The tool chitoan and method for the treatment of chronic pancreatitis and hepatitis b

 

(57) Abstract:

The invention relates to the field of creation of means of plant origin for the treatment of chronic pancreatitis and hepatitis C. treatment for chronic pancreatitis and hepatitis b is made in pill form and contains as active ingredients of the crushed seeds of the flax seed, grass Russian Thistle, grass, datisca the Konoplyova, chicory roots of the ordinary, chitosan and an excipient is microcrystalline cellulose, polyvinylpyrrolidone and Aerosil taken at a certain ratio of components. The method of treatment of chronic pancreatitis and hepatitis b is that the patient is given the proposed facility in the amount of 500 mg 3 times a day before meals for 2-4 weeks, diluting 50 ml of nonfat yogurt. The proposed tool has bacteriostatic, enveloping, regenerating, anti-inflammatory, antioxidant and immunostimulating action. The treatment by the proposed method shows high efficacy and a favorable prognosis. 2 S. and 1 C.p. f-crystals, 2 tab.

The invention relates to the field of medicine and for the creation of means of plant origin dlani multivitamins, immunomodulators, enzymes and so on (Sokolov, S. I., and others, Medicinal plants. Handbook, M., 1984). The use of enzymatic and anti-inflammatory drugs often leads to the development of drug resistance. However, when using immunostimulatory drugs therapeutic effectiveness of their aims to increase the resistance of the organism, a patient with pancreatitis, and virtually no effect on the recovery of the beta cells of the pancreas and does not eliminate the phenomenon giperfermentemii that contribute to the chronicity of the process (Fitoaromatah, Ed. by A. M. Gruzinskogo, Kiev, 1989).

The objective of the invention is to increase the effectiveness of therapy due to pathogenic selection treatments, expanding the range of herbal medicines for the treatment of inflammatory diseases of the pancreas and hepatitis C.

The task is achieved using the creation of phyto compositions of native plant materials containing significant amounts of natural compounds polysaccharides.

The proposed group of inventions combined to form a single inventive concept.

To reach the put is In, made in pill form, where the active substances it contains crushed seeds of the flax seed, grass Russian Thistle, grass, datisca the Konoplyova, the roots of chicory ordinary and chitosan, as well as auxiliary substances, microcrystalline cellulose, polyvinylpyrrolidone and are presented in the following ratio, wt.%:

the seeds of the flax seed 10

grass Russian Thistle 20

grass datisca the Konoplyova 15

the roots of chicory ordinary 20

chitosan 5

microcrystalline cellulose 28,6

polyvinylpyrrolidone 0,4

Aerosil 0,1

In addition, a method of treatment of chronic pancreatitis and hepatitis type b, namely, that the patient is given the above means in the amount of 500 mg 3 times a day before meals for 2-4 weeks, diluting 50 ml of fat-free yogurt.

The tool is called "Chitoan".

Medicinal plants used in the invention:

Chicory common - contains 40% carbohydrate inulin, soluble in hot water, bitter glycoside inhibin, protein, sugar, resin, which reinforce the processes of digestion, regulate the institutions and antimicrobial action.

Flax seed - annual technical and medicinal plant collection Linevich. The seeds contain up to 48% of fatty oil, protein, carbohydrates, mucus, vitamin a, organic acids and enzymes. In the composition of the fatty oils are glycerides of linoleic, linolenic, oleic, palmitic and stearic acids. Seed peel contains sinokorean, lietzenmayer, glycoside linamarin that have a coating, softening, anti-inflammatory effect and regulate the secretory and motor function of the pancreas and intestines.

Datisca Konopleva - perennial family Datskevich. The main active ingredients - 14 flavonoids, the main of which is detectin-3-rutinozide-3,5,7,2-tetrahydroxypregna. In medical practice is the sum of flavonoids called datscan as a choleretic, antispasmodic with cholecystitis, hypoacid gastritis and gastric ulcer and duodenal ulcer.

Salsola Collina - the active ingredients of the soup are the betaines, alkaloids, phenol-dicarboxylic acid and Sterol glycosides and saponins, carotenoids, flavonoids, Tocopherols, silicon soedinenii hepatoprotective effect on the liver parenchyma, prevents nitrosophenol the effect of various poisons, including alcohol, stabilizes the membrane of liposomes and the content of glycogen, increase the activity of enzymes of the mitochondria. An important feature of the plant is high antiradical activity, increasing the catalytic ability of cytochrome P-450 and increase regeneration of the liver parenchyma.

Preparations soup also contribute to the normalization of level of cholesterol in the blood and bile, blood sugar; remove alcohol intoxication and hangover.

The water-soluble chitosan is a water - soluble low molecular weight dietary chitosan, obtained from the shell of the far East crab on the technology developed by ZAO "Bioprogress" (, Shchelkovo, Moscow region). This aminopolysaccharide coated natural origin, obtained by acetylation of chitin shell crab. Chitosan has the ability to form complexes with electrophilic and nucleophilic agents, and based on this principle its detoxifying property, as well as the ability to bind fatty and bile acids and remove them from the body. The presence of chitosan in Chicopee" has the prolonging effect and enhances therapeutic effect due to the antioxidant effect.

For the preparation of tablets weighing 0.5 g use the powdered herb in the amount of: seeds of flax seed 0.05 g, grass Russian Thistle 0.1 g, grass, datisca the Konoplyova 0.075 g, the roots of chicory ordinary 0,1, Then add the chitosan in the amount of 0.025 g and filler for tabletting - microcrystalline cellulose 0,143 g, polyvinylpyrrolidone 0.002 g and Aerosil 0,005 g

Tablets are prescribed for 1 piece 3 times a day before meal with low fat yogurt. Treatment is 2-4 weeks.

The proposed method of treatment can effectively influence the pathogenesis of the disease, to eliminate the pathological symptoms of the disease, to neutralize HyperTerminal and increase remission of the disease. It is possible for a conservative, outpatient treatment of a wide range of patients, and can also be used for the treatment of concomitant chronic diseases (cholangitis, duodenitis, cholecystitis, cirrhosis, angiocholitis, gall-stone disease etc). The method is simple and economical to use.

The invention is illustrated by the following examples:

Example 1. Patient S.,33 years old, a resident, Dolgoprudny, Moscow region. Works as a house painter. Hurts pancreatitis since 1999, was Treated in hospital district the Itza with gemodeza and reopoliglyukine. However, the improvement was within 3 months. In September 2001, noted the appearance of the nuances of pain, bitterness in the mouth in the morning, weakness. Was admitted to the district hospital at the place of residence, where he received gemodez, Essentiale, multivitamin. Asked for a consultation 22.11.2002, with complaints of weakness, pale skin, weakness. Blood bilirubin total 77.2 mmol/l, direct - 37,0 mmol/l, indirect - to 20.1 mmol/l, the activity ACT - 93,0 u/l; ALT - 119 u/l

The assigned treatment regimen for 2 months (reception "Chicoana" 1 tablet 3 times a day during meals, drinking non-fat yogurt). When you re-inspection, the complaints of minor pain in the right hypochondrium saved. Paleness of skin and mucous membranes, weakness, yellowing of the sclera disappeared. Blood biochemical parameters: total bilirubin - to 27.0 mmol/l, associated with 14 mmol/l, ALT - 36 u/l, ACT - 41 u/l was within 6 months follow-up. The condition has not worsened.

Example 2. Patient I., aged 47. Moscow dweller suffering from chronic pancreatitis for about 3 years, have passed the course in the EMC Hepatology center. Was treated in therapeutic Department of the hospital №15 for 1.5 months, improved is echani 6.5 cm below the edge of the costal arch; on ultrasound diffuse changes in the liver and pancreas. A survey was conducted (see table.1).

The patient was assigned to "Chitoan" 1 tablet in the morning, at lunch and in the evening before eating, drinking fat free yogurt. therapy was about 1.5 months. Tolerability was good. No complications from therapy were observed. The patient is on maintenance therapy, which is held in the fall for 2 weeks. According to the presented laboratory data, patient And. in the course of treatment was marked correction of biochemical and clinical indicators, indicating the high efficiency of treatment and a favorable prognosis.

Example 3. Patient A., 41 years old, a resident, Korolev, Moscow region. Focused on advice from the clinic due to lack of treatment efficacy. Sick about 4 years hepatitis C. was Treated at the Department of gastroenterology MONICA, city hospital, Queen, where were treated Pancreatin Essentiale, holenzim, multivitamins, diet, and other laboratory Results (see tab.2).

Patient A. Received within 4 months of the claimed treatment method (accepting "Chicoana" 1 tablet 3 times a day before is chesla nausea, bitter taste in the mouth, recurrent pain in the right hypochondrium) has improved. The treatment continues. The patient is on a dynamic outpatient observation.

On the basis of clinical ishitani we can conclude:

therapeutic effect is enhanced by bacteriostatic, obvolakivayuschim, regenerating, immunostimuliruyushhim, anti-inflammatory and antioxidant action of the tool.

Indications: chronic disorders of the liver, pancreas, obesity, diabetes.

Contraindications: individual intolerance.

1. The treatment for chronic pancreatitis and hepatitis b, characterized by the fact that it is made in pill form and contains as active ingredients of the crushed seeds of the flax seed, grass Russian Thistle, grass, datisca the Konoplyova, chicory roots of the ordinary, chitosan and an excipient is microcrystalline cellulose, polyvinylpyrrolidone and are presented in the following ratio, wt.%:

The seeds of the flax seed 10

Grass Russian Thistle 20

Grass datisca the Konoplyova 15

Chicory roots of the Lydon 0,4

Aerosil 0,1

2. Means under item 1, characterized in that it is made in the form of tablets weighing 0.5 g

3. The method of treatment of chronic pancreatitis and hepatitis b, characterized by the fact that the patient is given the tool under item 1 in the amount of 500 mg 3 times a day before meals for 2-4 weeks, diluting 50 ml of nonfat yogurt.

 

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FIELD: medicine, cardiology, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

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