Derivatives of 1,3-dimethyl-8-(2-hydroxypropyl-1) thioxanthene displaying biological activity


C07D473/38 - attached in position 6

 

The invention relates to new derivatives thioxanthine General formulawhere R is C6H5(1a), CH2-CH=CH2, (1b) compounds according to the invention have greater inflammatory and bronchodilatory activity than aminophylline, being less toxic. 4 C.p. f-crystals, 4 PL.

Description text in facsimile form (see graphic part)and

Claims

1. Derivatives of 1,3-dimethyl-8-(2-hydroxypropyl-1)-thioxanthine formulas

where R is C6H5(1a), CH2-CH=CH2(1b).

2. Connection on p. 1, representing 1,3-dimethyl-8-(2-hydroxy-3-phenoxypropan-1)thioxanthen.

3. Connection on p. 1, representing 1,3-dimethyl-8-(2-hydroxy-3-allyloxymethyl-1)thioxanthen.

4. Derivatives under item 1, showing bronchodilatory activity.

5. Derivatives under item 1, showing the antispasmodic activity.

 

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