Substituted tryptophanase dipeptides with holetsistopankreatite or cholecystokinin activity

 

The invention relates to the field of medicine and relates to new N-pinakamaraming tryptophanase of dipeptides of the formula

C6H5-(CH2)n-CO-NH-(CH2)m-CO-X-Trp-R,

where n=1-5;

m=1-3;

X=L or D-configuration;

R=OH, OCH3OC2H5, NH2, NHCH3,

as well as pharmaceutical compositions containing them. Compounds have cholecystoenterostomy or holetsistopankreatity action. 2 S. and 6 C.p. f-crystals, 1 Il., 19 table.

Description text in facsimile form (see graphic part).

Claims

1. N-pinakamaraming tryptophanase dipeptides of the formula

With6H5-(CH2)n-CO-NH-(CH2)m-CO-X-Thr-R,

where n = 1-5; m = 1-3; X = L or D-configuration; R = OH, och3OS2H5, NH2, N3.

2. Connection on p. 1, representing

With6H5-(CH2)4-CO-Gl-X-Thr-R,

where X = L or D-configuration; R = HE, OS2H5, NH2or N3.

3. Connection on p. 1, representing

With6H5-(CH2)3-CO-Gl-X-Thr-R,

where X is Wallpapers

C6H5-CH2-CO-Gly-X-Trp-R,

where X = L-configuration; R = OC2H5or NH2.

5. Connection on p. 1, representing

With6H5-(CH2)5-CO-Gl-X-Thr-R,

where X = L or D-configuration; R = OS2H5or NH2.

6. Connection on p. 1, representing

With6H5-(CH2)5-CO--l-X-Thr-R,

where X = L or D-configuration; R = HE, OS2H2or NH2.

7. Connection on p. 1, representing

With6H5-(CH2)5-CO-DOUBLE-L-Thr-R,

where R = och3.

8. Pharmaceutical compositions containing as active ingredient a therapeutically active amount of the compounds on p. 1.

 

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