the anamnesis it is known that in early childhood the patient has suffered a traumatic brain injury. Magnetic resonance tomograms - ventricular system is symmetric, the data volume of the process the brain is not obtained. EEG is the main rhythm sharply deformed, pointed, combined with the slow theta activity, has a tendency to distant synchronization, indicating widespread changes with dysfunction of diencephalic structures. After the blockade of the starry host (20 minutes) re-EEG, which observed decrease signs of dysfunction diencephalic structures. Immediately after the control EEG patient started/drip reopoligliukina (400 ml), after which the newly made EEG-study. This positive adjustment of bioelectric activity: the component; despite overall positive alterations became more distinct local signs in the left temporal leads, which in previous posts pretended to be a fairly pronounced cerebral changes. Clinical data also noted positive dynamics in the condition of the patient, the frequency of seizures decreased by more than 2 times the background still anticonvulsant therapy. The patient was discharged from the hospital in satisfactory condition under the supervision of a neurologist on a residence (follow-up 1 year).

Using the proposed method allows to reduce the frequency of epileptic seizures in the vast majority of patients and improve the performance of bioelectric activity.

A method of treating epilepsy, including the introduction of anti-convulsants, characterized in that on the background of continuing anticonvulsant therapy additionally produce procaine blockade of the starry host and enter westrope tool.

 

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