Suppositories "epiproct" with wound-healing effect

 

(57) Abstract:

The invention relates to the field of pharmaceutical industry and relates to a method of obtaining a suppository "Epiproct", featured in complex therapy of inflammatory processes of the rectum, prostatitis, hemorrhoids, treatment for anal fissures. The invention lies in the fact that the proposed suppositories contain the homogenate drone brood or lyophilized drone brood, Royal jelly, pollen, honey, propolis tincture of calendula, beeswax, lanolin anhydrous, solid fat, or witepsol, or cocoa butter. The invention provides a complete release of active substances, has a pronounced therapeutic effect, has minimal risk of side effects.

The invention relates to the field of pharmacy and medicine and relates to a technology of soft medicinal forms, namely suppository "Epiproct".

In Russia registered a small number of rectal suppository with wound-healing and anti-inflammatory action. Thus, in clinical practice, apply domestic suppositories with Ichthyol (M. D. Mashkovsky, 1997), candles with tincture of calendula (VFS 42-2622-95), candles Prostotv, can be taken as a prototype (VFS 42-3453-99). The composition of these suppository next, g:

Royal jelly native (apilak) - 0,1

Pollen - 0,08

Ambrosia - 0,15

Honey - 0,12

Propolis - 0,31

Beeswax - 0,06

Anhydrous lanolin - 0,12

Cocoa butter - 1,97

Candles "Postopen" prepared for lipophilic base (cocoa butter), have anti-inflammatory, protivogemorroidalny actions.

The disadvantage of this drug is that it is expensive import basis.

The purpose of this invention is to provide a candle "Epiproct", which has anti-inflammatory and wound-healing actions for preparation which, in addition to cocoa butter, use relatively cheap and available domestic raw materials: solid fat, witepsol. Actual components candles "Epiproct" are products of beekeeping and the tincture of calendula. The components selected for suppositories weight of 2.2-2.5,

Tallow and witepsol registered in Russia as a basis for the preparation of suppositories (FS 42-8991-98, type a and WUT 3-78), are cheap substitutes for cocoa butter. Physico-chemical properties of these bases allow use the products of beekeeping and tinctures of calendula, contains a complex of biologically active substances, in the following ratio of components, g:

Example 1

The homogenate drone brood - 0,05-0,06

/or lyophilized drone brood - 0,03-0,04

Royal jelly - 0,05-0,06

Ambrosia - 0,11-0,13

Honey - 0,09-0,11

Propolis - 0,23-0,25

Tincture of calendula - 0.6 ml

Beeswax - 0,05-0,07

Anhydrous lanolin - 0,09-0,11

Tallow is sufficient for preparation of a suppository mass of 2.2-2.5 grams

Example 2

The homogenate drone brood - 0,05-0,06

/or lyophilized drone brood - 0,03-0,04

Royal jelly - 0,05-0,06

Ambrosia - 0,11-0,13

Honey - 0,09-0,11

Propolis - 0,23-0,25

Tincture of calendula - 0.6 ml

Beeswax - 0,05-0,07

Anhydrous lanolin - 0,09-0,11

Witepsol - sufficient for preparation of a suppository mass of 2.2-2.5 grams

Example 3

The homogenate drone brood - 0,05-0,06

/or lyophilized drone brood - 0,03-0,04

Royal jelly - 0,05-0,06

Ambrosia - 0,11-0,13

Honey - 0,09-0,11

Propolis - 0,23-0,25

Tincture of calendula - 0.6 ml

Beeswax - 0,05-0,07

Anhydrous lanolin - 0,09-0,11

Cocoa butter - a sufficient quantity d is witepsol, or tallow) and melted at a temperature of 40-45oC. After that, the reactor serves the melted wax and stir. Then melted the basis filtered through colatura with a double layer of cheesecloth. The whole weight of the framework is divided into two roughly equal parts by the overflow of its existing reactors.

To the powder propolis poured tincture of calendula, the mixture was thoroughly stirred for 30 minutes, then add crushed ambrosia and again mix until smooth. The resulting mixture contribute in part to the basics in a separate reactor and stirred for 30-45 minutes at a temperature of 40-45oC. Pre-thawed Royal jelly and the homogenate (lyophilisate) drone brood contribute to the mixer with lanolin and mix with a mixer until a homogeneous mass. Then the resulting mass parts contribute to the reactor with the required number decrystallizing honey and the mixture is stirred for 25 minutes at 35-38oC. the resulting mass make the second part of the molten base and stirred for 30 minutes at a temperature of 35-40oC. Then combine the mixture of the two reactors and stirred them for 30 minutes, after which suppozitornaja the weight used for you is as the basis of solid fat, or witepsol, or cocoa butter, and as an active component the following complex: Royal jelly, the homogenate drone brood, honey, propolis, wax, bee bread, tincture of calendula.

Advantages of the proposed compositions are:

- low cost of the product, as designed candles are made on domestic raw materials;

- the optimal combination of compatible complex article concludes pharmacologically active substances;

- minimal risk of side effects;

- using a new relatively cheap active component homogenate or lyophilized drone brood, which has close to Royal jelly composition.

Candles "Postopen" prepared for lipophilic base (cocoa butter), have anti-inflammatory, protivogemorroidalny actions.

The disadvantage of this drug is that it is expensive import basis.

The purpose of this invention is to provide a candle "Epiproct", which has anti-inflammatory and wound-healing action, prepared with the addition of cocoa butter to use relatively cheap and available domestic raw materials: solid fat, the remaining components selected for suppositories weight of 2.2-2.5,

Tallow and witepsol registered in Russia as a basis for the preparation of suppositories (FS 42-8991-98, type a and WUT 3-78), are cheap substitutes for cocoa butter. Physico-chemical properties of these bases allow you to use them for candles "Epiproct".

This goal is achieved by introducing the basis of bee products and tinctures of calendula, contains a complex of biologically active substances, in the following ratio of components, g:

Example 1

The homogenate drone brood - 0,05-0,06

/or lyophilized drone brood - 0,03-0,04

Royal jelly - 0,05-0,06

Therapeutic and preventive effects of suppository "Epiproct" caused by a complex of active components in their composition.

Royal jelly contains a complex of biologically active substances: proteins needed to build and repair tissues; amino acids contributing to the formation of collagen and elastin, the healing of wounds; saturated and unsaturated fatty acids, activates metabolic processes; steroids promote cell renewal, thickening of the epidermis, phospholipids, glycolipids, improving the delivery of active substances in the cells of the body and protivovospalitelnoe activity.

The homogenate or lyophilized drone brood is available and relatively inexpensive substitute Royal jelly, a similar composition. The male bee brood contain proteins, amino acids, carbohydrates, vitamins, enzymes, minerals, nucleic acids, hormones, lipids, and other compounds. The complex of biologically active components causes a pronounced anti-inflammatory and wound-healing action.

Propolis contains 55% resins and balsams, a large amount of wax, scented essential oils and flower pollen. In the composition of plant resins and balsams, which is the main component of propolis, including acids, alcohols, phenols, tannins and carbohydrates. Propolis is defined amino acids, terpenoids, ketones, flavones, flavanone, aliphatic and aromatic hydrocarbons, mineral compounds and other Complex of biologically active substances causes a pronounced pharmacological effects. Propolis has antibacterial and anti-inflammatory properties, is used as a strong anesthetic agent, against itching. Active compounds of propolis clear cell membranes in the body, affecting lipoproteins, spaceape, propolis is effective in the treatment of burns and wounds of various etiologies, has preservative properties.

The honey. The main components of honey are carbohydrates, represented by monosaccharides and oligosaccharides. This product contains glucose, fructose, enzymes (diastasis, invertase, catalase, peroxidase, lipase), organic acids (malic, tartaric, citric, oxalic, lactic acid), micro - and macronutrients. The chemical composition of mineral substances honey close to the plasma of human blood. In addition, the composition of the honey bee include vitamins, proteins, amino acids (Proline, phenylalanine, tyrosine, aspartic and glutamic acids), lipids, free fatty acids (palmitic, stearic, oleic, lauric, arachidonic) and lipids (sterols and phospholipids), hormone, antibiotic, volatile and other valuable substances. Honey has a different biological properties: it has immunotropic, anti-allergic, anti-radiation, anesthetic, anti-inflammatory and wound-healing actions, has a preservative, bactericidal action. It stimulates growth of tissues in the body, restores the metabolic processes of dull skin cells. Honey Shea is different, cardiovascular and other diseases.

The wax. A major component of beeswax are esters cellulose, Kirillovka and melissinos alcohol and fatty acids (palmitic and oleic), and hydroxy - and ketoacids. The wax contains sterols (B-sitosterol, cholesterol and cholesterol esters, alcohols, saturated and unsaturated hydrocarbons, vitamin A. This product is used in dermatology for the treatment of skin inflammations, burns, wounds with antiseptic and stimulating tissue growth tool.

Ambrosia - the combination of nutrients and bioactive components of plant and animal (bee) origin, contains a number of substances: minerals, amino acids, carbohydrates, essential oils, vitamins, lipids, fatty acids and other Ambrosia has a strong biological effect on the human body, helps to normalize all kinds of currency, it has stimulating properties, accelerates the growth and development of organs and tissues. Its biologically active components have a positive effect on the mucous membrane of the gastrointestinal tract, excretory function of the glands, liver function, thyroid and other organs. Ambrosia the two is s body. In Perge many phenolic compounds, characterized by a capillary, antioxidative, choleretic, diuretic, anti-inflammatory, anti-sclerotic, anti-tumor and anti-radiation action. This product is indicated for the treatment of atherosclerosis, inflammation of the meninges, diseases of the prostate.

Calendula officinalis (Calendula officinalis). In the flower baskets contain carotenoids: beta carotene, rubixanthin, lycopene, zaroxolyn, violaxanthin, planogram, flavoxanthin, hydrocarbons (sitosterol and others), resin, triterpene glycosides, slimy and bitter substances, organic acids (malic, pentadactyla, salicylic acid), ascorbic acid and other compounds. A wide range of pharmacological activity (anti-inflammatory, wound healing, antibacterial, inflammatory and choleretic action) due to the high content of biologically active compounds such as carotenoids, flavonoids, vitamins.

Thus, the composition of the suppository "Epiproct" are pharmacologically active and available components.

The use of the claimed composition suppository will organize mass production week is brilliant action, contains bee products - Royal jelly, pollen, honey, propolis, beeswax, basis, anhydrous lanolin, characterized in that it further contains the homogenate drone brood, tincture of calendula, as the basis of solid fat or witepsol, or cocoa butter in the following ratio of components, g:

The homogenate drone brood 0,05-0,06

(or lyophilized drone brood) 0,03-0,04

Royal jelly 0,05-0,06

Ambrosia 0,11-0,13

Honey 0,09-0,11

Propolis 0,23-0,25

Tincture of calendula 0.6 ml

Beeswax 0,05-0,07

Lanolin anhydrous 0,09-0,11

Solid fat or witepsol, or oil

cocoa Sufficient

for cooking

the suppository mass

the 2.2-2.5 g

 

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