Cosmetic based equioment sturgeon caviar or on the basis of equioment salmon roe, or on the basis of the set of equioment caviar of sturgeon and salmon (options)

 

(57) Abstract:

Group of inventions relates to biology, medicine and cosmetology. Space tool includes the active principle, pharmaceutically acceptable solvent and at least stabilizer. As active principle it contains equioment sturgeon caviar. And natural vegetable oils, essential oils, and optionally a fatty acid and-carotene. As natural vegetable oils it contains oil - grape, milk Thistle, as essential oils - oil of peppermint, geranium, lavender, monarda fistular, tea tree, as fatty acids - vitamin F - polyunsaturated fatty acids of marine origin and as a pharmaceutically acceptable solvent is distilled water. Cosmetic includes the active principle and a pharmaceutically acceptable solvent. As active principle it contains equioment salmon ROE. It also contains oils - castor, milk Thistle, oil of cloves, peppermint, bergamot, lavender, myrrh, monarda, Jasmine and fatty acid - vitamin F - polyunsaturated fatty acids of marine origin. Additionally it contains VI is farmacevtichesky acceptable solvent. As active principle, it contains a set of equioment caviar of sturgeon and salmon. And vegetable oil is castor oil, jojoba, sesame and milk Thistle, essential oils of lavender, Clary sage, myrrh, Jasmine, ylang-ylang, Basil. Additionally it contains a fatty acid - vitamin F - polyunsaturated fatty acids of marine origin, -carotene and grape seed oil. The invention improves the cosmetic efficacy of the products. 3 ad and 1 C.p. f-crystals.

Group of inventions relates to biology, medicine and cosmetology and may find application in the manufacture of medicinal and cosmetic external funds type of gels, balms, creams and lotions for the treatment and care of the problem and aging skin, as well as to stimulate cellular respiration and regeneration of the skin, strengthening its protective functions to adverse environmental factors.

In recent years in cosmetology significantly increased interest in biologically active substances on the basis of semen of animals and fish ROE. They possess a broad spectrum of activity, biocompatibility and complete by being of the body. The use of this class of substances has allowed us to create a new napravlenie.

Known cosmetic for skin care containing inactivated sperm cock, polyethylene oxide gel and as biologically active additives - sea buckthorn or fir oil, propolis extract (patent RF №2085185 MKI7A 61 K 7/42, publishing, 1997). The tool allows you to effectively work on the mechanism of aging and slow down the process of extinction of the mitotic activity of basal cells.

Widely known for the various funds based on seafood, which are non-toxic, have no irritant action on the skin, does not cause allergies.

To biologically active substances derived from seafood, refers chitosan is a polysaccharide preparation from crab shells; collagenase - proteolytic enzyme from the liver crabs; mussel extracts - carbohydrate-protein complex from the meat of the mussels. Chitosan and its derivatives are used in cosmetics as a gel, moisturizer and foaming agent. It is used in creams, shampoos, shower gels, gel toothpastes, styling and perming hair and lotions (Abdulov A. I., Frolov, M. A., Pilipino E. A. M. Properties of raw seafood for cosmetic PR, page 13). When using chitosan into cosmetics important feature is its adsorption, which is strongly dependent on pH and related substances, which leads to higher product.

Mussel extract contains a set of essential amino acids, melanoidins, biogenic macro - and trace minerals, a large number of unsaturated fatty acids and vitamins b and D. It is used in the composition of sunscreen creams and other dermatological compositions, while also reducing the negative effects of ultraviolet rays. However, mussel extract has no reducing action on the dermis.

Known cosmetic product on the basis of animal semen, including fish ROE (France application No. 2511243, And 61 For 7/40, publication 1983). This tool is made in the form of day and night creams, gels, lotions and lotions. Use salmon ROE, which are dezoksiribonukleinovoy acid and other components that have regenerating and light shielding effect on the skin.

Known cosmetic product, in which the active ingredient is DNA (deoxyribonucleic acid) from marine organisms (I. Nordby, O. Bø the magazine “Raw materials and packaging” No. 5 (24), publishing 2000, p. l2).

One of the richest sources of DNA is fish eggs. DNA extracted from fish eggs, as a rule transferred to the sodium salt, which contributes to its better solubility. DNA showed itself in cosmetics as a means of non-toxic, not having irritating, does not cause allergies.

Removing individual components from salmon caviar and sturgeon leads to reduction of total biological activity associated with incomplete use of the whole complex of biologically active substances in the product, as well as a large waste production, which leads to higher production of bioactive substances.

It is also known active principle and cosmetic products based on it (see patent RU NO. 2141310, MPK a 61 K 7/48, publ. 1999). This invention is the closest and is selected as a prototype. As a cosmetic active principle is proposed for use natural complex collagenolytic proteinases isolated from the digestive organs of the animals. In one embodiment, the cosmetic contains collagenolytic complex, stabilizer, perfume, surfactant ventvisors substances, isolated from the digestive organs of crustaceans, molluscs, echinoderms and coelenterates. Cosmetic product is designed to cleanse and nourish aging skin because it stimulates the metabolic processes.

Known cosmetic products when exposed to the skin effectively clean her improve her nutrition, appearance, and oseltamivir are effective on aging and problem skin, have a weak regenerating properties.

The above tool does not have a vessel restorative effect and bactericidal effect, and have a low anti-inflammatory effect due to the shallow penetration into the skin.

The basis of the invention the task is to expand the range of bio-complexes with active beginning to create new cosmetics and external medical devices and to improve anti-aging, hygienic and therapeutic effect due to the combination of high spots, anti-inflammatory and antibacterial effect, moisturizing and healing effect due to the deep penetration into the skin, without the provision of irritant and allergic effects, and reduce the cost of obtaining biologically active components from salmon caviar and sturgeon nagtungo beginning cosmetics applied equioment of salmon caviar and sturgeon the seafood.

The above result is achieved by the use equioment of salmon caviar and sturgeon fish - seafood as an active start to the outer health and beauty products, exhibiting anti-inflammatory and antibacterial properties, moisturizing and healing effect.

The problem is solved also by the fact that cosmetic product comprising the active principle, pharmaceutically acceptable solvent, stabilizer, as active principle contains equioment sturgeon caviar, or equioment salmon ROE, or a complex of equioment caviar of sturgeon and salmon, as a dietary Supplement, natural vegetable oils, essential oils, and optionally a fatty acid and-carotene.

To create a regenerating balm cosmetic product comprising the active principle, pharmaceutically acceptable solvent and at least stabilizer, as active principle contains equioment sturgeon caviar, and as a dietary Supplement natural vegetable oils, essential oils, and optionally a fatty acid and-carotene, and as a natural lavender, monardi fistular, tea tree, as fatty acids - vitamin F - polyunsaturated fatty acids of marine origin and as a pharmaceutically acceptable solvent is distilled water in the following ratio, wt.%:

Equioment sturgeon caviar 5-35

Grape 0,5-1,5

Milk Thistle oil 0,2-1,5

Essential oil of peppermint 0.1 to 1.5

Essential oil of geranium 0,2-1,5

Essential oil of lavender 0,2-2,5

Essential oil of monarda fistular 0,1-1,2

Essential oil tea tree 0,5-3

Vitamin F - polyunsaturated fatty

acids of marine origin 0,5-2

-carotene 0,001-0,01

The stabilizer 55-85

Distilled water the Rest

To create oil balm for intensive skin care bust cosmetic product comprising the active principle, pharmaceutically acceptable solvent and at least stabilizer, comprises as active principle equioment salmon ROE, as natural vegetable oils - castor oil and milk Thistle, as essential oils - oil of cloves, peppermint, bergamot is descent, as well as vitamin E - tocopherol acetate, -carotene, as a pharmaceutically acceptable solvent - oil grape in the following ratio, wt.%:

Equioment salmon ROE of 0.5-35

Castor oil 5-35

Milk Thistle oil 5-20

Essential oil of clove 1-5

Essential oil of peppermint 1-5

Essential oil of bergamot 0,5-3,5

Essential oil of lavender 1-5

Essential oil of myrrh 0.5 to 4.5

Essential oil of monarda fistular 0,5-5,0

Essential oil of Jasmine 0,5-5,0

Vitamin F - polyunsaturated fatty acids of marine origin 5-35

Vitamin E - tocopherol acetate 0,03-3,5

-carotene is 0.0001 to 0.1

Grape Rest

To create ultraleecher oil balm for intensive skin care eye cosmetic product comprising the active principle, pharmaceutically acceptable solvent and at least stabilizer, comprises as active principle complex equioment caviar of sturgeon and salmon, as a natural vegetable oil is castor oil, jojoba, sesame and milk Thistle, as essential oil-is F - polyunsaturated fatty acids of marine origin, and (-carotene and as a pharmaceutically acceptable solvent - grape oil in the following ratio, wt.%:

Complex equioment caviar of sturgeon and salmon 1,2-25

Castor oil 10-50

Jojoba oil 5-50

Sesame oil 5-50

Milk Thistle oil 2-25

Essential oil lavender 0.5 to 5

Essential oil Clary sage 2-5

Essential oil of myrrh 0,5-5

Essential oil of Jasmine is 0.5-5

Essential oil ylang-ylang 1.5-5

Essential oil of Basil 0,1-3,5

Vitamin F - polyunsaturated fatty acids of marine origin 1,5-25

-caroteneof 0.0001 to 0.01

Grape Rest

Cosmetic as the emulsion stabilizer comprises a base MIRRA No. 1” for cosmetic products manufactured by CJSC “MIRRA-M - self ingredient with the sanitary-epidemiological conclusion of the State sanitary-epidemiological service of the Russian Federation on compliance with the state rules and regulations and the Certificate of conformity of Gosstandart of the Russian Federation. One of the options on ride distilled, glycerin is distilled, stearate PEG-400, fatty alcohols, Katon, sodium hydroxide. In another embodiment, as an emulsifier cosmetic product contains, at least, beeswax, wax emulsion and stearin. As the pharmaceutically acceptable solvent cosmetic product contains 2-10% ethyl alcohol or distilled water.

The division of components into functional groups: stabilizers, biologically active additives and emulsifiers may be conditional, as of a specific combination of components cosmetic products, their ratio and destination depends on the priority of one or another of the pledged ingredients properties.

Part of equioment of salmon caviar and sturgeon includes a unique complex of biologically active compounds: proteins and amino acids, lipids (including phospholipids), vitamins, micro-and macroelements in a natural balanced proportions.

Equioment of salmon caviar and sturgeon fish is an ingredient that is made before the preparation of finished cosmetic products.

Homogenization of salmon caviar and sturgeon to obtain equioment is multistore).

Conditions of homogenization:

1. The dispersion medium is an isotonic solution of sodium chloride in distilled water.

2. The temperature of the room.

3. the pH of the finished equioment - 6,5-7,5 (supported, if necessary, the introduction of organic acids).

Specific examples of the invention presented below. Presents examples is not limited to the list of possible derived cosmetics.

Example 1. Regenerating “Mind-Balm”.

“Mind Balm contains active origin equioment sturgeon caviar and has the following composition, wt.%:

Equioment sturgeon caviar 20

Essential oil tea tree 1,5

Vitamin F - polyunsaturated fatty acids 0,66

Grape 0,6

Essential oil of lavender 0,45

Milk Thistle oil 0,34

Essential oil of geranium 0,3

Essential oil of monarda fistular 0,15

Essential oil of peppermint 0,09

-carotene 0,0021

Stabilisator 70

Distilled water the Rest

As a stabilizer balm contains emulsion base Mirra No. 1”.

Regeneris the pleasant natural smell with the aroma of essential oils. “Mind-balm has a strong nourishing, vessel restorative effect, bactericidal and anti-inflammatory effect.

Due to the presence concentrate nucleic acids sturgeon caviar, the drug enhances natural immunity, gives a powerful impetus to anti-aging processes in the skin, visibly improves skin tone, increases turgor. Also has moisturizing, healing and light bleaching effect. It should be noted property beneficial effect of the balm on dry and oily skin. When oily skin is accelerated normalization of lipid, water exchanges, then the restriction. If you have dry skin, improves tone, firmness, resolve seals. After a cycle of balm water content in the skin was increased by 15% from baseline.

Example 2. Cosmetic DERMIS BUST/ Stable microemulsion of equioment salmon ROE in oil-based - has the following composition, wt.%:

Equioment salmon ROE 1,2

Vitamin F - polyunsaturated fatty acids 18

Castor oil 10

Milk Thistle oil 9,7

Essential oil 3 cloves

Essential oil Laban who IRRI 1,2

Essential oil of Jasmine 0,9

Essential oil of monarda fistular 0,15

Vitamin E (tocopherol acetate) 0,03

-carotene 0,0001

Grape Rest

Cosmetic DERMIS BUST is ultraclean oil balm and is designed for special intensive care of the skin of the bust. The finest emulsion provides deep penetration into the skin tissue of the bust useful active components, essential for normal functioning of skin cells. Improves cellular respiration, relieves irritation, leaves skin smooth, smooth, velvety. The balm has a moisturizing effect, so it is especially suitable for the care of very dry and has a tendency to dry the skin, but also to care for aging skin, body and bust.

Example 3. Cosmetic EYE CONTOUR BAND/ Stable microemulsion complex equioment of salmon caviar and sturgeon fish in oil-based includes the following components, wt%:

Complex equioment caviar of sturgeon and salmon 1,6

Castor oil 20

Jojoba oil 10

Sesame oil 10

Essential oil Shal the polyunsaturated fatty acids 2,35

Essential oil of Jasmine 1,5

Essential oil of lavender 1,5

Essential oil of myrrh 1,5

Essential oil of Basil 0,4

-carotene 0,0001

Grape Rest

Cosmetic Eye contour bandage is ultraclean oil balm and is designed for intensive skin care age. “Eye contour-bandage provides General conitinues action, plumping the skin around the eyes, stimulate the circulation in the capillaries, improves metabolic processes, the turgor of the skin, prevents the appearance of bags, dark circles under the eyes, relieves fatigue, strengthens the immune properties of the skin. Due to the active nutrients, accelerating the cell renewal of the skin, restores the skin's ability to camouflagenew.

Example 4. Cream mask “MIND” for intensive skin care face and neck includes the following components, wt%:

Equioment sturgeon caviar 20

Grape 1,2

Milk Thistle oil 0,33

Essential oil of peppermint 0,09

Essential oil of geranium 0,3

Essential oil of lavender0,45

Essential oil of monarda fistular 0,15

Oil essential P>-carotene 0,0021

The stabilizer 70

Distilled water the Rest

Cream mask “Mind” has a fine soft texture, pleasant fragrance of essential oils, gentle color. Recommended for use in beauty salons at the stage of intensive care after cleaning your face, or aging skin.

From the above examples is visible versatility active start - equioment caviar of sturgeon and salmon, the invaluable effect of cosmetics active start to the skin.

Clinical and other tests.

The experiment consisted in the fact that mow from wool right side of the rat, the size of 2,02,0 cm was applied study medication in the amount of 0.5 g for a certain period. The control were intact animals, which as experienced were the standard mode of the vivarium. The evaluation time steps cosmetic preparation is common and due to the fact that, on the one hand, during this period most often manifests itself irritant and allergenic effect, and on the other hand, the biochemical processes in the skin subjected to correction under the action of the cutaneous applications of cosmetic products, as a rule, reach the effective action of the cosmetic preparation.

By the end of this period the animals were killed according to the rules of euthanasia of laboratory animals, approved by the Russian Ministry of health and for experimental studies, we took biopsies of the skin, to which was applied a study the drug.

Was determined by the following indicators: anti-inflammatory effect by the method of F. P. of Trinos with co., spots (moisturizing) action method of drying the skin S. J. Kaplanskaya, the lipids in the skin produced by the method Huergo et al., the protein according to the method of D. Bailey et al.

The results of these studies showed that chronic cutaneous (30 applications) application of regenerative “Mind-balm, stable microemulsions homogenate salmon ROE in oil-based the Dermis bust”, stable microemulsions homogenate salmon ROE in oil-based Eye contour-band”, cream-mask “Mind” production company “Mirra-M (Russia) revealed no General toxic, irritant and allergic effects on the animal skin, skin, hair, appetite, behavioral reactions; weight gain in the experimental animals did not differ from control.

Clinical trials cosmetices what type of skin, and with signs of peeling, excessive dryness of the skin and low elasticity. The term clinical research was not less than four weeks from the definition of the indicator hidratantes skin before and after applying cosmetics. This study was carried out on skin analyzer “Gebrauchsanweisung Skin Analyzer Softline” (Germany). The clinical status of probando was estimated with the frequency of monitoring once a week.

At the first stage, before clinical testing, the skin of the forearm probando were delivered to the skin tests. In any case, signs of irritation were noted.

Specialists dermatology, conducted clinical trials, as well as by the subjects, it was noted that cosmetics on the basis of equioment caviar of sturgeon and salmon convenient in practical application, including under makeup. They are made with modern technology and raw material level with the use of such biologically active substances, such as beta-carotene, natural vegetable oils, vitamin F - polyunsaturated fatty acids of marine origin essential oils, herbal extracts, and equioment of salmon caviar and OS the structure and active regeneration.

An objective assessment of the degree of hidratantes skin showed that after cycle for cosmetic use on the basis of equioment caviar water content increased on average by 15% from baseline, and this was reflected in her appearance.

1. Cosmetic based equioment caviar of sturgeon fishes, including the active principle, pharmaceutically acceptable solvent and at least stabilizer, characterized in that it as the active agent contains equioment sturgeon caviar, and natural vegetable oils, essential oils, and optionally a fatty acid and-carotene, and as natural vegetable oils - oil of grape and milk Thistle, as essential oils - oil of peppermint, geranium, lavender, monarda fistular, tea tree, as fatty acids, vitamin F - polyunsaturated fatty acids of marine origin and as a pharmaceutically acceptable solvent is distilled water in the following ratio, wt.%:

Equioment sturgeon caviar 5-35

Grape 0,5-1,5

Milk Thistle oil 0,2-1,5

Essential oil of peppermint 0.1 to 1.5

Essential oil tea tree 0,5-3

Vitamin F - polyunsaturated fatty

acids of marine origin 0,5-2

-carotene 0,001-0,01

The stabilizer 55-85

Distilled water the Rest

2. Cosmetic under item 1, characterized in that as it contains a stabilizer emulsion base Mirra No. 1” for cosmetic products.

3. Cosmetic based equioment salmon ROE, including the active principle, pharmaceutically acceptable solvent, characterized in that it comprises as active principle equioment salmon ROE, and vegetable oils - castor oil and milk Thistle and essential oils - oil of cloves, peppermint, bergamot, lavender, myrrh, monarda, Jasmine, vitamin F - polyunsaturated fatty acids of marine origin, as well as vitamin E - tocopherol acetate, -carotene, as a pharmaceutically acceptable solvent - oil grape in the following ratio, wt.%:

Equioment salmon ROE of 0.5-35

Castor oil 5-35

Milk Thistle oil 5-20

Essential oil of clove 1-5

Oil of eficacia essential myrrh 0.5 to 4.5

Essential oil of monarda fistular 0,5-5,0

Essential oil of Jasmine 0,5-5,0

Vitamin F - polyunsaturated fatty

acids of marine origin 5-35

Vitamin E tocopherol acetate 0,03-3,5

-carotene is 0.0001 to 0.1

Grape Rest

4. Cosmetic based equioment caviar of sturgeon and salmon, including the active principle, pharmaceutically acceptable solvent, characterized in that it comprises as active principle complex equioment caviar of sturgeon and salmon, and vegetable oil is castor oil, jojoba, sesame and milk Thistle, and essential oils of lavender, Clary sage, myrrh, Jasmine, ylang-ylang, Basil, vitamin F - polyunsaturated fatty acids of marine origin, and-carotene and as a pharmaceutically acceptable solvent - grape oil in the following ratio, wt.%:

Complex equioment caviar

sturgeon and salmon 1,2-25

Castor oil 10-50

Jojoba oil 5-50

Sesame oil 5-50

Milk Thistle oil 2-25

Essential oil lavender 0.5 to 5

Oil e is P>Essential oil ylang-ylang 1,5-5

Essential oil of Basil 0,1-3,5

Vitamin F - polyunsaturated

fatty acids marine

origin of 1.5-25

-carotene is 0.0001 to 0.01

Grape Rest

 

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