The method of obtaining a disinfectant (options)

 

The invention relates to a method for disinfectants that can be used in medicine, veterinary medicine, agriculture, water purification and air in the housing sector. The first alternative disinfectants produced by condensation in the melt diamine, and a derivative of guanidine within 1-2 hours at 180-200oC and a molar ratio of the diamine to the guanidine derivative equal to 1:(1,2-2). Cleaning the finished product is carried out in the liquid organic acids and introduce an equivalent amount of alkali metal salt of an organic acid. Then produce the finished product is in salt form and remove the inorganic salt. The second option disinfectants produced by condensation in the melt diamine dihydrochloride and hexamethylenebiguanide within 1-2 hours at 180-200oWhen the molar ratio of the diamine to the dihydrochloride hexamethylenebiguanide 1:1,2. Then process the finished product inorganic base and do the cleaning by extraction with an organic solvent. The product is then treated with an equivalent amount of organic or inorganic acids and videoleuchte toxicity, elevated stable disinfectant properties and with minimal corrosion activity. 2 S. and 2 C.p. f-crystals, 3 tables.

The invention relates to the field of organic chemistry, namely the synthesis of disinfectants based on the derivatives of hexamethyleneimino, and can be used in medicine, veterinary medicine, agriculture, clean air and water, housing and communal services, transport, etc.

In recent decades, the derivatives of hexamethyleneimino intensively used as disinfectants ([1] - Zotova L. I. and other Issues of balneology, physiotherapy and exercise therapy, 1993, N 6, pp. 36-38).

A method of obtaining hydrochloride, guanidine (hereinafter pgmg) [2] - "policept" based on the condensation in the melt of guanidine hydrochloride and diamine (hereinafter referred to as HMDA). However, the toxicity of the resulting product is associated with the presence of unreacted HMDA, corrosivity, solubility product only in selenopyran environments (water) significantly limits the scope of this bactericidal drug ([2] - SU 1616898, 1990).

A method of obtaining a disinfectant, which provides pnie pgmg interaction with inorganic base, and then the processing of water-soluble organic and inorganic acids and obtain a corresponding salt PGMG ([3] EN 2052453, 1996).

The need for cleaning hydrochloride pgmg associated with significant toxic, HMDA in the product, but the proposed treatment does not completely absolve the final product from HMDA as not eliminates impurities inorganic reagents, unreacted polymer and source connections. This result stems from the fact that the reaction of the receiving base is irreversible heterogeneous substitution, and formed the basis capable of mechanical grip in its mass reaction medium and inactivation internal areas for replacement and cleaning. In addition, the substitution effect of heterogeneity of the process is incomplete, as it is stated in the patent itself, which says that at least 10% chloride units in the polymer base remain unsubstituted. Thus, it is legitimate to talk about the product as mixed double salt, and not the net connection.

Finally, experimentally clarified during the implementation of this known method is that small deviations of the parameters of the technological mode (feed rate of the reactants, the stake is the future of the property.

A method of obtaining a disinfectant, where the reference compound is a carbonate pgmg [4] and to transform it into other salts add enough of an equivalent amount of an organic or inorganic acid, which provides non-equilibrium substitution, since PKandmost acids is much higher than that of coal. However, the receipt of original carbonate is very problematic, because oxygen-containing acid at a high temperature in one degree or another form amides of the amino groups of Guan-DIN [5] - Patterson P. Guanidine and Guanidine salts in Kirk-Othmer Encycl. Chem. TechnoL, 3-d Ed., NY, 1978, v.10, p.514-521.Thus, despite the fact that the guanidine carbonate cheaper and more available, its reaction with HMDA was not a basis for obtaining a disinfectant, because most experienced parties did not possess disinfectant properties ([4] - EN 2039735, 1995).

The closest present invention is a method of obtaining a disinfectant, which is carried out by condensation in the melt, GMDA with derivatives of guanidine and further purification of the finished product, the process is carried out for 1-2 hours at 180-200oC and a molar ratio of HMDA to a derivative of guanidine 1:(1,2-the first by rubbing or by recrystallization in excess of the inorganic acid, Sol HMDA or guanidine derivative which was used in the condensation reaction, and then the isolated product was washed with ethanol [6] EN 2170743, 2001.

According to the second variant, conduct condensation and further purification, but as a derivative of guanidine use dihydrochloride hexamethylenebiguanide, and the condensation process is carried out for 1-2 hours at 180-200oC and a molar ratio of HMDA to guanidine derivative equal to 1:1.2 and the resulting product is subjected before cleaning processing by the base or inorganic salt at 20-120oWith, produce clean water. In the end you get a derivatives hexamethyleneimino the following formula: [-NHC(= NHHA)NHC6H12]m- [-NHC(= NHHB)NHC6H12]nA, b=N2O, H3RHO4, NaH2PO4, Na2HPO4, NH4H2PO4HCl; m=1-90, n=0-90, m+n=1-90.

The greatest efficiency and stability have connections with degree of polymerization(SP) 6010, obtained by processing the original hydrochloride pgmg phosphate. However, excess phosphate to 2.2 equivalents does not allow you to get even statistical substitution (equal molar from the x displacement prevents the penetration of external (phosphate) anions in the inner sphere containing chloride anions. This is due to the substitution reaction under conditions of homogeneous equilibrium.

Attempt direct production of phosphate pgmg in the reaction of HMDA with languageline and ammonium phosphate (the excess of the latter as to melt and the reaction medium) leads to a low yield and low biocidal properties. Noted earlier, the interaction of oxygen-containing acids, leading to the acylated guanidinum, can be a factor in the reduction of output and cause a noticeable loss of disinfectant properties of the product.

Obtained by prototype products designed exclusively for use in the form of aqueous solutions, and sometimes makes them impossible to use, for example, for cases where used anhydrous, Malopolskie environment. Thus, problems arise with the introduction of the drug in oil paints, in addition, the drug is almost not effective against microorganisms that infect raw hides and drug use as an additive in polyethilenphthalate dishes for drinks so affects the organoleptic properties of the latter, making them impossible to use.

The task is and disinfectant properties, reduced toxicity and corrosivity.

Another object of the invention is a product with a stable, reproducible properties, allowing to expand the scope of its application is not limited to its use in the form of aqueous solutions.

The technical result of the proposed method in two variants consists in deriving hexamethyleneimine with a high degree of purity, and hence with reduced toxicity, increased sustainable disinfectant properties and, in addition, with minimal corrosivity.

The first variant of the proposed method includes obtaining a disinfectant condensation in the melt diamine, and a derivative of guanidine in 1-2 hours at 180-200oC and a molar ratio of the diamine to the guanidine derivative equal to 1:(1,2-2), respectively, with further purification and isolation of the finished product is in salt form. However what is new is that cleaning of the finished product is carried out in the liquid organic acid with the introduction of an equivalent amount of alkali metal salt of organic acid to further remove inorganic salts and Videora in a vacuum.

In addition, the best results can be achieved by the fact that before allocating the finished product in the reaction mixture was added an equivalent amount of acid, salt hexamethyleneimino derived which get.

The proposed method (the first option) is based on carrying out the reaction under conditions of homogeneous irreversible substitution derived hexamethyleneimine salt of organic acid in the solution is the same or a different acid. The homogeneity of the reaction is ensured sufficiently polar solvent which is an organic acid capable of dissolving both hydrogenogenic pgmg and its "basic" form, which this solution exists in the form of a salt of the acid, in which the reaction is carried out. Irreversibility substitution reactions is provided by introducing into the mixture of alkali metal salts of organic acid, this salt and plays the role of the Foundation, and extremely low solubility in the acid halides of alkali metals, formed as a result of the exchange. It should be noted that PKandacid forming a salt with alkaline metal was greater than the value PKandthe acid used to dissolve the mixture. Otherwise, the weaker acid is Wiesn otsutstvie other features you can get salt pgmg and with a weak acid, if its volatility is lower than the acid taken for the dissolution, and the resulting mixture was subjected to distillation of the solvent. The use of inorganic acid, which is often significantly stronger organic, leads to the formation of inorganic salts pgmg. For salts pgmg with inorganic acids, which falls from a solution of organic acids, sufficient mechanical separation of the precipitate, and for the more soluble salts is possible evaporation.

The second variant of the proposed method includes obtaining a disinfectant condensation in the melt diamine dihydrochloride and hexamethylenebiguanide for 2 hours at 180-200oWhen the molar ratio of the diamine to the dihydrochloride hexamethylenebiguanide 1:1,2 respectively, with further purification of the finished product and release it in salt form, according to the invention the finished product is transferred to the substrate processing inorganic base and are cleaned by extraction with an organic solvent, after which the finished product is treated with an equivalent amount of organic or inorganic acids. In addition, the second variations is TBE intermediate for re-engagement with HMDA.

Conducting the reaction under conditions of irreversible heterogeneous equilibrium - intermediate base from an aqueous solution of hydrogenogenic pgmg and alkali requires special admission. The complete replacement of the provided sample (preferred) dissolution (extraction) of the Foundation pgmg in an organic solvent. The solvent should have the following properties: a) high specificity (selectivity) extraction of the base, excluding removing a source of salt pgmg from the water environment; b) sufficient volatility, allowing you to remove it with the greatest weight of the solution or reaction mixtures to obtain the target derived using simple technological operations; C) to have minimal toxicity; g) sufficient stability for repeated use and regeneration.

Search and selection of solvents due to lack of information on Foundation properties pgmg. So, in a number of patents [3, 6] and the review [7] Gembicki P. A. and other Polymeric detergent polyhexamethylene guanidine, Zaporozhye: "polygraph", 1998, page 44 States that the solubility of the base in cold water does not exceed a few percent, and hot she patanol, but the solubility of the original chloride (SR=4) amounted to a few percent, with an increase in SP solubility is significantly reduced [8] - SU 944290, 1986.

Obtaining the necessary salt by mixing the base pgmg in the form of its solution in the organic solvent or after evaporation of this solution by interaction with an equivalent amount of organic or inorganic acids.

Carrying out the condensation in such relatively "soft" conditions with an excess of guanidine derivatives, fast shutter speed (1-2 hours) with a temperature not exceeding 200oProvides a cleaner product with yields of over 90% with minimal side products and unreacted starting compounds (primarily the highly toxic HMDA).

Replacement and additional purification is achieved by dissolving the crude salt in the organic acid and the introduction of an equimolar amount of alkali metal salt other organic acids or the same that was used for dissolution. As salts of guanidine use of the hydrochloride and hydrobromide (salt kislorodsodyerzhascikh acids, which are unable to form amides), as salts of organic acids - are the ing, propionic.

The need to replace to get the disinfectant is associated with the intended field of application, in particular in the food industry where there are not only requirements for high disinfectant properties of money, but severe restrictions on the toxicity of the agents used for humans, as well as the minimum corrosion of metallic equipment in contact with the disinfectant. No less important are these criteria and the inclusion of funds in the composition of paints and varnishes that can cover the metal surface, if the coating will corrode the metal, then this loss of consumer properties of the coating cannot be compensated for by the emergence of biocides, and the use of such coatings is problematic.

As inorganic bases use the hydroxides of sodium, potassium, organic acids - benzoic acid, oleic as inorganic phosphate, as an organic solvent - aliphatic and arylaliphatic alcohols.

Eventually, implement two variants of the proposed method are derived hexamethyleneimino following formula is b>, HBr, HCl, HO2C(CH2)2CH(NH2)CO2H, HBF4, CIS-CH3(CH2)7CH=CH(CH2)7CO2H, CH3C6H4SO3H, n=1-90The invention is further illustrated by the examples of the invention, which do not exhaust all possible embodiments of the invention.

Example 1. Obtaining di-L-glutamate hexamethylenebiguanide.

1.1. Getting dihydrochloride hexamethylenebiguanide (GMDH). Source dihydrochloride is obtained by condensation in the melt 19,11 g (0.20 mol) of guanidine hydrochloride NH2C(=NH)NH2HCl and are 11.62 g (0.10 mol) of HMDA at 180-200oC for 1 hour. The cooled melt is crystallized from a solution of Hcl, washed on the filter with a minimum number (about 15 ml) of ice-cold water and dried. Output 93,2%. TPL=174-176oC. n=1, AT=Hcl.

However, as shown by the data of [6] obtained the dihydrochloride too toxic and corrosive.

1.2. Getting diglutamate GMDG.

To improve the properties of the resulting chloride was transferred to salt of organic acid. To do this, dissolve 13,66 g (0.05 mol) dihydrochloride GMDG H2NC(=NH)NH(CH2)6NHC(=NH)NH22CCH(NH2)CH2CH2CO2NaH2O in 25 ml of propionic acid. The resulting mixture was intensively mixed, then incubated at room temperature for 30 min, filtered from the precipitated Sodium chloride, evaporated under vacuum at 70-80oC. Output 98,7%. TPL>250oC (with decomposition).

Detected in the final product, %: 43,700,03; N 7,730,02; N 22,650,04; CL 0,00.

Calculated, %: C 43,72; N 7,74; N Cushion 22.66; 25,88. n=1, AT=C5H9NO4.

Indicators of toxicity and corrosiveness received disinfectants, as well as their solubility in non-aqueous media are given in table. 1, and the characteristics of the disinfectants listed in the table.2.

Biocidal properties determined by the standard technique, developed UNHIDES: "instructions for the determination of disinfectants" (1986). As bioculture use bacteria (E. coli), virus (coliphage MS-2), mold fungal culture (Penicillium chrysogenum), spores You. cereus).

Example 2. Obtain di(tetrafluoroborate) GMDG.

To improve sporicidal and fungicidal properties of the preparation obtained according to example 1.1 crude hydrochloride was transferred to tetrafluoroboric acid. To the mixture was added a solution of 1.92 g (0.02 mol) of anhydrous sodium propionate C2H5CO2Na in 5 ml of propionic acid. The resulting mixture was intensively stirred, incubated 30 min, filtered from the precipitated NaCl. To a mixture of propionate GMDG add an equivalent amount of 40% aqueous solution terraforming acid, which is 4.5 g, and in terms of pure HBF4to 1.76 g (0.02 mol). When working with HBF4use Teflon, copper and other equipment as glassware and porcelain react with compounds containing bound HF.

Precipitated from the reaction mixture the residue is washed on the filter with 0.5 ml of a solution HBF4and dried. Output 83,1%. TPL=218-222oC.

Detected in the final product, %: 25,540,05; N 5,880,02; N to 22.350,05; Cl 0,00. Calculated, %: C 25,56; N 5,90; 5,75; F 40,43; N 22,36. n=1, HA=HBF4.

Together with the growth of the biocidal properties (table.2) disinfectant increased toxicity and corrosiveness.

Example 3. Getting acetate pgmg.

3.1. Getting hydrobromide pgmg.

With the aim of obtaining a more efficient product and reduce its toxicity must obtain a derived hexamethylene guanidine hydrobromide NH2C(=NH)NH2HBr and are 11.62 g (0.10 mol) of HMDA at 190-200oC for 2 hours. The hot melt was poured on a Teflon pan, cooled, crushed. The output is 91.4%.

Detected in the crude product, %: 37,700,05; N 7,200,03; N 18,850,05; VG 36,020,03.

Calculated for unit link, %: 37,85; N 7,26; N 18,92; Br 35,97.

Srednevozrastnoe molecular weight (hereinafter SUM) corresponds to n=555=NVG.

3.2. Getting acetate pgmg.

For the purification and reduction of toxicity obtained in example 3.1. the crude hydrobromide pgmg in the number 11,16 g (0.05 EQ.) dissolve in 50 ml of acetic acid at 75-85oWith intensive stirring to obtain a homogeneous mixture. The cooled mixture was added a solution of 4.10 g (0.05 mol) of anhydrous sodium acetate CH3CO2PA in 10 ml of acetic acid, the mixture is intensively stirred, incubated at room temperature for 30 min, filter the solution from the precipitated NaBr, and evaporated under vacuum. Output 97,2%.

Detected in the final product, %: 53,650,05; N for 9.470,03; N 20,900,06; VG 0,00.

Calculated for monoterpenes 4. Getting citrate pgmg.

With the aim of obtaining salt pgmg acid, which is not a solvent is used, the alkali metal salt of the acid derived pgmg which you want to receive. To do this, in solution 11,16 g (0.05 EQ.) hydrobromide pgmg obtained in example 3.1., in 50 ml of acetic acid injected a solution of 6.75 g (0,025 mol) of anhydrous disubstituted potassium salt of citric acid of the following formula:

in 15 ml of acetic acid, the mixture is intensively stirred, incubated at room temperature for 30 min, filtered fallen CVG, the solution is evaporated under vacuum. The output from 94.7%.

Found in product, %: 50,550,05; N 8,000,04; N 17,700,05; VG 0,00.

Calculated for unit link, %: 50,62; N 8,07; N 17,71; 23,60. SVM corresponds to n=555, ON=1/2C6H8O7.

Example 5. Getting oleate pgmg.

With the aim of obtaining the necessary salt pgmg from the source of chloride organic acid can be made in the resulting solution of acetate pgmg in acetic acid. For this purpose obtained in example 3.2. the solution of 11,16 g (0.05 EQ.) hydrobromide pgmg to its evaporation enter 14,13 g (0.05 mol) of oleic KIS,0%.

Found in product, %: 70,850,04; N 11,670,02; N 9,900,05; VG 0,00.

Calculated for unit link, %: 70,87; N 11,66; N 9,92; 7,55. SVM corresponds to n=605, HA=C18H34O2.

The resulting product is not soluble in water, which may allow you to use it as a preservative for liquids produced in polyethilenphthalate ware.

Example 6. Getting the base pgmg.

6.1. Getting hydrochloride pgmg.

Previously obtained the dihydrochloride GMDH can be used not only as a separate disinfectant, and as an intermediate to obtain the more biocidally and less toxicity than derived GMDG. Condensation are in the same conditions as in examples 1 and 3.

For carrying out the condensation to 32,8 g (0.12 mol) dihydrochloride GMDG obtained according to example 1.1., add with stirring 11.2 g (0.10 mol) of HMDA, maintaining the temperature of the mixture to about 180oWith in half an hour, then the mixture is incubated for another 1.5 hours at a temperature of 190-200oC. the Hot reaction mixture was poured on a Teflon pan, cooled, crushed. Output hydrochloride pgmg of 97.8%.

0,04; 119,990,05.

Calculated for unit link, %: 47,32; N Remaining 9.08; N 23,65; Cl 19,95. SVM corresponds to n=655=Hcl.

6.2. The choice of organic solvents for extraction of the Foundation is as follows.

To test organic solvents use the following procedure: to 3.0 ml of aqueous NaOH (252%) was added 1.0 ml of a 50% aqueous solution of the hydrochloride pgmg and 2.0 ml of solvent. The mixture was vigorously shaken for 20-30 minutes, the organic phase (lighter than water, with the exception of chloroform) was carefully separated, placed in pre-weighed Petri dishes and dried in a vacuum Cabinet at 65-75oWith 10-15 Torr for 1.5-2 hours until constant weight. The data obtained are presented in table.3.

Detected low solubility reasons pgmg in monopolarly hydrocarbons. Neither chloroform nor other galoidovodorodami have not checked out the basis pgmg in an appreciable degree from the reaction mixture. Also very poorly dissolved base and ethers even when the increase in their oxygen content and increasing polarity, as in the dimethyl ether of diethylene glycol.

However, the alcohols formed gel and WPI is saprophilous), notable alkali dissolution in anhydrous alcohols rather would suggest the dissolution of the alcohol in the aqueous phase, but the effect of vysalivaniya (the emergence of NaCl in the interaction of alkali chloride pgmg) have enabled a greater part of the alcohol to separate from the aqueous phase and extract the base. For ethanol showed a significant (over 20%) loss of himself in the aqueous phase that has not prevented the formation of the organic phase, containing only the base. These conditions are irreversible substitution of chloride pgmg aqueous alkali in an aqueous medium and selective extraction of base pgmg in the organic phase is allowed to completely replace the product and to achieve high purification.

More complete removal of the base pgmg noted for the group of tertiary amines (which included both the actual tertiary amines and nitrogen-containing aromatic heterocycles). However, the difficulty of the selection of these solvents with their own toxicity of solutions Foundation pgmg not possible to use them in this stage of obtaining a disinfectant. It is characteristic that the smell of pyridine was left in the product after exposure in a vacuum desiccator over P2O5or H2SO4.

Wasalive afla it showed complete dissolution in the aqueous phase.

Thus, for selective extraction of base pgmg were taken aliphatic and arylaliphatic alcohols.

6.3. Getting the base pgmg.

To obtain the base pgmg 17,77 g (0.10 equiv.) hydrochloride pgmg obtained in 6.1., dissolved in 20-25 ml of warm water (50-60oC) under stirring until complete dissolution of the product. To a cooled to 20oTo the mixture was added a solution of 6.0 g (0.15 mol, 50% excess) of NaOH in 10-15 ml of water and 20 ml of isopropyl alcohol3H7HE, the mixture was intensively shaken for 15-20 minutes (the reaction can be carried out in a separating funnel, or to provide for efficient mixing of all phases). After settling separated viscous upper layer and the lower aqueous layer again extracted with a base of 10 ml of isopropyl alcohol. The combined organic extracts evaporated under vacuum. Output 89.4 per cent.

Found in product, %: 59,500,06; N 10,760,03; N 29,710,04; Cl 0,00.

Calculated for unit link, %: 59,54; N 10,71; N 29,75. SWMM (in 10% solution of Hcl) corresponds to n=755=N2O.

Obtained in this example a disinfectant has the highest biocidal effect and Bistrot in this way. However, neither in the form of an alcohol solution or in the form of a free base, it cannot be stored more than six months without loss of stability of the disinfectant properties.

Example 7. Getting digidrofosfata pgmg.

With the aim of preserving the stability of the biocidal properties of the drug means rationally translate in any salt. Phosphate pgmg provides such stability, but a strong inorganic acid prevents the dissolution of the disinfectant in monopolarly organic media.

To obtain digidrofosfata pgmg by the method of example 6.3. pre-synthesize basis pgmg from 8,89 g (0.05 EQ.) hydrochloride pgmg (obtained from example 6.1.), 3,0 (0.08 mol) of NaOH, 15 ml of gasoline With alcohol6H5CH2HE (the portions 10 and 15 ml). To a solution of alcohol in gasoline are added during the mixing 3.5 ml of 85% phosphoric acid (containing 4.9 g (0.05 mol) of N3RHO4). After the reaction is filtered alcohol, washed with phosphate pgmg ether and dried. The yield of 87.8%.

Found in product, %: 35,100,04; N 7,600,03; N 17,600,05; P 13,010,01; Cl 0,00.

Calculated for unit link, %: To 35.15; N 7,58; N 17,57; P 12,95; ATA pgmg.

As discussed in example 7, the resulting phosphate pgmg not soluble in monopolarly organic media, to impart such properties disinfectant rationally be obtained in the form of salts of organic acids, in this case, you can expect while simultaneously reducing the toxicity and corrosiveness of the drug.

To obtain benzoate pgmg by the method of example 6.3. preliminary from 8,89 g (0.05 EQ.) hydrochloride pgmg, 3.0 g (0.08 mol) of NaOH synthesize basis pgmg in the form of its solution in ~20 ml of ethyl alcohol (for extraction are portions 15 and 10 ml). Alcohol solution pariveda under vacuum. In the flask with the residue from evaporation add 6,10 g (0.05 mol) of crystalline benzoic acid With6H5CO2H, heat the mixture prior to melting, stand her at 75-85oWith 15-20 minutes. After solidification of the mixture at 90oWith its cool. The output of 91.2 per cent.

Found in product, %: With 63.810,05; N 8,050,03; N 16,000,03; Cl 0,00.

Calculated for unit link, %: 63,85; N. Of 8.04; N 15,96; 12,15.

SVM corresponds to n=755, HA=C6H5CO2H.

Example 9. Getting tosilata pgmg
Moderate biocidal arylsulfonyl, and even more sulfa drugs with acid groups to salt formation with pgmg allows to expect a further strengthening of the disinfecting properties of the drug.

To obtain tosilata pgmg by the method of example 6.3. pre-synthesized from 8,89 g (0.05 EQ.) hydrochloride pgmg (obtained from example 6.1.), 4,21 g (0.08 mol) of KOH base pgmg in the form of its solution in ~20 ml of ethyl alcohol (for extraction are portions 15 and 10 ml). To the alcoholic solution of the base is added to a solution of 9.5 g (0.05 mol) of the monohydrate of n-toluenesulfonic acid n-CH3With6H4SO3NH2O, the mixture is heated, then pariveda under vacuum. The yield of 89.7%.

Found in product, %: 53,620,04; N 7,400,03; N 13,400,05; S of 10.250,07; Cl 0,00.

Calculated for unit link, %: 53,65; N 7,40; N 13,41; 15,31; S 10,23.

SVM corresponds to n=705, AT=C7H7SO3N.

The proposed method is industrially applicable, it includes the use of commercially available starting compounds, as well as standard process equipment.


Formula ia and a derivative of guanidine within 1-2 hours at 180-200C and a molar ratio of the diamine to the guanidine derivative equal to 1:(1,2-2), respectively, with further purification and isolation of the finished product is in salt form, characterized in that the cleaning of the finished product is carried out in the liquid organic acid with the introduction of an equivalent amount of alkali metal salt of organic acid, with subsequent removal of inorganic salts.

2. The method according to p. 1, characterized in that the selection of the finished product is carried out by evaporation of its solution in a vacuum.

3. The method according to p. 1, wherein before allocating the finished product in the reaction mixture was added an equivalent amount of acid, salt hexamethyleneimino derived which get.

4. The method of obtaining a disinfectant condensation in the melt diamine dihydrochloride and hexamethylenebiguanide within 1-2 hours at 180-200When the molar ratio of the diamine to the dihydrochloride hexamethylenebiguanide 1:1,2, respectively, with the further processing of the finished product inorganic base, purification and isolation in salt form, characterized in that the cleaning base exercise ex or inorganic acid.

 

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FIELD: medicine.

SUBSTANCE: the suggested disinfectant contains glutaric aldehyde, didecyldimethylammonium chloride, ethoxylated alcohol, propylene glycol and water at certain ratios. The method to treat objects, those of medicinal indications, among them, deals with treating an object with the above-mentioned disinfectant followed by keeping disinfectant on the object during the time and at temperature to provide disinfection and/or sterilization of the object followed by washing disinfectant off. The present innovation provides hermetic nature of elements and connective elements of flexible and rigid endoscopes, soldered and glued sites in the course of disinfection.

EFFECT: higher efficiency of application.

10 cl, 3 ex

FIELD: veterinary science, veterinary disinfection.

SUBSTANCE: the suggested disinfectant should be applied for sanitation of animal and poultry objects. It contains acetic acid, sodium monochloroacetate, sodium dichloroacetate, sodium acetate, sodium glycolate, sodium chloride and water at their certain ratio. At concentration of 0.3-1.0% at exposure of 3 h this preparation causes 100% lethality in sanitary-representative microorganisms.

EFFECT: higher efficiency of disinfection.

2 ex, 1 tbl

Disinfectant // 2252035

FIELD: veterinary science, veterinary disinfection.

SUBSTANCE: for disinfecting the objects of veterinary inspection one should apply a disinfectant that contains 30%-aqueous solution of acetic acid, alkyldimethylbenzylammonium chloride, sodium carbonate, boric acid and trisodium phosphate at a certain ratio of components. The suggested preparation is of wide range of action towards bacteria, viruses and fungi and at concentration of 0.3-1.0% at exposure of 3 h causes 100% lethality of Escherichia coli, Streptococci and Staphylococci.

EFFECT: higher efficiency of disinfection.

1 ex, 1 tbl

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