Method of treatment of psoriasis

 

The invention relates to medicine, dermatology, and can be used to treat patients psoriasisa. Enter hepatosis 1 capsule twice a day 15 minutes before meals daily for 10 days the infusion of sodium thiosulfate, pyridoxine hydrochloride (vitamin b6), cyanocobalamin (vitamin B12) and topical treatment with 5% sulfur-salicylic ointment. The invention enhances the efficiency of the treatment due to the correction of the individual parts of a metabolism, in particular lipid metabolism. 3 table.

The invention relates to medicine, namely to dermatology, and can be used for the treatment of patients with psoriasis.

Psoriasis is a chronic disease with unknown etiology and prevalence in the population to 2%. For the treatment of psoriasis traditionally used means having a detoxifying effect, vitamins. In recent years, due to the increasing number of torpid to conventional therapy cases are often used cytotoxic drugs, causing serious side effects.

A prototype of the invention is selected known method of complex treatment of psoriasis, including IEnumerable of 0.02% at 1 ml intramuscularly and topical treatment with 5% sulfur-salicylic ointment (Skin and venereal disease. A guide for physicians in 4 so, 2 ./ Edited by Y. K. Skripkin. - M.: Medicine, 1995, S. - 222-224).

However, it has low efficiency. In recent years significantly increased the number of patients with psoriasis, torpid to this therapy. This significantly increases the treatment time.

The task of the invention is to improve the effectiveness of treatment of patients with psoriasis and reduction of treatment time.

This object is achieved in that the patient is additionally administered hepatosis 1 capsule twice a day 15 minutes before meals daily for 10 days.

Hepatosis (registration 98/305/9) obtained on the basis of dried liver cells of animals. The drug enhances detoxification and velocimeters liver function, improves metabolic capacity of the liver cells, promotes the absorption and excretion of toxins. The mechanism of action of the drug has 2 phases: intestinal, in which the drug has a detoxifying effect due to the sorption of toxic products in the gut, and metabolic, in which the biological components of the drug to restore the functional activity of the liver. Previously, hepatosis in dermatology and, in particular, in the treatment of psoriasis is not pramanasamuccaya hepatosis into 1 capsule twice a day 15 minutes before meals daily for 10 days. At the same time the patient receives traditionally used for the treatment of psoriasis daily intravenous infusion of sodium thiosulfate and 30% at 10 ml intramuscular injection of 5% solution of pyridoxine hydrochloride in 1 ml of 0.02% solution of cyanocobalamin 1 ml and topical treatment with 5% sulfur-salicylic ointment.

For standardization method was used to assess patients using the index PASI (Psoriasis Area and Severity index) square psoriatic lesions and the severity of the process (Freriksson, T. Petersson, V. Dermatologica, 1978, 157, 238-44). This is a purely clinical evaluation system to determine the area affected body surface and the intensity of the main symptoms.

Examples Example 1. Patient C., 48 years old, medical history 162. Diagnosis: common psoriasis, progressive stage. Before treatment, the patient was observed multiple psoriatic lesions on the skin of the trunk, limbs and scalp. The PASI index of 9.4.

Was the treatment: sodium thiosulfate 30% 10 ml intravenously, pyridoxine hydrochloride 5% and 1 ml intramuscularly, cyanocobalamin of 0.02% at 1 ml intramuscularly and topical treatment with 5% sulfur-salicylic ointment.

Additionally, he was appointed hepatosis into 1 capsule twice a day 15 minutes before meals daily for protjagenii 25 days of inpatient treatment. The PASI index is 0.

Example 2. Patient M., aged 22. History N59. Diagnosis: common psoriasis, stationary phase. Prior to treatment was observed in psoriatic lesions on the skin of the trunk and extremities. The PASI index - 10,8.

Were treated, including sodium thiosulfate 30% 10 ml intravenously, pyridoxine hydrochloride 5% and 1 ml intramuscularly, cyanocobalamin of 0.02% at 1 ml intramuscularly and topical treatment with 5% sulfur-salicylic ointment.

Additionally, he was appointed hepatosis into 1 capsule twice a day 15 minutes before meals daily for 10 days.

As a result of combined treatment written with the disappearance of the cutaneous manifestations through 27 days of inpatient treatment. The PASI index is 0.

Example 3. Patient W., 31 year history 77. Diagnosis: common psoriasis, progressive stage. Before treatment the patient was observed multiple psoriatic lesions on the skin of the trunk and extremities. The PASI index - 15,0.

Was the treatment: sodium thiosulfate 30% 10 ml intravenously, pyridoxine hydrochloride 5% and 1 ml intramuscularly, cyanocobalamin of 0.02% at 1 ml intramuscularly and topical treatment with 5% sulfur-salicylic ointment.

Additionally, he was appointed hepatosis inside 1 capsulate discharged with significant improvement after 32 days of inpatient treatment. The PASI index of 5.0.

In the Department of chronic dermatoses Nizhny Novgorod NIQUE by the proposed method implemented treatment of 13 patients with psoriasis (table 1). No adverse events were observed. As a result of applying the above method of treating the disappearance of the clinical picture was observed in 4 patients, a significant improvement in 5, improvement in 4. Thus, the pronounced clinical effect (disappearance of symptoms and a significant improvement was obtained in 69% of patients. The average bed-day was 27.41,9. The PASI index decreased from 16.1of 1.3 to 5.41,3 (3 times).

In the comparison group included 19 patients with psoriasis treated with conventional therapy, specified in the prototype (sodium thiosulfate 30% 10 ml intravenously, pyridoxine hydrochloride 5% and 1 ml intramuscularly, cyanocobalamin of 0.02% at 1 ml intramuscularly and topical treatment with 5% sulfur-salicylic ointment). Pronounced clinical effect was achieved in 47% (disappearance of symptoms in 1, a significant improvement in 8). Improvement was observed in 10 patients. The average bed-day accounted for 32.81,6. The PASI index decreased from 13.9of 2.5 to 7.41.6 (1.9 times).

Determination of serum total lipids and triglycerides were carried out using sets of VITAL DIAGNOSTIC (, St. Petersburg), cholesterol - method Ilka.

Separation of lipids HDL was performed by the method of one-dimensional chromatography on Sorbfil plates (Russia). Extraction of lipids HDL isolated from blood serum of psoriasis patients and healthy individuals according to the method Kostner G. et al., carried out according to the method of J. Folch et al. Results (Mm) is represented in the percent area of each fraction of the lipids from the sum of the areas of all peaks in the chromatogram is calculated automatically when scanning densitometer.

If the total lipid metabolism (OL, cholesterol, triglycerides) were not significantly changed (table 2), on the fractional composition of HDL in patients receiving the proposed method of treatment, there was a significant p is an increase, specified in the prototype, expressed positive changes were found only in level XC.

Thus, the use of the proposed method in dermatological practice improves the efficiency and reduce the time of treatment of patients with psoriasis compared with the prototype and to correct disorders of lipid metabolism.

Claims

Method of treatment of psoriasis, including the introduction of sodium thiosulfate, pyridoxine hydrochloride (vitamin b6), cyanocobalamin (vitamin B12) and topical treatment with 5% sulfur-salicylic ointment, characterized in that it further impose hepatosis 1 capsule twice a day 15 minutes before meals daily for 10 days.

 

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