The means for the correction of components of the complement system blood in the treatment of chronic pyelonephritis

 

(57) Abstract:

Proposed: a new tool for the correction components of the complement system blood in the treatment of chronic pyelonephritis. It is a known immunomodulator Imunofan (Hexapeptide patterns Arg--Asp-Lys-Val-Tyr-Arg). The invention expands the Arsenal of tools for the treatment of chronic pyelonephritis and specifies the behavior of the connection. 3 table.

The present invention relates to medicine, namely internal medicine, and can be used for immune in the treatment of chronic pyelonephritis.

A prototype of this invention is the preparation oximetry (Byczkowski Century A. Immunological changes and their correction-methyluracil and oximation in complex treatment of chronic pyelonephritis single kidney: abstract of Diss. on competition of a scientific degree of Cand. the honey. Sciences. - Chelyabinsk, 1998, 25 C.).

Known evaluation of the effect of the drug Likopid in General complementary activity in model systems in vitro (Antchev A. C., Soskova B. C. to study the effect of immunomodulators on the activity of the complement system in model systems // Medical immunology, 2002, vol. 4, No. 2, S. 346).

The technical result - the expansion of the means of correction of complement components in the treatment of chronic pyelonephritis. This technical result is achieved by using imunofana as a correction components of the complement system.

For the correction of the complement system drug Imunofan (say. Pharmacological Committee of Ministry of health of Russia, registration number 96/283/5) used intramuscularly in a dose of 1 ml of 0.005% solution once a day for 10 days on the background of traditional therapy.

The use of this drug in 26 patients with chronic pyelonephritis contributed to the relief of the inflammatory process: 5-7 days of treatment was observed normalization of clinical and laboratory parameters.

Monitoring of indicators characterizing the activity of the complement system, showed increased levels of complement components in the blood of patients with chronic pyelonephritis (definition of complement components in plasma was performed immunofermentnym method) (table.1).

Clinical example No. 1.

Patient A., 58 years old, was admitted in the Nephrology Department of the city clinical hospital №21 10 08.01 (history No. 18484) complaining of aching pain in the lumbar region, shortness of mine chronic pyelonephritis about 11 years. Was treated with acute illness in hospital with the use of antibiotics and reseption. Over the past 11 years there has been a worsening of the disease 1 time per year. Objectively when entering a state of moderate severity, chills, body temperature - 37,2; palpation of the abdomen in the projection of the kidneys was determined pain, a symptom of "tapping" on the lumbar region was positive on both sides. On other systems without features.

Admission: General analysis of urine - protein - 0,1320/00leukocyte - in large quantities; urine analysis according to Nechyporenko - cells in large quantities; bacteriological urine cultures growth of microorganisms not found.

The ultrasound revealed an uneven seal walls and extending cavities Cup-pelvis system of the right kidney; excretory urography defined deformation of the Cup-pelvis renal systems.

Diagnosed with chronic pyelonephritis in the acute stage without renal dysfunction.

Treatment according to the following procedure: examp 1.0 g 4 times a day intramuscularly for 7 days, nitroxoline 0.05 g 4 times a day for 14 days, Imunofan 0,005% 1 ml / day intramuscularly for 10 days. In dyn is the realizations of body temperature.

At discharge (25.08.01 g) the patient had no complaints. Clinically palpation of the abdomen in the projection of the kidneys was observed in the reduction of pain, a symptom of "tapping" on the lumbar region is negative on both sides. In the analysis of urine: protein - negative, leukocyte - 1-2 in sight; Nechiporenko: leukocytes - 1000 in 1 ml of urine.

The results of the study of complement components are presented in table.2. According to the data (table.2) the patient A. during treatment was observed increased levels of C3, C4, C5 component of complement factor H.

Clinical example No. 2.

Patient A., 21 years old, was admitted in the Nephrology Department of the city clinical hospital №21 05.09.01 history No. 21046) with complaints of pain in the lumbar region, mainly to the right, chills, fever up to 38, frequent urination, weakness. Deterioration of health notes within two weeks.

Chronic pyelonephritis ill for about 1 year. Last exacerbation was in November 2000 - were treated in hospital with antibiotics. Objectively when entering a state of moderate severity, the body temperature of 37.5; palpation of the abdomen in the projection of the kidneys was determined soreness, si is Nesta.

Admission: General analysis of urine - protein - 0,440/00leukocyte - 10-11 in the field of view; urine analysis according to Nechyporenko - leukocytes 5500 in 1 ml of urine; bacteriological urine cultures growth of microorganisms not found.

On ultrasound examination revealed thickening of the walls of the cavities of the Cup-pelvis renal systems; excretory urography defined deformation of the Cup-pelvis system both kidneys.

Diagnosed with chronic pyelonephritis in the acute stage without renal dysfunction.

Treatment according to the following scheme: examp 1.0 g 4 times a day intramuscularly for 7 days, furagin 0.1 g 4 times a day - 7 days, Imunofan 0,005% 1 ml / day intramuscularly for 10 days.

In dynamics to 5 days the patient noted a significant decrease in pain in the lumbar region, General weakness, normalization of body temperature.

At discharge (18.09.01 g) the patient had no complaints. Clinically, is a symptom of "tapping" on the lumbar region is negative on both sides.

In the analysis of urine: protein - negative, leukocyte - 2-3 in the field of view; Nechiporenko: leukocytes - 1500 in 1 ml of urine.

The results of the study of complement components of blood are presented in tab, the 5 components of complement.

Thus, the use of imunofana in complex treatment of patients with chronic pyelonephritis contributed to the normalization of the changed parameters of complement components on the background of positive clinical dynamics.

The above indicates immunokorrigiruyuschy action imunofana on the state of the complement system in patients with chronic pyelonephritis.

The means for the correction of components of the complement system blood in the treatment of chronic pyelonephritis

Application imunofana as a means for correction components of the complement system blood in the treatment of chronic pyelonephritis.

 

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