Solid mix used for fire - proof transport

 

(57) Abstract:

Proposed: a solid mixture, intended for fire - proof transportation, it is a (4+x) wt.% nitroglycerin and (96-x) wt.% anhydrous lactose, calculated on the mixture of nitroglycerin and anhydrous lactose, where x represents a value from 0 to 9, in the particular case - 13 wt.% nitroglycerin and 87 wt.% anhydrous lactose. The invention allows to carry out international transport of this mixture not only road, rail, sea, and air transport due to the fact that this mixture is not classified as explosive. 2 C.p. f-crystals.

This invention relates to mixtures intended for transportation, in particular to the solid mixture, intended for fire - proof transportation.

Nitroglycerin (glyceryl trinitrate, propantriol-1,2,3-trinitrate) is a well-known liquid nitroethyl widely used as the active active ingredient in many medicines for the treatment of coronary vessels, which can be used in the form of fast-acting dosage forms for emergency cases, so the trated protect against strokes.

Depending on the composition of drugs used in the field of coronary therapy, such as oral, dermal or parenteral application, the possibility to use nitroglycerin in the manufacture of pharmaceuticals is a constant production problem. Nitroglycerin is an active substance with a high explosive ability, it can be used to transport only a phlegmatized (i.e. containing inert fillers and safe in the treatment of concentrates or final bulk drug, which can only be made with appropriate inert material carriers as excipients, which are selected in accordance with the special physico-chemical properties of nitroglycerin and are the subject of many books monographs on drugs.

Different types of drugs that contain nitroglycerin, require different types of excipients for admission nitroglycerin in the body in order to get the products, which themselves in extreme conditions, such as when exposed to fire, b is the transportation and end use.

Needs practice contributed to the development of mainly two different groups phlegmatized concentrates, which are commercial and are used as a pre-mixture for further processing.

Group a: Form of nitroglycerin in liquid excipients, such as alcohols, medium chain triglycerides, vegetable or synthetic oils, organic solvents, organic polymers (solutions, dispersions).

Group b: Form of nitroglycerin in solid excipients, such as sugars and polysaccharides, cellulose and its derivatives, polymeric materials, inorganic excipients.

Among the substances belonging to the group In that particular commercial interest are solid concentrates nitroglycerin in sugars, such as lactose, are widely used as pharmaceutical intermediate products for the production of, for example, tablets, capsules, ointments or patches.

Great value for the issuance of national and/or international transport authorities transport permits are the test results on the security and safety characteristics of substances, derived from national and/istii with regulatory requirements according to the standards Accord relatif au transport international des marchandises dangereuses par route (ADR, European Convention on the international transport of dangerous goods on land), internationale concernant le transport des marchandises dangereuses par chemin de fer (RID, international rules on the transport of dangerous goods by rail), International Air Transport Association (IATA), the international Association for the development of regulations on the transport of dangerous goods by air), Intergovernmental Maritime Consultative Organization (IMCO intergovernmental organization for the development of regulations on the transport of dangerous goods by sea transport), with the instructions of the UN and instructions for carrying out prescribed tests.

For the classification of a substance as an explosive or non-explosive substances are of great importance, the results of certain tests conducted to determine the following parameters:

thermal sensitivity at inclusion according to Koenen-Test; Reference tests UNPO, series 2 (b), “Koenen-Test”;

- detonation ability under 2"-steel test tube; Reference tests UN test And series A1, YOU 50/60 steel tube”;

- sensitivity to impact under test free-falling hammer; Reference tests UN test 3 (a), (i) “YOU - free falling hammer”;

- sensitivity to friction with the I sensitivity under test external fire bonfire-test” (test fire) with the use of containers for storage and transportation; Reference tests UN, external fire (bonfire)test series 6 (C).

For each test specified limit values, which must not be exceeded for non-explosive substances. But if the limit value, at least in one test, for example, when “Koenen-Test” and/or “bonfire-test” is exceeded, then the material is classified as an explosive substance. Non-explosive substances shall be necessary in the subsequent classification as dangerous goods, for example, class 3 (flammable substances), class 4.1 (flammable solids) or class 6 (poisonous substances).

Usually found in trade standard bulk form of nitroglycerin with solid excipients is a mixture of solids containing about 10 wt.% nitroglycerin (C3H5N3O9in 90 wt.% monohydrate lactose (C12H22O11x 1 N2O). This form was investigated in accordance with the above control program. If the results of the tests Koenen-Test”, “Steel tube-Test”, “YOU Fallhammer Test” and “YOU-friction apparatus-Test were below the limit, the test bonfire test” led to strong explosions. For example, casks for transport and storage, containing 50 kg (net) solid mixture from either the ene bags, has been for a long time an open flame, while regularly after 45 minutes there was a strong explosion.

For this reason, occurring in trade standard bulk form, comprising from about 10 wt.% nitroglycerin and 90 wt.% monohydrate lactose, classified national and international transport bodies as explosives of class 1.1 D. Production, storage and in particular transport activity so related legislative restrictive measures that the transportation of such material in international transport is excluded. So, for this material there is a General ban on air transport, transportation road, rail and sea transport can be realized only as the transportation of explosives. There are restrictions on the number of individual units and the total number of goods; transport costs are very high for each of the transit transport requires separate permit; depending on the recipient country must meet additional specific requirements for buildings (warehouse, manufacturing) and facilities for further processing; requires specially trained personnel and availability of STV, for example, finely ground (dispersion) of silicon dioxide (Aerosil), alkaline or alkaline earth carbonates, bicarbonates, hydroxides or oxides (U.S. patent US-A-428378; European patent application EP-A-0104877), does not affect the results of the relevant test on thermal sensitivity, for example, the test box of sheet steel, and can not prevent the explosion.

The objective of the invention is the provision of a solid mixture containing nitroglycerin, which has high thermal stability for transportation, eliminating the risk of explosion, allowing this mixture cannot be classified as an explosive substance.

The problem is solved by a solid mixture, intended for fire - proof transportation containing nitroglycerin and anhydrous lactose.

Studies of the reactions taking place during the explosion in “bonfire-test, were carried out using thermogravimetric analysis (TGA) showed that the monohydrate lactose, which is used as excipient for adsorption of nitroglycerin in known solid mixes, releases at elevated temperatures its crystalline water in the temperature range from 100 to 150C with subsequent PLA is Eski insoluble in water, washed off the released water (steam/condensate) from the surface of the crystal monohydrate lactose and separated. In this regard, changes the security status fully phlegmatized before that at ambient temperature the solid mixture. Through migration and enrichment nitroglycerin liquid phase mixture turns into a high explosive, exploding in the “bonfire-test”. These results are supported and documented subsequent examinations of the explosion and fragments of wreckage.

In contrast, studies of solid mixtures according to the invention, containing more than or equal to 10 wt.% nitroglycerin with an appropriate amount of anhydrous lactose, give all the above tests values that are below their respective limit values. And when conducting Brand-test for Flammability) solid mixture of the invention under examination does not lead to explosions.

A series of experiments to study thermal sensitivity showed that the used range thermal safety (Flammability) allows to increase the share of nitroglycerin above 10 wt.% with the appropriate amount of anhydrous lactose.

Offer tordu is Ino served dry anhydrous lactose according to the European standards, American or Japanese Pharmacopoeia (EP, USP, JP) and in terms of mixing serves pure nitroglycerin special (suitable for these purposes) of the dosing device. The mixture after feeding for a long period of not less than two hours, mix. Thus obtained homogeneous pounded solid mixture of nitroglycerin in anhydrous lactose Packed in fibre drums, lined inside with plastic bags, and store in a dry place at room temperature.

The solid mixture according to the invention, containing nitroglycerin and anhydrous lactose, should not be classified as an explosive substance according to the above standards for ADR, RID, IATA, IMCO and/or the UN. Therefore, it should be considered explosion-proof material.

According to a preferred form of execution of the present invention offer a solid mixture comprises a mixture of (4+x) wt.%, in particular, 13 wt.%, nitroglycerin and (96-x) wt.%, in particular 87 wt.%, anhydrous lactose, calculated on the mixture of nitroglycerin and anhydrous lactose, where x represents a value from 0 to 9, mostly 4, 6 or 8.

The invention is illustrated by the following examples.

Example 1

In conventional m the project of suitable dosing devices add 0.6 kg of nitroglycerin. The resulting mixture is stirred for 3 hours. Get a homogeneous solid mixture containing 4 wt.% nitroglycerin and 96 wt.% anhydrous lactose.

Example 2

Repeat example 1 with the only difference that the use of 13.05 kg dry anhydrous lactose and 1.95 kg of nitroglycerin. Get a homogeneous solid mixture containing 13 wt.% nitroglycerin and 87 wt.% anhydrous lactose.

Example 3

Repeat example 1 with the only difference that the use of 1.26 kg of dry anhydrous lactose and 0.24 kg of nitroglycerin. Get a homogeneous solid mixture containing 16 wt.% nitroglycerin and 84 wt.% anhydrous lactose.

Example 4

Repeat example 1 with the only difference that they use 13,80 kg dry anhydrous lactose and 1.20 kg of nitroglycerin. Get a homogeneous solid mixture containing 8 wt.% nitroglycerin and 92 wt.% anhydrous lactose.

Study of solid mixtures according to examples 1 to 4 given in all the above tests values that are below the relevant limit values, as well as for making Brand-test for Flammability) these mixtures do not cause explosions.

In addition, studies to determine the LD 50 acute oral toxicity and acute dermaline order more than 2000 mg/kg Therefore, on the basis of the above, you do not want to classify this material as belonging to the class 6 (toxic).

1. Solid mix used for fire - proof transportation containing nitroglycerin and anhydrous lactose.

2. A solid mixture under item 1, characterized in that it comprises a mixture of (4+x) wt.% nitroglycerin and (96-x) wt.% anhydrous lactose, calculated on the mixture of nitroglycerin and anhydrous lactose, where x represents a value from 0 to 9, mostly 4, 6 or 8.

3. A solid mixture under item 1 or 2, characterized in that it contains 13 wt.% nitroglycerin and 87 wt.% anhydrous lactose, calculated on the mixture of nitroglycerin and anhydrous lactose.

 

Same patents:

The invention relates to the technology of application of preventive antipremerskih funds, the preparation of carbon materials for transportation and can be used to reduce the freezing petroleum coke
The invention relates to materials (paronite) and various gaskets of them, intended for use in sealing the knots with flat sealing surfaces during operation of which the material is subjected to alternating thermal and mechanical loads - periodic compressions, heating, etc
The invention relates to the technology for a variety of adhesive compositions (adhesives, sealants, compounds, compositions for coating), which are magnetic and can be widely used in electronic and electronic industry, engineering, aviation, construction, manufacturing and repair of household appliances

The invention relates to the oil industry and can be used to prevent the formation of asphalt-maloperation deposits (ARPD) and metal corrosion in oilfield equipment

The invention relates to epoxy compositions to obtain a casting pinakamaganda used to fill gaps, insulation and hardening of the open frame and chassis electrical connectors by fill, seal and protect items of electronic equipment, to align the defective surfaces of insulation, gluing of metals and non-metals with large alternating gaps

The invention relates to macromolecular compounds, namely, hermetics, used in the aviation industry for sealing units aircraft structures operated in a wide temperature range (-60 to 280o(C)
The invention relates to plastic materials and, in particular, can be used as a sealing material for a water seal between movable relative to each other surfaces, for example, between the piston and the cylinder for sealing the pressure vessel, for repairing cracks casings and other products in the oil and gas, chemical and other industries

The invention relates to the oil industry and can be used for enhanced recovery of oil, remove asphaltene-resin, paraffin entities in the systems of production, transportation and storage of oil

The invention relates to a material for sealing threaded pipe joints and, in particular, to use when performing plumbing-water works for the purpose of receiving sealed connection pipe

The invention relates to installations for fire protection regular or special cargo or goods transported in containers, and is aimed at improving fire and explosion safety of the transported goods in case of fire on the vehicle

The invention relates to a fire extinguishing carbon dioxide

The invention relates to fire extinguishing systems of tanks, infantry fighting vehicles, self-propelled artillery

The invention relates to fire fighting equipment and its use, namely the device undercar fire fighting and method of engagement which allow you to apply extinguishing agent (S) to the fire that occurred in undercar space vehicle (SV) of a vehicle, in particular in undercar space PS underground

The invention relates to the field of storing and transporting liquid combustible substances and can be used in the manufacture and operation of tanks filled with a combustible fluid

The invention relates to fire extinguishing systems of tanks, infantry fighting vehicles, self-propelled artillery

Combine harvester // 2141190
The invention relates to kombajnostroenii and can be used to reduce losses of combine harvesters from fires

The invention relates to an auxiliary extinguishing equipment passenger cars

The invention relates to fire equipment and can be used to extinguish burning oil inside the furnace for heating
Up!