Treatment of gout with the help of the plasma

 

(57) Abstract:

The invention relates to medicine, to therapy, and can be used to treat gout. Spend the course of the plasma, consisting of three treatments with an interval of two days. This invention enhances the efficiency of the treatment of gout.

The invention relates to clinical medicine, in particular to therapy, and can be used to treat gout by using the plasma.

There is a method of treatment of gout with the help of hemosorption [1], when patients take blood, stabilize heparin and perfusion through carbon hemosorbent, achieving a reduction of uricemia, relief of symptoms of arthritis. This method of treating gout is an analogue of the present invention in terms of method of perfusion of biological fluid through hemosorbent and chosen as a prototype.

There is a method of cleaning the body from toxins and substances in excess accumulated in the body, using the plasma when the plasma perfusion through the column with hemosorbent [2]. This provides for a more efficient treatment of the biological fluid, because there is no adhesion thrombocytary by incorporating in the treatment method of the plasma.

This goal is achieved as follows.

The patient kateteriziruyut peripheral vein and with the aim of reducing the risk of hypovolemic complications spend volemic training by infusion of 400 ml reopoligliukina. Pre-heparinization carried out simultaneously with volemic preparation, in which the solution reopoligliukina add 12500 IU of heparin.

Then spend plasmapheresis procedure of a continuous production method according to the standard method, separating the blood into plasma and zitomers.

During the procedure, the liquid state of the blood in the extracorporeal circuit is supported fractional injection of heparin into the line of blood, directly at the site of venipuncture.

Titmuss goes into a bottle drive, which also serves as an "air trap". Plasma perpusilla through the column with hemosorbent and then fed into a bottle drive. Thus in a bottle-the storage titmuss resuspensions purified plasma and returned to the patient.

EXAMPLE

Patient B. C. A., 45 years old, was in the clinic with 23.02.2001 on 28.03.2001 with a diagnosis of Gout, chronic gouty arthritis, podagricus basic therapy due to ESRD (previously at the dose of 100 mg of allopurinol per day was marked by increased levels of creatinine in the blood) it was decided to hold the course of treatment of the plasma with the use of non-selective carbon hemosorbent.

After catheterization of peripheral veins was performed volemic training by infusion of 400 ml reopoligliukina with the addition 12500 IU of heparin. Plasmapheresis procedure on the device "PF-0,5" started 20-30 min.

During the procedure, the liquid state of the blood in the extracorporeal circuit was maintained fractional injection of heparin into the line of blood, directly at the site of venipuncture.

Then stable blood by means of a pump "Flow of blood" came in plasmofilter "PFM-800" where were divided into plasma and zitomers. Zitomers from the plasma filter came in a bottle-the drive, which also served as an "air trap". The separated plasma was perfesional through the sorption column, where she also acted in a bottle drive. Thus, in a bottle-the storage titmuss was resuspensions purified plasma and returned to the patient.

Course was conducted of the plasma, consisting of three treatments with an interval of 2 days (17, 20, and 23.03). The procedure was servirovaci 1000-1200 ml of plasma.

When carrying out the plasma was observed following lab dynamics: reducing uric acid levels with 653,4 to 322,1 Ámol/l after the first is/l, at discharge - 119,9 Ámol/L. it Was also noted improvement in renal function, which further enabled to assign the patient basic therapy with allopurinol.

In November 2001, the patient was examined in the outpatient setting: the level of uric acid - 431,2 Ámol/l, creatinine - 121,4 Ámol/l, the indices of renal function is normal.

LITERATURE

1. Matulis A. A., baracine I. P., Venalis A. I. Sorption methods of correction of hyperuricemia in treatment of gout.//Ter. arch. - 1987. - So 59. - 12. - S. 17-19.

2. Lopukhin Y. M., Molodenkov M. Hemosorption.//M - Medicine. - 1978. - 302 C.

A method of treating gout using hemosorbent, which consists in sampling the patient's blood, separation of blood cells from plasma, the return of the cell mass in a patient, characterized in that the conducting rate of the plasma, consisting of three treatments with an interval of two days.

 

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