The method of obtaining [1,2,4] triazolo [3,4-b] [1,3] benzothiazol - 3 (2h)-thione

 

(57) Abstract:

The invention relates to a method for producing [1,2,4]triazolo[3,4-b][1,3]benzothiazol-3(2H)-thione of the formula

including fusion [1,2,4]triazolo[3,4-b][1,3]benzothiazole with excess sulfur in for 5-20 minutes at a temperature of 180-200C, followed by separation of the target product. The technical result - the reduction of time for the process, increasing the yield of the target product.

The invention relates to a method for producing [1,2,4] triazolo [3,4-b] [1,3] benzothiazol -3 (2H)-thione of the formula

which can find application as Cinchona in the synthesis of drugs for the destruction of pathogenic organisms.

Known to produce [1,2,4] triazolo [3,4-b] [1,3] benzothiazol-3 (2H)-thione long (60 hours) boiling 2-hydrazinobenzothiazole with carbon disulfide (U.S. Pat. USA 4064261, class a 01 N 9/12, a 01 N 9/82, publ. 20.12.77 year).

The disadvantage of this method is the long duration of the process, the need to work with toxic and explosive disulfide.

The technical result is to reduce the time of implementation of the process, increasing the yield of the target product. In addition, it should be noted dostupna alloys with excess sulfur in for 5-20 minutes at a temperature of 180-200C, followed by separation of the target product.

Undergoes the following reaction:

Example 1. Alloy on a metal bath for 10 minutes at a temperature of 190C. a mixture of 10 g [1,2,4] triazolo [3,4-b] [1,3] benzothiazole and 10 g of sulfur. The melt is cooled, add 10% sodium hydroxide solution, heated to boiling and filtered. The cooled filtrate is neutralized 10% hydrochloric acid, the precipitated precipitate is filtered off and crystallized from ethanol. The output of 8.2 g (69%). MP. 240-242C.

Found:% 45,96; N 2,53; N 20,48; C8H5N3S2.

Calculated:% 46,38; N 2,42; N 20,29.

Example 2. In the conditions of example 1 to carry out the reaction for 20 minutes. Yield 61%.

Example 3. In the conditions of example 1 to carry out the reaction for 5 minutes. Yield 52%.

Example 4. In the conditions of example 1 to carry out the reaction at a temperature of 180C. the Yield 60%.

Example 5. In the conditions of example 1 to carry out the reaction at a temperature of 200C. a Yield of 45%.

If the temperature is less than 180, that is not the reaction, and if it is above 200C, there is a resinification product.

The advantage of the proposed method is the availability of source reagents, their low toxicity and explosive nature, the simplicity of instrumentation, low duration prozone, wherein said [1,2,4] triazolo [3,4-b] [1,3] benzothiazol alloys with excess sulfur in for 5-20 minutes at a temperature of 180-200C, followed by separation of the target product.

 

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