The method of determination of sensory thresholds person

 

The invention relates to medicine and can be used to determine sensory thresholds person. The method includes applying to the area of neuro-muscular tissue of the person increasing the amplitude of the electric voltage in the form of rectangular pulses. When this voltage serves as separated by time intervals of the series of the same number of pulses, and in one series of the amplitude of the electric voltage of all pulses are the same, and from series to series - grow. When the threshold condition elektrovojvodina person commits the magnitude of the electric current. The method can more accurately determine sensory thresholds person. 10 C.p. f-crystals, 2 tab., 1 Il.

The invention relates to medicine, namely to methods for determination of sensory thresholds of sensitivity of the person, and can be widely used for medical training of patients, in particular, for the selection of appropriate doses of drugs and their combinations for anesthesia and sedation by tracking the dynamics of time and their effect on people.

The invention can be used in the provision of emergency medical care, the burn is the work of medical institutions and departments, when the training of scientific personnel and the conduct of the educational process of the faculty of physicians and teachers, students, residents, interns, as well as in the offices and classrooms of functional diagnostics, neurology, physiotherapy, surgery, plastic surgery, dentistry.

As criterion of efficiency, in particular analgesic action of various drugs, it is customary to consider the magnitude response of the person when applying his irritation growing power.

For example, in dentistry such instrumental assessment is made by determining the magnitude response for various types of stimuli - pressure, irritation, warmth, irritation, electric shock, etc.,

Electrometric methods are typically based on the determination of sensory thresholds, i.e. the values of the densities of the electric current passing through the section of neuro-muscular tissue, corresponding to the moments of occurrence of the following generally accepted in medicine thresholds (States, phases) elektrovojvodina living tissue: threshold sensitivity (tactile), pain threshold and endurance threshold (to pain).

Discuss this in more detail. To characterize parachini consistently in the electrical circuit. Rheostat start gradually, starting with 0, to increase the voltage in this circuit.

By this method studies the sensitivity threshold is characterized by a value of an electric current, in which man first feels a light touch or movement at your fingertips.

A further increase in voltage over time and the value will cause the time will come when man will feel the first sharp jolt of current. The value of current at which it occurred, will determine the pain threshold. When this state of elektrovojvodina living tissue people can remain connected in the electrical circuit section neuromuscular tissue without orders himself to be included in the electrical circuit.

If you continue increasing the voltage in time and quantity, then there will come a moment when the person does not want and can no longer be connected in the circuit of the electric current by the area of neuromuscular tissue. The value of current at which this occurred, determines the threshold endurance to pain.

Of course, everyone is different. Sensory thresholds are different. Besides, one and the same person they may vary depending on, for example, from the time of day, from SOS is On the level of sensory thresholds there are three groups of people.

group 1. It includes people with low magnitude currents sensory thresholds. The threshold in this group is the value of electric current of about 0.2 milliampere, pain threshold - when the value of electric current of about 0.3 milliampere, endurance threshold - when the value of electric current of about 0.4 milliampere.

group 2. It includes people, characterized by average values of the values of the currents sensory thresholds. The threshold in this group may be the value of the electric current is the same as group 1, i.e. about 0.2 milliampere, however, the pain threshold is higher when the value of the electric current is about 0.5-0.6 milliampere, endurance threshold - when the value of electric current of about 0.8 milliampere.

group 3. It includes people with high values of current sensory thresholds. Values for all thresholds above those, which are available with 2 groups, especially the endurance threshold to pain, which ranges from 1 to 2 milliamps (see tab.1).

Depending on the group's doctor, for example, the dentist may choose the most appropriate analgesic drug that will promote the most effective treatment.

There is a method of determining sensornogo voltage in the form of rectangular pulses with fixing the values of the electric current, corresponding to the moments of occurrence of threshold States elektrovojvodina person: threshold, pain threshold and endurance threshold (table.1).

The downside of it is the lack of accuracy of measurement of electric current, because the method does not provide maximum sensory response of a patient to pass through the fabric electric current.

Another drawback is that you cannot accurately capture the electric current that characterizes the occurrence of a particular sensory threshold.

Another disadvantage is that the known method is not provided precise interference that may introduce error in the measurement.

The aim of the invention is the intention to find a technical solution of the method of determination of sensory thresholds of the person, which could be characterized by high measurement accuracy, ensuring maximum touch the patient's response to passing through the fabric electric current, would have the exact fixation of the electric current, characterizing the occurrence of a particular sensory threshold, and would not take into account occurs when carrying out the method of the interference.

To achieve these goals is declared the method defined is aktionscode voltage in the form of rectangular pulses with fixing the values of the electric current, corresponding to the moments of occurrence of threshold States elektrovojvodina person: threshold tactile sensitivity, pain threshold and endurance threshold, which according to the invention increasing the amplitude of the voltage fed in form of separated time intervals of the series of the same number of pulses, and in one series of the amplitude of the electric voltage of all pulses are the same, and from series to series - grow.

This set of common essential features is the essence of the invention. It is necessary and sufficient for all purposes of its implementation.

The applicant considers necessary to particularly draw the attention of the examination on the above-mentioned feature of the claimed method, namely, that increasing the amplitude of the voltage fed in form of separated time intervals of the series of the same number of pulses, and in one series of the amplitude of the electric voltage of all pulses are the same, and from series to series - grow. The significance of this method of increasing the supply voltage lies in the fact that, as found by the applicant, thus there is maximum is ishaat the accuracy of determination of sensory thresholds.

However, we believe it is necessary to highlight the following development and/or refinement of total essential features of the method relating to individual cases of implementation or use.

The number of pulses in each series of pulses may be, generally speaking, is different, however, it is most preferable that each series would consist of four pulses.

As found by the applicant, it is also desirable that in each series the pulse duration of the voltage would be equal to the pause between them.

When referred to the filing of increasing the amplitude of the electric voltage in the form of separated time intervals of the series of the same number of pulses great importance is the accurate recording of electric current, characterizing the occurrence of a particular sensory threshold.

According to the applicant, the greatest accuracy will occur when fixing the value of the electric current corresponding to the moments of occurrence of States of elektrovojvodina person, consistently determine the average value of the electric current in each subsequent series based on measurements of the maximum values of electric currents pulses this see electric current pulses subsequent series are greater than or equal to the average value of the electric current previous series, I would remember the average value of the electric current pulses subsequent series and would afford the following series of pulses, and if the average value of the electric current pulses subsequent series are less than or equal to zero, then stopped the flow of the series of pulses, and the average value of the electric current pulses of the previous series would codify as the magnitude of the electric current corresponding to the moment of occurrence of the threshold state of elektrovojvodina person.

When determining the average value of the electric current in each series on the basis of measurements of the maximum values of electric currents of pulses, it is desirable that determined the arithmetic mean value, as this would provide more accurate measurements.

Discuss this in more detail. If to consider specific impulse of any series, it is not strictly rectangular. At the initial moment of the pulse voltage is rapidly growing, and in the final moment - it is also falling rapidly. To obtain objective information in how advisable to be discarded, for example by the processor, these start and end values, and recorded only the maximum value of the current, fakih values. After this is determined by the arithmetic average of their values, which is used to determine the sensory threshold.

To improve measurement accuracy, it is important to identify interference or false alarms. For example, the patient in the measurement process accidentally drew back his hand, and then again closed by the fingers of the electrical circuit. In this case, the gap of the electric circuit was not caused by the occurrence of any sensory threshold and termination dimensions would be unreasonable. In this case the claimed method relates to interference. To prevent interference effects in the measurement of sensory thresholds, it is desirable that the determination of sensory thresholds person could be characterized by the fact that the supply of a series of pulses and record the average value of the electric current pulses of the previous series, as the magnitude of the electric current corresponding to the moment of occurrence of the threshold state of elektrovojvodina person would be executed if the average value of the electrical voltage pulses subsequent series of pulses are less than the average value of the electric voltage pulse for the previous series of pulses or equal to zero during the interval URGO the claimed method, for more than 0.5 seconds it is possible to speak with confidence about reaching a certain sensory threshold. If the patient withdrew the fingers at the time less than 0.5 seconds (this time interval is governed by the program), it is considered that this patient has not withdrawn the fingers, but there was an obstacle and is possible to continue the measurement.

Can different by locking obtained during the measurement of the electrical parameters, to process and submit for analysis. However, according to the applicant, most preferably, when fixing the values of the electric current corresponding to the moments of occurrence of state thresholds elektrovojvodina person, would be carried out by light indication via the display, for example, with the image values of the electric current or derived from them.

However, the most convenient, when light indication via the display contains information about the number group on the level of sensory thresholds to which the results of the test refers the patient.

It is also advisable to fixing the values of the electric current corresponding to the moments of occurrence of state thresholds elektrovojvodina person, would be carried out by sound and growth of the amplitude of the electric voltage in the range from 0 to 150 over a period of time of 30 seconds.

In addition, it is desirable that as the site of the neuromuscular tissue would be used in the area between the tips of the nameless and forefinger of a person.

In conclusion of this section describe the applicant considers it necessary once again to highlight some of the advantages of the claimed invention, which directly follow from the above description.

As noted earlier, the purpose of the present invention is to create a method with high accuracy measurement of sensory thresholds, provided the maximum touch the patient's response to passing through the fabric electric current.

An important advantage of the invention is that it is relatively simple and can be easily implemented on technological equipment, widely used at present in the domestic industry using cheap materials.

These and other advantages of the invention can be seen in more detail after the call to the drawing and the description of this application.

The invention is illustrated by the drawing, which shows a block diagram of a device that implements the claimed method.

Device for determination of sensory thresholds of the person contains a block pit is to measure sensory thresholds, and through the other output is a constant voltage of 5 V, which is designed to supply the entire electronic circuit device.

Through the power of 2 constant voltage of 150 V is applied to the unit pulse-width modulation 3, which generates increasing voltage under the control of the CPU 4 through the communication channel 5. Through the food channel 6 constant voltage of 5 V is supplied to the processor, the power supply voltage which is transmitted through it to the other blocks of the device to ensure its functioning.

On the other hand, through the channel power 8 generated by the unit pulse-width modulation 3 growing under the control of the processor 4 voltage is transmitted to the modulator 9. The modulator 9 through the communication channel 10 is connected with the processor 4. Under the control of the CPU 4 from coming out of the unit pulse-width modulation 3 voltage generated series of pulses with increasing amplitude. These pulses arrive at the electrode 11, and then through the unknown and forefinger of the hand 12 of the patient are held on the electrode 13, and then through the communication channel 14 are received in the processor 4 for processing. The processing results received by the processor 4 information perevyshin way.

Before starting the measurement, the patient puts nameless and index fingers 12 on pins 11 and 13, sequentially closing the electrical circuit, as shown in Fig.1. Then the signal "START" block pulse-width modulation 3 starts generating increasing voltage under control of the processor 4. This voltage is supplied to the modulator 9, which voltage is formed of a series of pulses with increasing amplitude from series to series. These pulses arrive at the electrodes 11 and through the unknown and forefinger of the hand 12 of a patient locked amperage 17 (Rt), which should be significantly smaller than the equivalent resistance of 18 patients (Re). For example, current load 17 (Rt) is a small resistor, a resistance of 1 Ohm, and the equivalent resistance of 18 patients (Re) is in the range from 150 to 400 ohms, that is at least 150 times. The voltage on the load current 17 in proportion to the pulse electric current passing through the fingers 12. It is through communication channel 14 is fed to the input of the inverter processor 4. The CPU 4 reads the data during the duration of the pulse. These data after conversion and processing of the go on is titelliste, the patient opens the electrical circuit, drawing back the fingers 12 from the electrodes 11 and/or 13. The processor 4 is the reaction, and the latest information on current are considered threshold. As noted above, are display on the device, or otherwise, displayed, three sensory threshold of man: the threshold, pain threshold, and the threshold of endurance. According to this data table to determine which group of people on the level of sensory thresholds refers the patient (see above) to conduct appropriate sedation, that is, the selection of drugs for receiving, for example, to ensure effective analgesic action. The device may also store the previous data and show an increase in the threshold percentage for the time between measurements. Data are memorized separately for each of several patients, for example in five patients.

To set the needed parameters, the processor 4 has various inputs, in particular, the inlet 19 through which the signal "START" to start the operation of the device for determination of sensory thresholds of man, the entrance 20, through which the management of the indicator 16, the inlet 21, through which you are virotech within the control generated by the unit pulse-width modulation 3 electric voltage, that is extremely convenient and useful, for example, in wide ranges to control the slew rate of an electrical voltage or the desired time to stop his growth, making a constant or reset sharply voltage to zero, and so on, In the prototype, you cannot change the slew rate of the voltage, so that the slew rate is determined by the product of the resistance of the resistor to the capacitor chain RxC, which is always.

Consider the processor 4 in more detail. It has four main functions.

1) the CPU 4 controls the unit pulse-width modulation 3, which was discussed above.

2) the Processor 4 generates a series of rectangular pulses with the required number of pulses in the series, optimally four, with the required repetition rate, the duration of a single pulse in each series and the pauses between the pulses in each series and pauses between each series.

The need for this is that the impact on the studied patient when determining its sensory thresholds to provide a series of voltage pulses. Each series consists of four consecutive pulses of the same amplitude. The interval (or pause) between the pulses in the series mean the hand, pause between adjacent series much longer than the length of one series of pulses of electric voltage of rectangular shape. It is important to note that the amplitude of the four pulses of each of the following series of pulses higher than the previous.

The reason for this continuous rise of the voltage provided by the processor 4, is that when applying pulses series provides maximum sensory (tactile) the response of the patient when exposed to a current, which improves the accuracy of the measurement.

When this measurement is made promptly. The ratio of time between the full duration of a series of pulses of electric voltage between pulses within a single series is that 30 seconds is provided by the voltage increases from 0 V to 150 C.

There are various correlations between the durations. However, according to the applicant, the most optimal ratio, which in one series all pulses in duration and forms are the same (in particular, each pulse has a rectangular shape and, in addition, the duration of one pulse and the interval between adjacent pulses of the same.

In the next series of pulses observed the same thing soo is isimat further functions of the processor 4, for clarity of disclosure of the invention, the applicant considers it necessary to draw the attention of the examination to the next feature of the claimed method implemented using a processor 4.

On the one hand, the controller 4 provides for the formation and growth above United in the series of voltage pulses for application to the tissue of the patient. These peculiarities of the functioning of the processor 4 were described in paragraphs 1) and 2) of the present description.

But, on the other hand, simultaneously, to determine sensory thresholds the same processor 4 carries out measurements of the pulses of electric current passing through the tissue of the patient, and corresponding said voltage pulses, because the definition touch threshold is the magnitude of the electric current. These pulse currents, of course, also be combined in series. The characteristics of these parties functioning of the processor 4 is devoted to the downstream paragraphs 3) and 4) description.

Consider them.

3) CPU 4 provides an optimal measurement of the electric current for each pulse received after the passage of an electric current body part examined patient.

Each pulse of each series he ASU is otret single pulse rectangular shape of any series, in the initial phase separate pulse voltage is rapidly growing, and at the final stage, the voltage rapidly falls. These values are the first and last parts of each pulse processor discards, and captures only the maximum value of current in pulse or "in the middle" of the pulse.

4) the Processor 4 provides the most accurate measurement of sensory thresholds at the condition of the growth stress in the form of a series of impulses.

Explain this feature of the method in more detail. As noted above, the processor 4 when an electric current passes through the tissue of the patient, measures the peak current of each pulse of a series of four pulses of electric current passing through the tissue of the patient. As a result, the CPU 4 receives four values of the peak currents for each series. Then it processes them, for example, calculates the average value and stores it.

Then similarly produced by the processor measures of individual pulses transmitted through the patient's electrical current following a series of pulses with higher amplitude and likewise is determined by the arithmetic average value of the electric current subsequent series of impulses.

If a subsequent series of pulses ele pulses and it turned out it is greater than or equal to the average value of the previous series of pulses, the previous average is erased, and the processor 4 is memorized arithmetic mean of the subsequent series of impulses transmitted through the patient's electrical current. Simultaneously, the processor 4 takes the following series of pulses of greater amplitude and the process repeats.

However, if fixed by the processor, the arithmetic mean value is passed through the tissue of the patient electric pulses subsequent series of impulses will be less than the average of the previous series of pulses, or equal to zero, for example, during the long interval of time (about 0.5 seconds), it is considered that the patient, snatching away his hand, tore measuring circuit due to the occurrence of a given sensory threshold and can be fixed (say) the occurrence of the mentioned sensory threshold. Indeed, when OTDELENIE patient both fingers, or at least one finger from the contact area of the contact between the fingertips and the contacts is reduced, leading to reduction of current in an electrical circuit, which is registered by the processor 4.

This is t on the display average current previous series of four pulses as one of the relevant sensory thresholds and stores this value for further processing. After fixation, the presence of sensory threshold of the CPU 4 stops the feeding of a series of impulses. And the arithmetic mean value of the electric current on the latest episodes with less arithmetic mean value of the current or zero current, not shown by the processor 4 and is not taken into account. For measurement of the next sensory threshold necessary to plot the neuromuscular tissue of the patient, for example, two fingers of one hand would be again connected in series in the electrical circuit and the processor would continue increasing the supplied voltage described above. Rheostat start gradually, starting with 0, to increase the voltage in this circuit.

If the patient withdrew the fingers at the time, for example, less than 0.5 seconds (this time interval is governed by the processor 4), it shall be deemed that the patient withdrew the fingers, but there was an obstacle, and is a continuation of the measurements.

The indicator 5 is intended for displaying the information received by the processor 4, in particular sensory thresholds, changing sensory thresholds in time and over time in percentage after taking the drug, the time between measurements for the same patient in minutes, group membership by type of patient etc.

The patient can break the chain or by otdergivanija fingers from contact, either by pressing a button on the device.

Before placing the fingertips to the surface of the electrodes, these finger pads moisten conductive gel, which is used for ECG, or saline (a salt solution of NaCl in distilled water).

In the claimed device can indefinitely to reduce the pulse duration of the series (up to several microseconds). In the prototype, which uses a mechanical relay, the pulse duration is much higher and reaches tens of milliseconds, and this duration cannot be reduced. Muscles are known to respond to continuous change in the magnitude of the impulses and nerve receptors respond to short pulses. For accurate measurement of sensory threshold, it is important to provide pain syndrome without muscle contraction. This is achieved in the claimed technical solution.

A device that implements the method, it is very convenient to measure. For example, simply remove your fingers from the contacts, and the unit memorizes the maximum value.

A device that implements the method, functionally. This stems from the fact that it is not necessary that all computing operations are carried out by the processor.

Electronic modulator (electronic key) provides long reliable operation for the formation of a series of pulses with increasing amplitude with stable parameters, while when the mechanical relay this cannot be achieved due to the phenomenon of "bounce" contacts. Used in the prototype mechanical relay cannot provide pulses of constant duration and constant form (especially the front and rear fronts) because of the mentioned phenomena "bounce" mechanical contacts, and, as you know, the person responds to the length (capacity) and pulse (signal). Therefore, a slow increase in voltage leads to errors in determining the sensory threshold.

For a more complete disclosure of the invention the applicant believes that it is possible to bring some of the characteristics of the parameters of the method. In this case the applicant emphasizes that these parameters are for example and can be rebuilt using the processor or otherwise.

The form of output pulses is rectangular.

The amplitude of the current pulses can be set by the processor in the interval 0...50 mA increments of 1 mA.

The relative deviation of the actual value of the current amplitude from the set can �r/177.gif">2000) Ohm.

The pulse duration can be set in the following intervals: interval 20...90 μs in increments of 10 microseconds; in the interval 0,1 0,9...MS in 0.1 MS; in the range 1,0...9,0 MS in increments of 1 MS; in the range 10...90 MS in increments of 10 MS. in the interval 0,1...0,3 s in increments of 0.1 C.

The relative deviation of the actual values of the pulse duration from the set should be no more than5% of all intervals.

- The duration of a pause between the series of pulses can be set in the following intervals: in the range of 0.1 to 2.0 with 0.1 increments; in the range of 3...20 - increments of 1 C.

The relative deviation of the actual duration of the pause between pulses from the set should be no more than5% of all intervals.

All installed and the obtained values of current amplitude, pulse duration and pauses can be indicated (displayed) on a digital display on the display screen.

On the display screen, the processor can immediately put the group on the level of sensory thresholds to which the results of the test refers the patient (see Table 1).

A device that implements the method may provide for switching the polarity of the output pulses. vetovo, but audible indication impulses.

The electrodes 11 and 13 must be resistant to the sanitation 3% hydrogen peroxide solution.

The device can operate from mains AC frequency (501) Hz voltage (22022) C.

Power implements the method of consumed them from the network, preferably should not exceed 10 watts.

Weight implements the method of the device without spare parts and accessories is not more than 3.0 kg, but in the complete set of delivery - not more than 6.0 kg

Approximate dimensions - 280315115 mm

Security implementing the method, the device must comply with the requirements of GOST R 50267 and relate to protection class II type BF (if the work does not require a safety ground connection).

The invention can be widely used in medicine.

Here are some of the applications.

Conducted monitoring the effectiveness of drugs used for sedation in the clinic of dentistry, patients, and volunteers. For sedation used metersin at a dose of 0.025, we Studied the change in the CE the e thresholds before taking the drug and after some time after taking the drug. Research results are reflected in Table 2.

On the basis of the conducted research the effectiveness of medications used for sedation in the clinic of operative dentistry, in particular metrazine, we can conclude that metersin increases sensory thresholds, especially the endurance threshold. This is clearly reflected in the above Table 2.

Another example.

Despite the great successes of modern anesthesiology issue of anesthesia on an outpatient dental reception remains relevant. Pain and anxiety associated with dental intervention, lead to emotional stress and functional changes in the body.

There is evidence of change in the total sensitivity and baseline sensory thresholds at the physiological level. So, pain sensitivity is increased in hypertension, soldier's heart dystonia, cerebral atherosclerosis, obesity. Patients with diabetes have changed all sensory thresholds, and the severity of these changes correlates with the level of sugar in the blood: by a reduction in pain sensitivity decreases significantly with increasing increases. Beremennost in the period of ovulation. It is known that stress can affect pain sensitivity. Some researchers have noted a reduction of pain sensitivity in these conditions, the development of stress analgesia, others, on the contrary, aggravation of the pain.

Applying different groups of psychotropic drugs for sedation, the authors of the present invention noted individual fluctuations in response to certain people depending on several conditions: the feeling of fear, anxiety, fatigue, absence or presence of pain, and so on,

These observations served as the basis for this study, the objective of which was the quantitative analysis of differences in the reactions of people with different source thresholds of sensitivity to substances that alter these thresholds.

The authors of the present invention have identified the source of pain sensitivity in all subjects, conditionally allocated group on this topic, paying particular attention to the doorsteps of people in history had hypertension I and II degrees, and examined the effect of metrazine and non-narcotic analgesics to persons distinguished by the nature of the original relationship to pain.

Sensory thresholds on the fingers defined instrumentalisation electric current, through just a limited section of neuro-muscular tissue, consistent with the occurrence of certain States (phases) of elektrovojvodina living tissue. Specific current density in (microampere 1 sq. cm body surface) and was an indicator of the occurrence of a particular phase, i.e. the threshold. Measured initial sensory thresholds - threshold (hereafter FC), pain threshold (hereinafter - PB) and the endurance threshold (hereinafter-PV) - 500 subjects aged from 18 to 70 years (nurses, physicians, and patients). 64 healthy individuals (volunteers) with different initial pain sensitivity was determined thresholds before and after taking their materina (0,025), amidopirina with dipyrone (0.25).

The following results were obtained research.

Measurement of initial sensory thresholds showed that they vary in a large range of values. On the basis of the mean values calculated thresholds we tentatively identified three groups: 1-I (250 people) - people with high sensitivity to pain, and with small initial values of the thresholds, 2-I (140 people) - people with moderate sensitivity to pain with average values of thresholds, 3-I (110 people) - people with relatively low sensitivity to pain, which all have high sensitivity to pain were seen more frequently in fearful and irritable people, low - people balanced. However, this coincidence is not always occurred. Sometimes outwardly calm person had a very small rapids PB, but the PV was large enough and so on, Especially large differences between groups were indicators PV: in the second group, they were more than in the 1st, doubled in the 3rd, more than 1 in 5 times.

Characterizing sensory thresholds within the same group, we noted the following. If the FC to rent for a unit, then PB in all three groups exceeded its about two times, and PV in the 1st group exceeded the inverter 3 times 2nd, 4 times 3rd 6 times. Thus, in the 1st group of subjects all thresholds are stacked in a relatively small range of values, and in the 3rd this range is several times higher.

Next, we analyzed the effectiveness for sedation drug metrazine and analgesics persons belonging to different groups. These data are presented in table 2. Receiving metersin persons 1, 2 and 3 groups were equally likely to have an impact on the inverter, but the performance of PB in individuals with hypersensitivity (1st group) were significantly higher than those in the group of subjects in whom the source of pain sensitivity was relatively low (group 3). Especially brightly these various the pain he has increased almost 3 times, than those relative to quietly tolerate the pain. Evaluating comparatively the effect prosolovych derivatives and metrazine, it should be noted that after analgesics it was more obvious in the case of FC and IB, and after neuroleptics, with respect to RO.

Analysis of the results of measurement of sensory thresholds of patients and subjects with hypertension - 65 (45 women and 20 men), various age groups (from 18 to 75 years) in 92% of cases meet the performance thresholds of the subjects of the first group (people with high sensitivity to pain with small initial values of thresholds).

Observations were carried out on the basis of the applied device that implements claimed in this application the high-precision method, show that the effect of our materials depends on the individual characteristics of a person - from the initial functional state of the Central nervous system, i.e., from initial his relationship to painful stimuli. Such patterns noted earlier. Our data in addition to existing information allow you to give specific quantitative characteristic of the original person's relationship to pain, and related effects on substance with ratnycele people with different types of threshold sensitivity. Substance from the group of neuroleptics affect PB and PV in individuals with increased sensitivity to pain and little change in their persons, relative to quietly tolerate the pain. Drugs that do not influence significantly on the emotional sphere (analgesics pirazolonovogo series), also have the most pronounced effect on sensory thresholds in individuals with increased excitability. In contrast to the information previously known, on the basis of measurements at the declared precision of the method was able to determine that metersin and analgesics varies affect sensory thresholds for people with initially high or low sensitivity to pain.

It is established that patients with hypertension I and II degree of severity relate to people with high sensitivity to pain (the first group).

Thus, the individual nature of man's relationship to painful stimuli can be quantified using digital characteristics of sensory thresholds, we applied for persons with different initial reaction to the pain. This will help the practitioner in the individual selection of adequate sedation.

The invention can be effectively used in the offices and classrooms of functional diagnostics, neurology, visiti.

Claims

1. The method of determination of sensory thresholds person by filing in the area of neuro-muscular tissue growing on the amplitude of the electric voltage in the form of rectangular pulses with fixing the values of the electric current corresponding to the moments of occurrence of threshold States elektrovojvodina person: threshold, pain threshold and endurance threshold, wherein increasing the amplitude of the voltage fed in form of separated time intervals of the series of the same number of pulses, and in one series of the amplitude of the electric voltage of all pulses are the same, and from series to series - grow.

2. The method of determination of sensory thresholds of the person under item 1, characterized in that each series consists of four pulses.

3. The method of determination of sensory thresholds of the person under item 1, characterized in that in each series the pulse duration of the electric voltage is equal to the pause between them.

4. The method of determination of sensory thresholds of the person under item 1, characterized in that for fixing the value of the electric current corresponding to the moments of occurrence of threshold States electrow the series based on measurements of the maximum values of electric currents of pulses in the series, compare it with the corresponding average value of the previous series of pulses, and if the average value of the electric current pulses subsequent series will be greater than or equal to the average value of the electric current previous series, remember that the average value of the electric current pulses subsequent series and serves the following series of pulses, and if the average value of the electric current pulses subsequent series will be less than or equal to zero, then stop the feed of the series of pulses and the average value of the electric current pulses of the previous series record as the magnitude of the electric current corresponding to the moment of occurrence of the threshold state of elektrovojvodina person.

5. The method of determination of sensory thresholds man p. 4, characterized in that to determine the arithmetic average value of the maximum of the pulses of one series.

6. The method of determination of sensory thresholds man p. 4, characterized in that the interruption of the series of pulses and record the average value of the electric current pulses of the previous series as the magnitude of the electric current corresponding to the moment of occurrence of the threshold state of elektrovojvodina man, I produce less than the average value of the electric voltage pulse for the previous series of pulses or equal to zero during the time interval of more than 0.5 sec.

7. The method of determination of sensory thresholds man p. 4, characterized in that the fixing of the values of the electric current corresponding to the moments of occurrence of state thresholds elektrovojvodina person, carried out by light indication via the display.

8. The method of determination of sensory thresholds of the person under item 7, characterized in that the light indication via the display contains information about the number group on the level of sensory thresholds to which the results of the test refers the patient.

9. The method of determination of sensory thresholds man p. 4, characterized in that the fixing of the values of the electric current corresponding to the moments of occurrence of state thresholds elektrovojvodina person, carried out by an audible indication.

10. The method of determination of sensory thresholds of the person under item 1, characterized in that ensure the growth of the amplitude of the electric voltage in the range from 0 to 150 over a period of time 30 sec.

11. The method of determination of sensory thresholds of the person under item 1, characterized in that as weka.

 

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The invention relates to medicine

FIELD: medicine.

SUBSTANCE: through puncture opening in proximal and distal directions one should perform osseous tunnels being coaxial to osseous log to connect, thus, the cavity of osseous cyst with medullary canal. Through the parts of healthy bone at the distance of 1-2 cm against cyst's edge in oblique direction one should implant rigid electrodes at the angle of 45 deg. against its center by applying beck's needles with dielectric covering. Subcutaneously one should implant elastic electrodes in projection of lesion focus and connect an electrostimulating unit to cutaneous ends of electrodes. Onto intraosseous electrodes one should supply impulse current of negative polarity, and onto elastic ones - of positive polarity at 10-20 mcA power and frequency of 0.5 Hz, of total duration and front of rectangular impulses cut being 200 mcsec, not more.. One should affect with impulse electric currents on the 24-h basis till complete covering the osseous defect observed.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine; cosmetics.

SUBSTANCE: method involves preparing and applying electrically activated cosmetic therapy substance. Preparation process involves passing alternating electric current through electrolyte material. The alternating current is applied for at least 10 min with preferential time being 4-8 h long for changing physical properties of the substance. Then the current is switched off. The active substance is administered as inhalation in pulmonary tract or as injections into human or animal body. The substance properties are retained for some limited time.

EFFECT: enhanced effectiveness of treatment; excluded electric current passage through patient tissues; excluded drug concentration in the vicinity of electrodes.

50 cl, 13 dwg

FIELD: medicine.

SUBSTANCE: method involves concurrently acting with stimulating electric pulses and back pressure pulses upon the prostate from the large intestine side synchronized with the stimulating electric pulses under excessive rinsing solution pressure into posterior urethra region. Device has pneumatic massage unit as elastic shell enveloping hollow cylindrical casing having a row of radial holes for supplying compressed air into the shell and periodic pulsating pressure source having at least one unit for producing electric pulses and pneumo-electromagnetic valve which electromagnet anchor is connected to electric pulse production unit outputs. Unit for electrically stimulating perineal muscles and prostate having stimulating catheter electrode and reservoir containing rinsing solution attached to catheter electrode are available in the device. Electric stimulation unit output is connected to input of unit for producing pressure pulses. Periodic pulsating pressure source is manufactured as elastic pneumatic chamber brought in continuous mechanical engagement with electromagnet anchor of the pneumo-electromagnetic valve and tightly joined via tube, cylindrical tube cavity and radial holes therein to the elastic shell of the massage member.

EFFECT: enhanced effectiveness of treatment; accelerated treatment course.

3 cl, 10 dwg

FIELD: medicine.

SUBSTANCE: method involves carrying out endoscopic operation. SCENAR-therapy is additionally administered with pulsating bipolar electric current being used without constant component as pulses at succession frequency from 10 to 350 Hz including swinging frequency mode within 30-120 Hz bandwidth with 2 to 8 pulses formed as batches at succession rate of 540 Hz to 4.5 kHz. The signal is modulated by varying ratio of action time to pauze duration within 1:1-1:5. 1-3 SCENAR-therapy courses are administered with 1-3 months long pauses. The first course begins at the first menstrual cycle occurred after endoscopic operation. Each course is carried out according to a scheme. 15-20 sessions are administered during the first menstrual cycle and 7-10 sessions are administered during the second menstrual cycle. The 25-40 min long sessions are applied daily.

EFFECT: enhanced effectiveness of treatment.

FIELD: medicine.

SUBSTANCE: method involves concurrently acting upon patient auditory system with acoustic signal produced by a musical composition selected on basis of patient health state and electric signals of the same musical composition acting upon patient skin. The electric signals amplitude-modulated with depth of 15-85%, act upon the patient via adhesive skin electrodes during 15-40 min. Hearing-add device is subjected to acoustic signals amplitude-modulated with depth of 15% and higher. Amplitude-modulation frequency is selected within the limits of 1.2-9.8 Hz. Modulation is carried out with frequency corresponding to patient disease frequency and action power is chosen on basis of subjective patient sensations. Device has unit for performing musical composition, the first and the second power amplifier, matching unit, adhesive electrodes and electroacoustic converter as well as electrostimulation modulator, acoustic modulator, the first and the second modulation depth regulator, the first and the second power control unit. Musical signal reproduction output unit is connected to the first inputs of electrostimulation modulator and acoustic modulator, which second inputs are connected to input of introduced controllable modulation frequency oscillator and modulation depth regulators are connected to their third inputs. Electrostimulation modulator output is connected to adhesive electrodes via the first power amplifier and matching unit. Sound modulator is connected to the electroacoustic converter via the second power amplifier. The first and the second power regulator are connected to the second inputs of the first and the second power amplifier. Unit for recording sessions is additionally introduced for replicating therapeutic sessions, its first input being connected to the electrostimulation modulator and the second one to the sound modulator output.

EFFECT: enhanced effectiveness of treatment.

4 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: method involves specifying disease stage, determining suggestibility degree, programming on abstinence from alcohol consumption for a 6-12 months long period the patient determines on the own free will. Treatment is administered with bipolar electric asymmetric current pulses of 3-5 mA being applied on the background of relaxing melody later on in reanimation room. Assurance in overcoming difficulties of life and becoming free of alcohol addiction is suggested on this background. Placebo is concurrently intravenously administered as drop infusion imitating coding preparation as alcohol receptor blocker. Suggestive accentuation is concentrated on possible complications caused by alcohol consumption after introducing the preparation. The aversion against alcohol is invoked by making drop infusion of medicament mixture causing fever sensation and myorelaxation. The patient swallows 2-3 gulps of alcohol and the provoked responses are associated to them with a cause-effect relation like alcohol-bad health state and fixed with intramuscular placebo injection simulating oil code preparation.

EFFECT: enhanced effectiveness of treatment; prolonged remission period.

6 cl

FIELD: medicine, neurosurgery.

SUBSTANCE: the present innovation deals with surgical treatment of neurological complications in patients with degenerative-dystrophic vertebral lesion and partial disorder of conductor-segmental spinal functions. One should surgically remove spinal compression due to resecting anterior departments of affected osseous-cartilaginous structures of vertebral-motor segment. One should apply electrodes: one pair - intraoperationally epidurally upon dura mater above anterior spinal departments being above the level of its lesion; then another pair of electrodes - by puncturing into area of posterior departments being below the level of its lesion to conduct electrostimulation. Moreover, therapy should be supplemented with phonophoresis with neuroprotector preparations. Electrostimulation of posterior spinal departments starts on the 2nd d, and that of anterior departments - on the 3d or 4th d after operation. Parameters of curative electrostimulation should be matches for every patient individually with the help of electroneuromyography. The innovation enables to decrease postoperative complications.

EFFECT: higher efficiency of therapy.

2 cl,1 ex

FIELD: medicine, traumatology, neurosurgery, microsurgery, neurotraumatology.

SUBSTANCE: one should fulfill autoneuroplasty of nervous defect, implantation of wire electrodes epineurally for both ends of contact areas of nerve's affected part at arranging insulation-free electrodes with their opened active ends along the direction of affected nerve. Moreover, before implantation of wire electrodes one should divide their ends into fibers to obtain filamentous wires and embrace nerve trunk and autoneurotransplant along their circumference. Electrodes should be placed at distal and proximal ends of affected nerve being about 5-10 mm above and below neurorhaphy area to perform electrostimulation. The method enables to accelerate regeneration of nervous fiber and decrease lesions of nervous tissue.

EFFECT: higher efficiency of therapy.

1 cl, 5 dwg, 1 ex

FIELD: medicine, physiotherapy.

SUBSTANCE: at the first stage, one should affect with magnetic field upon vertebral reflexogenic areas - volar surfaces - located at colored plates as straps. At the second stage, one should affect with magnetic field upon the area of vertebral column that helps to improve psychoemotional state in patients.

EFFECT: higher efficiency of therapy.

2 cl, 1 ex

FIELD: medicine, neurology, psychiatry.

SUBSTANCE: one should affect with amplipulsephoresis of "Berlition" preparation in rectified mode. One should apply types III and V of operations at modulation frequency being 130-150 Hz, modulation depth of 50-75%, impact duration for every type of operation lasts for 5-7 min. During the 1st d electrode-cathode should be located in inferior cervical - superior thoracic department of vertebral column, and electrode-anode - at anterior and posterior surfaces of forearms. During the 2nd d - in inferior thoracic - superior lumbar department of vertebral column and at anterior-lateral and posterior surfaces of shins, correspondingly. The present method improves clinico-electrophysiological and biochemical parameters.

EFFECT: higher efficiency of therapy.

5 ex, 8 tbl

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