Method of treating psoriasis in combination with chronic opisthorchiasis

 

(57) Abstract:

The invention relates to medicine, dermatology, and can be used for the treatment of patients with psoriasis in combination with chronic opisthorchiasis. Before deworming appointed nicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food "Popwin" 1 dessert spoon 2 times a day 30 minutes after meals for 7 days, after which assign oxygenated 0.25 g 3 times a day before meals for 14 days. This invention will reduce the number of complications and high efficiency de-worming, which is achieved by the use of biologically active food supplements "Poulin".

The invention relates to the field of medicine, dermatology and relates to methods of treating psoriasis in combination with chronic opisthorchiasis.

Closest to the present invention is a method of treatment of patients with combined pathology using praziquantel, appointed in the usual dose of 60 mg/kg of body weight on the night circuit 3 times with an interval of 4 hours deworming Efficiency was 100%. However, for patients with psoriasis, this treatment causes a complication to the controlled itching, that requested additional detoxification therapy gemodeza within 5 days (Belyalov I., "characteristics of psoriasis, stomach and biliary system when combined with chronic opisthorchiasis". The dissertation on competition of a scientific degree of candidate of medical Sciences, Tomsk, 1999).

A new technical result is a decrease in the number of complications and high efficiency deworming achieve application of a new method of treating psoriasis in combination with chronic opisthorchiasis, consisting of deworming during the stationary phase of the process, and before deworming naznachaut nicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food "Popwin" 1 dessert spoon 2 times a day 30 minutes after meals for 7 days, after which assign oxygenated 0.25 g 3 times a day before meals for 14 days.

The method is as follows:

Before beginning treatment for translation an advanced stage of psoriasis in inpatient ambulatory patient receives the following treatment: detoxification therapy (sodium thiosulfate 30 is trum" 1 capsule 1 time per day, 30 days), sedatives (sibazon 1 tablet at night 20 days). Outer: cream Unna.

Also the patient is undergoing physical examination (complete blood count, urinalysis, biochemical analysis of blood), liver ultrasound, duodenal intubation or enzyme-linked immunosorbent assay for opisthorchiasis to Ig G.

When in duodenal bile eggs opistorhisov or higher titer by ELISA, the patient receives outpatient treatment nicotina 0.5 g 3 times a day before meals for 14 days, then spend deworming biologically active additive to food "Popwin" 1 dessert spoon 2 times a day 30 minutes after meals for 7 days, after which assign oxygenated 0.25 g 3 times a day before meals for 14 days.

Biologically active food Supplement "Popwin" is a syrupy liquid, opaque brownish-red color, bitter taste, with low specific smell.

The composition contains a complex of biologically active substances aspen bark: phenolic glycosides (salicin, salikortin, tremuloides, tremulatsin and others), tannins, organic acids, triterpenoids, bitterness, pectin, carbohydrate; Salsola Collina: glycinebetaine, flavonoids, cathodically the Oia in the form of sulfates, chlorides and bicarbonates, trace elements (bromine, copper, lithium, and others), organic substances (lipids, amino acids, carboxylic acids).

"Populin has anti opisthorchosis, choleretic, anti-inflammatory, hepatoprotective effect.

Unlike hoksila and biltricide "Populin non-toxic, deprived allergenic, embryotoxic and mutagenic properties.

Indications for use: complex treatment of acute and chronic opisthorchiasis, especially when there are contraindications to the appointment hloksila and biltricide for repeated courses deworming, and also as a means of normalizing the function of the biliary system in opisthorchiasis and improves digestive processes.

How to use:

One admission for adults is 2 grams (1 teaspoon), children from 3 to 6 years - 1/3 of the adult dose. From 6 to 12 years - 2/3 of the adult dose, dissolved in 0.5 cups of water, after 30 to 40 minutes after a meal 3 times a day with an interval between receptions 6 hours Course hours - 7 days.

By-effects, contraindication is hypersensitivity of the individual components of the drug. Form release: vial of dark glass 45, shelf Life: 2 years.

"Popwin" produced by Political, 3.

This food additive of plant origin, which is favourable for the treatment of opisthorchiasis in patients with psoriasis. Dose and sequence of use of the drug selected on the basis of clinical observations. After treatment conducted duodenal intubation, according to which determined the efficacy of deworming. The rate of reception of biologically active food supplements "Popwin" necessary and sufficient, which is confirmed by clinical observations for this category of patients. When deworming during the period of less than 7 days reduces the effectiveness of deworming, and lengthening the period of more than 7 days, resulting in additional side effects that are undesirable to patients with psoriasis. In the day time the drug is given for the convenience of observation of patients in 2 hours to increase the concentration of the herbal drug to be more effective deworming. The dose is 1 teaspoon 2 times a day for 7 days is necessary and sufficient for the clinical observations for effective deworming in this category of patients. Purpose before deworming of nicotine with relegalization in more favourable conditions. The use of oxygenated, not bactericidal, establishes a positive effect on the state of the biliary system, as by this time reduced the signs of acute inflammation in the biliary tract, but remains hypotension gallbladder.

An example of the method for the patient:

Sick Eirich P. R., 47 years old, appealed to the Regional clinical hospital, Tomsk, diagnosed with Chronic opisthorchiasis. Chronic acalculous cholecystitis under mild exacerbation. Biliary dyskinesia on hyponatremia type. Concomitant diagnosis: Psoriasis, guttate-plaque, progressive stage, common, autumn and winter.

Upon receipt complained of heaviness in the right hypochondrium, a constant bitter taste in the mouth, nausea, decreased appetite.

From history revealed that the patient suffers from psoriasis for about 10 years. Last worsening appeared two months ago. Links with the nervous shock. Held the following treatment: detoxification therapy (sodium thiosulfate and 30% at 10 ml/10), antihistamines (claritin 1 tablet 1 time a day for 10 days), vitamins ("Centrum" 1 : cream Unna.

The last 3 years have trouble heaviness in the right hypochondrium, periodic pain in this area, fatty food intolerance, nausea.

Performed outpatient physical examination, ultrasound, duodenal intubation, ELISA opisthorchiasis to Ig G.

In General, the analysis of blood eosinophilia of up to 6%. In General urine analysis showed no pathological changes. Biochemical analysis of blood within normal limits.

According to chromatic miotroponogo duodenal intubation revealed dyskinesia of the gallbladder on hyponatremia type: gallbladder bile were due in large volume to 100 ml (normal 60 ml) and time to expiration was extended to 41 min (at a rate of 21 min). Revealed hypotonia of the sphincter of Oddi.

Microscopy bile discovered eggs opistorhisov (5-6 in the field of view). The higher titer by ELISA on opisthorchiasis to Ig G 0,45 (at a rate of 0.29).

By ultrasound gallbladder volume was significantly increased and amounted to 80 cm3(at a rate of 40-60 cm3).

When the transition process of the skin to the stationary phase patients received treatment of chronic opisthorchiasis.

Objective: Normotensive color, coalescing into plaques covered with silvery-white scales, which are easily removed by poskablivanii. Psoriatic triad positive (the phenomenon of stearic spots, the phenomenon of psoriasis of the film, the phenomenon of the point of bleeding). Tongue coated white bloom. In the lungs, the heart and without pathology. The abdomen is soft, with tenderness in the right hypochondrium moderately painful. Positive symptoms and Kera Murphy.

For the treatment of chronic opisthorchiasis and Hyper motility gallbladder dyskinesia was assigned to the following treatment: preparing for deworming nicotina 0.5 g 3 times a day before meals for 14 days, then were treated biologically active additive to food "Popwin" 1 dessert spoon 2 times a day 30 minutes after meals for 7 days, after which the patient received oxygenated 0.25 g 3 times a day before meals for 14 days.

Treatment the patient has suffered well. After deworming biologically active additive to food "Popwin" side effects were noted. The appearance of lesions on the skin, itching were observed. 5 day use "Paulina" disappeared sensation of heaviness in the right hypochondrium, bitter taste in the mouth, by the end of treatment was not feeling nausea, improved ARESVUMA study. According to the fractional duodenal volume of the gallbladder bile and the time to expiration is normalized and represented 61 ml (normal 60 ml) and 21 minutes (at a rate of 21 min). Microscopy revealed bile single egg opistorhisov. By ultrasound gallbladder volume was 56 cm3that is the norm. Within a week after treatment was reached regression psoriasis. One month after the treatment, the patient noted improvement in health complaints from the digestive tract is not present, nausea disappeared and normal appetite. A repeated duodenal intubation. Microscopy bile eggs opistorhisov not identified. The skin was at the stage regression.

In this way treated 7 patients with psoriasis in combination with chronic opisthorchiasis. Side effects of the skin, the gastrointestinal tract in the treatment of this method was not. The effectiveness of deworming amounted to 85.7%.

Thus, the proposed method allows to treat patients with combined pathology of biologically active food supplements "Popwin" produced from local raw materials. This gave the opportunity not ispolzovanie patients suffering from psoriasis.

Method of treating psoriasis in combination with chronic opisthorchiasis, consisting of deworming during the stationary phase of the process, characterized in that before deworming appointed nicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food “Popwin” 1 dessert spoon 2 times a day 30 minutes after meals for 7 days, after which assign oxygenated 0.25 g 3 times a day before meals for 14 days.

 

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