The hydrazides in a series of bacteriochlorophyll a with photodynamic activity, and method of production thereof

 

The invention relates to a hydrazides in a series of bacteriochlorophyll and General formula I, where R1=COCH3CH(OH)CH3CH=CH2; R2=H,CH3C2H5; R3and R4=H, CH3, Tos, and the method of obtaining hydrazides I by reacting derivatives of bacteriochlorophyll and with additional anhydrous cycle with hydrazinehydrate and subsequent cyclization of the resulting intermediate hydrazide by adding to the reaction mass of hydrochloric acid; the proposed hydrazides have high photoinduced activity; in the absence of light irradiation hydrazides I at concentrations 6-15 times phototoxic not affect the growth of the cell culture. 2 S. p. f-crystals.

Description text in facsimile form (see graphic part)and

Claims

1. The hydrazides in a series of bacteriochlorophyllthe General formula

R1=COCH3CH(OH)CH3CH=CH2;

R2=H,CH3C2H5;

R3and R4=H, CH3, Tos.

2. The method of obtaining hydrazides of General formula (1), namely, that the derivatives of bacteriochlorophyll

 

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