Method of treatment of chronic prostatitis

 

(57) Abstract:

The invention relates to medicine, in particular to urology, andrology. Intrarectal impose candles containing radon gradually increase the dosage. In the first 8 days of use rectal suppositories dosage radon 18 BCF. In the next 2-4 days with a dosage of 37 kBq, 2-3 times daily, treatment 10-12 days. The method of treatment without the addition of drug therapy enhances the effectiveness of treatment of patients with chronic prostatitis, complicated copulative dysfunction, and the prolongation of the remission period up to 12-16 months. 5 table.

The present invention relates to medicine, in particular to urology, andrology, and can be used in hospital, clinics and sanatoriums.

Chronic prostatitis with copulative dysfunction is an inflammatory disease of the prostate gland due to infection, congesta, allergies, etc. with long-term recurrent clinical course with periods of exacerbation, remission and associated diverse functional disorders of the genital organs.

Chronic prostatitis observed the 93-439; O. L. Tiktinsky, I. F. Novikov, V. C. Mickle. Diseases of the genital organs in men. - L.: Medicine, 1985. - 296 S.; D. C. Kahn. Chronic nonspecific prostatitis. //Mat. 3rd Vsesojuzn. Congress of urology. Minsk, 1984. - S. 180-187].

In 60-80% of men sexual disorders in the form of decreased libido, erectile dysfunction, ejaculation, dysorgasmia arise from somatic diseases (chronic prostatitis, hypertension, diabetes and others) [G. Wagner, R. green. Impotence (physiology, psychology, surgery, diagnosis and treatment): TRANS. from English. - M.: Medicine, 1985. - 240 p; Guide to urology /edited by N. A. Lopatkina. - M.: Medicine, 1998. - T. 2. - S. 393-439; O. L. Tiktinsky In. A. Mikhailichenko. Andrology. - SPb.: Mediapress, - 1999. - S. 274-298].

In addition, the disease in 40-50% of cases is a cause of infertility [the Imperial family of UNDA. Diseases of the male genital organs. - Kiev: Health, 1989].

Currently widely used etiotropic therapy for the elimination of the bacterial flora of the inflammatory process in the prostate gland. For this purpose broad-spectrum antibiotics and antiseptics taking into account the sensitivity of microorganisms to them in combination with immunomodulators (T-activin, polioksidony disturbed microcirculation, the elimination of inflammatory infiltrates in the prostate, improve outflow secret from her, etc. are used For this purpose various types of electrotherapy. In particular, for the treatment of patients with chronic prostatitis apply ultrasonic therapy [C. I. Karpukhin. Chronic prostatitis. - M., 1976. - 64 S.; C. I. Karpukhin. Physical therapy of diseases of the kidneys and urinary tract. //Balneology and physiotherapy. /Ed. by C. M. Bogolyubov. - M.: Medicine, 1985. - T. 2. - S. 261-283; I. C. Karpukhin, A. A. Minenkov, A. A. Lee, and other physical therapy in andrology. - M.: Halley-Print, 2000. - S. 153-183], therapy laser radiation [A. L. Abad, V. I. Rajkovic, R. M. Safarov. Technique and clinical results of laser therapy of patients with chronic prostatitis. //Urol., nephrol. - 1994. No. 6. - S. 26-29; I. C. Karpukhin, A. A. Minenkov, A. A. Lee, and other physical therapy in andrology. - M.: Halley-Print, 2000. - S. 153-183], inductothermy, sinusoidal modulated currents - CMT [C. I. Karpukhin. Chronic prostatitis. - M., 1976], microwave therapy on the area of the thyroid and thymus glands [C. M. Bogolyubov, I. C. Karpukhin, A. S. Bobkov and other Treatment of patients with chronic prostatitis complicated by infertility, the influence of microwaves (460 MHz) on the area of the thyroid and thymus glands. //The. chicken is a white emulsion, radon baths, microclysters sulfide water, irrigation of the colon radon water and other [C. I. Karpukhin. Physical therapy of diseases of the kidneys and urinary tract. //Balneology and physiotherapy. /Ed. by C. M. Bogolyubov. - M.: Medicine, 1985. - T. 2. - S. 261-183; I. C. Karpukhin, A. A. Minenkov, A. A. Lee, and other physical therapy in andrology. M: Halley-Print, 2000. - S. 153-183; I. C. Karpukhin, A. A. Lee, M. E. Gusev. Restorative therapy of urological and andrological patients resorts of Europe. - M.: Interprint, 2001. - S. 62-75; I. C. Karpukhin, A. A. Lee, M. E. Gusev. The use of turpentine baths of white emulsion in the treatment of patients with sexual dysfunctions. //Ecology prom. production. 2001. No. 1. - S. 29-32; I. I. Gusarov. The radon. M.: Medicine, 2000. - 200 S.].

In the presence of chronic prostatitis, complicated copulative dysfunction, the above physical factors in most cases are positive only on the underlying disease - chronic prostatitis and less effective in its complication - copulative dysfunction. The effectiveness of treatment of patients with chronic prostatitis specified physical factors is low and is 62-70%.

It is known that for therapy of patients with chronic prostatitis also primeway 39-40°C, the duration of retention for 30 minutes, daily or every other day, for a treatment course of 10-12 treatments. The effectiveness of treatment is 65-70% [I. C. Karpukhin, A. A. Minenkov, A. A. Lee, and other physical therapy in andrology. - M.: Halley-Print, 2000. - S. 153-183; I. C. Karpukhin, A. A. Lee, M. E. Gusev. - Restorative therapy of urological and andrological patients resorts of Europe. - M.: Interprint, 2001. - S. 62-75].

The disadvantages of this method are the low efficiency of treatment, short term remission, as there are a great loss of radon from the water during the procedure, a low concentration of radon radon in your water, inconveniences in two-three times daily procedure, the introduction into the rectum of a relatively large number of hot treatment fluid.

Currently there is no single effective treatment, the use of which has positively acted not only on the underlying disease - chronic prostatitis, but also its complications - copulative dysfunction, spermatogenesis, etc.

The closest in technical essence to the proposed method of treatment is a method of treatment of patients with chronic prostatitis, which consists in a daily two to three times the use of rectal and other Surlyn in combination with antibiotics, antiseptics [Guide andrology. /Ed. by O. L. taktische. - L.: Medicine, 1990. - S. 51-98; C. I. Karpukhin. Chronic prostatitis. - M.: Knowledge, 1976. - 64 S.].

The disadvantages of the prototype are: rectal suppositories drugs have weak anti-inflammatory and analgesic effects in chronic prostatitis, low treatment efficiency (30-40%), impossibility of independent use as monotherapy; the lack of positive action on the complications of chronic prostatitis - copulative dysfunction, abnormal ejaculation, spermatogenesis, etc.

The application prototype is effective in the treatment of patients with chronic prostatitis only in the case of its application in complex with etiotropic (antibiotics, antiseptics, anti-inflammatory drugs) and pathogenic (immunokorrigiruyuschy drugs, physiotherapy and other therapies.

The technical result of the proposed method of treatment are improving the treatment of patients with chronic prostatitis, complicated copulative dysfunction, elongation phase of remission and the exception of the addition of drugs.

The criminal code is tlaut intrarectal injection of candles, containing radon gradually increase the dosage during the first 8 days of use rectal suppositories dosage radon of 18.5 kBq (with 0.5 µci), and in the next 2-4 days with a dosage of his 37 kBq (1 µci), 2-3 times daily, treatment 10-12 days.

The proposed dosage of radon (18.5 and 37 kBq) rectal suppositories are the most physiologic for increasing local blood circulation in genitals, regression of the inflammatory process in the prostate gland and the elimination of complications of chronic prostatitis (copulative dysfunction, abnormal ejaculation, spermatogenesis, and others).

Single use rectal candles from cocoa butter, rich in radon [I. I. Gusarov, V. I. Abramov, A. C. Dubovsky and other Candle with radon for therapeutic application. - RF patent №2164132 from 20.03.2001,, bull. No. 8], with its dosage of 18.5 kBq per day is ineffective, and the use of rectal suppositories dosing radon 37 kBq more than 3 times a day is not desirable due to inhibition of spermatogenesis. The use of rectal suppositories containing radon doses of 18.5-37 kBq 2-3 times a day, contributes to a pronounced strengthening of local blood circulation in the sex organs, improving venous blood flow, reduce inflammation Proteinate procedure is achieved by prolonging the content of radon in the rectum, slower removal from the pelvic organs, loss prevention of radon in the process of the procedure. Additionally, there remains the possibility of the procedure by patients on an outpatient basis.

With the use of rectal suppositories containing radon doses of 18.5-37 kBq 2-3 times per day, the latter enters the prostate gland together with arterial blood in sufficient quantity.

The half-life of radon from the body when using rectal suppositories containing radon varies from 1 to 2 h 45 min (average T1/21.7 h).

In the rectum the radon from the cocoa butter is absorbed into the blood and completely excreted from the body through the lungs in about 6-8 hours, and out of the water when the micro - 2-3 hours

Rectal suppositories, containing radon, have a positive effect on the weak potency in patients with chronic prostatitis. This is because the hydrogen peroxide produced by the action of alpha-radiation in the tissues of the body, is involved in the synthesis of NO (nitric oxide) as a secondary activator expansion of blood vessels, including penile arteries and the cavernous bodies, which determines the potency in men [I. I. Gusarov, I. P. Bobrowniki with with ed. On the mechanisms of healing and so is AI. //The. A resort. - 2002 number 2. - S. 46-47].

With this in mind, a working hypothesis for the action of rectal suppositories containing radon with dosages of 18.5-37 kBq, patients with chronic prostatitis, complicated copulative dysfunction, is the following.

With the use of rectal suppositories containing radon doses of 18.5-37 kBq, is alpha-irradiation of endothelial cells, nerve tissue, mucous membranes of the various ducts of the reproductive organs and other education N2ABOUT2that activates the synthesis of NO in them with part-interferon (IFN-a) and lipopolysaccharide (LPS). Forth from the endothelium main part of the NO diffuses into the smooth muscle cells of the cavernous tissue, penile blood vessels by relaxing the smooth muscles and expanding them, and the other part NO remains in the blood stream, providing including a bacteriostatic effect.

Therefore, when the use of rectal suppositories containing radon, due to direct diffusion of radon and its daughter decay products from the rectum through a.rectalis inferior directly into the penile artery is observed more pronounced increased arterial blood flow to the cavernous tissue and therefore rapid recovery and stabilization of countinuation, complicated copulative dysfunction, compared to other rectal candles. In addition, the elevated levels of NO in the tissue of the spinal wire and neuroreceptor system erogenous zones and genitals increases the excitability of the neuromuscular apparatus of smooth muscles of the penis, perineum muscles and timely communication of positive nerve impulses to them, which also accelerates the recovery of the copulative function and prolong the period of remission in patients with chronic prostatitis.

A DESCRIPTION of HOW

With the patient lying on the left side or in the knee-elbow position nurse (or the patient himself) conducts during the first 8 days intrarectal injection of suppositories containing the radon dose of 18.5 kBq, and in the next 2-4 days with a dosage of his 37 kBq, 2-3 times daily, treatment 10-12 days.

This twice daily administration of rectal suppositories containing radon doses of 18.5-37 kBq shown patients with chronic prostatitis in remission, complicated copulative dysfunction, and three application - patients with chronic prostatitis in the latent phase of inflammation, complicated copulative dysfunction.

Examples assistant, objective data, clinical and laboratory research methods - ultrasound investigation (USI) prostate gland, ultrasound Doppler (Doppler ultrasound), blood, urine, prostate fluid, semen, the study of T - and b-lymphocytes, and others, proceed to the treatment of patients with chronic prostatitis, complicated copulative dysfunction of the proposed method.

Example 1. Patient A., 25 years. Diagnosis: chronic nonspecific prostatitis in remission. Copulative dysfunction. Upon receipt of a complaint of the patient on the sensation, sexual weakness, redness in the crotch area.

When finger rectal examination the prostate gland is not enlarged, painless, flabby consistence, its contours precise, equal, Magdalena groove defined. Ultrasound of the prostate: prostate size 352219 mm, the structure of the gland diffuse homogeneous. On USDG: linear blood flow velocity (BFV) in a.dorsalis penis: V sist (systolic) 28 cm/s, V diast (diastolic) 6.8 cm/s, V med (medium) 7 cm/s In the analysis of a secret of a prostate: leukocytes 10-20 in the field of view, erythrocytes 1-2 in sight, lecithin grains in moderation.

In semen analysis: sperm count 260%, abnormal 40%, leukocytes 10-20 in sight.

In the seeding of prostate secretion of urine revealed epidermal staphylococci in the number 2102CFU/ml.

The patient was prescribed course of treatment, rectal suppositories, saturated with radon gradually increase the dosage, with the first 8 days were used rectal suppositories dosage radon of 18.5 kBq, and in the next 2 days - candles with a dosage of his 37 kBq, 2 times a day. The course of treatment is 10 days.

Absorbed (exchange) the dose of alpha-irradiation of the rectal wall was 19.2 mSv (maximum permissible dose of alpha radiation in NRB-99 - 42 mSv). The radiation dose to the prostate was significantly lower.

Intrarectal injection of suppositories containing radon, was performed with the patient lying on the left side.

To do this, honey. sister pulls out a rectal suppository containing radon, for the patient And from the cooling chamber 945-950. When the rectal temperature of candles 18-20C at 10 am after Breakfast and emptying of the colon in the 1st time intrarectal introduction candles with dosage radon 18,5 KVK conducts honey. sister (or the patient himself). During the day, additional intrarectal introduction candles containing radon is the 2nd time in the 2200after dinner and what about the treatment approach, the patient has no sensation, redness in the perineum and recovered copulative function.

When finger rectal examination after treatment both lobes of the prostate gland is normal in size, softish consistency, painless, contours precise, equal, Magdalena groove defined.

Ultrasound of the prostate: prostate size HH mm, the structure of the gland uniform.

On USDG: linear blood flow velocity in a.dorsalis penis: V sist 35 cm/s, V diast 7 cm/s, V med 8 cm/s

In the analysis of a secret of a prostate: leukocytes 5-7 in the field of view, erythrocytes - no, lecithin grain in large quantities, epithelial cells 0-1 in the field of view.

In semen analysis: sperm count 60 million in 1 ml of ejaculate, the number of motile forms 72%, still forms 28% of normal spermatozoa 80%, abnormal 20%, leukocytes 5-7 in sight.

In the seeding of prostate secretion of urine growth of microorganisms in nutrient media not found.

Example 2. Patient C., 45 years. The diagnosis of chronic prostatitis in the latent phase of inflammation, complicated copulative dysfunction.

Upon receipt of a complaint of lower abdominal pain in the tailbone, sluggish stream of urine during urination, erection.

Ultrasound of the prostate: prostate size 484024 mm, fuzzy contours, structure of heterogeneous cancer.

USDG: LCS on a.dorsalis penis: V sist 18 cm/s, V diast 5 cm/s, V med 4 cm/s

In the analysis of a secret of a prostate: leukocytes 50-70 in the field of vision, epithelial cells 15-20 in the field of view, lecithin grain in moderation.

In the seeding of prostate secretion of urine selected E. coli in the amount of 104colonies in 1 ml

A semen analysis sperm count 34 million in 1 ml of ejaculate, mobile forms 43%, normal sperm 38%, abnormal 62%, leukocytes 50-60 in sight.

After clinical and laboratory examination the patient was treated with rectal suppositories containing radon, gradually increase the dosage, with the first 8 days were used rectal suppositories dosage radon of 18.5 kBq, and in the next 4 days with a dosage of his 37 kBq, 3 times a day, the course of treatment is 12 days.

Absorbed (exchange) the dose of alpha-irradiation of the rectal wall totaled 38.4 mSv (maximum permissible dose of NRB-99-42 mSv), i.e. the dose of the prostate in the application of the proposed method was lower than normal.

For the procedure to the patient C. the nurse pulls out a rectal suppository, rich in radon, from the cooling chamber 745-750. When the rectal temperature of candles 18-20C in the 800in the morning after Breakfast and emptying of the colon to the patient in the knee-elbow position on the couch, the nurse (or the patient himself) conducts the 1st time intrarectal introduction it with a dose of radon of 18.5 kBq, and then added in the course of the day is spent in the 1500(2nd time) introduction rectal candles in the rectum with a dose of 18.5 kBq after lunch and emptying of the colon and 3rd times - in the 2200after dinner and emptying of the colon (see treatment algorithm patient V., aged 45, PL.2).

After treatment the proposed method, the patient has no pain in the lower part of the abdomen and the tailbone, normalized urine flow was restored copulative function. When finger rectal examination of the prostate revealed a normal size of its shares, painless, softish texture, contours precise, equal, Magdalena groove defined.

Ultrasound of the prostate: prostate size 302618 mm, contours equal, precise, the structure of the gland uniform is rhenium, lecithin grain in large quantities, the microflora is missing.

In the seeding of prostate secretion of urine allocated epidermal staphylococci in the amount of 40 CFU/ml.

In semen analysis: sperm count 63 million in 1 ml of ejaculate, mobile forms 80%, still forms 20%, normal sperm 82%, abnormal 18%, leukocytes 5-7 in sight.

USDG: linear blood flow velocity in a.dorsalis penis: V sist 39 cm/s, V diast 7 cm/s, V med 5 cm/sec.

The proposed method of treatment was conducted in the clinical laboratory of reproductive and urologic diseases MZVM and To the health Ministry. The study included 60 patients with chronic prostatitis, including complicated copulative dysfunction.

The main complaints of patients at admission were pain in the lower abdomen, in the area of the sacrum, tailbone, perineum and testicles, and dysuric phenomena.

Any symptoms copulative dysfunction: the weakening or absence of erections (88%), libido decrease (90%), premature ejaculation (52%) and impaired spermatogenesis (78% of observations).

Before treatment with finger rectal examination was marked tenderness of the prostate (96%), uvelicheniya secret of the prostate gland: the number of leukocytes was 78±6 in the field of view, erythrocyte 6±0,4 in the field of view, lecithin grains in moderation.

In the analysis of sperm was a decrease in the number of spermatozoa in 1 ml of ejaculate in 76% of patients.

In addition, there was a decrease in the linear velocity of blood flow in the penile arteries according to the USDG, reduction of T-lymphocytes in the blood and other

After treatment of patients with the proposed method, it was noted positive dynamics of clinical and laboratory data. In particular, after treatment, no pain in the lower abdomen, sacrum, coccyx and perineum, dysuric phenomena. It was also observed spontaneous nocturnal erections, increase libido and improve overall health.

When rectal finger study by the end of treatment was determined painless, softish texture, normal size prostate gland (85% of cases).

Ultrasound of the prostate: revealed homogeneous shadow of its normal size, without inflammatory infiltrates (in 86% of cases).

After daily 2-3-single-use rectal suppositories containing radon, patients noted immunocorrective effect, manifested in the increase in the absolute and relative number of T-l is the train of C-reactive protein, lactate dehydrogenase (LDH) in the serum [see table. 3].

After treatment in the analysis of a secret of a prostate gland: the number of leukocytes was 8,0±0,5 in the field of view and erythrocytes 1,0±0,1 in the field of view (see tab. 4).

According to the table. 4 shows that after treatment the proposed method, there was a decrease of leukocytes and erythrocytes and an increase in lecithin seeds in the prostate secretion in patients with chronic prostatitis. According to the bacteriological examination of prostate secretion of urine was noted to be significantly (P<0.001) reduction of microflora (2,0±0,2)104to (2,0±0,2)102after the use of rectal suppositories containing radon.

We were Doppler ultrasound dorsal arteries of the penis in patients with chronic prostatitis before and after treatment by the proposed method (table.5).

According to the table. 5, all key indicators of the linear velocity of blood flow in the dorsal arteries of the penis increased after treatment radon candles, which contributed to the restoration of copulative function.

Therefore, the overall improvement of the patients after the use of rectal suppositories containing radon was associated with mind is om, as evidenced by a significant (P<0,001) decrease in leukocytes from 82±6 15±1,5, erythrocytes from 6±0.2 1±0.1 and microflora (2 ą 0.2)104up to (2±0,2)102according to the research of a secret of a prostate. Bacteriostatic and anti-inflammatory effects of radon therapy in chronic prostatitis sexual dysfunction, apparently, was associated with immunokorrigiruyuschy effect (increase in T-lymphocytes, a decrease of immunoglobulins G and A) and the local microcirculation in the sex organs.

Increase libido and night-time erections in patients with chronic prostatitis, complicated copulative dysfunction after treatment of the proposed method is explained not only by increasing blood supply to the genitals but also increase neuromuscular excitability receptor apparatus erogenous zones, including the penis.

Significant improvement and improvement was observed in 80% of patients with chronic prostatitis, complicated copulative dysfunction after administration of rectal suppositories containing radon.

Thus, the application of the proposed method for the treatment of patients with chronic prostatitis, complicated copulative dysfunction reduces the inflammatory activity of proceso actions radon. The improvement of the copulative function in patients with chronic prostatitis after the treatment approach is associated not only with improved arterial blood flow to the cavernous bodies, and increased neuromuscular excitability receptor apparatus erogenous zones, including the penis.

The application of the proposed method for the treatment of patients with chronic prostatitis, complicated copulative dysfunction, contributed to the improvement of the cavernous blood flow in the penis by increasing arterial blood flow, increased tone, blood pressure and improving venous outflow of blood from the genital organs, as well as the acceleration of inflammation in the prostate gland due to immune correcting activity of radon and increased excitability of the neuromuscular apparatus of the muscles of the penis, perineum, etc.

Using the proposed method of treatment without the addition of drug therapy helps improve therapeutic effect (treatment efficiency 80%) and the prolongation of the remission period up to 12-16 months in patients with chronic prostatitis.

Method for the treatment of patients with chronic prostatitis, including interactionsthere increase dosage, in the first 8 days of use rectal suppositories dosage radon of 18.5 kBq, and in the next 2-4 days with a dosage of his 37 kBq, 2-3 times daily, treatment 10-12 days.

 

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