The drug "phytochelatin" for the prevention and adjunctive therapy in the treatment of diseases of the liver and biliary tract

 

The invention relates to the pharmaceutical industry, and is intended for the prevention and adjunctive therapy in the treatment of diseases of the liver and biliary tract. A drug for prevention and adjunctive therapy in the treatment of diseases of the liver and biliary tract contains dry concentrate decoction of flowers of immortelle, dry concentrate of the extract of corn silk, crushed oats, dry concentrate infusions peppermint, dry concentrate decoction of the fruit of the barberry and the dry concentrate decoction of yarrow herb, citric acid, starch, calcium stearate and sugar, taken in a certain ratio. The drug is released in the form of tablets with a weight of 0.55, a Drug aimed at a comprehensive treatment of viral and bacterial infections, inflammatory processes in the liver and biliary tract. table 2.

The invention relates to pharmaceutical industry that manufactures drugs therapeutic and prophylactic purposes, and can be used for the prevention and adjuvant therapy of diseases of the liver and biliary tract.

Known application of extract of corn silk as cholagogue in holetsaticescoy M. D. Medicinal product. Kharkov. Torsing, 2 T., 1998, T. 1, S. 511].

The disadvantage of these drugs is the liquid form, the lack of therapeutic activity, small storage period.

Known drug "Hepatoma" /Pilate T. L. (ed) Federal register of biologically active additives to food. M, Kohelet, 2002, S. 292/, including honey and food processing plants: thick extracts of corn stigmas, immortelle, peppermint, chamomile. Used as a prophylactic and restorative agent for liver diseases and biliary tract. Available in the form of a thick gel.

The disadvantage of the drug is used in the form of a gel, a lack of therapeutic activity, short term storage, and also observed in individual patients, individual intolerance to some of the components of the drug.

Known drug "Fitopatologiya" /Pilate T. L. (ed) Federal register of biologically active additives to food. M, Kohelet, 2002, S. 284/, including food processing plants: dry concentrate decoction of immortelle, dry concentrate of the extract of corn silk, dry concentrate of the extract of burdock roots, crushed oats, as well as ascorbic acid, citric acid and spuskaetsa in pill form and is used as a preventive and aid in treatment of diseases of the liver and biliary tract.

A disadvantage of the known means is observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is to develop a new herbal remedies available with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases, convenient for use inside and with a long shelf life.

The invention is aimed at expanding Arsenal of drugs in complex treatment of viral and bacterial infections, inflammatory processes in the liver and biliary tract.

This result is achieved in that the drug for the prevention and adjuvant therapy of diseases of the liver and biliary tract, including dry concentrate decoction of flowers of immortelle, dry concentrate of the extract of corn silk, crushed oats, citric acid, starch, calcium stearate and sugar further comprises a dry concentrate infusions peppermint, dry concentrate decoction of the fruit of the barberry and the dry concentrate decoction of yarrow in the following ratio of ingredients in the tablet weight of 0.55 g, g:

dry concentrate is ntrat tincture of peppermint 0,000175-0,0014

dry concentrate decoction of the fruit of the barberry 0,0001-0,0008

dry concentrate decoction of yarrow 0,0001-0,0008

citric acid 0,0075-0,0600

oats crushed 0,0250-0,1000

starch 0,0250-0,1000

calcium stearate 0,0025-0,0200

sugar the rest

A drug for prevention and adjuvant therapy of diseases of the liver and biliary tract called "Phytochelatin".

The drug "Phytochelatin” has choleretic, anti-inflammatory, antimicrobial, antispasmodic, increases the secretion and the secretion of bile, normalize its chemical composition, removes dyspepsia, improves the digestive process.

The drug “Phytochelatin” is preventive and aid in treatment of acute and chronic diseases of the liver, cholangitis, cholecystitis, biliary dyskinesia.

Use the specified purpose combination previously used substances has become possible as a result of established more pronounced qualities, providing cholagogue, diaphoretic, diuretic, spasmolytic effect, leading to increased secretion of bile, promotes the discharge of small stones from the gall bladder.

Optimologist man know, but using them in a new composition and in small doses gives a new effect, allowing the use of biologically active additives as new pharmacological tools.

The invention is illustrated by the following example.

The sugar in the number of 78.5 kg and oats in the amount of 10.4 kg weighed, visually check for the presence of mineral and organic impurities, and then pulverized in the mill.

The output of powdered sugar to 77.7 kg

The output of crushed oats 10,3 kg

In enamel container for 15-20 l weighed on the scales 0,19 kg pre-powdered herb yarrow and 0.94 kg immortelle, pour 10,5 kg of water, incubated in a boiling water bath for 25 minutes, Cool 45 minutes, the broth is filtered, pressing plant material. Filtered through four layers of gauze.

The output of broth (2% dry) 7,5 kg

In enamel container 10 l weighed on the scales of 6.0 kg of broth and bring to a boil, prepare a suspension of 0.6 kg of starch and 1.5 kg of water, mix thoroughly and add to the boiling broth with constant stirring. The solution is brought to a boil.

The output of starch paste with 8.05 kg

In enamel container is weighed 1.87 kg pharmacopaea extract (4% dry) corn silk and 1.87 kg creations acid, then add 1.9 kg pharmacopaea syrup (6% dry) barberry and stirred for 10 minutes

Output 8,425 kg

Powdered sugar, oats, starch is sifted through a sieve with the hole diameter of 1 mm calcium Stearate is sifted through a sieve with the hole diameter of 0.5 mm, corn silk Extract and tincture of peppermint filtered through 4 layers of gauze.

In the mixer load to 77.7 kg powdered sugar, add 10,3 kg of crushed oats, 9.7 kg of starch, mix 10 minutes to Hydrate the mixture of corn silk extract, tincture of peppermint and syrup barberry 8,425 kg, stirred 10 min, then add the starch paste with 8.05 kg and stirred for 15 minutes

The product yield 114,175 kg

The wet mass in the number 114,175 kg load portions in the device for producing granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm Wet granules are collected in the receiver. From the receiver the wet granulate is passed for drying.

The output of granulate 114,175 kg

Hydrated tablets weight in the number 114,175 kg laid out on paper in the trays with a layer thickness of 1.5-2 cm and dried in a drying Cabinet at a temperature of 40-45

The dried pellet mixture in an amount of 102,06 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5 to 2.0 mm, the Dry granulate is collected in the receiver, from which the dry granules are loaded into the mixer, add 1,03 kg sieved calcium stearate. Include a stirrer and stirred for 10 minutes the Finished granulate is directed to tableting.

The tablet diameter of 12.0±0.3 mm;

the height of the tablets of 3.9±0.3 mm;

the average weight of the tablets 0.55 g ± 0,03.

During tabletting watching the machine work and quality tablets. Every 30 min check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for recycling. Tablets are collected in the receiver and sent to the dust.

The yield of 101.5 kg

The finished tablets are sieved by the vibrating screen through a hole 10 mm in diameter, weigh-in & m is control-analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets 100 kg.

The sequence of operations is the same regardless of the number of prepared composition.

A drug for prevention and adjuvant therapy of diseases of the liver and biliary tract "Phytochelatin" contains the famous authorized for use in medical practice medicines which are in the specified combination (see table.1, examples 1-4) provide for the reduction or disappearance of symptoms of biliary tract and liver.

Available in tablet form, which is convenient to use, has a long shelf life (2 years).

Clinical trials of the drug “Phytochelatin” was held in the city Advisory-territorial clinic of Moscow.

The study included 22 children with biliary dyskinesia (6 boys and 16 girls) aged 5 to 8 years.

During clinical testing for months due to a fractional power limitation mechanical and chemical food stimuli, fats patients of the experimental group was additionally administered the test drug is 1-3 tablets is Naya with 2-3 days after the start of the study, decreased the number of complaints of patients in the experimental group on the symptoms of diseases of the gallbladder and biliary tract, as dyspepsia, abdominal pain or discomfort in the abdomen. In the control group of a certain trend in the number of clinical signs of disease could not be detected.

In table.2 presents the number of cases of improvement of the second portion of bile in % relative to the first portion.

As a result of conducted research it can be concluded that use of the drug "Phytochelatin" contributed to the normalization of bile in patients. Since patients with chronic acalculous cholecystitis increased amount of bile, which has become transparent with alkaline reaction. In patients with biliary dyskinesia disappeared or became less pronounced intermittent secretion of bile, reduces its density.

Thus, the proposed drug "Phytochelatin" is a newly available drug with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases and biliary tract, easy to use NR is ACTICE and adjunctive therapy in the treatment of diseases of the liver and biliary tract, including dry concentrate decoction of flowers of immortelle, dry concentrate of the extract of corn silk, crushed oats, and citric acid, starch, calcium stearate and sugar, characterized in that it further comprises a dry concentrate infusions peppermint, dry concentrate decoction of the fruit of the barberry and the dry concentrate decoction of yarrow in the following ratio of ingredients in the tablet weight of 0.55 g, g:

Dry concentrate decoction of flowers of immortelle 0,0001-0,0008

Dry concentrate of the extract of corn silk is 0.0002-0,0016

Dry concentrate infusions peppermint 0,000175-0,0014

Dry concentrate decoction of the fruit of the barberry 0,0001-0,0008

Dry concentrate decoction of yarrow 0,0001-0,0008

Citric acid 0,0075-0,0600

Oats crushed 0,0250-0,1000

Starch 0,0250-0,1000

Calcium stearate 0,0025-0,0200

Sugar The Rest