Means for increasing the activity of neutrophils

 

(57) Abstract:

Proposed: the use of lithium ascorbate, formerly known as antiviral agent, as a means for increasing the activity of neutrophils. The invention expands the Arsenal of the declared destination. table 1.

The invention relates to chemical compounds based on lithium salts having the ability to increase the activity of neutrophils, and can be used for chemotherapy.

It is known that the chemical substance, lithium carbonate, has biological activity (1). However, it is a very toxic substance and has a low antioxidant activity.

The closest analogue to the proposed connection is a tool (2). However, it has a high toxicity and lack of activity against Klebsiella.

New technical problem - reducing the toxicity and the expansion of the means of possessing biological activity against Klebsiella.

The task to solve a new tool that improves the activity of neutrophils, and as this tool uses ascorbate lithium General formula Li C6H7·2H2O.

6H7·2H2O.

In the literature there is no information about the activity of ascorbate lithium.

The results of experimental and clinical studies have shown the presence of this type of activity of ascorbate lithium, and characterize it as a non-lethal tool.

Ascorbate lithium Li6H7ON2O is a white crystalline substance, soluble in water, used as a chemical substance.

The tests confirming the presence of activity towards neutrophils, and includes tests for acute toxicity, as illustrated by the following example.

Example.

Research confirming the impact of the proposed substances on the functional activity of polymorphonuclear leukocytes in the peripheral blood of healthy donors, conducted on the model of incomplete phagocytosis (3, 4). The research results are summarized in the table, which shows that after exposure to ascorbate lithium increases the percentage of active neutrophils capable of englobe staphylococci (16-32)%, 1.5-2 fold increased adsorption capacity of leukocytes (p<0,001) on Wed the g/l there is a significant deviation of the number of active human neutrophils, accompanied by lowering the absorption capacity of polymorphonuclear leukocytes (p<0,001), indicating a toxic effect of the base drug on neutrophil leukocytes that play an important role in anti-infective resistance of the organism.

Thus, for the first time identified a new property of ascorbate lithium, characterizing it as a tool that improves the activity of neutrophils with low toxicity.

Sources of information

1. P. D. Mashkovsky. Medicines, including 1. - M.: Medicine, 1993, S. 127.

2. RU # 98105150 AND 10.01.2000(prototype).

3. Laboratory methods in the clinic (Handbook /edited by centuries Menshikov. - M, Medicine, 1987, S. 360).

4. A. N. Mayansky. Phagocytosis: problems and prospects. - Bulletin of the Russian Academy of medical Sciences, 1993.

The use of lithium ascorbate as a means of increasing the activity of neutrophils.

 

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