The invention relates to the field of addiction and AIDS, providing a sobering effect. Proposed reducing the toxic effect of alcohol means and method thereof. The tool is a phytocomplex, including water-alcohol extract of the ridges of the grapes, water-alcohol extract of the herb St. John's wort and solid hips. The method is that the extracted water-alcohol solvent mixture of crushed white grapes, herbs St. John's wort and solid hips, taken at a ratio of 2:1:1. The means obtained in this way, eliminates amplification of intoxicating effect of alcohol. 2 C. and 7 C.p. f-crystals, 4 PL.
The invention relates primarily to the field of medicine and relates to means for reducing the toxic effect of alcohol on the human body.
Despite the fact that alcohol abuse affects the health of people and is one of the major causes of death, hope for the widespread failure of the population from alcoholic drinks or reduce their consumption to a level that does not cause adverse effects does not currently have.Describes a series of drugs with different chemical nature, in one way or another debilitating symptoms postintoksikatinom alcohol syndrome [RF Patent 2005391, And 23 L 2/00, 1994; RF Patent 2039556, a 61 K 31/19, 1995; RF Patent 2086237 And 61 To 31/045, 1997; RF Patent 2123845 And 61 To 31/22, 1998; RF Patent 2188632 And 61 To 31/185, 2001 and others].These tools basically should be taken for relief of already existing phenomena of intoxication.Traditionally a part of many means of mitigating the consequences of alcohol intoxication include extracts of plant material.For example, to remove postintoksikatinom syndrome in acute alcoholic intoxication recommended tool containing dry extract of Rhodiola rosea, dry peppermint extract, ascorbic acid, magnesium sulfate, caffeine-sodium benzoate, potassium chloride and sodium bromide [RF Patent 2146529, a 61 K 35/78, 1999].To relieve hangover can be used for the kt root Rhodiola rosea, leaf extract, peppermint leaf extract of roots of peony and water [RF Patent 2150871, And 23 L 2/39, 1999].Proposed medical fee for withdrawal syndrome hangover, consisting of ginger, cardamom, mint, lemon balm, nutmeg, Ferula, cloves, citric acid and cinnamon [RF Patent 2161038 And 61 To 31/78, 2000].To alleviate manifestations hangover recommended before or after drinking to take extracts of leaves, branches and roots of alder and mountain ash ordinary or finely ground powders of these plant tissues [U.S. Patent 5968520, a 01 N 65/00, 1997].Independent strategy for reducing toxic effects of alcohol is the inclusion of alcoholic beverages connections, modifying toxic effects of alcohol. The influence of such compounds can be manifested in the inhibition of ethanol metabolism or in mitigating the toxic effects of acetaldehyde is an indispensable intermediate product in the process of utilization of ethanol, which basically defines the entire range of impaired functioning of the systems and organs of the body. Thus inhibition of ethanol oxidation leads to a smoother formation of acetaldehyde, to a certain extent prevents sharp and b is the ISM which enzyme systems of the body can not cope.Biologically active food Supplement “VEGA+”, which is an aqueous extract of peritoneal fluid, diluted alcohol and enriched with thiamine and pyridoxine, is recommended as a restorative in chronic alcoholism and as a cardioprotective agent overdose of alcohol. This liquid Supplement can make an alcoholic beverage immediately before use [Leaflet to the drug VEGA+”].The patented method of preparation of alcoholic beverages, providing an introduction to the composition of the drug “allsoft”, which is a product of the hydrolysis of lactose obtained by the original method.Alcoholic drinks with this additive is called a reduced intensity postintoksikatinom alcohol syndrome, including, possibly due to the positive influence on the activity of the anaerobic intestinal microflora [RF Patent 2113466, With 12 G 3/06, 1997].In order to alleviate manifestations postintoksikatinom alcohol syndrome, especially in terms of protection of organs and tissues from the toxic effects of acetaldehyde, the formula of alcoholic drink were asked to enter the sodium salt of [poly-(2,5-dihydroxy varieties of vodkas use of succinic and fumaric acid, to facilitate exchange reactions associated with the oxidation of acetaldehyde, and have certain detoxifying effect [I. Komissarov, A., Rotenberg Y. S., Masterpole A. P. Mechanisms of action of ethanol and approaches to the correction of metabolic disorders in chronic alcohol intoxication. - M., 1976. - 72 S.].To suppress the craving for alcohol and for mitigating the consequences of intoxication recommended tool based on plant materials, including (in mg/g of product) leucoanthocyanin (219-270), catechins (153-187), flavonols (81-99), lignin (68-83), reducing sugar (120,6-410,76), pectin (16-24), organic acids (76,5-93,5), sterols (7,83-to 9.57), lignans (13,5-16,5), glycosides Lignano (9-11), aromatic aldehydes (4,5-5,5), alkylphenolate (4,5-5,5).This tool can be used as a medicine or as a component of alcoholic beverage [Patent UK 2198041, a 61 K 31/195, 1986].The implementation of the invention meets great difficulties. Getting listed individual groups of compounds involves serious difficulties technological character. Each of these groups of compounds characterized by qualitative diversity, and composition individual range of plants, which are preferred for obtaining a patent-pending complex or its parts. For these reasons, standardization of patented tools on the level of biological activity is not possible.Known for strong alcoholic drink “Kalieva”, which contains the root of aralia extract, Siberian ginseng, fresh berries lemon, honey, and a strong alcoholic drink “Golden horn”, which includes an extract of Siberian ginseng, seeds and berries of schisandra, and natural honey [Compounding liquors and vodkas. M: Light and food industry, 1981, S. 188, 206].The components mentioned drinks that have a vegetable origin, provided the reduced severity of postintoksikatinom alcohol syndrome after the consumption of these drinks.There is information about alcohol activity of preparations based on extracts of the herb St. John's wort.The herb St. John's wort is one of the oldest traditional medicines, and in the official medicine is used for preparing decoctions and tinctures. Decoctions and infusions prescribed for internal use as an astringent and antiseptic agent and rinse in dental prokhody to drugs on the basis of the herb St. John's wort due to the establishment they have antidepressant activity.In particular, clinical studies have shown that the effect of St. John's wort preparations is comparable to the effect of low doses of tricyclic antidepressants, but the frequency of side effects was twice lower [Kim H. L., L. Streltzer, Goebert D. St.John's wort for depression: a meta-analysis of well-defined clinical trials. J. Nerv. Ment. Dis., 1999, 187: 532-538].In parallel with the antidepressant activity of extracts of the herb St. John's wort in a series of publications have shown that these extracts reduce alcohol consumption in alcohol-preferring” lines of experimental animals under conditions of free choice of alcohol or water, which serves as a basis for further research in creating treatments for alcoholism [e.g., Roby C. A., Andersen G. D., E. Kantor, Dryer D. A., Burstein, A. H. St. Jon's wort effect on CYP3A4 activity. Clin. Pharmacol. Ther., 2000, 67: 451-457].Such behavior could be explained by the fact that “alcohol-preferring animals special lines have genetic disorders and are in a state of permanent depressivnopodobnogo status, and alcohol is a means of mitigating this condition. The antidepressant action of Hypericum extract reduces the need for animals in alcohol.It was found that a decoction of herbs soentoro syndrome [Ed. mon. THE USSR 1795581, A 61 K 35/78, 1990].It was reported that in the experimental conditions of aqueous extract of the herb St. John's wort has a sobering effect of acute alcohol poisoning [Dobrovolsky Yu N., Diordiychuk Centuries, Voitenko Centuries, Kornienko I.e., Lipkan, N. A sobering effect of aqueous extract of Hypericum perforatum for acute alcohol poisoning. 2nd national conference on medical botany. Kiev, 1988. S. 347-348].However, before this knowledge was produced “Bitter tincture of St. John's Wort, which is a spirituous extract the herb St. John's wort, the herb oregano and grass clover [Compounding liquors and vodkas. M: Light and food industry, 1981].Obviously, creating the recipe of this drink did not aim to reduce postintoksikatinom manifestations after its use as evidence-based background for this at that time was absent. Most likely, it was the industrial extension of the old household cooking traditions of alcoholic beverages by infusion of alcohol on different kinds of herbs to give the appropriate drinks new flavors and aroma.The drug, the possession is Yu [RF Patent 1107309, A 61 K 35/78, 1982].In experiments on human volunteers have shown the ability of aqueous-alcoholic extract of the ridges of grapes, made in soft drink, to modify the toxic effects of alcohol. It was found that the extract has the ability to slightly (as a tendency) to reduce the rate of elimination of alcohol, to increase its intoxicating effect, to limit the severity of circulatory disorders occurring in the phase of alcohol intoxication, and reduce the severity postintoksikatinom disorders [B. N., Litters Y. D., Kovalev A. C., L. Surkov A., Zaitseva E. B., Bulanov, A. E., Maximov, S. B., Litvinova N. M. Investigation of the effect of the extract of the ridges of the grapes on the acute toxic effects of alcohol in experiments on healthy people-volunteers // Narcology. - 2000. - N12. - S. 34-40].When studying the properties of strong alcoholic drink “Golden Fleece”, containing a water-alcohol extract of white grapes, with the commercial name of Caprim, was confirmed by its ability to weaken postintoksikatinom condition caused by alcohol. In addition, when field testing of this drink, it was found that alcohol consumption in the control the verbal psychosis [Brekhman, I. I., Bulanov, A. E., Polozhentsev M. I., Mudzhiri L. A., Atlas M. M., Fedorov, C. A., Mochalova D. P. Some results of experimental studies and field tests alcohol (independentwho) actions caprina // In Proc.: Valeology. Diagnostics, tools, and prevention of health. - Vladivostok: Dalnauka. - 1995. - Vol.2. - S. 140-149; B. N. Biological active additives based on an extract of the ridges of the grapes // Narcology. - 2002. No. 3. - S. 46-48].Essentially all of these optional components that are made in the formulation of alcohol to increase their consumer qualities can be thought of as additives modifying toxic effects of alcohol.The purpose of the present invention is to develop a means of reducing the toxic effect of alcohol on the body and intended primarily for the introduction to the recipe alcoholic beverages, which would combine the taste and aroma with the corresponding alcohol was preparing would be based on the available natural plant material, would have a pronounced ability to ease symptoms postintoksikatinom alcohol syndrome and do not impact the actual intoxicating effect of alcoholy crests of grapes, the herb St. John's wort and rosehips, preferably obtained by extraction of the mixture of crushed white grapes, chopped herbs Hypericum and whole (not crushed) hips.Technical result achieved from the use of the invention consists in weakening manifestations postintoksikatinom alcohol syndrome occurring after consumption of alcoholic beverages in more than minimal quantities, while preserving the familiar intoxicating effect of these drinks.The essence of the present invention is as follows.The proposed tool, modifying in a favorable direction toxic effect of alcohol, preferably intended for inclusion in the formulations of alcoholic beverages, but may be applied independently, using before taking alcoholic drink, while taking alcohol or immediately after administration of the alcoholic beverage.This tool is an integrated product that includes a water-alcohol extract of the ridges of the grapes, which is a waste of wine, water and alcoholic extract of the herb St. John's wort and water-alcohol extract of the fruit of the wild rose.In parallel, the applicant experimentally it was found that the extract of the herb St. John's wort, contributing to a decrease in the blood concentration of ethanol does not have a significant impact on the severity of the manifestations of alcohol intoxication. Presumably, this phenomenon is due to the ability of components of the herb St. John's wort can have a direct effect on the Central nervous system.It was hypothesized that the combination of the extract of white grapes and extract of the herb St. John's wort can prevent occurring under the influence of the extract of the ridges of the grapes inhibition of ethanol oxidation and observed the program and will substantially limit the development effects of alcohol intoxication.The suppositions were confirmed conducted at the National research centre of addictology research, and some of the obtained results is presented in Table 1 and Table 2.Rats male Wistar through 3 and 6 hours after intragastric administration of a 25% aqueous solution of ethanol at a dose of 3 g/kg intragastrically twice (30 minutes before and 2 hours after injection of ethanol) was administered extract of the ridges of the grapes in a dose of 100 mg/kg, the extract of the herb St. John's wort dose of 100 mg/kg and the combination of these extracts. The alcohol content was determined by gas chromatography in blood, gains from the caudal vessels. At the same time these animals once per hour for 7 hours evaluated the severity of drug actions of ethanol in the points, using the known special evaluation method [B. N., Demeshina I. C., Zabirova, I., Litvina B. N., samojlik L. C., L. Surkov A., Tezikov E. B. Influence of components of fusel oil and afuraldehyde faction on acute toxicity and narcotic effects of ethyl alcohol // Toxicological Bulletin. - 1999. - N 2. - N-2-8].From Table 1 it is seen that the combined use of the extract of white grapes and grass extract shobna grapes slowed the process of elimination, and an extract of the herb St. John's wort has accelerated this process.From the results shown in Table 2, it follows that the dynamics of the intensity of drug action of ethanol and the integral indicator of its intoxicating effects by using a combination of extract of white grapes and extract of the herb St. John's wort are slightly different from those in the control, although in some periods of observation and the overall rate of drug actions under the influence of the extract of the ridges of the grapes is significantly higher.The severity postintoksikatinom status was assessed, in particular, in the test of “spinning rod” [B. N., Demeshina I. C., Zabirova, I., Litvina B. N., Y. Lvov, A., samojlik L. C., L. Surkov A. assessment of the severity postintoksikatinom state, provoked acute alcoholic intoxication, in the experiment on animals // science news and technology VINITI. Series Medicine. Vol. Alcoholic disease. - 2000. No. 7. - C. 1-6].For this purpose, we first trained and tested for the ability to stay on a rotating rod rats were divided into several groups. All groups of animals was administered intragastrically 25 wt./vol.% a solution of ethanol at a dose of 6 g/kg mass of those which of injected solution extract ridges grapes, the solution of the extract of the herb St. John's wort or a solution of both extracts at the dose of 100 mg/ kg of body weight, the animals of the control group during the same period was introduced equiano amount of water. Testing was conducted twice - prior to the introduction of ethanol and 17 hours after its introduction.From Table 3 it follows that the duration of the retention time on the rod intact rats during repeated testing increases 2.4 times that is determined by the phenomenon of their training and increase adaptive capacity in extreme situations. Postintoksikatinom condition that develops in rats after administration of ethanol in sublethal doses, leads to a complete loss of the phenomenon of fitness and reduce adaptive capacity. Extracts of white grape and herb St. John's wort in some degree prevent the implementation of the toxic effects of ethanol. However, the most pronounced positive effect is achieved by the combination of the use of the extract of white grapes and extract of the herb St. John's wort.It should be noted that the biological effect provided by the combination of the extract of white grapes and extract of the herb St. John's wort, which is expressed in the preservation of normal drug on ntoxicating alcohol syndrome, it seemed obvious.In addition to the water-alcohol extract of the ridges of the grapes and water-alcohol extract of the herb St. John's wort proposed tool contains a water-alcohol extract of the fruit of the wild rose.Rosehips contain up to 1200 mg% of vitamin C. the content of vitamin B1they are in third place after green peas and mushrooms white dried, the amount of vitamin b2they occupy third place after mushrooms dried white tea and black tea. Due to the extremely high content of carbohydrates dry fruits have a very high energy value (253 kcal/100 g) [Chemical composition of food. / Ed. by A. A. Pokrovsky. - M.: Food industry, 1976. - 246 S.].It is known that the systematic use of alcohol leads to the development of partial malnutrition. Most often in persons who abuse alcohol, including in patients with alcoholism, found deficiency of vitamins C, b1IN2and some other nutrients [Clinic I. A. Sidorov, P. A., Soloviev A., Causes and clinical effects of metabolic disorders of vitamins in chronic alcoholism / addiction Issues. - 1997. No. 4. - S. 89-94].In addition, there is information about that plant polyphenols stabilize ascorbic acid with the formation of complex compounds (metabolic factor”), which is actively involved in important biological processes of a living organism. Thereby is achieved a more complete implementation of the positive impact of the potencies of ascorbic acid on the metabolic processes in the body [Shamray E. F. Chemical interaction and the biological relationship of ascorbic acid and some polyphenols. Abstract. Diss. Prof. Kiev, 1952].On the other hand, ascorbic acid stabilizes the oxidized polyphenols, resulting in their biological activity is retained to a greater extent [Baraboi Century A. In kN.: “Biological effects of plant phenolic compounds”. Kiev, 1976, S. 182-184].And extract the ridges of the grapes, and to a lesser extent the extract of the herb St. John's wort contain significant amounts of oxygenated compounds of phenolic nature, including Dolgoprudny.Thus, the combined use of extracts of white grapes, herbs St. John's wort and hips from different sides prevents the development postintoksikatinom alcoholic complications, and the effect of each component means complements the action of the other two.Indeed, when combined extract of the ridges of the grape extract of the herb St. John's wort eliminates the effect of amplification of intoxicating effect of alcohol inherent to extract ridges of grapes, and when combined extract, rose fruit extract ridges grapes and herbs Hypericum mutually stabilize the biological activity of polyphenolic compounds and vitamin C, which plays a direct role in the formation of protivoallergennogo actions total drug.It was investigated the effect of the total preparation, including the extract of the ridges of the grapes, the extract of the herb St. John's wort extract hips, on the dynamics of gravity of the syndrome of ethanol, the change of body weight and mortality of animals subjected to forced alcoholism.Of male rats Wistar were subjected to subacute intoxication with alcohol using a known method forced alcoholism [Abdrashitov A. H., Listvin macology and toxicology. - 1983. No. 3. - S. 94-98]. For this to rats for 6 days with an interval of 12 hours was administered intragastrically 30% solution of ethanol in doses varying in the range of 2-6 g/kg of body weight. The rats of one group were injected with ethanol, the rats of the other groups - ethanol, which was dissolved total extract ridges grapes, herbs St. John's wort and hips (the ratio of the extracts was 2:1:1). Each animal experimental group received 50 mg/kg of body weight of the total extract for an injection (100 mg/kg of body weight per day). Served as control rats, cotrim instead of ethanol was injected water.The severity of the syndrome of ethanol was evaluated in points on the special ranked scale [B. N., Savchuk, S. A., Demeshina I. C., Zabirova, I., Litvina B. N., samojlik D. C., L. Surkov A., Tezikov E. B. Composition and toxicity of samaganov from honey and sugar // the Abstract collection of VINITI. News of science and technology. Series Medicine. Vol. Alcoholic disease. - 1999. No. 6. - S. 1-10].The results obtained are presented in Table 4. From these results it follows that investigated the total extract significantly reduces the severity of the syndrome ethanol, reduces loss of body weight of the animals and prevent their death.In this regard, the extract of white grapes, it is advisable to standardize the content of the fraction of aromatic aldehydes and the fraction of oxygenated compounds of phenolic nature.On average, 1 ml of aqueous-alcoholic extract of the ridges of the grapes contains about 80 mg of dry matter.Components of the extract of the herb St. John's wort, manifesting his alcohol activity, not currently identified. Therefore, standardization of the extract should be conducted on indirect indicators. This criterion, for example, can serve the content in the extract of hypericin - specific metabolite produced by this plant. This indicator is ressante the effectiveness of the Hypericum extract was used preformed extract with standard - a 0.3% hypericin content that observed in a recent meta-review [Kasper, S., Schulz V. St. Johns wort extract as plant antidepressant. Johanniskraut-Extract als pflanzliches Antidepressivum. Schweiz Rundsch Med-Prax, 2000 Dec 21, Vol.89 (51-52), pp.2169-77].It can be assumed that the accumulation of hypericin in plants correlates with the accumulation of other metabolites. In other words, we can assume that the higher the extract hypericin content, the higher the content of other biologically active compounds. At least, standardization protivoallergennoy activity of Hypericum extract on the content of hypericin appears to be more reliable and relevant than standardization of the extract on the solids content.Moreover, it can be assumed that alcohol action of the extract of the herb St. John's wort may be due, including, with its antidepressant activity, reducing a conscious or unconscious need alcohol consumption.Usually in 1 ml of water-alcohol extract of the herb St. John's wort contains approximately 60 mg of dry matter.The active beginning of the extract, rosehips can be considered multivitamin complex, including witaminy C, K and R. the Receipt of additional quantities of these vitamins in the body, quiet can be broken under the influence of alcohol.The extract of the fruit of the wild rose can standartizaciisa on the content of ascorbic acid (vitamin C).Typically, 1 ml of aqueous-alcoholic extract of the fruits of the wild rose contains about 40 mg of dry matter.Therefore, the proposed facility in General to ensure reproducible biological effect can be standardized at the same time on the content of the fraction of aromatic aldehydes, the fraction of oxygenated compounds of phenolic nature, hypericin and ascorbic acid.In alcoholic drink should be made to this number means, which is capable of providing the minimum content of 1 liter of drink not less than 2.8 mg fraction of aromatic aldehydes, not less than 116 mg of the fraction of oxygenated compounds of phenolic nature, not less than 0,0005% hypericin and not less than 24 mg of ascorbic acid.The absolute concentration of the normalized components of the tool in alcoholic drink depends on the strength of the corresponding alcoholic drink - the higher the strength of the drink, the higher should be the concentration of the phytocomplex.In the case of independent use of the proposed facilities (i.e., not used in the composition of Ala is ogologo drink, containing the standard Supplement.We offer a phytocomplex can be prepared in the form of a solution or as a dry product. Her specific amount deposited in the alcoholic beverage, depends ultimately on the content of regulated compounds.The drying solution is performed in known methods, mainly at moderate temperatures, preferably at a temperature not exceeding 40C.The proposed tool can be added to the composition of alcoholic beverages containing from 7 to 45% vol. the alcohol. Preferably the use of this ' obtained by extraction of plant material with a water-alcohol mixture of the fortress, what is the fortress of alcoholic beverage, for the introduction and which is included in this tool.For the preparation of the proposed funds previously can be obtained separately water-alcohol extract of the ridges of the grapes, water-alcohol extract of the herb St. John's wort and water-alcohol extract of the fruit of the wild rose, which are then mixed in such proportions to provide standardized content in the finished product standardizovanih components. Thus the normalized content in addition standartnom drink the normalized concentrations of these components in the above regulated limits.To ensure that the proposed addition of the desired ratio of active principles are necessary, the individual listed extracts can be mixed usually in the ratio 2:1:1.The actual process of extraction in all cases carried out in a known manner, for example, using the technique of infusion, percolation or repercolation. It is desirable to carry out this process in the most moderate temperature conditions at a temperature not exceeding 40C, and even better at room temperature.Generally, the extraction is conducted 1-10 volumes of water-alcohol mixture, preferably 1-2 volumes, in the battery of 3-5 percolation for 10-48 hours, preferably for 10 to 30 hours.At the same time, uchityvaetsya that the plant material is characterized by a high ability to absorb fluid, and its pre-soaked volume of extractant, equal to the weight of the extracted material. Typically, the weight of the obtained extract should equal or be close to the weight of the extracted material.For preparation of the extract of white grapes can be used combs white or red grapes, pre-dried at a moderate temperature and Ismail dried and crushed to particle size of 0.1-0.5 see Preferably the use of the herb Hypericum perforatum (Hypericum perforatum L.) as the most common form, but in principle can be used and other types of this plant.To obtain the extract of the fruit of the wild rose used preferably whole (not crushed) fruits. Can be used rosehips and cinnamon (Rosa cinnamomea L.), thorny rose (Rosa acicularis Lindb.), the Daurian rose (Rosa dahurica Pall.), rose hips may (Rosa majalis Herrm.) and other types.The extraction of the crushed rosehips in the extract transferred some lignins, pectins and other compounds, further precipitating or forming a suspension. This leads to the need for additional processing feedbacki containing extract of the crushed rosehips. For these purposes, the liquid additive is necessary several times to withstand the cold and to separate the precipitation, which complicates the process.The best way of receiving the proposed means is that extraction is subjected to a mixture of crushed white grapes, chopped herbs Hypericum and unground hips in the ratio 2:1:1.If necessary, the extract Vysshaya - spray drying.On average, 1 ml of total extract obtained by extraction of the original plant material with a water-alcohol mixture strength of 40%, contains approximately 80 mg of dry matter, although this value may vary markedly.Upon receipt of the total extract, representing the proposed tool, in standard conditions, the extract containing 1 ml of liquid extract not less than 0.8 mg fraction of aromatic aldehydes, at least 30 mg of the fraction of oxygenated compounds of phenolic nature, not less than 0.1% hypericin and at least 6.5 mg of ascorbic acid.Obtained under standard conditions dry complex extract contains per 1 g of dry extract of at least 10 mg of the fraction of aromatic aldehydes, not less than 380 mg of the fraction of oxygenated compounds of phenolic nature, not less than 0.1% hypericin and at least 80 mg of ascorbic acid.The number of proposed feedbacki made into an alcoholic drink, depends on the strength of alcoholic beverage and should be the greater, the stronger alcoholic drink.The minimum amount of funds deposited in the alcoholic beverage (7% vol. alcohol should be takong fraction of oxygenated compounds of phenolic nature, not less 0,0009% hypericin and not less than 25 mg of ascorbic acid.The minimum amount of funds deposited in a strong alcoholic drink (45% vol. alcohol) must be such that 1 liter of alcoholic beverage contained at least 8 mg of the fraction of aromatic aldehydes, at least 300 mg of the fraction of oxygenated compounds of phenolic nature, not less 0,0009% hypericin and not less than 65 mg of ascorbic acid.These values are not critical and may need to be increased, since all components are of low toxicity.Received as described liquid extract is a dark brown color, tart taste and specific vegetable smell.The dry extract is a hygroscopic brown powder with a tart flavor and floral aroma.To improve the organoleptic characteristics of alcoholic beverage if desired, the proposed Fiorello may be combined with other flavors and fragrances.Alcoholic beverages, the composition of formulations which include the proposed tool, milder effect, and manifestations of postincarceration changed.The following Examples merely serve to illustrate the merits of the proposal and should not be restrictive.EXAMPLE 1.For the preparation of the proposed framework was prepared mixture consisting of 0.4 kg of crushed white grapes, 0.2 kg of chopped herbs Hypericum perforatum and 0.2 kg of whole rosehips may. The mixing ratio by weight was 2:1:1. This mixture was filled in 3 percolator United in the battery, each of which was placed on 0,266 kg of the mixture. The plant material was previously wetted equal weight of raw materials number of water-alcohol mixture fortress 45 vol.%, and then extracted in 1 l of water-alcohol mixtures of the same fortress. The extraction process was carried out at room temperature for 30 hours. They received a total of 0.8 l of extract, representing a dark brown liquid with a fruity odor.The resulting extract contained 8% of dry residue. The content in the extract fractions of aromatic aldehydes was 0.8 mg/ml, the fraction of oxygenated compounds of phenolic nature of 30.4 mg/ml of hypericin 0.1% ascorbic acid 6.4 mg/mlThe liquid extract was spray-dried sushi is th brown powder.The content of dry extract fractions of aromatic aldehydes was 10 mg/g, the fraction of oxygenated compounds of phenolic nature 380 mg/g, hypericin 1.25% and ascorbic acid 80 mg/gPrepared in the manner described phytonutrient, representing a liquid or dry extract, intended for the introduction of the alcoholic beverage with an alcohol content of 45% vol.To modify the toxic action of this alcoholic drink this drink minimum must contain per 1 l drink 8 mg fraction of aromatic aldehydes, 300 mg of the fraction of oxygenated compounds of phenolic nature, 0,0009% hypericin and 65 mg of ascorbic acid.Therefore, the composition of the alcoholic beverage must be made at least 10 ml of liquid extract or at least 800 mg of dry extract per 1 liter of drink.EXAMPLE 2.For the preparation of the proposed framework was prepared mixture consisting of 2 kg of crushed white grapes, 1 kg of chopped herbs Hypericum perforatum and 1 kg of solid hips cinnamon. The mixing ratio by weight was 2:1:1. This mixture was filled in 5 percolation, merge the n equal weight of raw materials number of water-alcohol mixture fortress 8,5 about, % and then was extracted 8 l water-alcohol mixture in the same fortress. The extraction process was carried out at room temperature for 20 hours. They received a total of 6 l of extract, representing liquid light brown color with a characteristic smell.The resulting extract contained 4% of dry residue. The content in the extract fractions of aromatic aldehydes was 0.28 mg/ml, the fraction of oxygenated compounds of phenolic nature of 11.6 mg/ml of hypericin 0.1% ascorbic acid 2.4 mg/mlLiquid extract pre-agglomerated twice on the vacuum evaporator, and then it was dried by sublimation method at a temperature not exceeding 40 ° C, and was obtained 320 g of dry extract. The dry extract was a brown powder.The content of dry extract fractions of aromatic aldehydes was 7 mg/g, the fraction of oxygenated compounds of phenolic nature 300 mg/g, hypericin 2.5% and ascorbic acid 60 mg/gPrepared in the manner described phytonutrient, representing a liquid or dry extract, intended for the introduction of the alcoholic beverage with an alcohol content of 8.5% vol.For modification of toxic dei is tion of aromatic aldehydes, 120 mg of the fraction of oxygenated compounds of phenolic nature, 0,0009% hypericin and 24 mg of ascorbic acid.Therefore, the composition of this alcoholic drink must be made at least 10 ml of liquid extract or not less than 0.4 g of dry extract.EXAMPLE 3.For the preparation of the proposed framework was prepared mixture consisting of 0.8 kg of crushed white grapes, 0.4 kg of chopped herbs Hypericum perforatum and 0.4 kg of whole Dahurian rose fruit. The mixing ratio by weight was 2:1:1. This mixture was filled in 3 percolator United in the battery, each of which was placed on 0,532 kg of the mixture. The plant material was previously wetted equal weight of raw materials number of water-alcohol mixture fortress 25 vol.%, and then extraheavy 2 liters of water-alcohol mixtures of the same fortress. The extraction process was carried out at room temperature for 25 hours. They received a total of 1.8 liters of the extract, representing a brown liquid with a characteristic odor.The resulting extract contained 6% of dry residue. The content in the extract fractions of aromatic aldehydes was 0.36 mg/ml, the fraction of oxygenated compounds Shen on the spray dryer at a temperature not exceeding 40 ° C, and was obtained 110 g of dry extract. The dry extract was a light brown powder.The content of dry extract fractions of aromatic aldehydes was 6 mg/g, the fraction of oxygenated compounds of phenolic nature 270 mg/g, hypericin 1,67%, ascorbic acid 27 mg/gPrepared in the manner described phytonutrient, representing a liquid or dry extract, intended for the introduction of the alcoholic beverage with an alcohol content of 25 vol.%.To modify the toxic action of this alcoholic drink this drink should contain minimal per 1 liter of the drink not less than 2.8 and not more than 8 mg of the fraction of aromatic aldehydes, not less than 120 and not more than 300 mg of the fraction of oxygenated compounds of phenolic nature, not less 0,0009% hypericin, not less than 25 and not more than 65 mg of ascorbic acid.The composition of the alcoholic beverage was made to 10 ml of liquid extract, equivalent to 600 mg of dry extract.The result is an alcoholic beverage containing per 1 liter of beverage 3.6 mg fraction of aromatic aldehydes, 162 mg of the fraction of oxygenated compounds of phenolic nature, 0,0009% hypericin, 45 mg Scola is Astia alcohol under the influence of the extract of the ridges of the grapes for significant strengthening of the ability to ease symptoms postintoksikatinom alcohol syndrome, increasing consumer properties of alcoholic beverages in recipes that she can be entered.The combination of biologically active compounds that form the basis of funds has been changed previously for similar purposes is not used.1. Means for reducing the toxic effect of alcohol, characterized in that it includes a water-alcohol extract of the ridges of the grapes, water-alcohol extract of the herb St. John's wort and water-alcohol extract of the fruit of the wild rose.2. Means under item 1, characterized by the fact that its oral use up alcoholic beverage during consumption of alcoholic beverage or directly after drinking alcohol.3. Means under item 2, characterized in that part of the recipe alcoholic drink.4. A tool according to any one of paragraphs.1, 2 or 3, characterized by the fact that standardized in content fraction of aromatic aldehydes, the fraction of oxygenated compounds of phenolic nature, hypericin and ascorbic acid.5. Means on p. 3, characterized in that minimally contains per 1 l of slatinany phenolic nature, not less 0,0009% hypericin and not less than 25 mg of ascorbic acid.6. Means on p. 3, characterized in that minimally contains per 1 liter of alcoholic beverage at least 8 mg of the fraction of aromatic aldehydes, at least 300 mg of the fraction of oxygenated compounds of phenolic nature, not less 0,0009% hypericin and not less than 65 mg of ascorbic acid.7. A method of obtaining a means of reducing the toxic effect of alcohol, characterized in that the mixture of crushed white grapes, chopped herbs Hypericum and solid hips extracted with a water-alcohol mixture and, if necessary, the extract was dried.8. The method according to p. 7, characterized in that the ratio of the extracted mixture of white grapes, herbs St. John's wort and hips is 2:1:1.9. The method according to any of the p. 7 or 8, characterized in that the extraction is carried out with a water-alcohol mixture of the fortress, what is the fortress of alcoholic beverage, for the introduction of which is intended tool.
The invention relates to the field of medicine and relates to new N-pinakamaraming tryptophanase of dipeptides of the formulaC6H5-(CH2)n-CO-NH-(CH2)m-CO-X-Trp-R,where n=1-5;m=1-3;X=L or D-configuration;R=OH, OCH3OC2H5, NH2, NHCH3,as well as pharmaceutical compositions containing them
The invention relates to new derivatives of benzothiadiazole, benzoxazoles and benzodiazines formula I in free base form or in the form of a pharmaceutically acceptable acid salt additive that can be used as an anxiolytic drug in the treatment of any condition, which is associated with increased endogenous levels of CRF or in which violated the regulation of the hPa system (hypothalamic - pituitary), or various diseases that are caused by CRF1or the manifestation of which contributes CRF1such as arthritis, asthma, allergies, anxiety, depression, etc
The invention relates to medicine, namely to addiction
The invention relates to medicine
The invention relates to means on the basis of natural ingredients with antitoxic action of alcohol poisoning, and can be used both in the medical and food industry
The invention relates to the field of medicine and relates to dosage forms of medicinal preparations, namely pharmaceutical forms of naltrexone
The invention relates to new guanidinium heterocyclic compounds of the formula (I), where R1denotes H, alkyl or is absent when R1missing link (a) is a double bond, D represents CR2, R2selected from H, alkyl, halogen, or, when is a CR3D can be N, denotes NR9, CR3=CR8, CR3, S, where R9denotes H, alkyl, alkenyl or quinil and where R3and R8selected from H, alkyl, alkenyl, quinil or cyano, R4, R5, R6each independently selected from H, alkyl, alkenyl, quinil, cyano, halogen or NH-C(= NR10)OTHER11(guanidine), R10and R11selected from H, methyl and ethyl, and where only one of R1, R5and R6is guanidines, R7selected from H, alkyl, alkenyl, quinil and halogen
The invention relates to new arylpyrimidines compounds of formula I having the effect of antagonist 5HT2B-receptor, and pharmaceutical compositions
The invention relates to medicine
The invention relates to medicine
The invention relates to medicine, obstetrics, and can be used for the prevention of preeclampsia in pregnant
The invention relates to medicine, obstetrics and gynecology, and can be used for the treatment of chronic placental insufficiency
The invention relates to medicine, in particular to gerontology and cosmetology
The invention relates to medicine, namely to the creation of technology of preparation of homeopathic medicines, herbal tablets
The invention relates to the field of creation of medicines, which have immunostimulating action
The invention relates to pharmaceutical industry and veterinary
The invention relates to animal husbandry
The invention relates to meat processing industry and can be used to obtain a number of valuable products containing biologically active substances
The invention relates to the creation of tools for the treatment of patients with vascular diseases lipid metabolism disorders and can be used in neurology and cardiology
FIELD: medicine, cardiology, phytotherapy, pharmacy.
SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.
EFFECT: valuable medicinal properties of supplement.