The method of obtaining 4-(2-amino-ethyl)phenol

 

The invention concerns a method for obtaining 4-(2-amino-ethyl)phenol (tiramina), which is an important therapeutic derivatives of 2-phenethylamine, which due to the fact that increase blood pressure, is called "pressure" drugs. Recently tyramine received new applications for medical purposes in the manufacture of textile material for medical purposes, as well as intermediate compounds in the synthesis of the enzyme Ha. How is that 4-(2-hydroxyethyl)-2,6-di-tert. the butylphenol heated at 120-130oWith Hydrobromic acid with simultaneous removal from the reaction mixture of water and tert.the butylbromide with obtaining 4-(2-bromacil)phenol, which is kept in a solution of methanol with ammonia at a temperature of 10-15oWith obtaining hydrobromide tiramina, which is treated with an alkaline solution. The method allows high yield tyramine from available source connection of two chemical stage, get hydrobromide tiramina of phenol without isolation and purification of intermediate 4-(2-bramaterra).

Description text in facsimile form (see graphic part).

F. the pet.the butylphenol heated at 120-130C With Hydrobromic acid with simultaneous removal from the reaction mixture of water and tert.the butylbromide with obtaining 4-(2-bromacil)phenol, which is kept in a solution of methanol with ammonia at a temperature of 10-15C, obtaining hydrobromide tiramina, translated by treatment with an alkaline solution of 4-(2-amino-ethyl)phenol.

 

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4 tbl, 4 ex

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1 cl, 3 dwg, 1 tbl, 12 ex

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1 cl, 2 dwg, 1 tbl, 1 ex

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6 cl, 3 dwg, 2 tbl, 14 ex

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