Derivatives benzylbiphenyl, methods for their production, biocidal composition, method of its production and the way of dealing with microorganisms

 

The invention relates to compounds of formula (I), their stereochemical isomeric forms, their salts obtained by the joining of acid or base, their N-oxides or Quaternary ammonium derivative, where the dotted line represents an optional bond; X is absent when the dotted line represents a bond, or X is a hydrogen or a hydroxy-group, when the dotted line is not a bond, R1, R2, R5and R6each independently selected from hydrogen, halogen, hydroxy-group, With1-4of alkyl, C1-4alkoxygroup, SO3N and the like; R3and R4each independently selected from hydrogen, halogen, hydroxy-group, With1-4of alkyl, C1-4alkoxygroup, nitro, amino, ceanography, trifloromethyl or cryptometer;represents a radical of the formula (a-1), (a-2), (a-3), (a-4), (a-5), (6), (7), (8), (9), (10), where a1represents a direct bond or C1-6alcander; And2represents a C2-6alcander; R7- R11represents hydrogen, C1-6alkyl, amino1-6alkyl and the like, provided that when L is a radical primenenie in agriculture. 7 C. and 8 C. p. F.-ly, 14 PL.

Description text in facsimile form (see graphic part).

Claims

1. Derivatives benzylbiphenyl formula (I)

their stereochemical isomeric form, and their salts accession acid or base, their N-oxides or Quaternary ammonium derivative,

where the dotted line represents an optional bond;

X is absent when the dotted line represents a bond, or

X represents hydrogen or a hydroxy-group, when the dotted line is not a bond;

R1and R2each independently selected from hydrogen, halogen, hydroxy-group, With1-4of alkyl, C1-4alkoxygroup, nitro, amino, ceanography, trifloromethyl, cryptometer, C1-6alkylcarboxylic, hydroxycarbonyl, C1-6alkoxycarbonyl, aminocarbonyl, di(C1-4alkyl)aminocarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfonyl, ingibiruet from hydrogen, halogen, hydroxy-group, With1-4of alkyl, C1-4alkoxygroup, nitro, amino, ceanography, trifloromethyl, cryptometer;

R5and R6each independently selected from hydrogen, halogen, hydroxy-group, With1-4of alkyl, C1-4alkoxygroup, nitro, amino, ceanography, trifloromethyl, cryptometer, C1-6alkylcarboxylic, hydroxycarbonyl, C1-6alkoxy-carbonyl, aminocarbonyl, di(C1-4alkyl) aminocarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfonyl, aminosulfonyl, di(C1-4alkyl) aminosulfonyl or SO3N;

L represents a radical of the formula

where a1represents a direct bond or C1-6alcander;

And2represents a C2-6alcander;

R7represents hydrogen, C1-4alkyl, phenyl or benzyl;

R8and R9each independently represents hydrogen, C1-6alkyl, amino1-6alkyl or mono - or di(C1-4alkyl)amino1-6alkyl;

R10represents hydrogen, C1-6alkyl, amino1-6alkyl or mono - or di(C1-4alkyl)amino1-61-4alkyl)amino1-6alkyl, provided that when L is a radical of formula (a-9), R11different from hydrogen.

2. Connection on p. 1, where L is a radical of formula (a-1), (a-2), (a-5), (a-7), (8) or (a-10) where R10represents hydrogen, C1-6alkyl or di(C1-4alkyl)amino-C1-6alkyl.

3. Connection on p. 1, where L is a radical of formula (a-3) or (a-9) where R11represents a C1-6alkyl, amino group, amino1-6alkyl or di(C1-4alkyl)amino1-6alkyl, and in the case of (a-3) R11is a hydrogen.

4. Connection on p. 1, where L is a radical of formula (a-4) or (a-6) where R8and R9each independently represents hydrogen, C1-4alkyl, amino1-6alkyl.

5. Connection on p. 1, where the connection is a

4-[[(1,1'-biphenyl)- 4-yl]phenylmethyl](1,4'-bipiperidine),

4-[[(1,1'-biphenyl)-4-yl]phenylmethyl]-1-piperidinophenyl,

N-[3-[(1,1'-biphenyl)-4-yl]-3-phenylpropyl]-1,3-propandiamine, and their salts accession acid or base, their stereoisomeric forms, their N-oxides or Quaternary ammonium derivatives.

6. Connection on p. 5, where salt accession acid represent from 8. Biocidal composition, acting on microorganisms, including one inert carrier or more and, if desired, other auxiliary substances and as an active ingredient biocide-effective amount of a compound according to any one of paragraphs.1-6.

9. Biocidal composition according to p. 8, additionally comprising one or more other active ingredients selected from bactericides, fungicides, insecticides, acaricides, nematicides and herbicides.

10. The composition according to p. 9, comprising an additional active ingredient in amounts giving a synergistic effect, and the media.

11. A method of obtaining a biocidal composition according to PP.8-10, characterized in that the active ingredients are mixed with the carrier until smooth.

12. The way to combat microorganisms through the application of one or more compounds according to any one of paragraphs.1-6 against the above-mentioned microorganisms.

13. The method of obtaining the compounds of formula (I), characterized in that magyarkanizsa biphenyl derivative of the formula (II')

where R1-R4are specified in paragraph 1 values;

hal represents chlorine, bromine or iodine,

subjected to interaction with the compound of the formula (III)

14. The method of obtaining the compounds of formula (I), characterized in that the compound of formula (V)

H-L',

where L' represents a radical of the formula (a-2), (a-3) or (a-6) to (a-10) specified in paragraph 1, where a1is a relation,

subjected to N-alkylation of an intermediate compound of formula (IV)

where R1-R6are specified in paragraph 1 values;

W represents a group to delete,

in an inert solvent and optionally in the presence of a suitable base to obtain the compounds of formula (I), where X represents hydrogen and the dotted line is no bond and L1have the above values, and if necessary, the resulting compound is transformed into another compound of formula (I) with the help of the obtained tting acid, or Vice versa, the salt of the compounds of formula (I) obtained by the joining of the acid is converted into the free base by treatment with alkali and, if desired, obtaining their stereochemical isomeric form.

15. The method of obtaining the compounds of formula (I), characterized in that the compound of formula (VI)

where R1- R6are specified in paragraph 1 values;

And1represents C1-6alcander,

W represents a group to delete,

subjected to interaction with the compound of the formula (VII) in an inert solvent, with a compound of formula (VII) has one of the following structures:

obtaining the compounds of formula (I), where L is a radical of the formula (a-6) to (a-10) specified in paragraph 1 and, if necessary, the compound obtained is transformed into another compound of formula (1) by known reactions, or, if desired, the compound of formula (I) is transformed into pharmaceutically acceptable salt obtained by the accession acid, or Vice versa, the salt of the compounds of formula (I) obtained by the joining of the acid is converted into the free base by treatment with alkali, and if gelatin the

 

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< / BR>
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< / BR>
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