Transdermal therapeutic system (tts) containing antioxidant

 

The invention relates to the pharmaceutical industry and relates to a pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methylphenylcarbinol and antioxidant, have higher stability as well as devices for transdermal administration. 2 s and 5 C. p. F.-ly.

Description text in facsimile form (see graphic part).

Claims

1. Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl] -N-methylphenylcarbinol (compound A) in free base form or in the form of an acid additive salt and an antioxidant.

2. The pharmaceutical composition under item 1, comprising 1-40 wt.% compounds in free base form or in the form of an acid additive salt.

3. The pharmaceutical composition under item 1 or 2, in which the antioxidant is a tocopherol and its esters, ascorbic acid, equivalent, butylhydroxyanisole or propylgallate, ascorbyl palmitate, preferably-tocopherol or ascorbyl palmitate.

4. The pharmaceutical composition according to any one of the preceding paragraphs, in which the antioxidant is present in amount from about 0.01 to about 0.5% in lane is tov, in which the antioxidant tocopherol is present in an amount of 0.1% based on the weight of the pharmaceutical composition.

6. The pharmaceutical composition under item 1, comprising a) a compound in free base form in the amount of 20-40 wt.%, b) polymethacrylate in the amount of 10-30 wt.%, C) a copolymer of acrylate in the amount of 40-60 wt.% and g)-tocopherol in an amount of 0.05-0.3 wt.%, where the total weight of the pharmaceutical composition taken as 100%.

7. Transdermal device comprising the pharmaceutical composition according to p. 1, a protective layer, which is the substrate for the pharmaceutical composition, the adhesive for contact and fixation farmacevticheskoi composition for a protective layer and separating the strip, in the absence of contact with this adhesive, it can be separated.

 

Same patents:

The invention relates to medicine, namely to pharmacology and psychiatry

The invention relates to new derivatives of benzothiadiazole, benzoxazoles and benzodiazines formula I in free base form or in the form of a pharmaceutically acceptable acid salt additive that can be used as an anxiolytic drug in the treatment of any condition, which is associated with increased endogenous levels of CRF or in which violated the regulation of the hPa system (hypothalamic - pituitary), or various diseases that are caused by CRF1or the manifestation of which contributes CRF1such as arthritis, asthma, allergies, anxiety, depression, etc

The invention relates to a new one with selective affinity to T6receptors, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]triazines General formula I, where X denotes a =C(R4)- or =N-, R1denotes phenyl, optionally substituted by one or more radicals of lower alkyl, halogen, lower alkoxygroup, tolyl, pyridyl, naphthyl or thiophenyl, R2denotes hydrogen, (ness.)alkyl, (ness.)thioalkyl or hydroxy(ness.) alkoxygroup, R3denotes amino(ness.)alkylamino, di(ness.)alkylamino, piperazinil, optionally substituted by one or more radicals, lower alkyl, benzyl, phenyl or hydroxy(NISS

The invention relates to medicine and can be used to prevent degeneration of nerve cells and accelerate the regeneration of nerve cells

The invention relates to medicine, namely to homeopathic, treatment and prevention tools for internal and external use, has tonic, anti-inflammatory, wound healing, detoxifying, anti-microbial, antianginal, anti-atherosclerotic, antioxidant, antihypoxic, neuroprotective, sedative, cardioprotective, anti-arrhythmic, angioprotective, stress-protective, immunotropic, antifungal, nephroprotective, hepatoprotective, gastroprotective, thermoprotector, lipoic, megaproducer, radioprotective, and retinoprotective anticoordination action

The invention relates to new Amida formula (1) (R1)(R2)-X-Y-Q-R3(1) where R1and R2taken together, constitute butylen or penttinen, each of which may be condensed with benzene, optionally substituted C1-C6alkoxy; R3represents phenyl, substituted with halogen, X represents CH, Y represents-NH - and Q is-C(O)-, provided that when R1and R2taken together, constitute butylen condensed with benzene, then indan ring formed when taking together R1, R2and S, substituted in position 2 by a group - Y-Q-R3and their salts

The invention relates to the field of medicine and relates to self-adhesive drug composition for percutaneous use of estrogen combined with progestogen containing 25-90 wt.% self-adhesive acrylate copolymer, 1-15 wt

The invention relates to medicine, specifically to the continuous process of forming a piece of patch for percutaneous exposure, contains the following stages: a continuous supply of strip material containing layer permeable membrane, a continuous supply for clamping the surfaces with the first strip, the second strip formed of an impermeable material basis, the joint transmission of the first and second strips through the position of the filling and sealing, in which the material containing the active substance is injected between the bands and the formation of pockets of the first covering devices that close up of the band with each other in the longitudinal direction of the strips, and the second covering device, that close up of the band with each other in the transverse direction of the bands; the size of the pockets regulate through regulating provisions and/or frequency of the first covering device and/or by regulating the quantity of provisions and/or the frequency of the second covering device

The invention relates to medicine, more specifically to the hormonal composition for local application system action to correct the deficiency POCs women in the premenopausal period and hormonal therapy for women in menopause, characterized in that it contains as active principle a synthetic progestogen that is derived 19-norprogesterone, carrier engaged in systemic passage of the indicated active agent selected from the group comprising solubilizers agent, an absorption promoter, film-forming agent, gelling agent, or mixtures thereof, combined or mixed with suitable excipients for pharmaceutical forms, such as gel and/or film
The invention relates to medicine and can be used in dentistry

The invention relates to medicine, namely to the adhesive polymer matrix applied to the device for percutaneous introduction of progestogenic, and this matrix is composed of a single layer (2) or the following sequential layers: if necessary, layer (1), called anchoring, formed of silicone polymer; a layer (2) formed of silicone polymer enriched Trimegestone and/or one or more pharmaceutically acceptable derivatives and, if necessary, a plasticizer; if necessary, the layer (3), called adhesive formed of silicone polymer

The invention relates to medicine, to compositions containing polar lipid composition on the basis of nicotine in liquid crystals and colloidal dispersions and their predecessors or secondary products, which are in contact with fluid body and/or under the influence of body temperature into liquid crystals, or a mixture of liquid crystals, which acts as a matrix with controlled release of nicotine, suitable for Smoking cessation and/or replacement area

The invention relates to medicine, and is intended for the treatment of inflammatory diseases of different etiology
The invention relates to medicine, namely to dentistry

The invention relates to medicine, in particular to the treatment of cancer, and can be used in the treatment of tumors of various origins
Up!