A method of treatment of peritonitis

 

(57) Abstract:

The invention relates to medicine, and is intended for the treatment of peritonitis. Carry out the introduction of non-drug “Splendid” 1 times a day for 3 days and irradiated with an infrared laser projection zones of the liver, spleen, small intestine, femoral vessels with two sides 1 time per day for 5 days. During one session irradiated with 5 fields 2-3 cm220 mW and a frequency of 100 Hz for 3 minutes Method can improve the effectiveness of the treatment, to achieve significant growth in a shorter time indices of cellular and humoral immunity, reduce toxicity, improve the clinical picture, to reduce the concentrations of drug of xenoculture.

The invention relates to medicine, in particular intended for the treatment of peritonitis.

The known method of complex treatment of peritonitis (see C. I. Korepanov. Guide to laser therapy. - M., 1995, S. 176 and 177), namely, that patients with peritonitis was performed laser irradiation of the blood and the anterior abdominal wall with the introduction in the complex treatment of antioxidants.

The disadvantages of the method are violations of the antioxidant system, red is high degree.

Also known is a method of treatment of peritonitis using xenoculture (C. N. Stagnina, C. A. Sitnikov, A. B. Tsypin Xanomeline in experiment and clinic. H. 1. - Izhevsk, 1994, S. 30), including the introduction of non-drug xenoculture 1 times within 3-6 days depending on the severity of the condition.

The disadvantage of this method, taken as a prototype, is the presence of thermal reactions to the drug, requiring symptomatic treatment.

The essence of the invention lies in the fact that according to the method of treatment of peritonitis, including the introduction of non-drug xenoculture, drug xenoculture enter 1 time per day for 3 days and irradiated with laser projection zones of the liver, spleen, small intestine, femoral vessels with two sides 1 time per day for 5 days.

This method can improve the effectiveness of the treatment, to achieve significant growth in a shorter time indices of cellular and humoral immunity, reduce toxicity, improve the clinical picture, to reduce the concentrations of drug of xenoculture to three. Used without supplemental treatment complex of antioxidants, can be used if exp is.

The method is as follows. The drug “Splendid”, developed at the research Institute of Transplantology and artificial organs, Moscow, A. B. Tsypin, 1995), available in standard vials, diluted to 3-5 ml saline and injected intravenously in 200 ml of physiological solution, 1 time a day for 3 days. Parallel to this is transcutaneous irradiation of infrared laser (e.g. “SEMICON”, , Samara), wavelength 0,88 μm, the following fields: the area of projection of the liver, spleen, small intestine (umbilically region), the femoral vessels from both sides. During one session is irradiated to 5 fields 2-3 cm220 mW and modulation 100 Hz for 3 minutes

Example 1. Patient A., 1966 R., was admitted to the hospital with a diagnosis of a ruptured stomach ulcer. Diffuse fibrinous-purulent peritonitis. The blood: leucocytes - 20,6109; stab leukocytes - 23%; lymphocytes - 1%; LII - 7,7; T-lymphocytes - 21%; T-helpers - 16%; IgA - 1.1 g/l; IgM - 4.1 g/l; IgG - 3.2 g/l; phagocytic activity of neutrophils - 50%; PSM (at a wavelength of 254 nm) - 0,560 srvc.ed.; Candidate of technical Sciences (at a wavelength of 280 nm) - 0,420 srvc.ed. Patient was operated: suturing perforated stomach ulcer. Sanitation, drainage of the abdominal cavity. After surgery with perevodilos irradiation of infrared laser projection zones of the liver. spleen, small intestine, femoral vessels with two sides once a day for 5 days. On the fourth day after surgery the blood: leucocytes - 6109; stab leucocytes - 1%; LII - 1,2; T-lymphocytes - 48%; T-helpers - 44%; IgA - 2.8 g/l; IgM - 6.3 g/l; IgG - 8,1 g/l; phagocytic activity of neutrophils - 76%; PSM (at a wavelength of 254 nm) - 0,267 srvc.ed.; PSM (at a wavelength of 280 nm) - 0,290 srvc.ed. The patient was discharged on day 7.

Example 2. Patient B., 1944 R., was admitted to the hospital with a diagnosis of gangrenous calculous cholecystitis, choledocholithiasis, mechanical jaundice. Spilled bile peritonitis. The blood: leucocytes - 2,3109; stab leukocytes - 12%; lymphocytes - 4%; LII - 9,7; T-lymphocytes - 18%; T-helpers - 14%; IgA - 1.0 g/l; IgM - 3.1 g/l; IgG - 2.8 g/l; phagocytic activity of neutrophils - 45%; PSM (at a wavelength of 254 nm) - 0,760 srvc. unit, candidate of technical Sciences (at a wavelength of 280 nm) - 0,580 srvc.ed.

The patient underwent surgery: cholecystectomy, choledocholithotomy, drainage choledochus by Vishnevskaya. Sanitation and drainage of the abdominal cavity. After the operation from the first day in the complex treatment entered the drug xenoculture “Splendid” once per day intravenously and transcutaneous laser irradiation of the projection zones of the liver, spleen, conceal the blood: leucocytes - 5,4109;stab leukocytes - 0%; lymphocytes - 26%; LII - 1,6; T-lymphocytes - 58%; T-helpers - 49%; IgA - 1.8 g/l; IgM - 5,3 g/l; IgG - 9,1 g/l; phagocytic activity of neutrophils - 73%; PSM (at a wavelength of 254 nm) - 0,167 srvc.ed.; PSM (at a wavelength of 280 nm) - 0,253 srvc.ed. The patient was discharged on the 10th day.

A method of treatment of peritonitis, characterized in that exercised by the introduction of non-drug "Splendid" 1 times a day for 3 days and irradiated with an infrared laser projection zones of the liver, spleen, small intestine, femoral vessels with two sides 1 time per day for 5 days, during one session irradiated with 5 fields 2-3 cm2with a capacity of 20 mW and a frequency of 100 Hz for 3 minutes

 

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FIELD: medicine, surgery, transplantology.

SUBSTANCE: embryonic spleen should be sampled, washed in nutritive medium № 199 to be placed into fresh medium № 199 to obtain homogenate in teflon homogenizer followed by centrifuging; then one should isolate the upper, medium and inferior layers, suck off medium layer and the upper part of inferior layer; the cell mixture obtained should be diluted in nutritive medium № 199 to be then introduced by injections into mesentery of small intestine or rectus muscle of abdomen. The present innovation favors the activation of immune system in patients undergone splenectomic operation and in those in case of surgical immunodefficient state due to high functional and regenerating activity of transferred embryonic splenic cells.

EFFECT: higher efficiency of prophylaxis.

6 dwg, 2 tbl

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