Method for the treatment of patients with infiltrative tuberculosis of the lungs

 

(57) Abstract:

The invention relates to medicine, pulmonology, and can be used for the treatment of patients with infiltrative tuberculosis of the lungs. Impose anti-TB drugs in retrocervical and jugular point and additionally in the parasternal point with one and/or both sides of the injected mixture consisting of 10 mg/kg of body weight of isoniazid, 2.5 to 5 thousand UNITS of heparin, 2.0 ml of 2.4% solution of aminophylline and 0.25% solution of novocaine, sequentially, by subcutaneous injection of 1 point per day, 3-5 times per week, 20-30 course of injections. This invention helps to accelerate elimination of the pathogen due to the receipt of medicines directly in the focus of inflammation through the lymphatic system of the body.

The invention relates to medicine, namely to Phthisiology, and can be used for the treatment of patients with infiltrative tuberculosis of the lungs and other specific forms of pneumonia in adolescents and adults.

There is a method of treatment of patients with infiltrative tuberculosis of the lungs with the use of lymphotropic the introduction of anti-TB drugs (Fences A. M., Ivanov A. K., Pauker M. Lymphotropic therapy for TB patients Leah". - Sochi, 1997. - S. 27).

The disadvantages of this method: use in combination lymphotropic points in the treatment of the armpits, from which anti-TB drugs penetrate through the lymphatic ducts in the mediastinal lymph nodes and lung tissue very slowly, and lymphotropic drugs only in one point. The first method does not allow to create a high concentration of the drug in the target organs, and the second can lead to poor absorption of the drug when repeated in the same place and inflammatory complications.

The invention is directed to solution of the problem: increasing the efficiency of treatment of patients with infiltrative pulmonary tuberculosis by improving the methods lymphotropic the introduction of anti-TB drugs.

This task is achieved by including in combination lymphotropic points for sequential injection instead armpits in parasternal point. This is due to the fact that introduced the drug in large numbers comes in hilar lymph nodes and lungs through the lymphatic vessels, non-vascular paths importantpart and through the right lim is and morphologically distribution of the dye of the study area in the thoracic cavity and biochemically concentration of isoniazid, injected parasternal, in the lung tissue, gilzem complex liver. As a drug take a mixture consisting of 10 mg/kg of body weight of isoniazid, 2.5 to 5 thousand UNITS of heparin, 2.0 ml of 2.4% solution of aminophylline and 0.25% solution of novocaine.

The method is as follows: 10% solution of isoniazid per kg of body weight in a mixture of C, 2.5 to 5 thousand UNITS of heparin and 2.0 ml of 2.4% of aminophylline (total amount of drug compound is not less than 15.0 ml bring 0.25% novocaine) is injected sequentially lymphotropic subcutaneously in the parasternal point with one or both of the parties: under the collarbone, in the first and second intercostal space; the jugular fossa and retrocervical point, sequentially by 1 point per day, 3-5 times per week, 20-30 injections on the course, on the background of a comprehensive anti-TB therapy.

Examples of specific applications

Example No. 1. Patient K., 26 years old, unemployed. Changes in the lungs identified during the periodic health examination. Complaints were not filed, objective signs of disease were not found. Clinico-radiologically diagnosed with infiltrative tuberculosis3the left lung in the phase of disintegration, VK+. In a comprehensive anti-TB therapy was included lymphotropic mixture of ioninycle 3 times a week. The radiological control after 2 months was determined significant resorption of infiltration, reduction of decay cavities in diameter 3-4 times, restoring the normal structure of the roots of the lungs, even after 2 months of oral healed. Patients stopped after 1 month.

Example No. 2. Patient D., aged 34, disability group II TB. TB is suffering for 2 years, 1 year ago operated on for cavernous process (resection1-2the right lung). In the postoperative period on a background of pregnancy was deteriorating specific inflammation in the form of infiltrative tuberculosis operated in the right lung in the phase of disintegration. Traditional treatment for 2 months did not lead to significant improvement. Then in the combined therapy was included lymphotropic mixture of isoniazid using parasternal point to the right (held just 30 injections 5 times a week). This allowed 2 months to achieve positive clinical and radiological improvement, the current scarring cavity, partial resorption infiltrative and focal changes.

Example No. 3. Patient N., aged 40, disability group II TB. Changes in laohutan. Objective examination the patient was lowered food, pale, light listen to hard breathing without wheezing. Clinico-radiologically was diagnosed with infiltrative tuberculosis1-2the right lung in the phase of decay and contamination, VK+. Started a traditional complex chemotherapy 4 anti-TB drugs. Over the next 2 months came some positive clinical dynamics: decreased cough. Radiographically improvement is not achieved. The detected resistance of tubercle bacilli to streptomycin, ethambutol, rifampicin. Intramuscular administration of isoniazid was replaced by lymphotropic, one of the 3 points used was parasternal, on both sides (in combination with retrocervical and jugular), 25 injections 5 times a week. After 2 months of treatment achieved better health, normalization of temperature, reduce cough, the patient gained weight 2 kg Radiographically also noted the positive dynamics in the form of partial resorption of infiltration and lesions, reduction in cavity size 1/4. Stopped smear-positive.

The positive effect from the use of the proposed method if the combination lymphotropic points parasternal areas which leads to faster resorption of inflammatory changes, reduction and scarring destruction cavities, smear conversion, significant and rapid improvement of the patients ' health; good effect of the treatment of patients with exacerbations and relapses of tuberculosis, including postoperative; possible use in drug resistance; reducing toxic effects of antibacterial drugs; improving the rheological properties of lymph through lymphotropic injection of aminophylline.

Method for the treatment of patients with infiltrative pulmonary tuberculosis by lymphotropic the introduction of anti-TB drugs in retrocervical and jugular point, characterized in that the combination lymphotropic points impose additional parasternal point with one and/or both sides, in which is injected a mixture consisting of 10 mg/kg of body weight of isoniazid, 2.5 to 5 thousand UNITS of heparin, 2.0 ml of 2.4% solution of aminophylline and 0.25% solution of novocaine, sequentially, by subcutaneous injection of 1 point per day, 3-5 times per week, 20-30 course of injections.

 

Same patents:

The invention relates to medicine, pulmonology and can be used for the treatment of pulmonary tuberculosis
The invention relates to medicine, pulmonology and can be used for the treatment of pulmonary tuberculosis

The invention relates to pharmaceutical industry
The invention relates to the field of medicine
The invention relates to medicine, pulmonology and can be used to treat children and adolescents with latent tuberculosis infection

The invention relates to the field of clinical medicine - Phthisiology and can be used in the treatment of patients with caseous pneumonia to reduce the severity of the intoxication syndrome, normalization of blood system, withdrawal side effects from anti-TB therapy

The invention relates to medicine, herbal medicine, namely to medicines of plant origin with anti-TB activity

The invention relates to medicine, pulmonology and can be used for the treatment of infiltrative pulmonary tuberculosis

The invention relates to medicine, pulmonology and Orthopaedics and can be used for hip joint arthroplasty in progressive and chronic destructive tuberculosis of the hip joint arthritis

The invention relates to pharmaceutical industry
The invention relates to medicine, namely to emergency cardiology, and can be used in the prehospital and hospital patients for the prevention and treatment of coronary heart disease (CHD)
The invention relates to medicine, specifically to cardiology, and relates to methods of treatment of acute coronary syndrome without ST segment elevation
The invention relates to medicine, anesthesiology and intensive care and surgery and it can be used for early treatment of gastrointestinal bleeding

The invention relates to medicine, namely to preimplantation processing of biological prosthetic blood vessels of small diameter for cardiovascular surgery

The invention relates to medicine, namely to preimplantation processing of biological prosthetic blood vessels of small diameter for cardiovascular surgery
The invention relates to medicine, namely to traumatology and orthopedics, and can be used in the replacement of large joints with the use of bone cement on the basis of methyl methacrylate
The invention relates to medicine, for the treatment of pulmonary embolism and can be used in therapy, surgery, neurology, cardiology, Oncology, trauma, resuscitation and intensive therapy

The invention relates to medicine, specifically to cardiology, and relates to methods of selecting the optimal dose nefrackzionirovannam heparin with subcutaneous injection in patients with acute coronary syndrome without ST segment elevation
The invention relates to medicine, surgery

The invention relates to pharmaceutical industry and relates to the application of biologically active isonicotinohydrazide phthalic acid (I) as a drug hypoglycemic drugs
Up!