Methods of obtaining discrete esters of stanol/sterol, connection
The invention provides a method of direct esterification of Stanlow and sterols with fatty acids with the formation of discrete stanulovic/stalowych esters of General formula Iwhere R1- C6-C23carbon chain, R2- C3-C15the carbon chain- possible unsaturation in position With5by interaction of the corresponding 3-hydroxy fatty acid CH3-(CH2)n-CO2N, where n=4-22, in the presence of a weak acid catalyst (NaHSO4in a vacuum, at a temperature of about 100-200oWith, the selection is carried out preferably using the water method. The method provides a synthetic route, which can be used in the industrial production of esters with high product yield. 3 C. and 10 C.p. f-crystals. Description text in facsimile form (see graphic part).
Claims1. A method of obtaining a discrete esters of scanalatura General formulawhere R1is6-C23carbon chain;R2is3and C5that includes the interaction of stanol/Sterol General formulawhere R2is3-C15carbon chain;has the above meaning,and fatty acid formulaCH3-(CH2)nCO2Nwhere n is an integer from 4 to 22, in the presence of a weak acid catalyst, under vacuum and at a temperature of about 100 - 200C, followed by separation of the target product.2. The method according to p. 1, in which the reaction is carried out in the absence of solvent in the molten fatty acid acts as a solvent.3. The method according to p. 1, in which the weak acid catalyst is NaHSO4.4. The method according to p. 1, in which the corresponding serology/stanulovic ester receive not less than about 98 wt.%.5. The method according to p. 1, in which R1complex ester stanol/Sterol has a value from C12to C21.6. The method according to p. 1, in which the selection of the appropriate stanovova/Stereolove of ester carried out using only water way.7. A method of obtaining a discrete esters of stanol/Sterol General formulais3-C15carbon chain;has the meaning specified in paragraph 1,including the interaction of stanol/Sterol formulawherehas the above meaning,with a polyunsaturated fatty acid with chain length from C6to C24carbon atoms in the presence of a weak acid catalyst, under vacuum and at a temperature of about 100 - 200C.8. The method according to p. 7, in which the reaction is carried out without added solvent in the molten fatty acid acts as a solvent.9. The method according to p. 7, in which the weak acid catalyst is NaHSO4.10. The method according to p. 7, in which the output of the corresponding stanovova/Stereolove of ester is not less than 98 wt.%.11. The method according to p. 7, in which the selection of the appropriate stanovova/Stereolove of ester is carried out using only water way.12. A compound selected from the group consisting oforwherehave the above meanings; R2is3Priorities for items:25.08.1998 on PP.1-13;15.12.1998 clarification of the characteristics of PP.1-13.
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FIELD: medicine, immunology.
SUBSTANCE: invention proposes an agent enhancing the immunogenic properties of tetanus anatoxin (adjuvant). Invention proposes the vegetable triterpenic compound miliacin as an agent enhancing immunogenic properties of tetanus anatoxin. Agent enhances the immune response value in its applying as a vaccine preparation of tetanus anatoxin. The agent miliacin elicits its stimulating effect for both the first and repeated administration of vaccine that allows suggesting its possible applying for prophylactic vaccinations with tetanus anatoxin. Taking into account the high tolerance of miliacin in the broad range of its doses it is suggested its practical applying as an agent promoting to the enhanced formation of vaccinal immunity in prophylactic vaccinations with tetanus anatoxin.
EFFECT: valuable medicinal properties of agent.