Derived cyclic amides, pharmaceutical composition and a drug containing, and a method of treating allergic diseases

 

Describes derivatives of cyclic amides of General formula I:where a means indenolol, phenyl, naftalina, dihydronaphthalene, pinolillo, pyridyloxy group which may be substituted; X is single bond, lower alkylenes group which may be substituted, bivalent residue of cycloalkane, fenelonov group, the divalent residue of pyridine or piperazine, aminogroup, which may be substituted, Y is a single bond, Allenova or alkylamino, Z - means-CH=CH-, -(CH=CH)2-, -CC-, -CC-CH=CH-, -CH=CH-CC-, fenelonov group which may be substituted, or a divalent residue of pyridine; the nitrogen atom or = CH-; m and n independently denote 2 or 3, provided that when-Y-X-Y - is the lowest alkalinous the group which is not substituted, and Z represents-CH= CH-, a is not phenyl group which is not substituted, pharmaceutical composition and a drug containing, and a method of treating immunological allergic diseases. 4 C. and 5 C.p. f-crystals, 11 PL.

Description text in facsimile form (see graphic part).

where a is indenolol, phenyl, naftilos, dihydronaphthalene, chinoline, peredelnoj group which may be substituted by 1-3 substituents selected from halogen atoms; groups of lower alkyl which may be substituted by 1-3 halogen atoms; lower alkoxy groups; lower alkylthio groups;

X represents a single bond; lower alkylenes group which may be substituted by one or more substituents selected from a carboxyl group, dialkylamino; divalent residue of cycloalkane having from 5 to 8 carbon atoms; fenelonov group; the divalent residue of pyridine or piperazine; aminogroup, which may be substituted by a lower alkyl group;

Y represents a single bond or lower alkylenes group or a lower alkylamino;

Z is a group-CH=CH-, -(CH=CH)2-, -CC -,- C-CH=CH-, -CH=CH-With phenylenebis group which may be substituted by one or more substituents selected from halogen atoms, nitro group, amino group, lower alkyl groups, lower alkoxygroup; or divalent residue of pyridine;

In is is ovii, when-Y-X-Y-is the lowest alkalinous the group which is not substituted, and Z represents-CH=CH-, a is not phenyl group which is not substituted,

salt of this compound or MES this connection.

2. Drug, possess inhibitory effect on the production of antibodies of class IgE, characterized in that it contains a compound of General formula I, its salt or its MES under item 1.

3. Drug under item 2, characterized in that it is an agent for the prevention and treatment of immunological allergic diseases.

4. Drug on PP.2 and 3, characterized in that it is an agent for prevention and treatment of asthma, atopic dermatitis, allergic rhinitis, inflammatory diseases of the large intestine, contact dermatitis or allergic ophthalmopathy.

5. Pharmaceutical composition having inhibitory effect on the production of antibodies of class IgE-containing compound, its salt or its MES under item 1 and a pharmaceutically acceptable carrier.

6. The compound, its salt or its MES under item 1 as drugs having inhibitory effect on the production of antibodies of the IgE class.

7. Connection, ergotrate and treatment of immunological allergic diseases.

8. The compound, its salt or its MES under item 6, characterized in that the said drug is an agent for prevention and treatment of asthma, atopic dermatitis, allergic rhinitis, inflammatory bowel disease, contact dermatitis or allergic ophthalmopathy.

9. A method of treating immunological allergic diseases, which comprises introducing the compound, its salt or its MES under item 1.

 

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And means

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