Taurolidine and/or taurultam in the treatment of infectious ulcer disease or infectious gastritis

 

Proposed: the use of taurolidine, taurultam or combinations thereof as a means for the treatment of diseases of the gastrointestinal tract of mammals, caused by Helicobacter pylori, Helicobacter heilmanni or a combination of these microorganisms, the method of treatment of relevant diseases and compositions based on a combination of taurolidine, taurultam or their combination with a drug which forms a protective coating on the lining of the stomach of the patient, and compositions based on a combination of taurolidine, taurultam or their combination with a proton pump inhibitor. The invention allows not only to suppress the growth of these species of Campylobacter, but also to block their adhesion to the epithelial cells of the gastric mucosa, so that bacteria become pathogenic and stop the allocation of cytotoxin VacA. 4 C. and 5 C.p. f-crystals.

Description text in facsimile form (see graphic part).

Claims

1. Application of antimicrobial drug selected from the group comprising taurolidine, taurultam and their combination as a therapeutic agent for the treatment of diseases of the gastrointestinal tract of mammals caused by infec is Eesa fact, the specified antimicrobial drug is administered in the form of tablets, capsules, liquids, suspensions or syrups.

3. Pharmaceutical composition for treating diseases of the gastrointestinal tract of mammals, caused by infection with Helicobacter pylori, Helicobacter heilmanni or a combination of these microorganisms, characterized in that it includes antimicrobial drug selected from the group comprising taurolidine, taurultam and their combination, in combination with a pharmaceutically acceptable drug, covering the surface of the stomach, which forms a protective coating on the lining of the stomach of the patient, and a pharmaceutically acceptable gastric antacid agent, neutralizing the acid of the gastric juice.

4. Pharmaceutical composition for treating diseases of the gastrointestinal tract of mammals, caused by infection with Helicobacter pylori, Helicobacter heilmanni or a combination of these microorganisms, characterized in that it includes antimicrobial drug selected from the group comprising taurolidine, taurultam and their combination, in combination with a proton pump inhibitor.

5. The pharmaceutical composition according to p. 4, characterized in that the inhibitor Prem, the proton pump inhibitor is Rabeprazole.

7. A method of treating gastro-intestinal tract of mammals, caused by infection with Helicobacter pylori, Helicobacter heilmanni or a combination of these microorganisms, characterized in that the mammal is administered an antimicrobial amount of an antimicrobial drug selected from the group comprising taurolidine, taurultam and their combination.

8. The method according to p. 7, characterized in that the antimicrobial drug is administered in a dose equivalent to 200-1000 mg of taurolidine.

9. The method according to p. 8, characterized in that the antimicrobial drug is administered in a dose equivalent to 300-500 mg of taurolidine.

 

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