Derivatives of 2-aminopyridine, pharmaceutical composition and method of reception

 

The invention relates to new derivatives of 2-aminopyridine F.-ly (1) where denotes unsubstituted or substituted phenyl, pyridyl, thienyl, thiazolyl, hinely, cinoxacin-2-yl or Antonelliana derivatives; D is unsubstituted or substituted phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, hinely, triazolyl, oxazolyl, isoxazolyl or Antonelliana derivatives, provided that C and D are not simultaneously have the following values: S - phenyl, and D is phenyl, S - phenyl, and D - pyridyl, With - pyridyl and D - phenyl, - pyridyl and D - pyridyl; R1- R4- hydrogen, NO2or NH2. Connections F.-ly (1) exhibit hypolipidemic activity and can be used in medicine for treating disorders of lipid metabolism. 3 S. and 1 C. p. F.-ly, 1 PL.

Description text in facsimile form (see graphic part) TC

Claims

1. Derivatives of 2-aminopyridine formula I

where is phenyl, pyridyl, thienyl, thiazolyl, hinely, cinoxacin-2-yl or Antonelliana derivatives, and aromatic or heteroaromatic residue may be replacing the l, imidazolyl, hinely, triazolyl, oxazolyl, isoxazolyl or Antonelliana derivatives, and aromatic or heteroaromatic residue may be single or twofold substituted by chlorine, CF3, (C1-C8)-alkyl, (C1-C8-alkoxyl, (C0-C6-alkylpyridinium or (C0-C6)-alkyl-phenyl, and the phenyl residue may be substituted with halogen,

provided that C and D are not simultaneously have the following meanings:

With a = phenyl and D = phenyl, B = phenyl and D = pyridyl, C = pyridyl and D = phenyl, B = pyridyl and D = pyridyl;

R1, R2, R3and R4independently from each other hydrogen, -NO2or NH2.

2. The compounds of formula I on p. 1, characterized in that the C - phenyl, pyridyl, thienyl, thiazolyl, hinely, cinoxacin-2-yl, and aromatic or heteroaromatic residue may be substituted (C1-C8)-alkyl; D is phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, hinely, triazolyl, oxazolyl, isoxazolyl, and aromatic or heteroaromatic residue may be single or twofold substituted by chlorine, (C1-C8)-alkyl, provided that C and D are not simultaneously have the following values: C = phenyl and D = phenyl, B = phenyl and D = the other hydrogen, -NO2or NH2.

3. The pharmaceutical composition exhibiting hypolipidemic activity and containing one or more compounds under item 1 or 2.

4. A method of obtaining a pharmaceutical composition with lipid-lowering activity, characterized in that one or more compounds of the formula I under item 1 or 2 is mixed with a pharmaceutically acceptable carrier and this mixture is prepared in a form suitable for administration forms.

 

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< / BR>
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< / BR>
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< / BR>
represents an optionally substituted divalent residue of benzene, where the substituents are selected from unsubstituted lower alkyl groups, unsubstituted lower alkoxygroup, unsubstituted lower acyl group, a lower allylthiourea, lower alkylsulfonyl group, halogen atom, etc. or unsubstituted pyridine; Ar represents a phenyl group which may be substituted by one to four groups selected from unsubstituted lower alkyl group, the unsubstituted alkoxygroup, low allylthiourea, lower alkylsulfonyl group, and so on, optional substituted amino group, alkylenedioxy; X is-NH-, oxygen atom or sulfur atom; Y is a sulfur atom, sulfoxide or sulfon; Z represents a single bond or-NR2-; R2- the atom of hydrogen or unsubstituted lower alkyl group; l = 2 or 3; m = 2 or 3; n = 1, 2, or 3, or their salts, or their solvate

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