Tool to stimulate epithelialization of wounds

 

The invention relates to medicine, namely to the means for treatment based on blood, and can be used in the treatment of patients with defects in epithelial tissues of various etiologies. The tool that contains the components of autoplasma, obtained by separation of cryoprecipitate and supernatant, vysalivaniya last 30-50% saturation with ammonium sulfate, separation of the resulting precipitate components with 10 Mm CD from which components acidic nature with their subsequent liofilizirovannam. Technical result: the tool provides a reduction of treatment time specified group of patients. 1 Il.

The invention relates to medicine, namely to the means for treatment based on blood, and can be used in the treatment of patients with defects in epithelial tissues of various etiologies.

Known drugs developed on the basis of the donor blood or animal blood [1, 2], which are used topically in the form of topical applications either in the form of brainwashing. However these drugs in some cases cause reactions associated with immune incompatibility.

Known drug "Fibrolan" [3] containing plasmin and desoksiribonukleaza - gidroliticheskaya this medicine may develop allergic reactions. The preparation is indicated primarily for the treatment of complicated necrotic process damage epithelial tissues and poorly effective in the treatment of them during the formation of granulations. In addition, the use of the drug provides multiple overlay during the day, due to the nature of the action.

The objective of the invention is to develop tools that allow for the reduction of treatment time due to differential stimulation of epithelization processes in damages of integumentary tissues of various etiologies.

This task is solved in that the means to stimulate the process of epithelization of wounds containing components autoplasma, obtained by separation of cryoprecipitate and supernatant, vysalivaniya last 30-50% saturation with ammonium sulfate, separation of the resulting precipitate components with 10 Mm CD from which components acidic nature with their subsequent liofilizirovannam.

A means to stimulate the process of epithelization of the wound is illustrated by the description, an example of its production and use.

To obtain the patient's blood sample in an amount of 50 ml, of which well-known techniques of isolated plasma, and then share it on cryopreser is of 30-50% concentration. In the result, get the cake, which by means of gel chromatography share molecular weight to obtain a fraction with 10 Mm CD. Of the fractions obtained, for example, by using ion-exchange chromatography, produce acidic components that cialiswhat against distilled water and then freeze-dried, sterilized and subsequently stored at a temperature of 4-6oC. the resulting tool is a dry substance of white color.

When signs of the beginning of the process of epithelialization of the wound the patient of the proposed remedy in the form of a 0.1% solution applied to the surface of the wound. The application produces once a day until complete epithelialization of the wound.

Practical collection and use of tools to stimulate the process of epithelization of the wound illustrated by the following clinical supervision.

Example 1.

Patient T., 42 years old, was admitted in RISC "RTO" them. Acad. G. A. Ilizarov, diagnosed with atherosclerosis Obliterans of the lower extremities. Occlusion of right femoral artery, artery of the foot. Trophic ulcer of the right foot.

To stimulate collateral blood flow and activation of regenerative processes in tissues affected limb primene 3 months of treatment resulted in improved blood supply to the limbs. However, after the dismantling of the apparatus at the foot remained trophic ulcer size 1,2x1,2 see

In order to accelerate the healing of ulcers on the stage of the formation of granulation tissue, the patient was treated using the proposed tool. In this case, the patient had previously taken blood in a volume of 50 ml and by the described method has received a fraction of the plasma with 10 Mm CD, which has allocated acid components. Last liofilizirovanny and sterilized.

Obtained after maturation of granulation tissue was applied to the area of the defect once per day in the form of a 0.1% solution for 14 days. After 7 days of its application noted signs of contraction ulcers. By the end of the second week of the ulcer was covered with a crust of yellow-brown color. After separation of scab after 8 days on the site of the ulcer was located a young epithelial tissue pale pink color (drawing).

The use of the proposed tool provides a reduction of treatment time due to the targeted stimulation of the process of epithelialization of wounds in damages of integumentary tissues of various etiologies, eliminates the possibility of development of immune complications by making funds from autologous material.

Sources informacijska medicine. - 1984. - 3. - S. 96-97.

2. On The Main Page. Drugs in Russia: a Handbook. - M. : Attraversare. - 1995. - S. 242.

3. On The Main Page. Drugs in Russia: a Handbook. - M. : Attraversare. - 1995. - S. 931.

Claims

Tool to stimulate epithelialization of wounds containing components autoplasma, characterized in that it is obtained by separation of cryoprecipitate and supernatant, vysalivaniya last 30-50% saturation with ammonium sulfate, separation of the resulting precipitate components with 10 Mm CD from which components acidic nature with their subsequent liofilizirovannam.

 

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