A method of treating cardiovascular disease in patients with erosive and ulcerative lesions esophagogastroduodenal zone

 

(57) Abstract:

The invention relates to medicine and can be used in cardiology and gastroenterology. For the treatment of comorbidity suggest the use of anti-ulcer drugs together with askolong. After a month in the absence of erosive and ulcerative mucosal defects continue treatment askolong one or two records per day in the form of appliques on the gum for a long period of time. In addition, ASColor may be administered in combination with antianginal and other cardiovascular drugs. The method provides a reduction of possible scarring of erosive and ulcerative changes in the mucous membrane of the gastroduodenal zone along with the anti-ischemic effect by improving microcirculation in the tissues. 1 C.p. f-crystals.

The invention relates to methods for treating cardiovascular diseases by the use of drugs containing acetylsalicylic acid, and can be used in cardiology and neurology, and gastroenterology. Especially important is the invention has for an effective treatment of cardiovascular diseases in patients with erosive and ulcerative lesions of esophagogastric ofgastrointestinal zone (AGZ), account for more than half of all patients with combined pathology of internal organs. The incidence of coronary heart disease gastric ulcer and 12 duodenal ulcer in recent years has increased significantly.

In cardiovascular diseases, including the most common form of CHD, there is a high risk of arterial thrombosis. Along with this, about half of the cases of erosive and ulcerative changes in the mucous EGGS due to circulatory disturbances in the system of the abdominal arteries.

In this regard, treatment of these diseases requires the use of drugs normalizing hemorheological parameters, first of all, antiplatelet agents, among which are the drug of choice is acetylsalicylic acid (ASA). Unfortunately, traditional tablets, including enteric-soluble form of the ASC, is contraindicated in gastric ulcer and 12 duodenal ulcer and even in case of its absence can cause stomach and intestinal bleeding due to the irritant action.

Known means for reducing platelet aggregation in the blood, including acetylsalicylic acid, mobilisierung on the polymer-carrier (patent RF № 209 contains 12.5 mg of acetylsalicylic acid.

There is a method of treatment of patients with erosive and ulcerative lesions esophagogastroduodenal areas that have cardiovascular disease, through laser therapy, aimed at improving the mucosal microcirculation in this area by reducing blood viscosity, stabilization of the vascular wall and increase the amount of blood oxygen (newsletter of the Department of health of Moscow “peculiarities of clinical course and treatment of peptic ulcer disease in persons with coronary heart disease”, M., 1995. C. 4).

The restrictions on the use of this method is its high cost and low availability of special equipment for the General population.

Closest to the invention is a method of treating cardiovascular disease in patients with concomitant erosive-ulcerative lesions esophagogastroduodenal zone by use of drugs, improves microcirculation and prevent the development of thrombosis, such as trental, dipyridamole prescribed in combination with anti-ulcer and cardiovascular drugs (newsletter of the Department of health of Moscow “clinical Features of the flow the way may develop serious side effects of the above drugs. So, dipyridamole and trental is contraindicated in patients with ischemic heart disease because of the possibility of the emergence of “syndrome victimize”.

The aim of the invention is to increase the effectiveness of treatment through the use of new dosage forms of askolong. In it a small amount ASC has antiplatelet effect, acting in the bloodstream through the oral mucosa without direct contact with the mucous of esophagus and stomach and duodenum 12. If the ASC does not cause damaging effects on the mucous membranes of the gastrointestinal tract.

This objective is achieved in that in the method of treating cardiovascular disease in patients with erosive and ulcerative lesions esophagogastroduodenal zone, including the use of drugs, improves microcirculation and prevent the development of thrombosis, use of ASColor. After the course of askolong in combination with antiulcer drugs are esophagogastroduodenoscopy and, in the absence of erosive and ulcerative lesions, continue treatment askolong. His appoint one record per day in the form of application to the gums. In addition, ASColor may be administered in combination with antianginal and each is="ptx2">

Before treatment, all patients with cardiovascular disease requiring medication, improves microcirculation and prevent the development of thrombosis, perform esophagogastroduodenoscopy.

This study allows to determine the presence of erosive or ulcerative mucosal changes and the degree of infection by the bacterium Helicobacter pylori.

In case of erosive and ulcerative changes in the mucous membrane, according to the proposed method, the drug ASColor administered in combination with anti-ulcer therapy.

The nature of antiulcer therapy depends on the degree of detected infection of Helicobacter pylori. After 1 month of treatment control esophagogastroduodenoscopy. In the absence of erosive or ulcerative mucosal changes antiulcer therapy cancel and continue the treatment askolong.

Monitoring the status of the gastroduodenal carry out at least 1 time in 3 months.

The choice and conduct of anti-ulcer therapy is carried out by the following method.

1. In the presence of infection Helicobacter pylori is applied "triple therapy" (two antibiotics - clarithromycin, amoxicillin in combination with Inga is tsya controlling esophagogastroduodenoscopy.

2. In case of repeated detection of Helicobacter pylori is "quadrature, including preparations containing bismuth and metronidazole (1. Proton pump inhibitors 2. Antibiotics: klacid, formamid, tetracycline 3. Metronidazole 4. Bismuth).

Example

Examined 82 patients with cardiovascular diseases, including 45 people with the presence of erosive and ulcerative changes in EGGS, 25 people with the absence of such changes, and 12 patients with refluxgastroesophageal disease.

Patients underwent esophagogastroduodenoscopy baseline, after 1, 2 and 3 months of treatment by the proposed method. The study was conducted randomized, placebo-controlled manner.

ASColor applied in combination with standard anti-ulcer therapy has a positive effect on the time of healing of erosive or ulcerative changes. Subsequent treatment with one askolong on leads to negative changes in the mucous membrane of the esophagus, stomach and duodenum 12 due to caused by this drug, improvement of microcirculation.

Platelet aggregation was decreased by 30-37%.

The combination of askolong with an is attained not only ischemic but the antiplatelet effect.

1. A method of treating cardiovascular disease in patients with concomitant erosive-ulcerative lesions esophagogastroduodenal zone, consisting in the use of drugs, improves microcirculation and prevent the development of thrombosis, appointed at the initial stage of their use in combination with antiulcer drugs, characterized in that the quality of the drug, improve microcirculation and prevent the development of thrombosis, use of ASColor, and one month after the appointment of askolong in combination with antiulcer drugs are esophagogastroduodenoscopy and in the absence of erosive and ulcerative lesions prescribe long-term treatment askolong one or two records per day in the form of application to the gums.

2. A method of treating cardiovascular disease in patients with erosive and ulcerative lesions esophagogastroduodenal zone under item 1, characterized in that ASColor administered in combination with antianginal and other cardiovascular drugs.

 

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