The tool sobering actions

 

(57) Abstract:

The invention relates to the field of addiction and AIDS, providing a sobering effect. The proposed tool, sobering actions and debilitating manifestation postintoksikatinom alcohol syndrome, containing as active principle an aqueous extract of the herb elecampane, obtained by extraction of the original plant material 10-50 volumes of water at a temperature not exceeding 70, and containing not less than 0.04 wt.% the fraction of oxygenated compounds of phenolic nature. Also used the flowers of inula. Receiving means provides accelerated elimination of alcohol, as evidenced by the decrease in the concentration of alcohol in exhaled air. 6 C.p. f-crystals, 10 PL.

The invention relates to the field of addiction and AIDS, providing a sobering effect.

Alcohol abuse is one of the most common causes of loss of health and premature death among the exposed to this evil persons.

To prevent and mitigate the adverse consequences associated with alcohol consumption, there is an extensive range of medications, different napravlennost the iskow, and D. W. Godwin [Liskov B. J., Godwin D. W. Pharmacological Treatment of Alcohol Intoxication, Withdrawal and Dependence: A Critical Review. // The Journal of Studies on Alcohol. -1987. -Vol.48. -N. 4. -P. 356-370] and includes the following groups of drugs: 1) funds for relief of the syndrome of alcohol; 2) tools that reduce the craving for alcohol; 3) the means causing aversive reaction; 4) funds for relief of mental disorders with alcohol; 5) sobering tools.

Among these groups of medicines funds that have a sobering effect, attract the attention of those that are of interest both from the point of view of solving problems of immediate addiction and domestic point of view.

Before emergency narcology, including, is the problem of reducing the concentration of alcohol in the blood during acute alcohol poisoning.

Thus, it is necessary to bear in mind that a real possibility of increasing the rate of oxidation of ethanol is very limited. On the one hand, despite numerous attempts to increase the rate of metabolism of ethanol, it was not possible to increase it by more than 50% [Biggins J. J. Control ofethanol oxidation and its interaction with other metabolic systems. In: Biochemistry and Pharmacology of Ethanol (Eds. Majchrowics E. and E. P. Noble), p. 249 of 351. Plenum Press, New York, 1979]. However, relatively recently was the blood, the use of which in the experiment made it possible to reduce the concentration of alcohol in the blood of rats twice [European patent 1066835, a 61 K 35/78, 2000].

On the other hand, such a radical activating enzyme systems that are not stagespecific in relation to ethanol, when you try to use a similar tool in medical practice for the purposes of sober can lead to unpredictable consequences. For this reason, even a small decrease in the concentration of exogenous ethanol in the blood is a success, contributing in some cases the removal of a patient from a critical state when alcohol poisoning.

In a domestic environment also occurs in certain situations, the need to reduce the degree of intoxication from abusing alcohol persons not related to threats to his life caused by acute alcohol poisoning.

In a detailed review, sobering funds, prepared by C. K. Erickson [Erickson, S. K. An update on amethystic agents. In: G. Edwards And J. Littleton (Eds.) Pharmacological Treatments for Alcoholism, New York: Methusen. Inc., 1984, p. 111-117], the latter considered from the point of view of the prospects of the use of certain drugs of different pharmacological groups and highlighted the following four napraviti (amphetamine, caffeine, kordiamin, korazol and others); b) fructose and other funds (GL) for enhancing the excretion of ethanol.

Moderately promising, requiring more precise experimental studies confirming the feasibility of their use in the clinic: a) inhibitors prostaglandin synthetase (indomethacin, acetylsalicylic acid, acetaminophen, and others); b) amino acids (glycine, taurine, and others); C) naloxone.

Very promising drugs, but require more fundamental research: (a) modulators of neurotransmitter function (phentolamine, propranolol, apomorphine, physostigmine and others); b) hyperbaric oxygen therapy and oxygen therapy; lithium ions, rubidium, cesium, calcium, etc.

Very promising and deserves a thorough clinical trials: a) the donators of sulfhydryl groups, inactivating acetaldehyde (dimercaprol, penicillamine, cysteine, and others); b) the thyrotropin-releasing hormone.

Presents the hierarchy of the sobering prospect of funds is not recognized by all authors. In particular, in one of his works called “Useful if sobering agents ?”, stating no until the perfect sobering funds, but as a positive otlichie of fructose solution in alcohol-induced coma, and it suggests that one promising sobering means is caffeine, despite its relatively weak effect [Schuckit M. A. Are there useful amethystic agents ? // Vista Hill Foundation. Drug abuse and alcoholism newsletter. - 1994 Feb. - Vol.XXIII. - N1].

Mechanisms of antagonism tiroliberina, which is a hypothalamic peptide hormone consisting of three amino acids, and ethanol is described in a separate review [Bulaev C. M., Egorov, C. F., the Hormone as sobering means of broad-spectrum. // Addiction issues.in 1993. -N4. -C. 86-90]. In this review have been cited classification protivoallergennyh funds B. J. Liskow and D. W. Godwin and classification sobering funds C. K..Erickson.

It can be stated that the lack of specific medicines, sobering action type of indirect evidence or lack of effectiveness potentially applicable for these purposes, medications, or if they have adverse or unwanted effects.

Recently it was proposed, and other funds, sobering activity that does not quite fit into the above classification system.

In particular, as sobering tool can be used kombinasi, on the basis of which can be prepared individually or complex preparations, problema sobering ability.

To speed up the process sober it is recommended that the infusion of peppermint leaves and grass yarrow [Phytotherapy with the basics of clinical pharmacology. The Handbook. Edited by C. G. Kukes. - M.: Medicine, 1999, pages 130-131].

For the treatment of acute alcohol poisoning as otrezvlyayusche and antitoxic tools can be applied infusion of nettle. Experimental studies have shown that infusion reduces the duration of ethanol narcosis in rats and mice, which indicates that awakens the effect of infusion of [the Patent of the Russian Federation 2011382, a 61 K 35/78, 1989].

Known to be the remover of alcohol, including alcohol tincture of mint or mint oil, succinic acid, sugar or fructose [RF Patent 2012350, a 61 K 35/78, 1994].

Describes the collection of medicinal plants with pronounced watersplashes action, which contains grass cudweed herb brown, herb, rose hips, peppermint leaves, marjoram, thyme herb and rhizome with the roots of leuzea [RF Patent 2129008, a 61 K 35/78, 1998].

The existence of the mentioned sobering means on the basis of plant material does not mean that the problem is solved and does not preclude further research in this direction, keeping in mind that the mechanisms sobering actions can be different, as well as individual sensitivity to these tools, different groups of patients.

In particular, in the literature, there appeared an interesting message about drugs on the basis of Valerian, stating that “according to some infusion and decoction of flowers promotes rapid sobering; if they drink before or after taking alcohol, allegedly did not get drunk” [Yefremov A. P., Schroeter A. I. Herbalist for men. - M.: "Asadal", 1996, page 75].

While the authors of the above work notice that their information is not based on any published materials, and was obtained from one of the folk healers in private.

Currently in official medicine is only permitted using the broth underground parts (rhizomes and roots) of Valerian as an expectorant [Mashkovsky M. D. Medicines. - M.: Medicine, 1988, T. 1, S. 362].

However, a considerable number of scientific publications devoted to the study of the biological activity of drugs derived from this plant, particularly from its aerial parts.

It was found that the extracts of flowers and leaves of inula have antifungal activity [C. Cafarchia, De Laurentis N., M. A. Milillo, Losacco V., V. Puccini Research ofantifungal activity of flowers and leaves of Inula viscosa (Asteraceae). // Parassitologia. - 1999 Dec. -Vol.41. -N4. -P. 579-582], and an active beginning of the extracts is a sesquiterpene lactone tomentose [C. Cafarchia, De Laurentis N., M. A. Milillo, Losacco V., V. Puccini Fungistatic activity sesquiterpene lactone (tomentosin) isolated from fresh Inula viscosa (Asteraceae) flowers from the Puglia region. // Parassitologia. - 2001 Sep. -Vol.43. -N3. -P. 117-121], and also essential oil obtained from the leaves of inula [C. Cafarchia, De Laurentis N., M. A. Milillo, Losacco V., Puccini V. Antifungal activity of essential oils from leaves and flowers of Inula viscosa (Asteraceae) by Apulian region. // Parassitologia. -2002 Dec. -Vol.44. -N3-4. -P. 153-156].

There are reports that an aqueous extract of the flowers of inula exhibits hepatoprotective activity when experimentational conditions hepatoprotective activity of hepatitis, induced immunological disorders and chemical substances [lijima, K., Kiyohara H., Tanaka, M., Matsumoto T., Cyong, J. C., Yamada H. Preventive effect of taraxasteryl acetate from Inula britannica subsp. Japonica on experimental hepatitis in vivo // Planta Med. - 1995 Feb. -Vol.61. -N1. -P. 50-53].

It is noted that a previously installed anti-inflammatory activity of extracts of the herb Valerian is due (at least partially) antioxidant activity of these extracts. While the presence of anti-inflammatory activity is associated with the presence in the extracts of flavonoid compounds and the highest activity was recorded extract of the flowers of inula [Schinella G. R., Toumier H. A., Prieto J. M., Mordujovic D., Rios J. L. Antioxidant activity of anti-inflammatory plant extracts. // Life Sci. -2002 Jan. 18. -Vol.70. -N9. -P 1023-1033].

In several publications indicated on the cardioprotective activity of extracts of Valerian [Miller A. L. Botanical influences on cardiovascular disease // Altem Med Rev. -1998 Dec. -Vol.3. -N6. -P. 422-431; Seth S. D, Maulik M, Katiyar C. K, Maulik S. K. Role of Lipistat in protection against isoproterenol induced myocardial necrosis in rats: a biochemical and histopathological study. -1998 Jan. -Vol.42. -N1. -P. 101-106].

It also diuretic, antipyretic, astringent, antihelminthic, expectorant, antiseptic, sedative, diuretic action of various drugs from underground and aerial parts of inula [Closev P. A. ava biologically active substances of plant inula spectrum and their properties, suggest that on the basis of this plant can be obtained effectively, sobering funds. Special attention was unconfirmed data availability in the flowers of inula compounds with sobering activity, as well as scientific results, indicating the presence in the aerial parts of inula compounds with hepatoprotective, cardioprotective and antioxidant properties.

This combination of biological properties of an aqueous extract of the herb Valerian is very attractive from the point of view of its practical use: preparations on its basis in addition to the sobering activity (in case of its approval) be able (which follows from the literature data) to weaken the toxic manifestations of acetaldehyde. It is well known that the adverse effects of alcohol intoxication are mainly associated with damage caused by acetaldehyde, the most dangerous among them are violations of the liver and cardiovascular system, which can lead, and often lead to a fatal outcome.

Along with the classification system, sobering funds, this C. K. Erickson, these sredstvami, under “sobering effect” should be understood restore (at least partial) functions of the brain and Central nervous system, leading to the normalization of coordination, orientation in time and space, adequate perception of reality and cognitive abilities impaired as a result of alcohol intoxication, sobering effect is not raspostranaetsa on the elimination or prevention of other manifestations provoked by alcohol.

In this regard, sobering funds can be divided into two groups, implement a fundamentally different approaches: A) a means to promote the recovery of brain function, the oppressed alcohol, and B) a means of reducing the concentration of alcohol in the blood.

Funds group And refer to drugs of the Central actions are, as a rule, synthetic products have a wide range of biological actions, cannot be considered specific drugs sobering orientation. Such medicines should have a high stimulating activity, sufficient to overcome the dampening effect of alcohol, and application of the funds does not eliminate the inevitability of the onset of the entire spectrum of manifestations postintoksikatinom alcohol syndrome, edema which more effort is needed.

The effect provided by the group B, can theoretically be achieved in different ways, and these tools can be divided into several categories: 1) means of reducing the concentration of alcohol in the blood due to the forced evacuation of alcohol from the stomach by lavage or by stimulating gag reflex; 2) means of reducing the concentration of alcohol in the blood by increasing urine output; 3) a means of reducing the concentration of alcohol in the blood by activation of its enzymatic oxidation alcoholdehydrogenase.

Using these tools reduce the concentration of alcohol in the blood, except for the use of funds, stimulating the enzymatic oxidation of ethanol, leads not only to the sobering down the patient but also to the automatic weakening his manifestations postintoksikatinom alcohol syndrome. However, the use of the first two groups is not physiological and gives the patient some discomfort.

When specific activation of the enzyme alcoholdehydrogenase achieved accelerated physiologically natural reduction in blood concotions reactions of acetaldehyde, what can weight postintoksikatinom complications, if not to take additional measures.

In most cases, except obviously apparent, the mechanisms of action practically means used to reduce the concentration of alcohol in the blood does not fully investigated and it can be assumed that the known preparations, in particular obtained on the basis of plant material can implement several mechanisms of action.

Thus, targeted search actually sobering drugs aimed at identifying biologically active compounds capable in one way or another to reduce the blood concentration of alcohol.

The purpose of the present invention consisted in finding sobering means, effectively reducing the blood alcohol level, not only weight while postintoksikatinom alcohol syndrome and devoid of adverse side effects, but also are able to reduce the severity postintoksikatinom alcoholic manifestations.

This goal is achieved by using as a sobering means of an aqueous extract of the herb elecampane, obtained by extraction of plant material the weight.% oxygenated compounds of phenolic nature.

The technical effect of application of the invention consists in significantly lower concentrations of exogenous ethanol in the blood after administration of the proposed funds, without weighting the manifestations postintoksikatinom alcohol syndrome, and braking and weakening manifestations postintoksikatinom alkogolnyj complications.

The invention consists in the following.

As a means of having a sobering effect, it is proposed to use an aqueous extract of the herb elecampane, containing not less than 0.04 wt.% oxygenated compounds of phenolic nature. However, it is most preferable to use extract only the flowers of inula.

From the Botanical point of view, the term “grass plants” includes all above-ground part of the plant, including leaves, flowers, fruits. It can be assumed that in this case the effectiveness of the extract of the herb elecampane significantly determined by the presence of the extract of the flowers of this plant.

For the purposes of the invention can be used all growing on the territory of Russia types of elecampane, including, elecampane (Inula helenium L.), elecampane large (Inula macrophylla Karr. et Kir.), elecampane UALITY (Inula salicina L.), elecampane British mi water at room or elevated temperature, not exceeding, however, 70C. Carrying out the extraction at higher temperatures is undesirable because of the possibility of inactivation of part of biologically active products, although the principal biological activity funds saved for the extraction of the herb in boiling water. The actual extraction process can be implemented in various modes-maceration, infusion, percolation, repercolation, other methods. The duration of extraction is usually 10-40 hours. The resulting aqueous extract on average contains 9-12 mg/l of solids.

It should be noted that the parameters and modes of the extraction process are not critical and can range within wide limits, but the above options are the best.

The resulting aqueous extract may be dried using conventional techniques, preferably in the most possible mild conditions, preferably at a temperature not exceeding 70 ° C.

To improve the reproducibility of the biological effects of extracts of the herb elecampane as a sobering means deemed appropriate to standardize the extracts according to their content of total faction noooobody in one of the last successful works, aimed at reducing the concentration of alcohol in the blood, in experimental conditions could increase the elimination rate of alcohol from the blood of experimental animals and its removal from the body 45 and 50%, respectively. These results were obtained when the test contained in nettle aloe aloin-glycoside derivative of anthraquinone.

The mechanism of accelerated degradation of ethanol in this case is also explained by the fact that the oxidation of ethanol to acetaldehyde catalyzed by NAD+dependent alcohol-dehydrogenase and OVER+is reduced to NADH. When the system quinoid compounds (in this case, aloe-emodina), the latter restored generegulatory in hydrochinone connection (in this case, aloin) and NADH is oxidized to NAD+. In the regenerated NAD+may again be used for further oxidation of ethanol [Jin-Ho Lee, Jeong-Cheol Cheong, Joo-Young Lee, Hyung-Keun Roh, Young-Nam Cha. Acceleration of the Alcohol Oxidation Rate in Rats with Aloin, a Quinone Derivative of Aloe. // Biochemical Pharmacology-1996. -Vol.52-P. 1461-1468].

In this regard, the presence in the extract of the herb elecampane oxygenated compounds of phenolic nature, able to participate in the oxidation-reduction of the initial point, which can be expected to affect the rate of ethanol oxidation in vivo.

Although currently active principle of the herb extract of Valerian, telling him, sobering properties not identified, it can be assumed that some contribution to its biological activity in this direction and make oxygenated compounds of phenolic nature, including flavonoids contained in the flowers of inula.

The presence in the flowers of inula oxygenated compounds of phenolic nature is known. Ongoing studies allow to identify new compounds. In particular, recently reported on the allocation of the flowers of inula and identification of three new acylated flavonoid glycosides [Park, E. J., Kirn Y., Kim J. Acylated flavonol glycosides from the flowers of Inula britannica. // J. Nat. Prod. -2000 Jan. - Vol.63. -N1. -P. 34-36].

Described can be recommended as sobering a means or as an integral part of this tool extracts of the herb elecampane, containing not less than 0.04 wt.% the fraction of oxygenated compounds of phenolic nature and obtained by extraction of the original plant material 10-50 volumes of water at a temperature not exceeding 70 ° C.

Effective research conducted at the National research centre of addictology and Russian scientific research Institute of health. While most studies used an aqueous extract of the flowers of inula, containing not less than 0.04 wt.% the fraction of oxygenated compounds of phenolic nature, and which is the most promising.

It was shown that an aqueous extract of the flowers of inula increases the duration of the latent period (retards timing narcotic sleep) and reduces the duration of the narcotic sleep in mice after intraperitoneal administration of ethanol.

In the experiment used mice of F1(DBA/lac C57D1/6) weighing 22-24 g flower Extract of elecampane in the form of tincture 1:10 was introduced in the amount of 15 ml/kg Estimated dose of dry extract was approximately 50 mg/ml of the Extract was injected intragastrically 30 minutes prior to intraperitoneal administration of ethanol in the amount of 3.5 g/kg of body weight.

The results obtained are presented in table.1 and show a reliable increase in latent period and shortening the duration of the lateral position of the experimental animals.

Further, it was confirmed that an aqueous extract of the flowers Devas the political effect of ethanol modeled the intragastric administration to rats of the same test extract at the same dose.

The results shown in the table.2 and 3, indicate that the tested extract reduced the severity of drug action of ethanol in all periods of observation and has been a decrease in the concentration of ethanol in the blood at the height (in 2 hours) and on the decline (after 6 hours) alcohol intoxication.

Of practical importance is the fact that stimulating the bioconversion to ethanol, an aqueous extract of the flowers of inula not weight manifestations postintoksikatinom alcohol syndrome, as it could be expected. On the contrary, it turned out that the extract of the flowers of inula in General has the ability to ease the burden postintoksikatinom condition that develops in rats after a single injection of ethanol in sublethal dose, and alleviate the severity of the manifestations of the syndrome of ethanol.

The reduction in the severity postintoksikatinom status in experimental animals was confirmed in the test “Spinning rod” [B. N., Demeshina I. C., Zabirova, I., Litvina B. N., Y. Lvov, A., samojlik L. C., L. Surkov A. assessment of the severity postintoksikatinom state, provoked acute alcoholic intoxication, in the experiment on animals. // Science news and technopanic and tested for the ability to stay on a rotating rod rats were divided into several groups. Two groups of animals was administered intragastrically 30 weight./vol.% a solution of ethanol at a dose of 6 g/kg of body weight. Animals one of these groups after 2 hours after administration of ethanol and 2 hours before the test was administered intragastrically solution of the extract of the flowers of inula at a dose of 200 mg/ kg of body weight, other animals of these groups at the same time entered the water. The control group of animals instead of ethanol intragastrically injected water. Testing was conducted twice - prior to the introduction of ethanol and 17 hours after its introduction.

Presented in table.4 the results indicate that the extract of the flowers of inula has the ability to ease the burden postintoksikatinom state

The effects of an extract of the flowers of inula manifestations of the syndrome of ethanol, in particular, is illustrated by data shown in table.5 and 6.

From the data presented in table.5, it is seen that the severity of withdrawal syndrome in rats treated with ethanol extract of the flowers of inula, during all periods of observation was less pronounced than in rats that received only ethanol. Said further confirmed by the fact that such serious symptoms of ethanol withdrawal in rats, as creak teeth, catatonia and spontaneous vocalization that follows from the data, are given in table.6.

Thus, it can be concluded that aqueous extract of the flowers of inula has a sobering effect, reducing blood ethanol concentration, and thus not only contributes to the simultaneous increase in the blood concentration of acetaldehyde and aggravates manifestations postintoksikatinom alcohol syndrome, but also shows the ability to inhibit and reduce the symptoms of alcohol intoxication.

This favorable combination of properties of the extract of the herb elecampane was established by the applicant for the first time and gives this extract as a sobering tool, special advantages.

Valid to assume that an aqueous extract of the flowers of inula able to accelerate the degradation of acetaldehyde or neutralize its toxic effect.

In passing it should be noted that an aqueous extract of the underground parts of Valerian (rhizome and roots) in doses of 100 and 200 mg/kg of body weight of rats injected before and after the introduction of ethanol, not only reduces the narcotic effect of ethanol and does not reduce the concentration of ethanol in the blood of experimental animals, but also slightly increases these figures.

Supporting evidence contained in the table.7 the e effect of ethanol under the influence of the extract of the underground parts of inula expressed slightly stronger compared to a control group animals not treated with the extract as on the total score and in the dynamics. With the exception of figures 6 and 7 hours after administration of ethanol on the background of the introduction of the extract in the amount of 100 mg/kg when the drug effect was significantly higher than that in the control.

From the data table.8 it follows that the content of ethanol in the blood of rats after 3 and 7 hours after administration of ethanol on the background of the introduction of the extract at a dose of 200 mg/kg was significantly higher than in the control.

Thereby, it is shown that the extract of the underground part elecampane has no sobering effect.

An extract of the herb or flower elecampane can be used as a standalone tool, sobering actions; he cannot enter into the composition of complex products, sobering orientation; its practical use can be combined with other therapeutic interventions.

Aqueous extract of herbs or flowers of inula can form the basis of drugs or dietary supplements. If necessary, similar drugs or biologically active additives can optionally contain auxiliary substances or Dunya additives can be prepared in any suitable occasion formulation.

The following examples merely serve to illustrate the practicability of the invention and should not be restrictive.

EXAMPLE 1. 5 kg flower elecampane (Inula helenium L.) extracted 250 l of distilled water by infusion for 20 hours at 50C. The extract was filtered to remove suspended solids and spray dried at a temperature of 60C. Received 549 g of dry aqueous extract containing fractions of oxygenated compounds of phenolic nature 0,053 wt.%.

EXAMPLE 2. 10 kg of the herb elecampane large (Inula macrophylla Karr. et Kir.) was extracted with 100 liters of distilled water in the regime of percolation for 40 hours at room temperature. The extract was subjected to filtration and spray drying at a temperature of 65 degree Celsius. They received a total of 912 g of dry aqueous extract containing fractions of oxygenated compounds of phenolic nature 0,049 wt.%.

EXAMPLE 3. 6 kg of flowers of inula large (Inula macrophylla Karr. et Kir.) was extracted with 180 l of distilled water in the regime of percolation for 35 hours at a temperature of 35C. The extract was subjected to filtration and spray drying at a temperature of 60C. They received a total of 621 g of dry aqueous extract containing Plasil Valitova (Inula salicina L.) with content 0,041% wt. the fraction of oxygenated compounds of phenolic nature was tested on healthy human volunteer No-ve. The subject in the first and second day of testing in the morning on an empty stomach to drink vodka with an alcohol content of 40 vol.% at a dose of 0.5 g/kg in terms of absolute alcohol. On the first day of testing for 20 minutes before drinking the subject Nor in the received inside 50 ml of water (control), and the second day, 50 ml of water in which was dissolved 800 mg of dry extract of the herb elecampane (experience). Every 20 minutes for 4 hours after drinking alcohol was carried out measuring the alcohol content in exhaled air through the meter AKE-01.

The results of the study are presented in table.9 and it follows that an extract of the herb elecampane helps reduce the alcohol concentration in the exhaled air, which is especially noticeable in the last periods of observations. Given that the alcohol concentration in the exhaled air is proportional to the concentration of alcohol in the blood, it becomes apparent that this extract has a significant sobering effect and provides accelerated elimination of alcohol.

When the survey Respondent Nor the society it was noted that the severity of alcohol while taking the extract of the herb elecampane was clearly lower than in the control, and postintoksikatinom manifestations of Oleksii of oxygenated compounds of phenolic nature was tested on healthy human volunteer M-ve. The subject in the first and second day of ispytani in the morning on an empty stomach to drink vodka with an alcohol content of 40 vol.% at a dose of 0.5 g/kg in terms of absolute alcohol. On the first day of testing after 20 minutes after drinking the subject M is received in the interior of 50 ml of water (control), and the second day, 50 ml of water in which was dissolved 600 mg of dry extract of the herb elecampane (experience). Every 20 minutes for 4 hours after drinking alcohol was carried out measuring the alcohol content in exhaled air through the meter AKE-01.

The results of the study are presented in table. 10 and it follows that an extract of the herb elecampane helps reduce the alcohol concentration in the exhaled air, which is especially noticeable in the last periods of observations. Given that the alcohol concentration in the exhaled air is proportional to the concentration of alcohol in

in the blood, it becomes apparent that this extract has a significant sobering effect and provides accelerated elimination of alcohol.

When the survey Respondent M-VA was observed that after administration of the extract he has previously ceased to feel the intoxication and hangover effects were noticeably smoothed.

2. Means under item 1, characterized in that it comprises a dry aqueous extract of Valerian.

3. Means under item 2, characterized in that it comprises a dry aqueous extract of the herb elecampane (Inula helenium L.).

4. Means under item 1, characterized in that it contains an aqueous extract of the flowers of inula.

5. Means on p. 4, characterized in that it comprises a dry aqueous extract of the flowers of inula.

6. Means on p. 5, characterized in that it comprises a dry aqueous extract of the flowers of elecampane (Inula helenium L.).

7. A tool according to any one of paragraphs.1-6, characterized in that it additionally contains other biologically active and/or auxiliary substances.

 

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FIELD: medicine, cardiology, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

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