The method of treatment of drug addiction
(57) Abstract:The invention relates to medicine, namely to addiction. The drug therapy is performed using a low-energy microwave field, modulated in the range of resonant frequencies of the brain. When this microwave field modulate the frequency range from 0.1 to 60 Hz with a duty cycle varying in stochastic mode quasi-white noise. The modulation frequency microwave fields change in the range of resonant frequencies of the brain in the following ratio of the frequency ranges in the total spectrum of the modulating signal, %: Delta-range 1-51, Theta-range 2-67, alpha range 2-59, Beta-range 1-33, Gamma-range 1-26. The method allows to increase the effectiveness of the treatment. 2 C.p. f-crystals, 2 tab. The invention relates to medicine, namely to methods of treatment of drug addiction. The invention relates to physiotherapy, as is a method for the treatment of drug addiction resonant electromagnetic therapy.Drug addiction, drug dependency, i.e., the syndrome of “I can't live without drugs”, which has both mental and physiological nature. Regular use of the drug reduces the number of receptors, with affinity to opea the Andes do not have targets for binding. This effect underlies the formation of physical dependence. The cage needs to exogenous opioids as a substitute for endogenous opiates, becoming drug dependent.Under the syndrome of dependence understand irrepressible desire for the drug to achieve psychological well-being, which is manifested in the constant thoughts about the drug, depression and dissatisfaction if absent. When there is a change in the motivational system of the person, his behavior aimed at obtaining pleasurable sensations through drug use, in the absence of which in a patient experiencing strong negative emotions and impulsive uncontrollable urge to narcotic substances.The syndrome of dependence is one of the most challenging problems in addiction treatment, as even in the absence of physical dependence, the patient is always under the impression deep emotional experiences associated with the use of the drug.The syndrome of physical dependence determines the need for repeated taking drugs already not to achieve a state of mental comfort and to relieve withdrawal symptoms i.e. withdrawal symptomological dysfunction neuroregulatory systems and continuous improvement doses of exogenous drugs needed for the relief of pathological dysfunction. No drug or insufficiency dose leads to a withdrawal syndrome.Abstinence syndrome (withdrawal) is expressed in physical suffering, causing an irresistible urge to anesthesia. The need for the drug is so strong that replaces even such vital desire as hunger and thirst.Physical dependence suppresses and eliminates self-control, determines the behavior, motivation and social behavior of patients.To date, the primary method of treatment of drug addiction include: detoxification therapy, the replacement of a strong narcotic agonist on weaker antagonists-agonists, symptomatic treatment of withdrawal symptoms, psychotherapy coding with unconditional reinforcement, etc. For symptomatic therapy using medicines from the group of neuroleptics, tranquilizers, calcium blockers, GABA-ergicheskie and other drugs, can reduce the various manifestations of withdrawal syndrome.The need for drug abuse treatment comprehensive means acting on different pathophysiological ptx2">When developing non-pharmacological methods of treatment of addictive disorders (alcohol dependence, drug abuse) has been shown promising approaches associated with the use of a variety of physical systems using the principles of biofeedback.Known methods of drug treatment, based on the use of physiotherapy treatment on neuroregulatory systems of the body through the use of generators, emitting electromagnetic waves in the range of extremely high frequencies [1, 2].However, in the process of this treatment, unfortunately, is not reduced neither mental nor physical dependence is only observed decrease in severity of disease symptoms associated with intoxication of drugs.The prototype of the present invention is a method of drug therapy based on the use of biologically active electromagnetic radiation of the microwave range . The disadvantage of this method is its relatively low efficiency and expediency of application only as a means of adjuvant symptomatic therapy aimed at achieving an anti-inflammatory, antispasmodic methods, contributing to the restoration of affinity for opiate receptors and their endogenous ligands.The aim of the invention is to develop a method addiction therapy based on the use of electromagnetic radiation, can have a specific therapeutic effect, with a higher efficiency and a broader spectrum of therapeutic action, as compared with the prototype.The essence of the proposed invention is that the drug therapy is performed using a low-energy microwave field, modulated in the frequency range of the EEG.In addition, in accordance with the invention, the microwave field modulate the frequency range from 0.1 to 60 Hz with a duty cycle varying in stochastic mode quasi-white noise.In addition, in accordance with the invention, the modulation frequency microwave fields change in the range of resonant frequencies of the brain in the following ratio of the frequency ranges in the total spectrum of the modulating signal %The Delta range 1-51Theta range 2-67The alpha range 2-59Beta range 1-33Gamma-range 1-26Resonance (FR.) from l the system, coming when approaching the frequency of the external harmonic effects, to the frequency of one of the natural oscillations of the system.The development of modern technologies bioresonance therapy with the use of electromagnetic radiation have shown that the human body is a deeply self-organizing and self-regulating system, consisting of hierarchically interacting cellular structures capable of sufficiently responding to the influence of electromagnetic waves subthreshold capacity .Given that the brain is well protected from external factors, it was important to correctly define the energy carrier that can cause planned “information” (i.e., depends only on the nature of the modulating signal) response aimed at restoring the disturbed spatial-temporal patterns of bioelectric processes and self-regulation of the patient. Such a universal medium, according to our data, may be electromagnetic microwave field, modulated in the frequency range of the brain, the energy flux density 1-10 µw/cm2. To the structures of the brain was obtained the maximum response on so little energy, heart and soul is lebani. At the stage of preliminary studies for the simulation of this problem, the authors used mathematical apparatus of differential equations with deviating argument.According to our data, a specific action is modulated in accordance with the invention, the microwave field is implemented through a system of biological amplification, which includes the CA++ - binding protein calmodulin and camp and cGMP-dependent protein kinase involved in regulation of conformational processes at the cellular membrane opioid receptors.Example 1. Studies made on the basis of the 1st interregional drug dispensary, S.-Petersburg. Clinical testing of the method was carried out on 20 patients with drug addiction, with experience of drug use for at least 3 years with a daily dose of heroin with the/in the introduction from 0.5 to 1.0, All patients before treatment repeatedly treated by other methods without effect. The maximum duration of remission to treatment for 2 months. All patients were pre survey:- cardiovascular system,- Ultrasound diagnosis- EEG,biochemical studiesvirological studies.After the floor is e carried out in the direction of the head - legs stationary generator UHF (Ranet MSK 20-2) through a consistent antenna. The microwave field is modulated in the frequency range of the electrical activity of the brain, namely 0.1 to 60 Hz. Table.1 digital data describing the spectrum of the modulating signal, is presented below.the 1st procedure is carried out after the complete abolition of the drug against the background of significant withdrawal symptoms (watery eyes, runny nose, chills, pain in muscles and bones, tachycardia, blood pressure reduction, motor restlessness, aggressiveness, on the rhythm and ECG absence of respiratory waves). The duration of the procedure - 65 minutes After 25-30 minutes from the start of the procedure marked improvement, stopped tearing, runny nose and chills, decreased the intensity of the pain syndrome. By the end of the procedure showed a significant decrease in the severity of withdrawal symptoms in 80% of patients.the 2nd procedure was performed within 24 hours Before the procedure 100% of patients complained of the state pedlosky” (mild fever, runny nose, watery eyes, etc). After 25-30 minutes after the start of the procedure, the patients were asleep. After the procedure it was noted the absence of complaints and subjective assessment as good in 80% of patients.4th procedure was performed within 24 hours Before the procedure, only 5% of patients complained of the state pedlosky”. After 10-15 min after the beginning of the procedure, all patients were asleep. After the procedure it was noted the absence of subjective complaints and self-reported status as good in 100% of patients.The average duration of treatment course of 8 treatments over a period of 8 days. Physical dependence was charged at 100% of patients. Duration of remission for up to 14 months (observation period).Example 2. For pharmacological evaluation revealed therapeutic effects of modulated microwave field experimental investigations were carried out on Guinea pigs. Animals were divided into 4 groups of the same age, weight and sex. Animals of the 2nd, 3rd and 4th groups for 10 days) was subcutaneously injected morphine hydrochloride in a dose of 0.001 g/kg of the Evaluation of the sensitivity of opioid receptors mu - type endogenous ligands was performed 24 h after the last injection drug using method-receptor analog of met-enkefalina. in increasing concentrations (dilutions of 10-7 to 10-4).It is established that blockade of evoked activity PCMS was observed in 1 control (intact) group of animals using similar meth-enkefalina in a dilution of 10-7. While in the 2nd experimental group (active control), this effect was evident at higher concentrations similar meth-enkefalina not less than 100 times. These data indicate a decline in the sensitivity of the opioid mu-receptors to endogenous ligand for the background of the exogenous introduction of drugs. With the medical purpose used two methods of therapeutic treatment of the electromagnetic field.the 1st method is applied microwave field, pulse modulated which was implemented in the frequency range from 0.1 to 60 Hz with a duty cycle varying in stochastic mode quasi-white noise. This mode is used within 24 h after the last injection of the drug (procedure 4 exposure for 30 min each at 1, 2, 3 and 4-th day after the last injection of the drug). The application of this regime restored the sensitivity of the opioid mu-receptors to met-enkephalin up to 60% level 1 control group.the 2nd method is applied microwave field, which is modulated in the range of the store signal, below.The described method of exposure, which was applied 1 day after the last injection of the drug (procedure 4 exposure for 30 min each at 1, 2, 3 and 4-th day after the last injection of the drug), fully restored the sensitivity of the opioid mu-receptors to met-enkephalin.Sources of information1. Brant I. L. Mikhailov, C. I., Kozhemyakin A. M. a New method of bioresonance therapy etidronova addiction. “Russian journal of psychiatry”, 19992. Votoropin C. D., Liang N. In., Liang C. N. A method of treatment of substance abuse. Application for invention No. 99125726/14(027151) from 06.12.99.3. RF patent №2113253 from 20.06.1998,4. Illarionov C. E. Medical information-wave technology. - M.: CC MK “Protection”, 1998 1. The way addiction therapy involving the use of electromagnetic radiation in the microwave range, wherein, in order to restore affinity for opiate receptors, their endogenous ligands and relieve withdrawal symptoms, the microwave field modulate the frequency bioelectrical activity of the brain of 0.1-60 Hz.2. The method according to p. 1, characterized in that the microwave field modulate the frequency range from 0.1 to 60 Hz with squares is astato the modulated microwave fields change in the range of resonant frequencies of the brain in the following ratio of the frequency ranges in the total spectrum of the modulating signal, %:The Delta range 1-51Theta range 2-67The alpha range 2-59Beta range 1-33Gamma-range 1-26
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl