Device for implantation of cell culture with excretory function
The invention relates to the field of medicine and medical technology and is designed to improve the quality of life of patients after operations involving destruction of the liver, pancreas, and others, as well as patients with the expressed violations of function of the listed bodies. Inside of neutral polymer are camera, with between chambers containing cell culture, and a chamber in which there is a concentration of the filtrate, the valves prevent the back-flow of the filtrate. Between the camera, which is filtered, and the tube is installed remotely operated valve. The wall of the chamber, in which there is a concentration of the filtrate, made of a membrane permeable to water in the space between this camera and the housing. The filtered liquid is returned to the bloodstream through the anastomosis with Vienna. Membrane, through which the chamber containing a cell culture, arterial filters, made in the form of a prosthetic blood vessel or arteriovenous anastomosis. 1 C.p. f-crystals, 1 Il. The invention relates to the field of medicine and medical equipment, namely, gastroenterology, and is the eat liver, pancreas and others, as well as patients with the expressed violations of function of the listed bodies.Attempts to model the excretory function of the removed organ of the author in the available literature, not found. Complete removal of the liver is not compatible with life. Pancreatoduodenal resection accompanied by a great mortality. Surviving patients need constant replacement therapy.The aim of the invention is to improve the quality of life of patients after operations involving the complete or almost complete removal of the liver, pancreas, and others , as well as patients with the expressed violations of function of the listed bodies. At the same time using the proposed device can be modeled by the function, for example, breast cancer.This object is achieved in that remote either completely lost organ function is compensated by the implantation of a cell culture, which is protected from the effects of the antibodies of the device shown in the drawing, which is a case of the neutral polymer with filler, inside which is located a few cameras 1, which is cell culture. Through a semipermeable membrane 2 of Arran prevents penetration into the camera, which is a cell culture, antibodies and cellular elements. The flow rate of filtrate through the camera 1 should be sufficient to maintain the required concentrations of glucose, ions, and such that the concentration of the secret did not exceed those concentrations, which will be the impact on the cell culture. The valve 3, the separating chamber 1 from the camera 4, should prevent the back-flow of the filtrate. In chamber 4 is separated from the intestine 11 valve 8, there is a concentration of the filtrate by liquid displacement through the membrane 5 into the chamber 6 under the action of excess pressure in the blood vessel. Fluid from the chamber 6 is returned to Vienna 10 through the anastomosis 7. After a meal remotely operated valve 8 is opened, the filtrate with concentrated secret enters the intestine, after which the valve is closed, starts the concentration of secreted cell culture secret due to displacement under the action of fluid pressure from the chamber 4 into the chamber 6 through the membrane 5.Possible options with interchangeable cassettes with filler that will help when you slow current of the filtrate through the housing to change tapes during endoscopic surgery.Intensivstation semi-permeable membrane may take the form of a prosthesis artery, and arteriovenous anastomosis.
Claims1. Device for implantation of a cell culture, comprising a housing and a semi-permeable membrane, characterized in that it introduced the camera for cell culture, located in the housing, one of the walls of the chambers is a prosthetic trunk blood vessel or arteriovenous anastomosis, made in the form of a membrane, between the said chambers for cell culture and Luggage for concentration of the filtrate, made of semi-permeable membrane, having the ability to pass water into the space between it and the body is equipped with valves to prevent back flow of the filtrate, and between the chamber concentration of the filtrate and a tube for connection with the intestines installed remotely operated valve.2. The device under item 1, characterized in that used replaceable cartridge with filler to replace the cell culture without removing the case.
FIELD: medicinal equipment.
SUBSTANCE: the present innovation deals with means for restoring and/or keeping the lumen of blood vessel at treating cardio-vascular diseases due to implanting intravascular prostheses. The latter should be designed as a perforated cylindrical tube with grooves of patterned-cellular type which form at initial state periodically repeated rows of oval open rings connected with longitudinal and cross-sectional crosspieces. Repeated rows consist of the cells which in their initial state are of open oval rings the ends of which steadily come into cross-sectional crosspieces to unite these cells into the row. The second row of cells is developed due to mirror image of the first row being connected with the latter with longitudinal crosspieces. Next pairs of cellular rows are connected between each other with longitudinal crosspieces. By another variant for carrying out intravascular prosthesis, the second row of cells should be developed due to shifting the first row for the half of cellular width being connected with it by longitudinal crosspieces, as for the next cellular rows they are connected with longitudinal crosspieces. The method enables to improve flexibility of intravascular prosthesis at initial state and its rigidity at open state.
EFFECT: higher efficiency.
20 cl, 8 dwg
FIELD: stomatologic techniques and materials.
SUBSTANCE: proposed membrane comprises at least two porous polytetrafluoroethylene layers: one adjusting parodentium tissues and the other being outside layer, the two having different porous structure. Layer adjusting parodentium tissues is characterized by volume portion of hollow space equal to 78-94%, specific surface of hollow space 0.5-0.9 mcm2/mcm3, average distance between hollows 20.0-50.0 mcm, and average volumetric chord 20.0-30.0 mcm. Outside layer is characterized by volume portion of hollow space equal to 30-60%, specific surface of hollow space 0.1-0.5 mcm2/mcm3, average distance between hollows 1.8-15.0 mcm, and average volumetric chord 1.0-15.0 mcm.
EFFECT: increased regenerative activity and simplified use.
7 cl, 7 dwg, 1 tbl, 6 ex
FIELD: medicine, surgery.
SUBSTANCE: one should introduce a basis into the body and remove it out of the body after forming the structure on it with cells and tissues of connective tissue of one's own body at thickness being sufficient for tissue suturing. Then one should suture the basis into plasty area. In peculiar case, one should introduce the basis in the form of a tube, or a sac, or a skin section. In peculiar case the basis could be designed out of Millipore, in peculiar case, the basis should be introduced subcutaneously or retroperitoneally. The innovation enables to obtain autoprostheses for greater quantity of different organs and tissues.
EFFECT: more simplified technique to obtain autoprostheses.
6 cl, 1 tbl
FIELD: medical engineering.
SUBSTANCE: device has a set of active ingredients. At least one structural ingredient based on extracellular substance, minimum one ingredient providing cell migration, minimum one adhesive ingredient, minimum one ingredient providing growth or maturation are used for producing the implantable prosthesis. External endoprosthesis surface is minimum partially coated with a set of active ingredients. The endoprosthesis has also minimum one internal cavity filled with a set of active ingredients.
EFFECT: long service life; accelerated engraftment in organism; greater load applied at earlier stage.
4 cl, 4 dwg, 2 tbl
FIELD: prosthesis techniques.
SUBSTANCE: invention, in particular, relates to cardiovascular surgery involving use of artificial mitral valves and also can be utilized in manufacture of implants of other organs in orthopedics, stomatology, traumatic surgery, and the like, as well as in various technical fields. Material of invention contains boron, silicon, and isotropic pyrocarbon in specified proportions.
EFFECT: increased strength, hardness, and wear resistance.
1 tbl, 3 ex
FIELD: medicine, plastic surgery.
SUBSTANCE: the suggested endoprosthesis is designed out of polymeric bioinert material and has a membrane, its surface is designed with protrusions as inclined cone-shaped, sharpened flexible projections. Direction, location at ends and interval between projections are made to be different depending upon target indication of endoprosthesis. Excessive ends of protrusions above the surface according to indication correspond to 0.01 up to 5 mm. The innovation enables to provide strong fixation of endoprosthesis in a patient's body.
EFFECT: higher efficiency.
7 cl, 12 dwg
FIELD: medical engineering.
SUBSTANCE: device has porous ceramic carrier layers and transverse bracing members, connected carcass having pores most of which have size from 20 to 1000 mcm and possessing density of 40% with respect to the theoretical one. Volume of the pores is optionally filled with a drug known to have controllable release rate from the filler.
EFFECT: enhanced effectiveness in providing controllable drug release rate from the filler.
30 cl, 3 dwg, 1 tbl
SUBSTANCE: the present innovation is directed to obtain a covering that provides high ability for developing bony tissue. This result should be fulfilled due to applying suspension upon titanium and its alloys with direct or impulse current under conditions of spark discharge, drying at about 80-120° C and roasting at about 600-800° C for 0.5-1 h, where as suspension one should apply synthetic and biological hydroxyapatite powder at the following quantitative ratio of components, weight%: synthetic hydroxyapatite powder 10-90, biological hydroxyapatite powder 10-90.
EFFECT: higher efficiency.
2 dwg, 3 ex, 1 tbl
SUBSTANCE: method involves incubating transplants for preventing calcinosis occurrence in salt solution containing no calcium and phosphate ions but calcium chelators in the amount enough for initiating donor cells death and preventing calcinosis centers formation. Ethylene diamine tetraacetic acid is applied as chelator in 0.2-2.0% concentration or sodium citrate in 1-2.5% concentration. Digitonin is applied in concentration reaching 0.1% for increasing effectiveness and donor cells death. Incubation is carried out at salt solution pH being within the range of 5.0-7.5 and temperature from 10 to 37°C during 2-4 days.
EFFECT: enhanced effectiveness in preventing calcinosis and causing donor cells death; high transplant biocompatibility.
2 cl, 3 dwg
FIELD: medical devices, namely processes for forming coatings on surfaces of implants made of titanium in recrystallized or nano-structure state.
SUBSTANCE: coating contains, mass %: calcium titanate, 7 - 9; titanium pyrophosphate, 16 - 28; calcium phosphate compounds, the balance. Method comprises steps of anodizing implant by pulse electric current at condition of electric-spark discharge in phosphoric acid solution containing hydroxyapatite and calcium carbonate. Anodizing is realized by means of pulse current with next parameters: pulse time period, 50 - 200 ms; pulse repetition frequency 50 - 100 Hz; initial electric current density, 0.2 - 0.25 A/mm2; final voltage 100 -300 V. Invention allows to receive coating with thickness 40 - 80 micrometers.
EFFECT: possibility for forming coating whose composition is similar to that of osseous tissue with high content of calcium, improved osteoinductive and mechanical properties of coating.
7 cl, 3 ex