Method of prevention and treatment of diseases of the gastrointestinal tract and urogenital system

 

(57) Abstract:

The invention relates to medicine, for the treatment and prevention of diseases of the gastrointestinal tract, hepatitis, post-cholecystectomy syndrome and diseases of the genitourinary system. Bred natural bischofite brine natural or tap water to a total salinity of 1.2-2.8 g/DM3obtaining mineral water containing anions and cations in the ratio, mg/DM3: HCO3-- 250-450, SO42-- less than 150, Cl-- 700-1700, Br-- 5-25, Ca2+- less than 100, Mg2+- 200-500, (Na++K+) - 100-400, water - the rest. Prepared with mineral water appointed to the daily intake 1/2 Cup for 30-60 minutes before meals for 24-30 days with a temperature of 37-40oC. the Method allows to optimize the conditions of treatment due to the narrow range of total mineralization of used mineral water. 1 C.p. f-crystals.

The invention relates to medicine, for the prevention and treatment of diseases of the gastrointestinal tract, hepatitis, post-cholecystectomy syndrome and diseases of the genitourinary system.

There is a method of treatment of diseases of the gastrointestinal tract and the genitourinary system by assigning reception m/00, 1997) /1/ prototype.

Natural mineral bischofite is harmegnies salt mined in the form of brine in the Narimanov area of the Volgograd reservoir. It is an oily liquid with General mineralization 415-460 g/l Density of bischofite is from 1.3 to 1.32 g/cm3, pH 4.5 to 4.7. Part of bischofite includes magnesium chloride to 434,5 g/l, magnesium bromide - 4-9 g/l, calcium sulfate, up to 1 g/l, bicarbonate calcium - 0.5 g/l, potassium chloride up to 5 g/l, NaCl - 5 g/l, calcium chloride up to 5 g/L.

According to a known method for the treatment of diseases of the gastrointestinal tract and urogenital system, it is recommended to assign a therapeutic water with a total mineralization of 8-12 g/l, prepared by dilution of bischofite distilled water in the ratio 1:(38-58). It is also recommended to assign to the medical table water with a total mineralization of 2-8 g/l was prepared by diluting the bischofite distilled water in the ratio 1:(58-230), as well as medical-table water with a total mineralization of 5.0-6.0 g/l, prepared by dilution of bischofite distilled water in the ratio 1:(76-92). In addition, this information source is described table water (a refreshing drink) with a total min-460) and which is recommended to be administered systematically, without prescription as mineral water dining room. This information source is an indication that the dose and timing of application of water, prepared by dilution of bischofite in the specified ratio of bischofite - water is not limited.

However, prolonged use of the waters, prepared by dilution of bischofite, in the conditions of sanatorium "Dubovka" in the Volgograd region and outpatient in MMU 18, Volgograd showed that for the treatment of diseases of the gastrointestinal tract and urogenital system applies water only with a narrow range of values of total mineralization.

The technical result achieved by the present invention is to increase the effectiveness of treatment of diseases of the gastrointestinal tract and urogenital system through the use of mineral water with a narrow optimal range of total mineralization, prepared by dilution of bischofite drinking water.

This technical result is achieved in that in the method for the prevention and treatment of diseases of the gastrointestinal tract and the genitourinary system by assigning to receive mineral water, prepared by dilution of natural bischofite brine with obtaining mineral Na++K+and water, the distinguishing feature is that bischofite diluted natural or piped drinking water to the total mineralization of 1.2-2.8 g/DM3obtaining mineral water containing anions and cations in their following ratio, mg/DM3:

THE HCO3-- 250 - 450

SO42-- Less than 150

CL-- 700 - 1700

Br-- 5 - 25

Ca2+- Less than 100

Mg2+- 200 - 500

(Na++K+) - 100 - 400

Water - the Rest

and prepared mineral water appointed to the daily intake 1/2 Cup for 30-60 minutes before meals for 24-30 days.

Pets appointment to receive mineral water with a temperature of 37-40oC.

Taking into account the level of total mineralization and predominantly magnesium cation composition of the mineral water used by the method according to the invention for the treatment of diseases of the gastrointestinal tract and urogenital system, is a medicinal and table water and occupies an intermediate position among the well-known packaged in an industrial scale mineral waters XVI, XX and XXVII groups (GOST 13273-88). Water given the name "Aqua-Bi".

Below are examples illustrating isobligatory according to examples 1-3, on reparative regeneration processes in the stomach.

Experimental studies were performed on 40 white rats male Wistar breed. Studied the effect of sodium chloride-magnesium water prepared by diluting the natural bischofite drinking water. Used variants of the water had a total salinity of 1.2 g/DM3, 2.0 g/DM3and 2.8 g/DM3that corresponded to the three compounds, mg/DM3:

THE HCO3-- 250; 350; 450

SO42-- 100; 120; 140

CL-- 700; 1200; 1700

Br-- 5; 15; 25

Ca2+- 50; 70; 90

Mg2+- 200; 350; 500

(Na++K+) - 100; 250; 400

Water - the Rest

Studied the effect of three samples prepared with water on the acetate models of gastric ulcer. A group of 40 rats were divided into 4 subgroups. In 10 rats as control was used tap water. 30 the experimental rats were divided into three subgroups and examined, respectively, the three samples prepared with water. All experimental rats daily administered orally 1 time a day for 3 ml of water through a needle with an olive on the end for 21 days. Histological studies were performed after the animals were scored after 15 treatments and drinking on the 6th day of the period aftereffect. About the defects, complete epithelization, the mitotic activity of the epithelium at the edges of ulcers, the development of granulation tissue.

It is shown that after 15 procedures watering animals warmed up to 37-40oMineral water (all three variants) showed activation of cell proliferation in the connective and epithelial tissues of the stomach with the development of blood vessels and granulation tissue and primary phenomena epithelialization in the edges of the ulcers. There was a trend to decrease the size of ulcers.

In General, in the period of the weakening of inflammatory and dystrophic necrotic phenomena happened in the strengthening of biosynthetic processes, which is the basis for the development of protective and adaptive-compensatory reactions.

During aftereffect on 6th-10th days after the end of course drinking was a decrease of the size of ulcers compared with control 64,5%, and completely healed ulcers amounted to 53.1%.

Example 2. Clinical examination of 120 patients (55 men, 65 women), who were divided into two groups of 60 each.

In the first group consisted of 40 patients with gastric ulcer and duodenal ulcer, and 20 ill the comorbidities in this group was presented chronic cholecystitis, hepatitis, pancreatitis, gastritis and hypertension. The second group consisted of 60 patients with the same primary and concomitant diseases. The average age of patients 38-43 years.

Patients of the first group received drinking water treatment is made according to the invention: breeding bischofite natural drinking or drinking tap water with production of mineral medical-table water with General mineralization, respectively, 1.5 g/DM3, 2.2 g/DM3and 2.5 g/DM3. Water was applied warmed up to 37-40oC. the Treatment was performed in the conditions of sanatorium "Dubovka" in the Volgograd region and outpatient in MMU 18, Volgograd.

Patients of the second group received treatment of sulphate-magnesium mineral water "Smirnovskaya".

Patients in both groups was performed traditional physical examination. The diagnosis of gastric ulcer and duodenal ulcer was established using accepted diagnostic criteria: complaints, survey data, physical examination, laboratory and instrumental investigations: x-ray and endoscopy. According to FGS patients in the stomach was determined moderate quantity of liquid, the thicker tops, and also ulcerative defects on the lesser curvature of the stomach of an average diameter of 0.6-0.9 cm from the bottom, covered with fibrin and inflammatory shaft around. Ulcer defects in the duodenal bulb was in a diameter of 0.3-0.5 cm

Patients of both comparison groups took 1/2 Cup of water 3 times for 30-60 minutes before meals for 24-30 days. Water temperature 37-40oC.

After treatment in patients with two comparison groups was noted subjective improvement: increased appetite, decrease heartburn, disappearance of pain in the epigastrium. According to the endoscopic studies in 72% of patients of the first group mentioned the disappearance of edema of the mucosa, reducing the size of erosions on average 1.9 times and amount 1.5 times. Ulcer defects decreased to an average of 2.0 times, appeared expressed their epithelialization.

In 63% of patients of the second group also noted the disappearance of edema of the mucosa, reducing the size of erosions on average 1.5 times their number by a factor of 1.2. Ulcer defects decreased to an average of 1.8 times, while there was reasonable epithelialization.

Thus, clinical studies have shown that patients taking mineral water according to izaberete the political, anesthetic, toning and regenerating effects, and improved somatic status.

Example 3. The group of patients out of 200 people with gastric ulcer and erosive gastritis was divided into three subgroups: 20, 90 and 90, respectively. Patients first, second and third subgroups took water with General mineralization, respectively, 1.0 g/DM3, 2.2 g/DM3and 3.2 g/DM3prepared by cultivation of bischofite natural drinking water or drinking tap water. All patients were prescribed water in the amount of 1/2 Cup in three receptions for 30-60 minutes before meals for 24-30 days. Water temperature 37-40oC.

After the course of treatment in the three comparison groups were obtained different results.

In another subgroup of patients treated with mineral water, prepared according to the invention, it was noted subjective improvement: increased appetite, decrease heartburn, disappearance of pain in the epigastrium. In 80% of patients in this group indicated the disappearance of edema of the mucosa, reducing the size of erosion on average 1.9 times. Ulcer defects decreased on average 2 times, appeared expressed their epithelialization.

Patients of the first and third pourvoi subgroups and in seven patients the third subgroup was noted deterioration. In some patients, a third subgroup was expressed liquid stools, which may be connected with a high level of magnesium in water that exceeds the level recommended by the present invention.

Example 4. Water according to the invention with a total mineralization of 1.2-2.8 g/DM3appointed as an additive to therapeutic feeding women with diseases of the gastrointestinal tract associated with fibrocystic breast pain. The water was heated up to 37-40oWith and appointed in the amount of 1/2 Cup three times a day for 30-60 minutes before meals for 24-30 days. The water intake was accompanied by a decrease in pain, decrease in turgor breast tissue.

Example 5. In contrast to the known sulphate-sodium water ("Jermuk", "Smirnovskaya", "Essentuki-17" mineral water "Aqua-Bi", prigotavlivaemy breeding bischofite natural or tap water to a total salinity of 1.2-2.8 g/DM3is chloride-magnesium water with a high content of magnesium ions, which actively affect the biliary function, and enhances gallbladder reflux, change the physico-chemical properties of bile, increase the content of bile pigments and acids. Available in water "Aqua-Bi calcium ions to Ecotechnie mucous membranes. According to the Institute of Pharmacology, Volgograd medical Academy when using drugs magnesium develops cardioprotection in myocardial infarction, stopped by an arrhythmia of the heart, manifested antihypertensive effect, eliminated the chronic fatigue syndrome. Magnesium products are used in violation of cerebral circulation, with kidney stones and osteoporosis.

In the study of mineral water "Aqua-Bi", prepared by dilution of bischofite natural drinking water, Department of pharmacology, Volgograd medical Academy, it was shown that water has gipoholesterinemicheskoy activity. When using water in the treatment of liquidators of the Chernobyl NPP was observed normalization of psychophysiological state, celebrated its immunomodulatory effects and decrease the production of histamine, serotonin, bradykinin.

Example 6. Mineral water "Aqua-Bi, prepared according to the invention of bischofite, used for the treatment of patients with chronic urogenital diseases. The observations were carried out in 17 patients suffering from urolithiasis, chronic pyelonephritis in remission, chronic prostatitis in stage d is two, three-day course of treatment with mineral water all patients noted improvement in health, all patients had a positive clinical dynamics laboratory (urinalysis, complete blood count, urine analysis according to Nechyporenko).

Example 7. Since may 1999 chloride-magnesium mineral water "Aqua-Bi" with a total mineralization of 1.2-2.8 g/DM3prepared by dilution of bischofite piped drinking water, is used in the complex of therapeutic measures in patients of the Department of rehabilitation sanatorium "Dubovka, Volgograd oblast, who underwent surgery on the organs of hepato-billiardo zone or on the bowel. Research has shown the following:

1. Mineral water "Aqua-Bi have no negative impact on the course of diseases.

2. Water has excellent organoleptic properties and eagerly eaten by the sick.

3. Water has a positive effect on patients suffering from chronic hepatitis, dyskinesia of the gallbladder on hypotonic type, chronic colitis and spastic intestinal dyskinesia.

4. Water helps to improve overall health, normalization of laboratory values and speedy rehabilitation of the sick is e rapid reduction of inflammatory processes in the liver, gallbladder and biliary tract, and colon.

6. Water provides positive dynamics of indicators (complete blood count, urinalysis, urine analysis according to Nechyporenko) in patients with chronic urogenital diseases (urolithiasis, chronic pyelonephritis, chronic prostatitis).

During the application of mineral water "Aqua-Bi" in the sanatorium treated:

1. In 1999, 320, from which a positive result was observed in 319 (99,7%). Unexpressed result was observed only in one person (0,3%).

2. In 2000, 547 people, of which a positive result was observed in 540 people (98,7%). Unexpressed result was observed in 7 (1.3%), and

3. In 2001, for the period from January to August inclusive - 577 people. A positive result was observed in 566 people (98,1%). Unexpressed result was observed in 11 people (1,9%).

Example 8. Breeding bischofite piped drinking water has prepared several samples of mineral water, differing from one another with total mineralization; 1.2 g/DM3, 2.8 g/DM3, 3.2 g/DM35 g/DM3, 6 g/DM3, 7 g/DM3. Patients willingly ate the first two sample mine is red taste. The use of this water sample was brought on the second or third day to liquid stool, which was accompanied by painful sensations in the gut. In the second or third days of the patients refused to drink the water of this sample. Samples of the fourth, fifth and sixth were too pronounced bitter-salty taste. All patients refused their use.

The analysis of the information contained in the known information source /1/ that the patients took for 1.5 months three times a day over a quarter of a glass of mineral water, obtained by dilution of bischofite to the total mineralization of 5.0-6.0 g/l, makes you think that people take this water only in diluted form, as his own observations show that the water with this level of total mineralization causes a gag reflex, and its organoleptic characteristics disgust patients. In addition, the use of sick water with such a high level of total mineralization certainly leads to sustainable, tedious, difficult normalized by the liquid chair. And acceptance of such water sick diluted makes it non-standard, differing from reception to reception, but, nevertheless, approaching the water according to this the new mineral water "Aqua-Bi" with a total mineralization of 1.2-2.8 g/DM3produced by natural breeding or piped drinking water natural bischofite brine, can be recommended as a therapeutic and prophylactic drug for people suffering from chronic hepatitis, biliary dyskinesia in hypokinetic type, chronic colitis and patients who underwent cholecystectomy and intervention in the biliary tract, and people suffering from chronic diseases of the urogenital (urolithiasis, chronic pyelonephritis, chronic prostatitis). The purpose chloride-magnesium mineral water "Aqua-Bi" as a Supplement to the nutritional appropriate hepatitis, biliary dyskinesia, postcholecystectomy syndrome and colitis of various origins. In addition, water is reasonable to recommend the use of women with diseases of the gastrointestinal tract associated with fibrocystic breast disease with pain.

Mineral water prepared from bischofite in accordance with the present invention, corresponds to the principle of sanatorium-resort treatment of patients with gastric ulcer, duodenal ulcer, erosive gastrico recommended by the invention, mineral water does not show those healing properties that it is within the parameters recommended by the invention.

The source of information

1. RF patent 2076713, MCI And 23 L 2/00, 1997.

1. Method of prevention and treatment of diseases of the gastrointestinal tract and the genitourinary system by assigning to receive mineral water, prepared by dilution of natural bischofite brine with obtaining mineral water containing anions HCO-3SO2-4, CL-, VG-the cations CA2+Mg2+, (Na++K+) and water, characterized in that the bischofite diluted natural or piped drinking water to the total mineralization of 1.2-2.8 g/DM3obtaining mineral water containing anions and cations in the following ratio, mg/DM3:

HCO-3250-450

SO2-4Less than 150

Cl-700-1700

Br-5-25

CA2+Less than 100

Mg2+ 200-500

(Na++K+) 100-400

Water the Rest

and prepared mineral water appointed to the daily reception of the1/2cups for 30-60 minutes before meals for 24-30 days.

2. The method according to claim

 

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